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Inclusion Complex Of Novel Curcumin Analogue CDF And β-Cyclodextrin (1:2) And Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer
P. Dandawate, A. Vyas, A. Ahmad, S. Banerjee, J. Deshpande, K. Swamy, Abeda Jamadar, Anne Catherine Dumhe-Klaire, S. Padhye, F. Sarkar
Published 2012 · Chemistry, Medicine
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PurposeSeveral formulations have been proposed to improve the systemic delivery of novel cancer therapeutic compounds, including cyclodextrin derivatives. We aimed to synthesize and characterize of CDF-β-cyclodextrin inclusion complex (1:2) (CDFCD).MethodsThe compound was characterized by Fourier transform infrared, differential scanning calorimetry, powder X-ray diffraction studies, H1 & C13 NMR studies and scanning electron microscopic analysis. Its activity was tested against multiple cancer cell lines, and in vivo bioavailability was checked.ResultsCDF-β-cyclodextrin was found to lower IC50 value by half when tested against multiple cancer cell lines. It preferentially accumulated in the pancreas, where levels of CDF-β-cyclodextrin in mice were 10 times higher than in serum, following intravenous administration of an aqueous CDF-β-cyclodextrin preparation.ConclusionsNovel curcumin analog CDF preferentially accumulates in the pancreas, leading to its potent anticancer activity against pancreatic cancer cells. Synthesis of such CDF-β-cyclodextrin self-assembly is an effective strategy to enhance its bioavailability and tissue distribution, warranting further evaluation for CDF delivery in clinical settings for treatment of human malignancies.
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