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Targeted Anti-cancer Prodrug Based On Carbon Nanotube With Photodynamic Therapeutic Effect And PH-triggered Drug Release

Jianquan Fan, Fang Zeng, Jiangsheng Xu, Shuizhu Wu
Published 2013 · Materials Science
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Herein, we describe a multifunctional anti-cancer prodrug system based on water-dispersible carbon nanotube (CNT); this prodrug system features active targeting, pH-triggered drug release, and photodynamic therapeutic properties. For this prodrug system (with the size of ~100–300 nm), an anti-cancer drug, doxorubicin (DOX), was incorporated onto CNT via a cleavable hydrazone bond; and a targeting ligand (folic acid) was also coupled onto CNT. This prodrug can preferably enter folate receptor (FR)-positive cancer cells and undergo intracellular release of the drug triggered by the reduced pH. The targeted CNT-based prodrug system can cause lower cell viability toward FR-positive cells compared to the non-targeted ones. Moreover, the CNT carrier exhibits photodynamic therapeutic (PDT) action; and the cell viability of FR-positive cancer cells can be further reduced upon light irradiation. The dual effects of pH-triggered drug release and PDT increase the therapeutic efficacy of the DOX–CNT prodrug. This study may offer some useful insights on designing and improving the applicability of CNT for other drug delivery systems.
This paper references
SYNTHESIS AND CHARACTERIZATION OF
Ko Kang Ning (2011)
10.1021/ac2014788
Efficient spectrofluorimetric analysis of single-walled carbon nanotube samples.
J. R. R. Rocha (2011)
10.1021/la102556u
Nanocomposites containing gold nanorods and porphyrin-doped mesoporous silica with dual capability of two-photon imaging and photosensitization.
Tingting Zhao (2010)
10.1002/anie.200503389
Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway.
Nadine Wong Shi Kam (2006)
10.1007/S11051-011-0376-1
Multiwalled carbon nanotubes effect on the bioavailability of artemisinin and its cytotoxity to cancerous cells
Behzad Rezaei (2011)
10.1002/anie.200906891
Innovative inorganic-organic nanohybrid materials: coupling quantum dots to carbon nanotubes.
Christian Schulz-Drost (2010)
10.1634/theoncologist.2007-0180
Concept and clinical evaluation of carrier-mediated anticancer agents.
William C. Zamboni (2008)
10.1007/s11051-012-0964-8
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
10.1021/es048940x
Fullerol-sensitized production of reactive oxygen species in aqueous solution.
Karen D. Pickering (2005)
10.4155/TDE.12.66
Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays.
K. Gulati (2012)
10.1021/la035981i
Ethylene glycol monolayer protected nanoparticles: synthesis, characterization, and interactions with biological molecules.
Ming Zheng (2004)
10.1517/17425247.2010.538678
Use of nanoscale delivery systems to maintain synergistic drug ratios in vivo
Awa Dicko (2010)
10.1158/0008-5472.CAN-08-1468
Drug delivery with carbon nanotubes for in vivo cancer treatment.
Zhuang Liu (2008)
10.1021/bc060117y
An intramolecular cyclization reaction is responsible for the in vivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin.
Cameron C Y Lee (2006)
10.1016/j.biomaterials.2009.07.020
Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery.
Mani Prabaharan (2009)
10.1002/CHIN.200816270
Functionalized Carbon Nanotubes in Drug Design and Discovery
Maurizio Prato (2008)
10.1002/CHIN.201231239
Targeting Carbon Nanotubes Against Cancer
Chiara Fabbro (2012)
10.1007/S11051-011-0533-6
Synthesis and characterization of “mulberry”-like Fe3O4/multiwalled carbon nanotube nanocomposites
Haojie Song (2011)
10.1007/s11051-012-0829-1
Enzyme-encapsulated silica nanoparticle for cancer chemotherapy
Yi-Rong Chiu (2012)
10.1002/anie.201201991
Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile.
Khuloud T. Al-Jamal (2012)
10.2174/092986708785132997
Recent trends in targeted anticancer prodrug and conjugate design.
Yashveer Singh (2008)
10.1089/EES.2010.0103
Comparison of Methods for Fullerene Detection and Measurements of Reactive Oxygen Production in Cosmetic Products
So-Ryong Chae (2010)
10.1021/bm049884v
Targeted worm micelles.
Paul Dalhaimer (2004)
10.1007/s00216-009-3062-8
Fluorimetric characterization of single-walled carbon nanotubes
R Bruce Weisman (2010)
10.1021/ja050930o
Functional single-wall carbon nanotube nanohybrids--associating SWNTs with water-soluble enzyme model systems.
Dirk M Guldi (2005)
10.1021/la901813t
Aromatic electron acceptors change the chirality dependence of single-walled carbon nanotube oxidation.
Fritz J. Knorr (2009)
10.1039/C2JM30454F
Zippered release from polymer-gated carbon nanotubes
Afnan Mashat (2012)
10.1021/JA805570F
Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery.
Jingyi Chen (2008)
10.1007/s11051-012-1127-7
Aggregation of gold nanoparticles followed by methotrexate release enables Raman imaging of drug delivery into cancer cells
C. V. Durgadas (2012)
10.1002/adma.200401340
COVALENT SURFACE CHEMISTRY OF SINGLE-WALLED CARBON NANOTUBES
Sarbajit Banerjee (2005)
10.1016/S0009-2614(01)01035-1
END-GROUP AND DEFECT ANALYSIS OF SOLUBLE SINGLE-WALLED CARBON NANOTUBES
Mark A. Hamon (2001)
10.1039/B614305A
A highly water-soluble C60-NVP copolymer: a potential material for photodynamic therapy.
Yuko Iwamoto (2006)
10.1002/smll.201201456
Water-dispersible fullerene aggregates as a targeted anticancer prodrug with both chemo- and photodynamic therapeutic actions.
Jianquan Fan (2013)
10.1021/bm301424r
Polymer micelle with pH-triggered hydrophobic-hydrophilic transition and de-cross-linking process in the core and its application for targeted anticancer drug delivery.
Jianquan Fan (2012)
Synthesis and characterization of ‘ ‘ mulberry ’ ’ - like Fe 3 O 4 / multiwalled carbon nanotube nanocomposites
HJ Song (2011)
10.1039/b500266d
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.
Younsoo Bae (2005)
10.1002/CMDC.200700159
Prodrug strategies in anticancer chemotherapy.
Felix Kratz (2008)
10.1021/JP711975A
Kinetically Controlled Side-Wall Functionalization of Carbon Nanotubes by Nitric Acid Oxidation
Hao Yu (2008)
10.1016/S1369-7021(11)70161-4
Carbon materials for drug delivery & cancer therapy
Zhuang Liu (2011)
10.1021/nl072969s
Single-particle tracking of endocytosis and exocytosis of single-walled carbon nanotubes in NIH-3T3 cells.
Hong Jin (2008)
10.1021/ES702172W
Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water.
Ernest M. Hotze (2008)
10.1006/viro.1998.9488
Characterization of avian H5N1 influenza viruses from poultry in Hong Kong.
Kennedy F. Shortridge (1998)
10.1016/S0165-022X(03)00150-7
Reduced nonspecific adsorption on covalently immobilized protein surfaces using poly(ethylene oxide) containing blocking agents.
Filip Frederix (2004)
10.1021/bc060401p
In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments.
Younsoo Bae (2007)
10.1039/C0JM03851B
Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility
Qianjun He (2011)
10.1021/nn700040t
Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery.
Zhuang Liu (2007)
10.1016/s1369-7021(11)70004-9
Ultrasensitive microwave detector
Laurie D. Donaldson (2011)
10.1006/viro.1997.8916
The M1 and M2 proteins of influenza A virus are important determinants in filamentous particle formation.
Paul Christopher Roberts (1998)
10.1039/c0cc02411b
Carbon nanostructures for solar energy conversion schemes.
Dirk M Guldi (2011)
10.1007/s11051-012-0984-4
Magnetic carbon nanotubes: synthesis by a simple solvothermal process and application in magnetic targeted drug delivery system
Deli Xiao (2012)
10.1016/j.addr.2006.09.020
Thermo- and pH-responsive polymers in drug delivery.
Dirk Schmaljohann (2006)
10.3390/ma5020278
Carbon Nanotubes: Solution for the Therapeutic Delivery of siRNA?
Donald L. Kirkpatrick (2012)
10.1021/es901165q
Evaluation of the oxidation of organic compounds by aqueous suspensions of photosensitized hydroxylated-C60 fullerene aggregates.
So-Ryong Chae (2009)
10.1021/bc900422j
Tumor-targeting, pH-responsive, and stable unimolecular micelles as drug nanocarriers for targeted cancer therapy.
Xiaoqiang Yang (2010)
10.1021/nn100069k
Higher dispersion efficacy of functionalized carbon nanotubes in chemical and biological environments.
Elena Heister (2010)
10.1038/nnano.2007.70
Shape effects of filaments versus spherical particles in flow and drug delivery.
Yan Geng (2007)
10.1021/es901110m
Mechanisms of bacteriophage inactivation via singlet oxygen generation in UV illuminated fullerol suspensions.
Ernest M. Hotze (2009)
10.1039/c2cc17690d
A multi-drug delivery system with sequential release using titania nanotube arrays.
M. Aw (2012)
10.1007/s11051-012-1185-x
A novel method for synthesis of 56Co-radiolabelled silica nanoparticles
I. Cydzik (2012)
10.1021/JA073975T
Spectroscopic characterization of photolytically generated radical ion pairs in single-wall carbon nanotubes bearing surface-immobilized tetrathiafulvalenes.
M. Herranz (2008)
10.2174/157341311795542444
Carbon nanotubes as an advanced drug and gene delivery nanosystem
J. E. N. Dolatabadi (2011)
10.1021/ja100065h
Immobilizing water-soluble dendritic electron donors and electron acceptors-phthalocyanines and perylenediimides-onto single wall carbon nanotubes.
Uwe Hahn (2010)
Waterdispersible fullerene aggregates as a targeted anticancer prodrug with both chemo- and photodynamic therapeutic
JQ Fan (2013)
10.1088/0957-4484/22/45/455102
Targeted anticancer prodrug with mesoporous silica nanoparticles as vehicles.
Jianquan Fan (2011)
10.1021/ja0350278
Ethylene glycol monolayer protected nanoparticles for eliminating nonspecific binding with biological molecules.
Ming Zheng (2003)
10.1007/s11051-011-0695-2
Modeling the binding of peptides on carbon nanotubes and their use as protein and DNA carriers
Vanesa Sanz (2012)
10.1002/ADMA.200800548
In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy
Hsiung-Lin Tu (2009)



This paper is referenced by
10.1201/B18724-30
- Applications of Functionalized Carbon-Based Nanomaterials
J. Sadhik Basha (2015)
10.2174/1381612825666190902155957
Combination therapies of Artemisinin and its derivatives as a viable approach for future cancer treatment.
M. Sumanth Kumar (2019)
10.1201/b19457-21
Encapsulation: Characterization of Carbon Nanotubes for Doxorubicin Encapsulation
Pavel Kopel (2016)
10.3390/bios7010009
Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment
Alessandro Sanginario (2017)
10.1002/9783527683451.CH17
Nanoparticle Bioconjugates: Materials that Benefit from Chemoselective and Bioorthogonal Ligation Chemistries
Melissa Massey (2017)
Synthesis, characterization and cytotoxicity evaluation of carboxylated carbon nanotubes functionalized with silibinin, betulinic acid and levodopa for drug delivery
Julia Meihua Tan (2015)
10.3390/molecules21111585
Carbon-Based Materials for Photo-Triggered Theranostic Applications
Karunya Albert (2016)
10.1155/2014/862148
Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
Julia Meihua Tan (2014)
10.1016/j.biomaterials.2014.02.022
The cancer targeting potential of D-α-tocopheryl polyethylene glycol 1000 succinate tethered multi walled carbon nanotubes.
Neelesh Mehra (2014)
10.1016/J.MOLLIQ.2018.04.097
Molecular dynamics study on the configuration and arrangement of doxorubicin in carbon nanotubes
Li Zhang (2018)
10.1208/s12248-014-9638-z
Prodrug Applications for Targeted Cancer Therapy
Irene Giang (2014)
10.1007/s11051-014-2781-8
Self-assembled nanocomplexes of anionic pullulan and polyallylamine for DNA and pH-sensitive intracellular drug delivery
Lalit Vora (2014)
10.25148/ETD.FIDC000130
Multifunctional Nanoparticles for Theranostic Applications
Supriya Srinivasan (2015)
10.1007/s11051-018-4239-x
Synthesis, characterization, and interactions of single-walled carbon nanotubes modified with doxorubicin with Langmuir–Blodgett biomimetic membranes
Dorota Matyszewska (2018)
10.1021/mp500720a
One platform comparison of estrone and folic acid anchored surface engineered MWCNTs for doxorubicin delivery.
Neelesh Kumar Mehra (2015)
10.3892/etm.2019.7510
Multi-walled carbon nanotube-based systems for improving the controlled release of insoluble drug dipyridamole
Wenquan Zhu (2019)
10.1007/s11051-015-3181-4
Comparison of cellular toxicity between multi-walled carbon nanotubes and onion-like shell-shaped carbon nanoparticles
Seunghyon Kang (2015)
10.1680/SI.13.00040
Drug delivery systems in the transport of doxorubicin
Dorota Matyszewska (2014)
10.3390/polym11050896
Receptor-mediated Uptake of Folic Acid-functionalized Dextran Nanoparticles for Applications in Photodynamic Therapy
Kathrin Butzbach (2019)
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