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In Vitro Sortase A Inhibitory And Antimicrobial Activity Of Flavonoids Isolated From The Roots Of Sophora Flavescens

Ikhoon Oh, Woo-Young Yang, Soon-Chun Chung, Tae-Yoon Kim, K. Oh, Jongheon Shin
Published 2011 · Biology, Medicine

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A series of flavonoids (1–14) was isolated from the roots of Sophora flavescens. We evaluated their ability to inhibit both microbial growth and sortase A, an enzyme that plays a key role in cell wall protein anchoring and virulence in Staphylococcus aureus. Most prenylated flavonoids (7–13) displayed potent inhibitory activity against gram-positive and gram-negative bacteria except E. coli, with minimum inhibitory concentrations values ranging from 4.40 to 27.7 μM, and weak or no activity against fungal strains tested. Kurarinol (6) was a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. A preliminary structure-activity relationship, including essential structural requirements, is described.
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