Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Compatibility Of Medroxyprogesterone Acetate And Pharmaceutical Excipients Through Thermal And Spectroscopy Techniques

R. Gao, B. Sun, J. Lin, Xiao-Li Gao
Published 2014 · Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Studies of active drug-excipient compatibility represent an important phase in the preformulation stage of the development of all dosage forms. For the development of conjugation estrogens and medroxyprogesterone acetate (MPA) double-layer tablets, techniques of thermal, isothermal stress testing (IST), and molecular vibrational spectroscopy analysis were performed to access the compatibility. Differential scanning calorimetry (DSC) studies were used as an important and complementary tool during preformulation to determine drug-excipient compatibility. On the basis of DSC results, MPA was found to be compatible with polyethylene glycol 6000. However, the results of Raman and IST studies showed that all the excipients defined in the prototype formula were found to be compatible with MPA. Overall, the compatibility of selected excipients with MPA was successfully evaluated using a combination of thermal and IST methods, and the formulations developed using the compatible excipients were found to be stable.
This paper references
10.1016/S1461-5347(99)00181-9
Differential scanning calorimetry: applications in drug development.
Clas (1999)
10.1080/03639040500306153
Compatibility Studies Between Ibuprofen or Ketoprofen with Cellulose Ether Polymer Mixtures Using Thermal Analysis
M. L. Vueba (2005)
10.1007/S10973-009-0382-Z
Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques
G. Bruni (2010)
10.1002/JPS.2600820715
Multiple-layer, direct-compression, controlled-release system: in vitro and in vivo evaluation.
R. Fassihi (1993)
10.1002/JPS.2600790314
Design and in vitro evaluation of slow-release dosage form of piretanide: utility of beta-cyclodextrin:cellulose derivative combination as a modified-release drug carrier.
K. Uekama (1990)
10.1081/DDC-100101284
Preparation and Evaluation of a Sustained-Release Formulation of Nifedipine HPMC Tablets
G. Yan (2000)
10.1007/s10973-012-2638-2
A DSC study of some biomaterials relevant to pharmaceutical industry
A. Singh (2012)
10.1081/PDT-120018476
A New Approach to Accelerated Drug-Excipient Compatibility Testing
J. L. Sims (2003)
10.2478/v10007-007-0038-0
Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride
C. N. Patra (2007)
10.1111/j.2042-7158.1993.tb05631.x
Design and In‐vitro Evaluation of a Modified‐release Oral Dosage Form of Nifedipine by Hybridization of Hydroxypropyl‐β‐cyclodextrin and Hydroxypropylcellulose
Z. Wang (1993)
10.1016/0378-5173(94)00374-E
Utilization of differential scanning calorimetry as a screening technique to determine the compatibility of ketoprofen with excipients
P. Mura (1995)
10.3109/03639048909040221
Compatibility Study Between Ketoprofen and Tablet Excipients Using Differential Scanning Calorimetry
S. Botha (1989)
10.1016/S0939-6411(99)00019-3
Formulation of biphasic release tablets containing slightly soluble drugs.
L. Maggi (1999)
10.1016/S0731-7085(98)00171-X
Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy.
P. Mura (1998)
Pharmaceutical thermal analysis : techniques and applications
J. L. Ford (1989)
10.1023/A:1010153014302
DSC in the Chemical Analysis of Drugs. Determination of diclofenac in pharmaceutical formulations
R. Bucci (2000)
10.1007/s10973-012-2577-y
Crystal growth, structural, thermal, and dielectric characterization of Tutton salt (NH4)2Fe(SO4)2·6H2O crystals
G. Ganesh (2012)
10.1208/pt0803076
Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen
Carla Martins Lopes (2008)
10.1016/S0378-5173(03)00288-6
Thermal analysis of the antiretroviral zidovudine (AZT) and evaluation of the compatibility with excipients used in solid dosage forms.
A. A. Araújo (2003)
10.5860/choice.37-6004
Concise dictionary of pharmacological agents: properties and synonyms.
I. K. Morton (1999)
10.1007/S10973-010-1185-Y
Thermal characterization of antimicrobial drug ornidazole and its compatibility in a solid pharmaceutical product
M. Soares (2011)
10.1007/s10973-011-1299-x
Application of DSC, IST, and FTIR study in the compatibility testing of nateglinide with different pharmaceutical excipients
N. R. Pani (2011)
10.1016/S0731-7085(96)01869-9
Application of differential scanning calorimetry and high performance liquid chromatography to determine the effects of mixture composition and preparation during the evaluation of niclosamide-excipient compatibility.
C. E. Malan (1997)
10.1016/S1461-5347(98)00066-2
Contribution of thermal methods and related techniques to the rational development of pharmaceuticals—Part 2
Danièle Giron (1998)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar