Online citations, reference lists, and bibliographies.
← Back to Search

Host Innate Immune Response To Mycobacterium Tuberculosis

K. Bhatt, P. Salgame
Published 2007 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-γ-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.
This paper references
10.1126/SCIENCE.1068819
Adaptive Immune Response of Vγ2Vδ2+ T Cells During Mycobacterial Infections
Y. Shen (2002)
10.4049/jimmunol.166.12.7033
Infection of Human Macrophages and Dendritic Cells with Mycobacterium tuberculosis Induces a Differential Cytokine Gene Expression That Modulates T Cell Response1
E. Giacomini (2001)
10.1091/MBC.E02-12-0780
Mycobacterium's arrest of phagosome maturation in macrophages requires Rab5 activity and accessibility to iron.
V. A. Kelley (2003)
10.1126/SCIENCE.1133515
Dendritic Cell Stimulation by Mycobacterial Hsp70 Is Mediated Through CCR5
R. Floto (2006)
10.4049/jimmunol.173.5.3287
CCR5-Deficient Mice Control Mycobacterium tuberculosis Infection despite Increased Pulmonary Lymphocytic Infiltration1
Holly M. Scott Algood (2004)
10.1091/MBC.E03-05-0307
Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion.
I. Vergne (2004)
10.4049/jimmunol.169.7.3565
Pulmonary Surfactant Protein A Up-Regulates Activity of the Mannose Receptor, a Pattern Recognition Receptor Expressed on Human Macrophages1
A. Beharka (2002)
The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.
T. Means (1999)
10.1084/JEM.134.3.713
RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES
J. Armstrong (1971)
10.1016/J.COI.2005.06.006
Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection.
P. Salgame (2005)
10.1084/jem.20051239
The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis
P. Kang (2005)
10.1038/nature02837
A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
M. Reed (2004)
10.1111/j.1365-2249.2004.02577.x
IL‐10 down‐regulates costimulatory molecules on Mycobacterium tuberculosis‐pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients
S. de la Barrera (2004)
10.1016/S0140-6736(99)02301-6
Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study
R. Wilkinson (2000)
10.4049/jimmunol.167.2.910
Toll-Like Receptor 2-Dependent Inhibition of Macrophage Class II MHC Expression and Antigen Processing by 19-kDa Lipoprotein of Mycobacterium tuberculosis1
E. Noss (2001)
Disease-specific changes in gammadelta T cell repertoire and function in patients with pulmonary tuberculosis.
B. Li (1996)
10.1016/S1074-7613(03)00300-5
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
A. Villarino (2003)
10.1002/1521-4141(200204)32:4<994::AID-IMMU994>3.0.CO;2-6
Autocrine IL‐10 impairs dendritic cell (DC)‐derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL‐12 production
C. Demangel (2002)
Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra.
S. A. Fulton (1998)
ML: Cutting edge: Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation
SK Bromley (2000)
10.1016/S0966-842X(02)02440-X
Why are rod-shaped bacteria rod shaped?
A. Koch (2002)
10.4049/jimmunol.173.2.715
Understanding the Pro- and Anti-Inflammatory Properties of IL-271
A. Villarino (2004)
10.4049/jimmunol.170.3.1174
IFN-αβ Released by Mycobacterium tuberculosis-Infected Human Dendritic Cells Induces the Expression of CXCL10: Selective Recruitment of NK and Activated T Cells 1
R. Lande (2003)
10.4049/jimmunol.175.5.3268
In Vivo Depletion of CD11c+ Cells Delays the CD4+ T Cell Response to Mycobacterium tuberculosis and Exacerbates the Outcome of Infection1
T. Tian (2005)
10.1016/S1471-4906(03)00067-X
Novel IL-12 family members shed light on the orchestration of Th1 responses
F. Brombacher (2003)
10.1164/RCCM.200508-1294OC
Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis.
V. Guyot-Revol (2006)
10.1164/ARRD.1967.95.5.729
Pathogenesis of a first episode of chronic pulmonary tuberculosis in man: recrudescence of residuals of the primary infection or exogenous reinfection?
W. Stead (1967)
10.1128/IAI.66.11.5508-5514.1998
Role of γδ T Cells in Immunopathology of Pulmonary Mycobacterium avium Infection in Mice
B. Saunders (1998)
10.1182/BLOOD-2005-03-1281
Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.
V. Abadie (2005)
10.1016/S1359-6101(03)00054-6
Chemokines and tuberculosis.
H. Algood (2003)
Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha.
P. Tessier (1997)
10.4049/jimmunol.168.3.1294
Dendritic Cells Are Host Cells for Mycobacteria In Vivo That Trigger Innate and Acquired Immunity1
Xin'an Jiao (2002)
10.1159/000029291
Tuberculosis and HIV Infection: A Global Perspective
J. F. Murray (1998)
10.1126/SCIENCE.1088063
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
J. MacMicking (2003)
10.1083/JCB.200106049
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
R. Fratti (2001)
10.1086/429994
Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis.
H. Algood (2005)
10.1016/J.CLIM.2004.07.016
Mechanisms of mycobacterial persistence in tuberculosis.
D. Kusner (2005)
Target cell lysis and IL-2 secretion by gamma/delta T lymphocytes after activation with bacteria.
M. E. Munk (1990)
10.4049/jimmunol.177.7.4662
IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1
E. Lockhart (2006)
10.1111/j.1365-2249.2006.03027.x
A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis
R. Ribeiro-Rodrigues (2006)
10.1046/j.1365-2567.2003.01600.x
Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on γδ cells
E. Ferrero (2003)
10.1084/JEM.193.3.271
The Relative Importance of T Cell Subsets in Immunity and Immunopathology of Airborne Mycobacterium tuberculosis Infection in Mice
T. Mogues (2001)
10.1615/CRITREVIMMUNOL.V20.I5.30
Critical roles of Toll-like receptors in host defense.
T. Kaisho (2000)
10.1128/IAI.61.8.3482-3489.1993
Cytokine production at the site of disease in human tuberculosis.
P. F. Barnes (1993)
10.4049/jimmunol.170.4.1939
Constrained Intracellular Survival of Mycobacterium tuberculosis in Human Dendritic Cells 1
Ludovic Tailleux (2003)
10.4049/jimmunol.175.2.788
IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available1
S. Khader (2005)
10.1073/pnas.131207398
Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis
W. Peters (2001)
10.4049/jimmunol.172.7.4425
Toll-Like Receptor 2 (TLR2)-Dependent-Positive and TLR2-Independent-Negative Regulation of Proinflammatory Cytokines by Mycobacterial Lipomannans1
V. Quesniaux (2004)
10.4049/jimmunol.175.7.4611
Role of NK Cell-Activating Receptors and Their Ligands in the Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium1
R. Vankayalapati (2005)
10.4049/jimmunol.165.1.15
Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation1
S. Bromley (2000)
10.1111/j.1365-2249.1991.tb08149.x
Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol
M. Denis (1991)
10.1006/CLIM.1999.4752
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis Patients
F. Gerosa (1999)
10.1189/jlb.69.6.1036
Different Toll‐like receptor agonists induce distinct macrophage responses
B. Jones (2001)
CD4(+) T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients.
F. Gerosa (1999)
10.1016/J.MICINF.2005.12.023
A role for dendritic cells in the dissemination of mycobacterial infection.
I. Humphreys (2006)
10.4049/jimmunol.168.3.1328
Induction of TNF in Human Alveolar Macrophages As a Potential Evasion Mechanism of Virulent Mycobacterium tuberculosis1
M. Engele (2002)
10.1128/IAI.66.4.1277-1281.1998
Macrophage Receptors for Mycobacterium tuberculosis
J. Ernst (1998)
10.1136/ard.2005.042531
Immunological control of tuberculosis: role of tumour necrosis factor and more
S. Stenger (2005)
10.1038/nri1648
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
C. Hunter (2005)
10.1128/IAI.00621-06
Neutralization or Absence of the Interleukin-23 Pathway Does Not Compromise Immunity to Mycobacterial Infection
A. Chackerian (2006)
SM: in vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection
T Tian (2005)
Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha.
M. K. Balcewicz-Sablinska (1998)
10.4049/jimmunol.169.6.3155
Toll-Like Receptor 4 Expression Is Required to Control Chronic Mycobacterium tuberculosis Infection in Mice1
B. Abel (2002)
10.4049/jimmunol.171.11.6039
NK Cells Respond to Pulmonary Infection with Mycobacterium tuberculosis, but Play a Minimal Role in Protection 1
A. P. Junqueira-Kipnis (2003)
10.1002/path.1906
New insights into the function of granulomas in human tuberculosis
T. Ulrichs (2006)
10.1146/ANNUREV.IMMUNOL.19.1.93
Immunology of tuberculosis.
J. Flynn (2001)
10.1038/35021228
Toll-like receptors in the induction of the innate immune response
A. Aderem (2000)
10.1146/annurev.immunol.21.120601.141126
Toll-like receptors.
K. Takeda (2003)
Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice.
A. G. Castro (1995)
Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages.
C. D. Gaynor (1995)
10.4049/jimmunol.172.10.6272
Mycobacterium tuberculosis Inhibits Macrophage Responses to IFN-γ through Myeloid Differentiation Factor 88-Dependent and -Independent Mechanisms1
S. Fortune (2004)
10.4049/jimmunol.170.6.3154
Human NKT Cells Express Granulysin and Exhibit Antimycobacterial Activity 1
J. Gansert (2003)
10.1073/PNAS.0400983101
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.
F. Verreck (2004)
10.4049/jimmunol.165.5.2596
Mycobacterium tuberculosis Infection in Complement Receptor 3-Deficient Mice1
C. Hu (2000)
IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells.
R. Lande (2003)
10.1016/J.CHEMBIOL.2005.10.013
The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2.
M. Gilleron (2006)
10.1128/IAI.70.12.6672-6679.2002
Transgenic Mice Expressing Human Interleukin-10 in the Antigen-Presenting Cell Compartment Show Increased Susceptibility to Infection with Mycobacterium avium Associated with Decreased Macrophage Effector Function and Apoptosis
C. Feng (2002)
10.1128/IAI.70.11.6302-6309.2002
Activation of NKT Cells Protects Mice from Tuberculosis
A. Chackerian (2002)
10.1128/IAI.71.7.4112-4118.2003
Toll-Like Receptor 4-Defective C3H/HeJ Mice Are Not More Susceptible than Other C3H Substrains to Infection with Mycobacterium tuberculosis
A. Kamath (2003)
10.1056/NEJM198903023200901
A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection.
P. Selwyn (1989)
10.1128/IAI.68.2.577-583.2000
Neutrophils Play a Protective Nonphagocytic Role in Systemic Mycobacterium tuberculosis Infection of Mice
J. Pedrosa (2000)
10.1016/1074-7613(95)90001-2
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.
J. Flynn (1995)
Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.
L. Schlesinger (1990)
10.1128/IAI.68.5.2671-2684.2000
Deviant Expression of Rab5 on Phagosomes Containing the Intracellular Pathogens Mycobacterium tuberculosis andLegionella pneumophila Is Associated with Altered Phagosomal Fate
D. Clemens (2000)
10.1056/NEJM199806043382301
Global surveillance for antituberculosis-drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance.
A. Pablos-Mendez (1998)
10.1016/S1473-3099(03)00545-0
Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management.
M. Gardam (2003)
10.1128/IAI.65.1.298-304.1997
Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis.
J. Keane (1997)
10.1126/SCIENCE.291.5508.1544
[Induction of direct antimicrobial activity through mammalian toll-like receptors].
S. Stenger (2002)
10.4049/jimmunol.177.10.7086
NK Cell-Derived IFN-γ Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis
C. Feng (2006)
10.4049/jimmunol.178.8.5192
Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs1
L. Pompei (2007)
10.1046/j.1365-2567.2003.01680.x
Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis
A. Kipnis (2003)
10.1126/SCIENCE.1099384
Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages
Anne Walburger (2004)
10.1126/science.1123933
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
P. Liu (2006)
10.1128/IAI.70.11.5946-5954.2002
Mycobacterium tuberculosis in Chemokine Receptor 2-Deficient Mice: Influence of Dose on Disease Progression
H. Scott (2002)
Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.
Y. Shen (2002)
Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma.
D. Russell (1996)
10.1084/JEM.142.1.1
Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival
J. Armstrong (1975)
10.1084/JEM.182.6.1759
T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)- mediated apoptosis of CD4+ T cells from human immunodeficiency virus- infected persons
J. Estaquier (1995)
10.1086/315114
Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy.
C. Hirsch (1999)
10.1126/SCIENCE.8303277
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase.
S. Sturgill-Koszycki (1994)
10.1084/jem.20052545
Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
S. Khader (2006)
10.1016/J.PLEFA.2005.05.018
Anti-inflammatory pathways as a host evasion mechanism for pathogens.
J. Aliberti (2005)
10.1038/nature03419
Ipr1 gene mediates innate immunity to tuberculosis
H. Pan (2005)
10.1086/508894
Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs.
A. Kahnert (2007)
AM: in vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice
J Turner (2002)
10.1086/515698
Regulation of Interleukin-12 by Interleukin-10, Transforming Growth Factor-β, Tumor Necrosis Factor-α, and Interferon-γ in Human Monocytes Infected with Mycobacterium tuberculosis H37Ra
S. A. Fulton (1998)
10.4049/jimmunol.172.8.4672
Cutting Edge: Early IL-4 Production Governs the Requirement for IL-27-WSX-1 Signaling in the Development of Protective Th1 Cytokine Responses following Leishmania major Infection1
D. Artis (2004)
10.4049/jimmunol.173.12.7490
IL-27 Signaling Compromises Control of Bacterial Growth in Mycobacteria-Infected Mice1
J. Pearl (2004)
10.4049/jimmunol.168.9.4620
TNF Regulates Chemokine Induction Essential for Cell Recruitment, Granuloma Formation, and Clearance of Mycobacterial Infection1
D. R. Roach (2002)
10.4049/jimmunol.177.1.422
Mycobacterium tuberculosis LprA Is a Lipoprotein Agonist of TLR2 That Regulates Innate Immunity and APC Function1
Nicole D. Pecora (2006)
10.4049/jimmunol.169.11.6343
In Vivo IL-10 Production Reactivates Chronic Pulmonary Tuberculosis in C57BL/6 Mice1
J. Turner (2002)
10.4049/jimmunol.174.7.4203
Inverse Correlation of Maturity and Antibacterial Activity in Human Dendritic Cells1
M. Buettner (2005)
10.1084/JEM.184.4.1349
The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin
D. Clemens (1996)
10.1016/J.COI.2006.05.019
Autophagy as an immune defense mechanism.
V. Deretic (2006)
10.1038/nrmicro1538
Who puts the tubercle in tuberculosis?
D. Russell (2007)
CCR 2dependent trafficking of F 4 / 80 dim macrophages and CD 11 cdim / intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis
W Peters (2004)
10.1086/376451
Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro.
W. Hanekom (2003)
10.1164/ARRD.1965.91.6.811
THE PATHOGENESIS OF PULMONARY TUBERCULOSIS AMONG OLDER PERSONS.
W. Stead (1965)
Immune control of tuberculosis by IFN-gamma-inducible LRG-47.
J. MacMicking (2003)
10.1016/j.cell.2004.11.038
Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages
M. Gutierrez (2004)
Regulation of human CD4(+) alphabeta T-cell-receptor-positive (TCR(+)) and gammadelta TCR(+) T-cell responses to Mycobacterium tuberculosis by interleukin-10 and transforming growth factor beta.
R. Rojas (1999)
10.4049/jimmunol.168.3.1322
Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present1
A. Cooper (2002)
10.4049/jimmunol.168.9.4636
Mycobacterium tuberculosis Induces Differential Cytokine Production from Dendritic Cells and Macrophages with Divergent Effects on Naive T Cell Polarization1
S. P. Hickman (2002)
10.4049/jimmunol.176.5.3019
Potent Inhibition of Macrophage Responses to IFN-γ by Live Virulent Mycobacterium tuberculosis Is Independent of Mature Mycobacterial Lipoproteins but Dependent on TLR21
N. Banaiee (2006)
10.1128/IAI.69.3.1847-1855.2001
Effects of Tumor Necrosis Factor Alpha on Host Immune Response in Chronic Persistent Tuberculosis: Possible Role for Limiting Pathology
V. Mohan (2001)
10.1128/IAI.73.9.5782-5788.2005
Pulmonary Interleukin-23 Gene Delivery Increases Local T-Cell Immunity and Controls Growth of Mycobacterium tuberculosis in the Lungs
K. Happel (2005)
10.1086/345920
Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis.
A. A. Awomoyi (2002)
10.1136/jmg.2005.037960
No associations of human pulmonary tuberculosis with Sp110 variants
T. Thye (2006)
10.1128/JB.188.4.1364-1372.2006
Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione.
Yaswant K Dayaram (2006)
10.1073/PNAS.96.9.5141
Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls
I. Apostolou (1999)
10.4049/jimmunol.172.12.7647
CCR2-Dependent Trafficking of F4/80dim Macrophages and CD11cdim/intermediate Dendritic Cells Is Crucial for T Cell Recruitment to Lungs Infected with Mycobacterium tuberculosis1
W. Peters (2004)
10.4049/jimmunol.169.7.3480
Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with Mycobacterium tuberculosis1
N. Reiling (2002)
10.1126/SCIENCE.285.5428.732
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
H. Brightbill (1999)
10.1172/JCI9918
IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.
V. Boussiotis (2000)
10.1016/S1473-3099(03)00741-2
Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection.
J. Tufariello (2003)
10.1074/jbc.272.20.13326
Arrest of Mycobacterial Phagosome Maturation Is Caused by a Block in Vesicle Fusion between Stages Controlled by rab5 and rab7*
L. Via (1997)
10.1038/ncb1036
Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria
E. Anes (2003)
10.1016/J.CLIM.2005.04.005
Immune regulation of γδ T cell responses in mycobacterial infections
Z. Chen (2005)
10.1016/S0966-842X(00)01845-X
The Toll receptor family and microbial recognition.
R. Medzhitov (2000)
10.1073/pnas.0603340103
Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa
K. Tosh (2006)
10.4049/jimmunol.174.7.4185
Maintenance of Pulmonary Th1 Effector Function in Chronic Tuberculosis Requires Persistent IL-12 Production
C. Feng (2005)
10.1111/j.1462-5822.2004.00449.x
Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV
V. Deretic (2004)
10.4049/jimmunol.172.5.2748
Cutting Edge: A New Approach to Modeling Early Lung Immunity in Murine Tuberculosis1
K. Bhatt (2004)
10.4049/jimmunol.178.3.1723
The Chemokine Receptor CXCR3 Attenuates the Control of Chronic Mycobacterium tuberculosis Infection in BALB/c Mice1
Soumya D. Chakravarty (2007)
10.1128/IAI.00196-06
Constitutive Differences in Gene Expression Profiles Parallel Genetic Patterns of Susceptibility to Tuberculosis in Mice
M. O. Orlova (2006)
10.1084/jem.20051782
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
A. Báfica (2005)
10.1016/J.IMMUNI.2005.12.001
Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.
F. Winau (2006)
10.1016/S0952-7915(03)00075-X
Immune evasion by Mycobacterium tuberculosis: living with the enemy.
J. Flynn (2003)
Will DOTS do it? A reappraisal of tuberculosis control in countries with high rates of HIV infection.
De Cock Km (1999)
Disparity in mycobacterium tuberculosis-induced IL-12 release in dendritic cells and macrophages is due to utilization of distinct Toll-like receptors
L. Pompei (2007)
10.1111/j.1348-0421.2003.tb03404.x
Mycobacterial Infection in TLR2 and TLR6 Knockout Mice
I. Sugawara (2003)
10.1097/00000441-190612000-00018
IMMUNITY IN INFECTIVE DISEASES
Elie Metchnikoff (1906)
10.1002/eji.200323956
Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3‐signaling chemokines
P. Seiler (2003)
10.1016/0092-8674(89)90676-4
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
V. Kindler (1989)
10.1126/SCIENCE.288.5471.1647
Essential role for cholesterol in entry of mycobacteria into macrophages.
J. Gatfield (2000)
10.1046/j.1365-2249.1998.00636.x
Mice incapable of making IL‐4 or IL‐10 display normal resistance to infection with Mycobacterium tuberculosis
R. North (1998)
10.1046/j.1462-5822.2003.00330.x
Role of macrophage phospholipase D in natural and CpG‐induced antimycobacterial activity
G. Auricchio (2003)
10.1128/IAI.65.9.3644-3647.1997
Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages.
Y. Nozaki (1997)
10.1038/nm906
Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
U. Schaible (2003)
IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.
J. Flynn (1995)
10.1172/JCI117611
T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection.
M. Zhang (1994)
10.1097/00019048-200112000-00012
Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.
J. Keane (2001)
10.1016/S1286-4579(02)00082-5
Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis.
W. Peters (2003)
10.4049/jimmunol.173.4.2660
Mycobacterium tuberculosis LprG (Rv1411c): A Novel TLR-2 Ligand That Inhibits Human Macrophage Class II MHC Antigen Processing1
A. Gehring (2004)
10.4049/jimmunol.173.5.3392
IL-6 and IL-10 Induction from Dendritic Cells in Response to Mycobacterium tuberculosis Is Predominantly Dependent on TLR2-Mediated Recognition1
Sihyug Jang (2004)
10.1073/pnas.0737613100
Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest
R. Fratti (2003)
10.1111/j.0105-2896.2005.00227.x
Defects in the interferon‐γ and interleukin‐12 pathways
S. Rosenzweig (2005)
10.1111/j.1462-5822.2005.00612.x
Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension
M. Tsai (2006)
Role of gamma delta T cells in immunopathology of pulmonary Mycobacterium avium infection in mice.
B. Saunders (1998)
10.1016/J.TUBE.2004.10.003
Chemokine receptor 5 and its ligands in the immune response to murine tuberculosis.
A. P. Badewa (2005)
10.1128/IAI.69.2.800-809.2001
Fate of Mycobacterium tuberculosis within Murine Dendritic Cells
K. Bodnar (2001)
10.1016/J.MIB.2003.12.011
A tale of two lipids: Mycobacterium tuberculosis phagosome maturation arrest.
J. Chua (2004)
10.1002/j.1460-2075.1996.tb01088.x
Mycobacterium‐containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.
S. Sturgill-Koszycki (1996)
10.1074/JBC.272.1.117
Mycobacterium smegmatis Phosphoinositols-Glyceroarabinomannans
M. Gilleron (1997)
10.1001/JAMA.1995.03520270054031
Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic.
M. Raviglione (1995)
10.1084/JEM.175.4.1111
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages
J. Chan (1992)
10.1002/eji.200535727
Impaired maturation and function of dendritic cells by mycobacteria through IL‐1β
M. Makino (2006)



This paper is referenced by
10.1128/IAI.05574-11
Mycobacterium tuberculosis Hip1 Dampens Macrophage Proinflammatory Responses by Limiting Toll-Like Receptor 2 Activation
Ranjna Madan-Lala (2011)
10.1111/j.1365-2249.2011.04406.x
The in vivo immunomodulatory effect of recombinant tumour necrosis factor‐alpha in guinea pigs vaccinated with Mycobacterium bovis bacille Calmette–Guérin
J. Kramp (2011)
The Effect of Mycobacterium avium subspecies paratuberculosis Exposure on Animal Health
Katelyn McSpadden (2013)
10.1038/s41598-018-20433-x
Recombinant Mtb9.8 of Mycobacterium bovis stimulates TNF-α and IL-1β secretion by RAW264.7 macrophages through activation of NF-κB pathway via TLR2
S. Liu (2018)
10.17037/PUBS.01856014
The association between the magnitude of T-cell interferon-gamma responses to Mycobacterium tuberculosis specific antigens and risk of progression to tuberculosis in household contacts tested with QuantiFERON-TB Gold In-Tube Assay
K. Shanaube (2014)
10.1086/590565
Tuberculosis in poorly controlled type 2 diabetes: altered cytokine expression in peripheral white blood cells.
B. Restrepo (2008)
Clinical strains of mycobacterium tuberculosis induce strain-specific patterns of cytokine production, gene expression and pathway changes in pulmonary alveolar epithelial cells.
Nontobeko Eunice. Mvubu (2016)
Lipids as Indirect Biomarkers of Pulmonary Tuberculosis in Patients with and Without Hiv Infection in Addis Ababa, Ethiopia
Yemane Amare (2014)
Pertussis in infants: options for prevention
(2008)
10.4049/jimmunol.1700829
Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection
Xavier Michelet (2018)
10.1111/j.1365-3083.2008.02214.x
Effect of Vibrio cholerae on Chemokine Gene Expression in HT29 cells and its Modulation by Lactobacillus GG
N. Nandakumar (2009)
Avaliação de biomarcadores para diagnóstico e monitoramento do tratamento da tuberculose pulmonar
I. Takenami (2015)
10.1371/journal.pone.0164458
Mycobacterium tuberculosis Rv2882c Protein Induces Activation of Macrophages through TLR4 and Exhibits Vaccine Potential
Han-gyu Choi (2016)
10.1007/s00284-008-9172-2
Mycobacterium tuberculosis Antigen Wag31 Induces Expression of C-Chemokine XCL2 in Macrophages
W. Cao (2008)
10.1080/21645515.2018.1514224
IgY antibodies for the immunoprophylaxis and therapy of respiratory infections
A. Abbas (2019)
10.3389/fimmu.2017.00084
Mycobacterial Dormancy Systems and Host Responses in Tuberculosis
Vidyullatha Peddireddy (2017)
Immune function alterations in Asian elephants (Elephas maximus) infected with Mycobacterium species
J. Landolfi (2013)
10.1038/nrmicro2437
Nanobead-based interventions for the treatment and prevention of tuberculosis
Gareth Griffiths (2010)
Diabetes and tuberculosis: how strong is the association and what is the public health impact?
F. Pearson (2013)
10.1016/j.febslet.2008.01.007
Mycobacterial lipomannan induces MAP kinase phosphatase‐1 expression in macrophages
E. Elass (2008)
FACULDADE DE CIÊNCIAS FARMACÊUTICAS Programa de Pós-Graduação em Farmácia Área de Análises Clínicas Estudo dos mecanismos de virulência de cepas resistentes e sensíveis de Mycobacterium tuberculosis
Jamile Couto (2008)
10.1038/nrmicro2387
Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?
S. Behar (2010)
10.1016/j.jconrel.2018.10.012
Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins
Roberta Guagliardo (2018)
Evaluation of immunological markers for the diagnosis of active and latent tuberculosis
E. Borgström (2018)
10.1089/aid.2010.0004
Interferon-γ and IL-5 production correlate directly in HIV patients co-infected with mycobacterium tuberculosis with or without immune restoration disease.
B. Oliver (2010)
10.3389/fmicb.2011.00281
Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages
L. Danelishvili (2012)
Novel particulate BCG-loaded delivery system for mucosal immunization against tuberculosis
L. A. Caetano (2016)
Caracterização bioquímica, dinâmica molecular e propriedades imunomoduladoras da prolil oligopeptidase de Mycobacterium tuberculosis
Brina Portugal (2014)
10.1186/1476-0711-11-12
Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report
Jihyun Lee (2012)
10.1080/21691401.2018.1557674
Enhancement of the effect of BCG vaccine against tuberculosis using DDA/TDB liposomes containing a fusion protein of HspX, PPE44, and EsxV
Davood Mansury (2019)
Diagnostic tools and genetic susceptibility factors associated with bovine paratuberculosis infection
P. Pinedo (2008)
Estudio del rol de la vía de PD-1 sobre la respuesta inmune de células Nk y de los mecanismos inmunológicos inducidos por las células Th9 frente a la infección por M. tuberculosis
Ivana Belén Alvarez (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar