Online citations, reference lists, and bibliographies.

Ectopic Growth Hormone-releasing Hormone Secretion By A Metastatic Bronchial Carcinoid Tumor: A Case With A Non Hypophysial Intracranial Tumor That Shrank During Long Acting Octreotide Treatment

Patricia Fainstein Day, Lawrence A. Frohman, Hernán García Rivello, Jean Claude Reubi, Gustavo Emilio Sevlever, Mariela Glerean, Tomas Fernández Gianotti, Marcelo Pietrani, Alejandra T. Rabadán, Silvina Racioppi, Martin Bidlingmaier
Published 2007 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Ectopic acromegaly represents less than 1% of the reported cases of acromegaly. Although clinical improvement is common after treatment with somatostatin (SMS) analogs, the biochemical response and tumor size of the growth hormone-releasing hormone (GHRH)-producing tumor and its metastases are less predictable. Subject A 36-year-old male was referred because of a 3-year history of acromegaly related symptoms. He had undergone lung surgery in 1987 for a “benign” carcinoid tumor. Endocrine evaluation confirmed acromegaly Plasma IGF-1: 984 ng/ml (63–380), GH: 49.8 ng/ml (<5). MRI showed a large mass in the left cerebellopontine angle and diffuse pituitary hyperplasia. Pulmonary, liver and bone metastases were shown by chest and abdominal CT scans. Ectopic GHRH secretion was suspected. Methods Measurement of circulating GHRH levels by fluorescence immunoassay levels and immunohistochemical study of the primary lung tumor and metastatic tissue with anti-GHRH and anti-somatostatin receptor type 2 (sst2A) antibodies. Results Basal plasma GHRH: 4654 pg/ml (<100). Pathological study of liver and bone biopsy material and lung tissue removed 19 years earlier was consistent with an atypical carcinoid producing GHRH and exhibiting sst2A receptor expression. Treatment with octreotide LAR 20–40 mg q. month resulted in normalization of plasma IGF-1 levels. Circulating GHRH levels decreased dramatically. The size of the left prepontine cistern mass, with SMS receptors shown by a radiolabeled pentetreotide scan, decreased by 80% after 18 months of therapy. Total regression of pituitary enlargement was also observed. No changes were observed in lung and liver metastases. After 24 months of therapy the patient is asymptomatic and living a full and active life.
This paper references
10.1007/s002590050269
Somatostatin receptor imaging in intracranial tumours
Matthias E. Schmidt (1998)
10.1006/frne.1999.0183
Somatostatin and Its Receptor Family
Yogesh Patel (1999)
10.1093/ajcp/85.1.13
Immunocytochemical demonstration of growth hormone-releasing factor in gastrointestinal and pancreatic endocrine tumors.
Yogeshwar Dayal (1986)
Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies.
Eva Tiensuu Janson (1998)
10.1126/science.279.5350.563
Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study
June M. Chan (1998)
10.1111/j.1365-2265.1991.tb00326.x
Plasma growth hormone (GH)-releasing hormone levels in patients with lung carcinoma.
Jochen Schopohl (1991)
10.1210/jcem.84.9.6001
Hormonal and volumetric long term control of a growth hormone-releasing hormone-producing carcinoid tumor.
Annick Van den Bruel (1999)
[Five year remission of GHRH secreting bronchial neuroendocrine tumor with symptoms of acromegaly. Utility of chromogranin A in the monitoring of the disease].
Marek Bolanowski (2006)
10.1210/edrv.19.6.0350
The cytogenesis and pathogenesis of pituitary adenomas.
S. Asa (1998)
10.1002/1097-0142(19880115)61:2<221::AID-CNCR2820610203>3.0.CO;2-3
Acromegaly from ectopic growth hormone-releasing hormone secretion by a malignant carcinoid tumor. Successful treatment with long-acting somatostatin analogue SMS 201-995.
Ariel L. Barkan (1988)
10.1016/s0889-8529(18)30203-2
Ectopic acromegaly.
Giovanni Faglia (1992)
10.1677/erc.1.01191
Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2.
Emanuele Ferrante (2006)
10.1210/jc.2004-2156
Somatostatin analogs in vitro effects in a growth hormone-releasing hormone-secreting bronchial carcinoid.
Maria Chiara Zatelli (2005)
10.1046/j.1365-2265.2001.01268.x
Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly.
Nor Hayati Othman (2001)
10.1002/cncr.20659
Carcinoid metastasis to the brain.
R. Hlatký (2004)
10.1210/jcem.83.9.5088
Long-acting lanreotide induces clinical and biochemical remission of acromegaly caused by disseminated growth hormone-releasing hormone-secreting carcinoid.
Marlys R. Drange (1998)
10.1097/01.ten.0000089860.69958.83
Acromegaly Secondary to Ectopic Growth Hormone-Releasing Hormone-Secreting Bronchial Carcinoid Cured After Pneumectomy
Vaneska Spinelli Reuters (2003)
10.1210/jcem-68-2-499
Octreotide suppresses both growth hormone (GH) and GH-releasing hormone (GHRH) in acromegaly due to ectopic GHRH secretion.
David E. Moller (1989)
10.1097/01.pas.0000174013.14569.90
Value of Immunohistochemistry for Somatostatin Receptor Subtype sst2A in Cancer Tissues: Lessons From the Comparison of Anti-sst2A Antibodies With Somatostatin Receptor Autoradiography
Meike Körner (2005)
10.1210/jc.2005-0633
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
Paola Luciani (2005)
10.1093/annonc/12.suppl_2.S89
Ectopic secretion of growth hormone-releasing hormone (GHRH) in neuroendocrine tumors: relevant clinical aspects.
Mauro Doga (2001)
10.1172/JCI112679
Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus.
Lawrence A. Frohman (1986)
10.1258/0022215053945886
Indium111 pentetreotide single photon emission computed tomography (In111 pentetreotide SPECT): a new technique to evaluate somatostatin receptors in chordomas.
Stefano Di Girolamo (2005)
10.1016/S0003-4975(96)00435-3
Molecular markers help characterize neuroendocrine lung tumors.
Valerie Rusch (1996)
10.1097/00006123-200206000-00029
Acromegaly Caused by a Growth Hormone-releasing Hormone-secreting Carcinoid Tumor: Case Report
Thomas J. Altstadt (2002)
[Intracerebral metastasis of a bronchial carcinoid tumor].
A. Ohnsmann (1992)
10.1210/endo-125-2-801
Immunohistochemical analysis of human growth hormone-releasing hormone gene expression in transgenic mice.
Anoop K. Brar (1989)
10.1530/eje.0.1330320
Subcutaneous octreotide treatment of a growth hormone-releasing hormone-secreting bronchial carcinoid: superiority of continuous versus intermittent administration to control hormonal secretion.
Sharon Lefebvre (1995)
10.1210/jcem-67-2-395
Medical management of acromegaly due to ectopic production of growth hormone-releasing hormone by a carcinoid tumor.
Shlomo Melmed (1988)
10.1172/JCI109658
Partial purification and characterization of a peptide with growth hormone-releasing activity from extrapituitary tumors in patients with acromegaly.
Lawrence A. Frohman (1980)
10.1046/j.1365-2265.2002.01535.x
Ectopic growth hormone-releasing hormone secretion by thymic carcinoid tumour.
Esther Boix (2002)
10.1016/s0889-8529(18)30256-1
Extrapituitary acromegaly.
Shlomo Melmed (1991)
10.1016/s0169-5002(86)80053-8
Neuroendocrine neoplasms of the bronchopulmonary tract. A classification of the spectrum of carcinoid to small cell carcinoma and intervening variants.
William H. Warren (1985)
10.1111/j.1365-2265.2004.02084.x
Systematic dose-extension of octreotide LAR: the importance of individual tailoring of treatment in patients with acromegaly.
Helen E Turner (2004)
10.1016/S0928-4257(00)00206-0
Signal transduction of somatostatin receptors negatively controlling cell proliferation
Géraldine Ferjoux (2000)
10.1210/edrv-9-3-357
Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations.
Toshiaki Sano (1988)



This paper is referenced by
10.5772/17560
Acromegaly and Gigantism
Fulya Akin (2011)
10.1186/s13104-016-2132-1
Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature
Sebastian Krug (2016)
10.1007/s11154-007-9060-2
Current diagnosis of acromegaly
Rocio A. Cordero (2007)
[Paraneoplastic endocrine syndromes].
Robert Krysiak (2016)
Acromegaly due to Pulmonary Carcinoid
Farida Chentli (2013)
10.2147/OTT.S39987
A review of the use of somatostatin analogs in oncology
Ozge Keskin (2013)
Biomarkers in Pulmonary Carcinoid Tumors
Tiina Vesterinen (2020)
10.1210/jc.2011-2930
Clinical characteristics and outcome of acromegaly induced by ectopic secretion of growth hormone-releasing hormone (GHRH): a French nationwide series of 21 cases.
L. Garby (2012)
10.1007/s11102-008-0146-y
Acromegaly secondary to an incidentally discovered growth-hormone-releasing hormone secreting bronchial carcinoid tumour associated to a pituitary incidentaloma
E. Verrua (2008)
10.1007/s12020-012-9790-0
Ectopic acromegaly due to growth hormone releasing hormone
A. A. Ghazi (2012)
10.3390/cancers10120510
Management of Typical and Atypical Pulmonary Carcinoids Based on Different Established Guidelines
Rohit Gosain (2018)
10.1530/ERC-17-0036
Paraneoplastic endocrine syndromes.
Georgios K Dimitriadis (2017)
10.1007/s11060-008-9606-5
Regulation of cell invasion and signalling pathways in the pituitary adenoma cell line, HP-75, by reversion-inducing cysteine-rich protein with kazal motifs (RECK)
Daizo Yoshida (2008)
10.1517/14728222.2011.555403
The molecular pathogenesis and management of bronchial carcinoids
Mehtap Cakir (2011)
ctopic secretion of GHRH by a pancreatic neuroendocrine tumor associated with an empty sella écrétion ectopique de GHRH par une tumeur neuroendocrine pancréatique associée à un syndrome
Fatma Mnif (2011)
10.1016/j.ando.2011.06.002
Ectopic secretion of GHRH by a pancreatic neuroendocrine tumor associated with an empty sella.
Mouna Mnif Feki (2011)
Semantic Scholar Logo Some data provided by SemanticScholar