Online citations, reference lists, and bibliographies.
← Back to Search

A Comparative Study Of Levocetirizine Loaded Vesicular And Matrix Type System For Topical Application: Appraisal Of Therapeutic Potential Against Atopic Dermatitis

Ravi Raj Pal, Anish Kumar Maurya, Poonam Parashar, S. Saraf
Published 2020 ·

Cite This
Download PDF
Analyze on Scholarcy
Share
Background Topical drug delivery offers improved therapeutic effect and reduced systemic adverse effects of the administered compounds. Objective The present work was aimed at developing and comparing levocetirizine loaded polymeric nanoparticles and niosomal formulation(s), respectively, against dinitrochlorobenzene-induced atopic dermatitis animal model. Methods The niosome and chitosan nanoparticle were developed and evaluated for particle size distribution, drug loading, and entrapment efficiency. The formulations were optimized through Box-Behnken design. The optimized formulations were dispersed in carbopol gel and evaluated for ex vivo permeation, retention, and in vivo studies. Results The optimized niosomes and chitosan nanoparticle exhibited a particle size range of 384.4 ± 64.3 nm and 382.7 ± 59.2 nm, drug loading of 18.99 ± 0.02% and 12.2 ± 1.6%, and entrapment efficiency of 46.63 ± 2.12% and 29.6 ± 1.6%, respectively. The permeation and retention studies displayed less permeation and significantly ( p  < 0.01) high retention percentage of LCZD by OPT-N gel when compared with OPT-CN gel. In in vivo studies revealed that OPT-N significantly ( p  < 0.05) reduces erythema score (from 3 to 1) and scratching frequency (70–25 scratches/20 min). Conclusion OPT-N gel shows high entrapment efficiency and skin retention capacity of the drug along with better topical applicability and higher therapeutic efficacy. The OPT-N also manifested the maximum peripheral action of LCZD against AD as compared with optimized chitosan gel and plain LCZD gel.
This paper references
10.1016/j.msec.2016.08.011
Novel genipin crosslinked atorvastatin loaded sericin nanoparticles for their enhanced antihyperlipidemic activity.
Jovita Kanoujia (2016)
10.3109/03639045.2013.828219
Recent advances in gel technologies for topical and transdermal drug delivery
K. Rehman (2014)
10.1039/C6RA15166C
Development of an α-linolenic acid containing soft nanocarrier for oral delivery: in vitro and in vivo evaluation
M. Singh (2016)
10.1016/J.JDDST.2019.04.032
A novel plier-like gemini cationic niosome for nucleic acid delivery
Supusson Pengnam (2019)
10.1080/08982104.2016.1174943
Oral delivery of allopurinol niosomes in treatment of gout in animal model
Neelu Singh (2017)
10.3109/08982104.2014.899365
Novel flexible vesicles based topical formulation of levocetirizine: in vivo evaluation using oxazolone-induced atopic dermatitis in murine model
Shishu Goindi (2014)
10.1016/j.ijbiomac.2016.04.070
Development of chitosan nanoparticles coated with hyaluronic acid for topical ocular delivery of dexamethasone.
M. A. Kalam (2016)
10.1016/J.JDDST.2019.01.033
Formulation of thymoquinone loaded chitosan nano vesicles: In-vitro evaluation and in-vivo anti-hyperlipidemic assessment
Aljoufi Fakhria (2019)
10.1517/14712598.2013.758708
New era of biologic therapeutics in atopic dermatitis
E. Guttman-Yassky (2013)
10.1016/j.colsurfb.2016.08.027
Drug nanocarrier, the future of atopic diseases: Advanced drug delivery systems and smart management of disease.
Mei Shao (2016)
10.1159/000370220
Atopic Dermatitis: Global Epidemiology and Risk Factors
S. Nutten (2015)
10.1016/j.ijbiomac.2018.12.014
Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation.
A. Barbosa (2019)
10.1038/jid.2013.446
The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions.
R. Hay (2014)
10.1016/j.nano.2009.04.007
Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method.
M. R. Avadi (2010)
10.1080/02652048.2019.1637474
Tamanu oil potentiated novel sericin emulgel of levocetirizine: repurposing for topical delivery against DNCB-induced atopic dermatitis, QbD based development and in vivo evaluation
Ravi Raj Pal (2019)
Sustained release of acyclovir from nano-liposomes and nano-niosomes: An in vitro study
B. Mukherjee (2007)
10.2332/ALLERGOLINT.O-06-458
A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice.
M. Yamamoto (2007)
10.1007/s13346-016-0322-y
Wound healing applications of sericin/chitosan-capped silver nanoparticles incorporated hydrogel
J. Verma (2016)
10.1016/j.msec.2016.07.043
Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis.
Seyedeh Raziyeh Mahdavi Moghddam (2016)
10.1016/j.ejpb.2017.04.012
Preparation and characterization of dutasteride‐loaded nanostructured lipid carriers coated with stearic acid‐chitosan oligomer for topical delivery
Norhayati Mohamed Noor (2017)
10.1080/08982104.2019.1614952
Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
Panikchar Wichayapreechar (2019)
10.1016/J.IJPHARM.2006.02.015
Microemulsion-based hydrogel formulation of ibuprofen for topical delivery.
Huabing Chen (2006)
10.1016/J.BFOPCU.2016.12.003
Exploring preclinical and clinical effectiveness of nanoformulations in the treatment of atopic dermatitis: Safety aspects and patent reviews
Nida Akhtar (2017)
10.1007/s13346-017-0439-7
Potential treatment of atopic dermatitis: tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects
Muhammad Irfan Siddique (2017)
10.1016/J.POWTEC.2016.04.014
Preliminary studies of rosmarinic acid microencapsulation with chitosan and modified chitosan for topical delivery
Francisca Casanova (2016)
Development and characterization of nanostructured lipid carriers of Vetiveria zizanoides oil for therapeutic potential in prickly heat treatment
D Rawat (2015)
10.1016/j.ijpharm.2012.08.015
Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized guinea pig model of Microsporum canis--dermatophytosis.
N. Aggarwal (2012)
10.1016/J.COLSURFA.2017.04.056
DHA and l-carnitine loaded chitosan hydrogels as delivery systems for topical applications
I. Solé (2017)
10.3109/10717544.2014.945130
Enhanced transdermal delivery of luteolin via non-ionic surfactant-based vesicle: quality evaluation and anti-arthritic assessment
L. Abidin (2016)
10.1016/j.ijpharm.2018.05.076
Chitosan based polymer‐lipid hybrid nanoparticles for oral delivery of enoxaparin
Wei Dong (2018)
Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
10.1201/b14413
Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form
M. Gibson (2001)
10.3109/10717544.2013.870260
Formulation by design-based proniosome for accentuated transdermal delivery of risperidone: in vitro characterization and in vivo pharmacokinetic study
S. S. Imam (2015)
10.1007/s40265-016-0682-0
Sedative Effects of Levocetirizine: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
Kornkiat Snidvongs (2016)
10.1016/j.ejpb.2019.08.015
Recent advances in non-ionic surfactant vesicles (niosomes): fabrication, characterization, pharmaceutical and cosmetic applications.
S. Chen (2019)
10.1039/c9tb00965e
Flexible, microstructured surfaces using chitin-derived biopolymers.
Sayantan Pradhan (2019)
10.1016/j.msec.2019.01.036
Chitosan grafted-poly(ethylene glycol) methacrylate nanoparticles as carrier for controlled release of bevacizumab.
Corina-Lenuța Savin (2019)
10.1016/j.carbpol.2018.12.050
Super-hydrophilic and high strength polymeric foam dressings of modified chitosan blends for topical wound delivery of chloramphenicol.
Georgia Michailidou (2019)
10.1016/j.colsurfb.2019.110352
Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.
Shikang Meng (2019)
10.1016/J.JDDST.2018.04.005
Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention
X. Liu (2018)



Semantic Scholar Logo Some data provided by SemanticScholar