← Back to Search
Surface Modification Of Cellulose Nanocrystal With Chitosan Oligosaccharide For Drug Delivery Applications
Seyedeh Parinaz Akhlaghi, R. Berry, K. C. Tam
Published 2013 · Materials Science
Download PDFAnalyze on Scholarcy
A novel drug delivery system based on two of the most abundant natural biopolymers was developed by modifying the surface of oxidized cellulose nanocrystal (CNC) with chitosan oligosaccharide (CSOS). First, the primary alcohol moieties of CNC were selectively oxidized to carboxyl groups using the 2,2,6,6-tetramethylpiperidine-1-oxyl radical catalyst. The amino groups of CSOS were then reacted with carboxylic acid groups on oxidized CNC (CNC-OX) via the carbodiimide reaction using N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide as coupling agents. Successful grafting of CSOS to CNC-OX was confirmed by infrared spectroscopy, thermogravimetry, potentiometric titration, and zeta potential measurements. The grafting resulted in a conversion of ~90 % carboxyl groups on CNC-OX and the degree of substitution was 0.26. CNC–CSOS nanoparticles showed a binding efficiency of 21.5 % and a drug loading of 14 % w/w. A drug selective electrode was used to directly measure the concentration of procaine hydrochloride released from CNC–CSOS particles. The in vitro drug release was studied at pH 8 and the nanoparticles revealed a fast release of up to 1 h, which can be used as biocompatible and biodegradable drug carriers for transdermal delivery applications.
This paper references
Rodlike Cellulose Microcrystals: Structure, Properties, and Applications
M. M. S. Lima (2004)
The use of nanocrystalline cellulose for the binding and controlled release of drugs
J. Jackson (2011)
Stability of water-soluble carbodiimides in aqueous solution.
M. A. Gilles (1990)
Chitin Based Biocomposites for Removal of Contaminants from Water: a Case Study of Fluoride Adsorption
J. R. Rangel-Mendez (2010)
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
M. George (2006)
Application of drug selective electrode in the drug release study of pH-responsive microgels.
Jeremy P. K. Tan (2007)
Surface modification of cellulose fiber via supramolecular assembly of biodegradable polyesters by the aid of host-guest inclusion complexation.
Q. Zhao (2010)
Fibrous macromolecular systems. Cellulose and muscle. The colloidal properties of cellulose micelles
B. G. Rånby (1951)
New strategy for chemical modification of hyaluronic acid: preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels.
P. Bulpitt (1999)
PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release.
N. Bhattarai (2005)
Small-scale systems for in vivo drug delivery
David A. LaVan (2003)
Thermally sensitive gels based on chitosan derivatives for the treatment of oral mucositis.
S. Rossi (2010)
Advances in mucoadhesion and mucoadhesive polymers.
V. Khutoryanskiy (2011)
The combustion of starch, cellulose and cationically modified products of these compounds investigated using thermal analysis
P. Aggarwal (1997)
Physicochemical Characteristics of Self-Assembled Nanoparticles Based on Glycol Chitosan Bearing 5β-Cholanic Acid
Seunglee Kwon (2003)
Isothermal titration calorimetry
E. Freire (1990)
Semiquantitative study of the EDC/NHS activation of acid terminal groups at modified porous silicon surfaces.
S. Sam (2010)
Atomic force microscopy characterization of cellulose nanocrystals.
Roya R. Lahiji (2010)
Review of recent research into cellulosic whiskers, their properties and their application in nanocomposite field.
M. A. S. Azizi Samir (2005)
TEMPO-mediated oxidation of cellulose III.
Denilson da Silva Perez (2003)
Biobased nanocomposites from layer-by-layer assembly of cellulose nanowhiskers with chitosan.
J. P. de Mesquita (2010)
TEMPO-Mediated Oxidation of Polysaccharides: Survey of Methods and Applications
P. Bragd (2004)
Cationic surface functionalization of cellulose nanocrystals
M. Hasani (2008)
Biodegradable and biocompatible polyampholyte microgels derived from chitosan, carboxymethyl cellulose and modified methyl cellulose
Neha Dhar (2012)
Mechanism of amide formation by carbodiimide for bioconjugation in aqueous media.
N. Nakajima (1995)
Encyclopaedia of controlled drug
S Brocchini (1999)
Synthesis of albumin-dextran sulfate microspheres possessing favourable loading and release characteristics for the anticancer drug doxorubicin
Y. Chen (1994)
Characterization and electromechanical performance of cellulose-chitosan blend electro-active paper
Zhijiang Cai (2008)
Bio-based nanocomposites obtained through covalent linkage between chitosan and cellulose nanocrystals.
J. P. de Mesquita (2012)
TEMPOmediated oxidation of cellulose
D da Silva Perez (2003)
Polymer Architecture and Drug Delivery
L. Y. Qiu (2005)
TEMPO-mediated oxidation of native cellulose. The effect of oxidation conditions on chemical and crystal structures of the water-insoluble fractions.
T. Saito (2004)
Preparation and characterization of hydrophobic derivatives of TEMPO-oxidized nanocelluloses
R. K. Johnson (2011)
Chiral-nematic self-ordering of rodlike cellulose nanocrystals grafted with poly(styrene) in both thermotropic and lyotropic states
Jie Yi (2008)
Coupling onto surface carboxylated cellulose nanocrystals
Nadège Follain (2010)
Deoxycholic acid-conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier.
S. Chae (2005)
Chitosan and Its Derivatives for Drug Delivery Perspective
C. P. Sharma (2011)
Zink-Sharp A (2011) Preparation and characterization of hydrophobic derivatives of TEMPOoxidized nanocelluloses
RK Johnson (2011)
TEMPO-mediated surface oxidation of cellulose whiskers
Y. Habibi (2006)
TEMPO-mediated Oxidation of Native Cellulose
T. Saito (2005)
Steric Stabilization of a Cellulose Microcrystal Suspension by Poly(ethylene glycol) Grafting
J. Araki (2001)
Effects of Ionic Strength on the Isotropic−Chiral Nematic Phase Transition of Suspensions of Cellulose Crystallites
X. Dong (1996)
Preparation by grafting onto, characterization, and properties of thermally responsive polymer-decorated cellulose nanocrystals.
Firas Azzam (2010)
Development of tailor-made collagen-glycosaminoglycan matrices: EDC/NHS crosslinking, and ultrastructural aspects.
J. S. Pieper (2000)
Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles.
M. Dunne (2000)
Review of recent research into cellulosic whiskers, their properties and their application in nanocomposite
MAS Azizi Samir (2005)
nano - crystals
Q Zhao (2010)
Grafting of zwitterion from cellulose membranes via ATRP for improving blood compatibility.
P. Liu (2009)
An approach to the evaluation of RNA solution structure and metal coordination chemistry by titration calorimetry
T. Ohyama (1996)
Formation and properties of chitosan-cellulose nanocrystal polyelectrolyte-macroion complexes for drug delivery applications.
Hezhong Wang (2011)
Grafting onto microfibrils of native cellulose
E. Lasseuguette (2008)
Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres.
N. Lin (2011)
Optimization of the isolation of nanocrystals from microcrystalline cellulose by acid hydrolysis
Daniel P Bondeson (2006)
The Synthetic Strategies for Unique Properties in Cellulose Nanocrystal Materials
Ilari Filpponen (2009)
by acid hydrolysis
PL Bragd (2004)
Ion exchange resins as drug delivery carriers
S. Sivaneswari (2015)
Topochemistry of carboxylated cellulose nanocrystals resulting from TEMPO-mediated oxidation
S. Montanari (2005)
Temperature-induced chiral nematic phase changes of suspensions of poly(N,N-dimethylaminoethyl methacrylate)-grafted cellulose nanocrystals
Jie Yi (2009)
pH-dependent interactions between adsorbed chitosan layers
P. Claesson (1992)
This paper is referenced by
Nature-derived fibrous nanomaterial toward biomedicine and environmental remediation: Today's state and future prospects
Fahanwi Asabuwa Ngwabebhoh (2019)
Multi-technique surface characterization of bio-based films from sisal cellulose and its esters: a FE-SEM, l-XPS and ToF-SIMS approach
Bruno V. M. RodriguesElina (2014)
Nanocellulose, a tiny fiber with huge applications.
Tiffany Abitbol (2016)
Bioadhesives: A Review
S. Khanlari (2013)
Nanocellulose-based polymer hybrids and their emerging applications in biomedical engineering and water purification
Dinesh K. Patel (2019)
[N-Methyl-2-pyrrolidone][C1-C4 carboxylic acid]: a novel solvent system with exceptional lignin solubility.
Liwen Mu (2015)
Biotemplated synthesis of cellulose nanocrystal@PVP-assisted polydopamine@Ag nanoparticle as conductive composites
Li Chen (2019)
Enhancement of Curcumin Bioavailability Using Nanocellulose Reinforced Chitosan Hydrogel
Thennakoon M. Sampath Udeni Gunathilake (2017)
Use of isothermal titration calorimetry to study surfactant aggregation in colloidal systems.
W. Loh (2016)
Nanocrystalline cellulose: Preparation, physicochemical properties, and applications in drug delivery systems.
A. Karimian (2019)
One-pot synthesis of trifunctional chitosan-EDTA-β-cyclodextrin polymer for simultaneous removal of metals and organic micropollutants
Feiping Zhao (2017)
Surface chemical functionalization of cellulose nanocrystals by 3-aminopropyltriethoxysilane.
Hossein Khanjanzadeh (2018)
Preparation and characterizations of oil palm fronds cellulose nanocrystal (OPF-CNC) as reinforcing filler in epoxy-Zn rich coating for mild steel corrosion protection.
Nur Fatin Silmi Mohd Azani (2020)
Aqueous synthesis and biostabilization of CdS@ZnS quantum dots for bioimaging applications
L. Chen (2015)
Cellulose-graft-poly(methyl methacrylate) nanoparticles with high biocompatibility for hydrophobic anti-cancer drug delivery
Lin Dai (2017)
Facile isolation of colloidal stable chitin nano-crystals from Metapenaeus ensis shell via solid maleic acid hydrolysis and their application for synthesis of silver nanoparticles
Liqin Liu (2020)
Cellulose nanocrystals: a versatile nanoplatform for emerging biomedical applications
Rajesh Sunasee (2016)
Use of Cellulose Nanocrystals in Chitosan Nanoparticles Carrier System for the Controlled Release of Ketoprofen
Abo-Elseoud Ws (2020)
Synthesis and characterization of pH-responsive and fluorescent poly (amidoamine) dendrimer-grafted cellulose nanocrystals.
L. Chen (2015)
Multi-technique surface characterization of bio-based films from sisal cellulose and its esters: a FE-SEM, μ-XPS and ToF-SIMS approach
Bruno V. M. Rodrigues (2014)
Preparation and release behavior of carboxylated cellulose nanocrystals-alginate nanocomposite loaded with rutin
Lia Asri (2018)
Functionalization of Cellulose Nanocrystals with Inorganic Nanoparticles
Li Chen (2016)
Eco-friendly extraction of cellulose nanocrystals from grape pomace and construction of self-healing nanocomposite hydrogels
Qichao Fan (2020)
Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose
A. Vikulina (2020)
The Application of Chitooligosaccharides on Biomaterials
Qiming Chen (2019)
Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone.
Ahmad Hivechi (2019)
Synthesis of amine functionalized cellulose nanocrystals: optimization and characterization.
Seyedeh Parinaz Akhlaghi (2015)
Design and synthesis of functionalized cellulose nanocrystals-based drug conjugates for colon-targeted drug delivery
Lirong Tang (2018)
Enhanced colloidal stability and antibacterial performance of silver nanoparticles/cellulose nanocrystal hybrids.
Zengqian Shi (2015)
Electrospun Cellulose and Nanocellulose Composites as a Biomaterial
Jaime A. Santillán-Mercado (2017)
Enhanced Antibacterial Performance and Cytocompatibility of Silver Nanoparticles Stabilized by Cellulose Nanocrystal Grafted with Chito-Oligosaccharides
X. Ni (2018)
Extraction of Cellulose Nanofibers and Their Eco/Friendly Polymer Composites
S. C. Agwuncha (2019)See more