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Synthesis Of Peptides Employing Protected-Amino Acid Halides Mediated By Commercial Anion Exchange Resin

K. M. Bhaskara Redddy, Y. B. Kumari, K. Ananda
Published 2012 · Chemistry

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Coupling of protected-amino acid halides (chloride, fluoride) mediated by commercial anion exchange resin for the solution phase synthesis of peptides is described. The reaction was carried out in an organic medium, circumventing the use of an organic base or an inorganic base. The coupling is fast, clean and racemization free. The anion exchange resin functions as a solid-phase basic scavenger, soaking up the HCl produced and allowing the amine to react. The method is extended for the coupling of sterically hindered α,α,-dialkylamino acids.Graphical Abstract
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