Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

The Stellate Cell System (vitamin A-storing Cell System)

H. Senoo, Y. Mezaki, M. Fujiwara
Published 2017 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Past, present, and future research into hepatic stellate cells (HSCs, also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells) are summarized and discussed in this review. Kupffer discovered black-stained cells in the liver using the gold chloride method and named them stellate cells (Sternzellen in German) in 1876. Wake rediscovered the cells in 1971 using the same gold chloride method and various modern histological techniques including electron microscopy. Between their discovery and rediscovery, HSCs disappeared from the research history. Their identification, the establishment of cell isolation and culture methods, and the development of cellular and molecular biological techniques promoted HSC research after their rediscovery. In mammals, HSCs exist in the space between liver parenchymal cells (PCs) or hepatocytes and liver sinusoidal endothelial cells (LSECs) of the hepatic lobule, and store 50–80% of all vitamin A in the body as retinyl ester in lipid droplets in the cytoplasm. SCs also exist in extrahepatic organs such as pancreas, lung, and kidney. Hepatic (HSCs) and extrahepatic stellate cells (EHSCs) form the stellate cell (SC) system or SC family; the main storage site of vitamin A in the body is HSCs in the liver. In pathological conditions such as liver fibrosis, HSCs lose vitamin A, and synthesize a large amount of extracellular matrix (ECM) components including collagen, proteoglycan, glycosaminoglycan, and adhesive glycoproteins. The morphology of these cells also changes from the star-shaped HSCs to that of fibroblasts or myofibroblasts.
This paper references
Vitamin A transport in plasma of the non-mammalian vertebrates: isolation and partial characterization of piscine retinol-binding protein.
Y. Shidoji (1977)
10.1002/AJA.1001670205
Some observations on the structure of Suncus liver with special reference to the vitamin A-storing cell.
E. Matsumoto (1983)
Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system.
M. Rojkind (1995)
10.1055/S-2001-17552
Extracellular matrix degradation and the role of hepatic stellate cells.
R. Benyon (2001)
10.1002/HEP.510300236
MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells
N. Théret (1999)
10.1053/j.gastro.2008.01.014
Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.
Y. Inagaki (2008)
10.1007/BF02899415
Collagenase of hepatocytes and sinusoidal liver cells in the reversibility of experimental cirrhosis of the liver
I. Montfort (1990)
10.1194/JLR.M500036-JLR200
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M500036-JLR200
C. E. Yen (2005)
10.1016/J.IMMUNI.2006.11.011
Ito cells are liver-resident antigen-presenting cells for activating T cell responses.
F. Winau (2007)
10.1021/BI00350A005
Basement membrane complexes with biological activity.
H. Kleinman (1986)
10.1056/NEJM200102083440604
Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct.
P. Hammel (2001)
10.1136/gut.52.2.275
Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover
P. Phillips (2003)
Colocalization of three types of intermediate filament proteins in perisinusoidal stellate cells: glial fibrillary acidic protein as a new cellular marker.
G. Buniatian (1996)
10.1074/JBC.270.28.16970
Perilipins Are Associated with Cholesteryl Ester Droplets in Steroidogenic Adrenal Cortical and Leydig Cells (*)
D. A. Servetnick (1995)
10.1016/S0168-8278(00)00087-8
Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells.
K. Rombouts (2001)
10.1002/HEP.1840060505
Phagocytosis, an unrecognized property of murine endothelial liver cells
A. Steffan (1986)
10.1172/JCI105889
Retinol-binding protein: the transport protein for vitamin A in human plasma.
M. Kanai (1968)
10.1074/jbc.M006775200
TIP47 Associates with Lipid Droplets*
N. Wolins (2001)
10.1002/hep.20974
Reversal of hepatic fibrosis — Fact or fantasy?
S. Friedman (2006)
10.1001/ARCHPEDI.1970.02100050134008
Hepatic injury in chronic hypervitaminosis A.
E. Rubin (1970)
10.1096/fasebj.9.14.7589981
The extracellular matrix in hepatic regeneration
Antonio Martinez‐Hern Andez (1995)
10.1172/JCI22675
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.
J. Duffield (2005)
10.1002/AR.A.10036
Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules--a comparative study.
N. Higashi (2003)
10.1006/EXCR.1993.1121
Transcriptional activation of type I collagen genes by ascorbic acid 2-phosphate in human skin fibroblasts and its failure in cells from a patient with alpha 2(I)-chain-defective Ehlers-Danlos syndrome.
S. Kurata (1993)
Long cellular processes of hepatic stellate cells cultured on or in type I collagen gel
M Sato (1997)
10.1016/s0016-5085(99)70521-4
Schiff's diseases of the liver
Herrine (1999)
10.1034/J.1600-0676.2002.01726.X
Mesenchymal cells in the liver--one cell type or two?
G. Ramadori (2002)
10.1007/BF02976809
Ueber die sogenannten Sternzellen der Säugethierleber
C. Kupffer (1899)
10.1016/S0076-6879(82)81111-7
Vitamin A storing cell.
E. Yamada (1982)
10.1016/j.exger.2007.04.008
Age-related changes in the hepatic microcirculation in mice
Y. Ito (2007)
10.1002/JEMT.1060140306
Ultrastructure and function of hepatic fat-storing and pit cells.
A. Geerts (1990)
10.1002/HEP.510290103
Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells
T. Mitaka (1999)
Morphological Regulation of Cultured Hepatic Stellate Cells by Extracellular Matrix through Intracellular Signaling
M. Sato (1998)
10.1016/J.DLD.2004.05.012
The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1(I), TIMP-1 and MMP-2.
A. di Sario (2004)
10.1016/S0168-8278(88)80042-4
Desmin distinguishes cultured fat-storing cells from myofibroblasts, smooth muscle cells and fibroblasts in the rat.
S. Takase (1988)
10.1053/J.GASTRO.2006.04.012
Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.
E. Haughton (2006)
10.1247/CSF.28.505
Stimulation of pro-MMP-2 production and activation by native form of extracellular type I collagen in cultured hepatic stellate cells.
Daren Wang (2003)
10.1152/physrev.00013.2007
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.
S. Friedman (2008)
10.1007/s00335-01-2055-5
The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin
X. Lu (2001)
Storage of vitamin A in extrahepatic stellate cells in normal rats.
N. Nagy (1997)
10.1016/S0092-8674(00)80622-4
Structural Basis of Collagen Recognition by Integrin α2β1
J. Emsley (2000)
10.1053/GAST.2002.32995
Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat.
K. Ikejima (2002)
10.1042/BJ0370166
The vitamin A content and toxicity of bear and seal liver.
K. Rodahl (1943)
Ultrastructural changes in livers of two patients with hypervitaminosis A.
Z. Hruban (1974)
10.1007/s00795-003-0230-3
Structure and function of hepatic stellate cells
H. Senoo (2003)
10.1016/j.cbpb.2011.11.011
Characterization of a cellular retinol-binding protein from lamprey, Lethenteron japonicum.
Y. Mezaki (2012)
10.1034/j.1600-0676.2003.00811.x
Impact of oestrogens on the progression of liver disease
I. Shimizu (2003)
10.1097/01.LAB.0000017365.18894.D3
Effects and Regulation of Connective Tissue Growth Factor on Hepatic Stellate Cells
V. Paradis (2002)
10.1002/HEP.1840160328
Fat‐storing cells of the rat liver synthesize and secrete C1‐esterase inhibitor; modulation by cytokines
S. Schwögler (1992)
10.3748/WJG.V7.I5.647
Effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells.
P. Chen (2001)
10.1016/j.febslet.2005.04.071
Peroxynitrite‐mediated matrix metalloproteinase‐2 activation in human hepatic stellate cells
K. Migita (2005)
10.1016/0076-6879(90)90008-O
Isolation, purification, and characterization of liver cell types.
H. F. Hendriks (1990)
10.1016/0304-419X(95)00005-Z
Signal transduction by cell adhesion receptors.
C. Rosales (1995)
10.1093/OXFORDJOURNALS.JMICRO.A049891
The localization of the vitamin A in the mouse liver as revealed by electron microscope radioautography.
K. Hirosawa (1973)
Origin and early development of the liver in various vertebrates
H Elias (1955)
Characterization of carotenoid, vitamin A
WS Blaner (1996)
Desmoulière A (2002) Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic
K Uchio (2002)
Hepatic stellate cells: Morphology, function, and regulation
D Li (2001)
Autocrine regulation of lipocyte matrix production: activation by extracellular matrix
SL Friedman (1989)
Kupffer’s original article of discovery of the stellate cell in liver
K Wake (1978)
Fat-storing (Ito) cell biology
A. Geerts (1994)
1994a) a-Smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma
H Enzan (1994)
10.1128/MCB.20.8.2818-2826.2000
The DNA Binding Protein BTEB Mediates Acetaldehyde-Induced, Jun N-Terminal Kinase-Dependent αI(I) Collagen Gene Expression in Rat Hepatic Stellate Cells
A. Chen (2000)
Activation of peroxisome proliferator-activated receptor-c by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells
J Lin (2008)
10.1002/HEP.510230634
Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4‐induced fibrotic rat livers
T. Niki (1996)
10.1016/J.BIOCEL.2003.10.005
Circulating fibrocytes: collagen-secreting cells of the peripheral blood.
Timothy E. Quan (2004)
10.1083/jcb.200311079
Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye
Y. Imanishi (2004)
10.2337/dc06-2426
Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes
Y. Cho (2007)
10.1097/00001888-200009001-00015
University of Colorado School of Medicine.
G. Merenstein (2000)
10.1086/512203
Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation.
F. Pasutto (2007)
10.1056/NEJM199304223281620
Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8
E. Friedman (1993)
10.1017/CBO9780511546198.068
Endothelial Biomedicine: Stellate Cell–Endothelial Cell Interactions
H. Senoo (2007)
10.1074/jbc.273.36.23183
Role of NF-κB in the Antiproliferative Effect of Endothelin-1 and Tumor Necrosis Factor-α in Human Hepatic Stellate Cells
Cyrille Gallois (1998)
10.1172/JCI105468
The intestinal absorption and metabolism of vitamin A and beta-carotene in man.
D. S. Goodman (1966)
10.1201/9781482277562
Vitamin A in Health and Disease
R. Blomhoff (1994)
High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans.
Norbert Stefan (2007)
10.1053/JHEP.1997.V26.PM0009328313
Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells.
M. Okuno (1997)
10.1006/TAAP.2000.9059
2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum and kidney retinoic acid levels and kidney retinol esterification in the rat.
C. Nilsson (2000)
10.1007/s00441-004-0891-9
Cell–cell junctions between mammalian (human and rat) hepatic stellate cells
N. Higashi (2004)
10.1016/S0006-291X(03)00232-8
Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells.
J. Oben (2003)
10.1007/s00418-008-0449-0
Lipid droplets: a classic organelle with new outfits
T. Fujimoto (2008)
10.1053/JHEP.2001.27804
Enhanced expression of B7‐1, B7‐2, and intercellular adhesion molecule 1 in sinusoidal endothelial cells by warm ischemia/reperfusion injury in rat liver
N. Kojima (2001)
10.1053/GAST.2002.35384
Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells.
R. Fischer (2002)
10.1083/JCB.63.2.683
DEVELOPMENT OF VITAMIN A-RICH LIPID DROPLETS IN MULTIVESICULAR BODIES OF RAT LIVER STELLATE CELLS
K. Wake (1974)
Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis.
M. Seeliger (1999)
10.1152/AJPLUNG.00234.2003
On the sources of retinoic acid in the lung: understanding the local conversion of retinol to retinoic acid.
A. Ross (2004)
10.1679/AOHC1950.37.369
A scanning electron microscopic study on endothelial cells and Kupffer cells in rat liver sinusoids.
M. Muto (1975)
Hepatocytes (hepatic parenchymal cells) produce a major part of liver collagen in vivo.
R. Hata (1984)
Absorption of vitamin A. In: Blomhoff R (ed) Vitamin A in health and disease
DE Ong (1994)
Contraction and relaxation of hepatic stellate cells in culture
N Kawada (1993)
10.1002/HEP.1840210440
Cyclosporin A and FK‐506 in inhibition of rat ito cell activation in vitro
H. Ikeda (1995)
L-Ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissuelike substance by skin fibroblast
R Hata (1989)
Retinol-binding protein and the regulation of vitamin A transport.
J. E. Smith (1979)
10.1002/NEU.20242
Overview of retinoid metabolism and function.
R. Blomhoff (2006)
10.1126/science.2218545
Transport and storage of vitamin A
R. Blomhoff (1990)
10.1042/BJ20040966
Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein/Endo180.
S. A. Mousavi (2005)
10.1053/J.GASTRO.2004.10.003
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.
F. Oakley (2005)
10.1083/JCB.98.5.1696
Immunocytochemical studies on the localization of plasma and of cellular retinol-binding proteins and of transthyretin (prealbumin) in rat liver and kidney
M. Kato (1984)
10.1053/J.GASTRO.2004.08.001
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.
S. Fiorucci (2004)
10.1074/JBC.M107582200
Ligands of Peroxisome Proliferator-activated Receptor-γ Block Activation of Pancreatic Stellate Cells*
A. Masamune (2002)
10.1136/gut.2005.074427
Pancreatic stellate cells: new kids* become mature
M. Pinzani (2006)
10.1006/BBRC.1997.8193
Transdifferentiation of rat hepatic stellate cells results in leptin expression.
J. Potter (1998)
Internalization of retinol-binding protein in parenchymal and stellate cells of rat liver.
H. Senoo (1990)
10.1172/JCI14006
CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism.
M. Febbraio (2001)
10.1016/S0016-5085(03)00666-8
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats.
S. Dooley (2003)
10.1016/0048-9697(92)90245-N
Arctic contaminants: sources, occurrence and pathways.
L. Barrie (1992)
10.1016/j.exger.2003.07.002
Hepatic sinusoidal pseudocapillarization with aging in the non-human primate
V. Cogger (2003)
10.1038/nature03711
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Q. Yang (2005)
Isolation and characterization of the lipid-containing interstitial cell from the developing rat lung.
H. J. Maksvytis (1981)
10.1002/hep.21036
Proteasome inhibition induces hepatic stellate cell apoptosis
A. Anan (2006)
10.2220/BIOMEDRES.5.451
STELLATE CELLS (VITAMIN A-STORING CELLS) ARE THE PRIMARY SITE OF COLLAGEN SYNTHESIS IN NON-PARENCHYMAL CELLS IN THE LIVER
H. Senoo (1984)
10.1126/SCIENCE.3353726
Molecular cloning of human and rat complementary DNA encoding androgen receptors.
C. Chang (1988)
10.1016/0014-4827(82)90283-X
Fat-storing cells of the rat liver. Their isolation and purification.
D. Knook (1982)
10.1053/JHEP.2003.50182
Toll‐Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
Yong-Han Paik (2003)
10.1126/SCIENCE.3753802
Sequence and expression of human estrogen receptor complementary DNA.
G. Greene (1986)
Long cellular processes of hepatic stellate cells cultured on or in type I collagen
M Sato (1997)
Sinusoidal endothelial cells and perisinusoidal fat-storing cells
A Brouwer (1988)
Craxı̀ A (2008) Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis C virus genotype
S Petta (2008)
Human embryology and developmental biology, 2nd edn
BM Carlson (1999)
10.1002/HEP.510240429
Subcellular distribution of glucocorticoid receptor in cultured rat and human liver‐derived cells and cell lines: Influence of dexamethasone
D. Raddatz (1996)
10.1016/J.JHEP.2003.10.012
Commitment of bone marrow cells to hepatic stellate cells in mouse.
S. Baba (2004)
10.1172/JCI43122
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.
S. Rashid (2010)
Retinol-binding protein and the regulation of vitamin A transport.
S. Je (1979)
10.1074/jbc.M510094200
Peroxisome Proliferator-activated Receptor γ Suppresses Proximal α1(I) Collagen Promoter via Inhibition of p300-facilitated NF-I Binding to DNA in Hepatic Stellate Cells*
Sharon Yavrom (2005)
10.1016/s0021-9258(18)48436-0
Direct mobilization of retinol from hepatic perisinusoidal stellate cells to plasma.
K. B. Andersen (1992)
10.1016/j.cmet.2007.12.007
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
W. Jeong (2008)
10.1002/hep.20476
Stellate cells: A moving target in hepatic fibrogenesis
S. Friedman (2004)
10.1053/J.GASTRO.2006.01.036
The bone marrow functionally contributes to liver fibrosis.
F. P. Russo (2006)
10.1016/S0960-9822(01)00257-3
Lipid droplets: Proteins floating on a pool of fat
D. Brown (2001)
10.1016/0955-0674(95)80110-3
Integrin transmembrane signaling and cytoskeletal control.
K. Yamada (1995)
10.1016/0022-5320(72)90089-5
An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells.
E. Wisse (1972)
10.1053/j.gastro.2008.03.002
Cellular and molecular mechanisms of liver injury.
H. Malhi (2008)
10.1159/000107400
Pancreatic Stellate Cells Potentiate Proinvasive Effects of SERPINE2 Expression in Pancreatic Cancer Xenograft Tumors
A. Neesse (2007)
10.1006/BBRC.1995.1247
Characterization of endothelin receptors mediating rat hepatic stellate cell contraction.
D. Rockey (1995)
10.1152/AJPGI.2000.279.6.G1333
Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation.
A. Lang (2000)
10.1053/J.GASTRO.2006.01.038
Toll-like receptor signaling in the liver.
R. Schwabe (2006)
10.1007/BF03403533
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
R. Bucala (1994)
10.1111/J.1600-0676.1988.TB00972.X
The streaming liver. II. Hepatocyte life history.
N. Arber (1988)
Fat-storing cells (lipocytes) in human liver.
S. Bronfenmajer (1966)
10.1002/HEP.1840070630
The role of hepatic fat‐storing (stellate) cells in retinoid metabolism
H. F. Hendriks (1987)
10.1172/JCI12373
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.
E. Olaso (2001)
10.1002/ar.20661
Old Age and the Hepatic Sinusoid
D. L. Le Couteur (2008)
Lysosomes in the hypervitaminosis A rat liver, with special reference to storage of vitamin A in the perisinusoidal stellate cells
K Wake (1975)
Structure of the sinusoidal wall in the hypervitaminosis A rat liver
K Wake (1976)
Regulation of morphology, proliferation, and collagen metabolism of perisinusoidal stellate cells by extracellular matrix
H Senoo (1995)
The embryonic liver
AM Du Bois (1968)
So-called Kupffer cells and hepatic stellate cells
K Wake (1980)
Inhibition of T-cell responses by hepatic stellate
MC Yu (2004)
Vitamin A-storing system in mammals and birds in Arctic area-a study in the Svalbard archipelago
H Senoo (1999)
Inhibition of inhibitor of kB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
F Oakley (2005)
Regulation of the murine
L Wang (2002)
10.1016/0014-4827(84)90714-6
Preparation of isolated liver endothelial cells and Kupffer cells in high yield by means of an enterotoxin.
R. Blomhoff (1984)
10.1111/jgh.1998.13.s1.19
Molecular mechanisms in the reversible regulation of morphology, proliferation and collagen metabolism in hepatic stellate cells by the three‐dimensional structure of the extracellular matrix
H. Senoo (1998)
10.1055/S-2008-1040455
Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis.
Gressner Am (1990)
10.1007/BF01966373
Studien über die Schicksale körniger Farbstoffe im Organismus
Dr. E. Ponfick (2005)
10.1007/BF02776820
Inhibitory effect of acyclic retinoid (polyprenoic acid) on hepatic fibrosis in CCl4-treated rats
M. Okuno (2007)
10.1016/s0021-9258(18)61109-3
Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels.
B. H. Davis (1987)
Norum KR (1988c) Transfer of retinol
R 60233–239 Blomhoff (1988)
Kupffer cells
J Armendariz-Borunda (1989)
10.1016/S0074-7696(08)61977-4
Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs.
K. Wake (1980)
10.1038/324641A0
The c-erb-A gene encodes a thyroid hormone receptor
C. Weinberger (1986)
10.1006/cbir.1998.0234
INDUCTION OF CELLULAR PROCESSES CONTAINING COLLAGENASE AND RETINOID BY INTEGRIN‐BINDING TO INTERSTITIAL COLLAGEN IN HEPATIC STELLATE CELL CULTURE
M. Sato (1998)
10.1002/dvdy.10455
Contribution of mesothelium‐derived cells to liver sinusoids in avian embryos
J. M. Pérez-Pomares (2004)
10.1111/j.1530-0277.2008.00827.x
Molecular mechanisms of alcoholic fatty liver.
V. Purohit (2009)
10.1001/ARCHINTE.1943.00210100012002
Relation between Hepatic and Plasma Concentrations of Vitamin A in Human Beings.
H. Popper (1943)
10.1074/jbc.274.6.3834
Molecular and Biochemical Characterization of Lecithin Retinol Acyltransferase*
A. Ruiz (1999)
10.1016/J.GENE.2003.12.005
Nuclear retinoid receptors and the transcription of retinoid-target genes.
J. Bastien (2004)
10.1079/BJN19880095
Distribution of retinol in rat liver cells: effect of age, sex and nutritional status.
R. Blomhoff (1988)
10.1073/PNAS.88.19.8392
Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.
L. Kornberg (1991)
10.1053/JHEP.2003.50180
Peripheral blood mononuclear cell expression of toll‐like receptors and relation to cytokine levels in cirrhosis
S. Riordan (2003)
10.1002/hep.22229
Temporal‐spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia
Nissa I. Erickson (2008)
10.1210/jc.2007-2536
Retinol binding protein-4 elevation is associated with serum thyroid-stimulating hormone level independently of obesity in elderly subjects with normal glucose tolerance.
S. Choi (2008)
10.1016/j.cell.2006.07.024
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
Kazutoshi Takahashi (2006)
Histochemical method for detection of vitamin A
H Senoo (1988)
Cells in and around the hepatic sinusoid: past, present and future
K Wake (1997)
Ponfick E (1869) Studien ueber die Schiksale koerniger Farbstoffe im Organismus
Distribution of retinoids, retinoid-binding proteins and related parameters in different types of liver cells isolated from young and old rats
HFJ Hendriks (1988)
Stellate cell-endothelial cell interactions. In: Aird WC (ed) Endothelial biomedicine
H Senoo (2007)
10.1136/gut.46.4.443
Is liver fibrosis reversible?
P. Bonis (2001)
10.1002/hep.20488
Inhibition of T‐cell responses by hepatic stellate cells via B7‐H1–mediated T‐cell apoptosis in mice
M. Yu (2004)
10.1074/JBC.M212927200
The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression*
S. Reif (2003)
Endothelial and pit cells
F. Braet (2001)
10.1016/S0014-5793(97)00024-0
Transforming growth factor‐β1 induces activation of Ras, Raf‐1, MEK and MAPK in rat hepatic stellate cells
T. Reimann (1997)
10.1152/AJPENDO.1977.232.1.E69
Vitamin K1 intestinal absorption in vivo: influence of luminal contents on transport.
D. Hollander (1977)
Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells
V Carloni (1996)
10.1016/J.ABB.2004.05.004
Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors.
L. Wang (2004)
10.1002/HEP.1840070212
Characterization of desmin‐positive rat liver sinusoidal cells
M. Tsutsumi (1987)
10.1016/j.febslet.2006.08.040
A proposed model of fat packaging by exchangeable lipid droplet proteins
N. Wolins (2006)
10.1016/S0014-5793(98)00990-9
Stimulation by anaphylatoxin C5a of glycogen phosphorylase in rat hepatocytes via prostanoid release from hepatic stellate cells but not sinusoidal endothelial cells
H. Schieferdecker (1998)
10.1016/J.BIOCEL.2005.08.021
Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved.
Christelle Guyot (2006)
10.1053/jhep.2003.50392
Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation.
O. Viñas (2003)
10.1002/hep.24784
Protease‐activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells
V. Knight (2012)
10.1002/ar.20679
Vascular Development and Differentiation During Human Liver Organogenesis
S. Collardeau-Frachon (2008)
10.1016/S0016-5085(99)70407-5
Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential.
T. Knittel (1999)
10.2741/OKUNO
Retinoids in liver fibrosis and cancer.
M. Okuno (2002)
10.1016/S0014-5793(01)02655-2
TGFβ1 in liver fibrosis: time to change paradigms?
M. Bauer (2001)
10.1016/S0168-8278(02)00275-1
Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor.
K. Rombouts (2002)
10.1172/JCI20530
Epithelial-mesenchymal transition and its implications for fibrosis.
R. Kalluri (2003)
10.1111/j.1478-3231.2008.01740.x
Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia
K. Harada (2008)
10.1093/JN/134.1.276S
Vitamin A: overlapping delivery pathways to tissues from the circulation.
J. Paik (2004)
10.1016/0168-8278(92)90160-Q
Phenotypical modulation of liver fat-storing cells by retinoids. Influence on unstimulated and growth factor-induced cell proliferation.
M. Pinzani (1992)
10.1016/S0168-8278(88)80460-4
Isolation and culture of Kupffer cells from human liver. Ultrastructure, endocytosis and prostaglandin synthesis.
A. Brouwer (1988)
10.1016/S0016-5085(98)70209-4
Identification, culture, and characterization of pancreatic stellate cells in rats and humans.
M. Bachem (1998)
Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway inactivation
F Jiang (2006)
Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis C virus genotype
S Petta (2008)
Does retinol-binding protein
Chapman (2008)
10.1177/003693300404900101
Reversal of Liver Fibrosis and Cirrhosis — An Emerging Reality
J. Fallowfield (2004)
The stellate cell system (vitamin A-storing cell system
10.1016/0955-0674(95)80117-0
A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression.
C. Roskelley (1995)
10.1002/hep.22890
Hepatic stellate cells express functional CXCR4: Role in stromal cell–derived factor‐1α–mediated stellate cell activation
F. Hong (2009)
Some observations on perisinusoidal lipocyte (Ito cell) of Carassius auratus liver as revealed by electron microscopy.
Shin Yc (1981)
10.1002/AJA.1001310202
A morphological study of the development of the human liver. I. Development of the hepatic diverticulum.
C. Severn (1971)
10.1053/J.GASTRO.2007.03.075
Hepatic stellate cells: the only cells involved in liver fibrogenesis? A dogma challenged.
A. Desmoulière (2007)
10.1016/0014-5793(93)80544-5
Regulation of endothelin‐1 action on the perfused rat liver
T. Tran-Thi (1993)
10.1074/jbc.M102630200
Characterization of a Stellate Cell Activation-associated Protein (STAP) with Peroxidase Activity Found in Rat Hepatic Stellate Cells*
N. Kawada (2001)
Moellendorff’s Handbuch der mikroskopishen Anatomie des Menscen
W Pfuhl (1932)
10.1053/JHEP.2003.50044
Vascular mediators in the injured liver
D. Rockey (2003)
Long-term cultivation of adult rat hepatocytes that undergo multiple cell divisions and express normal parenchymal phenotypes.
C. Tateno (1996)
10.1038/330444A0
A human retinoic acid receptor which belongs to the family of nuclear receptors
M. Petkovich (1987)
10.1073/PNAS.82.24.8681
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
S. Friedman (1985)
10.1046/j.1440-1746.2002.02804.x
High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis
B. Vollmar (2002)
10.1053/JHEP.2003.50176
The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells
M. Gascon-Barré (2003)
10.1373/clinchem.2007.099002
Retinol-binding protein 4 and lipocalin-2 in childhood and adolescent obesity: when children are not just "small adults".
C. Kanaka-Gantenbein (2008)
10.1152/AJPLUNG.00171.2005
BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.
N. Izumi (2006)
10.1083/JCB.99.2.536
Analysis of the role of microfilaments and microtubules in acquisition of bipolarity and elongation of fibroblasts in hydrated collagen gels
J. Tomasek (1984)
10.1002/HEP.510290131
Ex vivo liver cell morphogenesis: One step nearer to the bioartificial liver?
A. Strain (1999)
10.1016/J.JHEP.2003.11.007
Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells.
David L. Suskind (2004)
Digestion, Metabolism. In: Krinke GJ (ed) The digital handbook of experimental laboratory animals: the rat
H Senoo (2000)
10.1083/JCB.115.4.887
An analysis of vertebrate mRNA sequences: intimations of translational control
M. Kozak (1991)
Physioanatomic considerations. In: Schiff ER, Sorrell MF, Maddrey WC (eds) Schiff’s diseases of the liver, 8th edn
IR Wanless (1999)
13-di-cisretinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-b mediated fibrogenesis in vivo
M Okuno (1999)
10.1074/jbc.273.42.27300
Platelet-derived Growth Factor-BB and Thrombin Generate Positive and Negative Signals for Human Hepatic Stellate Cell Proliferation
A. Mallat (1998)
Tumor necrosis factor-a inhibits peroxisome proliferator-activated receptor c activity at a posttranslational level in hepatic stellate cells
CK Sung (2004)
10.1093/emboj/18.17.4633
Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein
L. Quadro (1999)
10.1194/JLR.M400137-JLR200
The role of extrahepatic retinol binding protein in the mobilization of retinoid stores Published, JLR Papers in Press, August 16, 2004. DOI 10.1194/jlr.M400137-JLR200
L. Quadro (2004)
10.1038/nm1663
TLR4 enhances TGF-β signaling and hepatic fibrosis
E. Seki (2007)
10.1016/S0934-8832(89)80034-4
Kupffer cells from CC1(4)-treated rat livers induce skin fibroblast and liver fat-storing cell proliferation in culture.
J. Armendáriz-Borunda (1989)
Human Embryology and Developmental Biology
B. Carlson (1994)
10.1001/JAMA.1986.03380100140043
Bloom and Fawcett: A Textbook of Histology
R. B. Hill (1986)
10.1055/S-2008-1037541
Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis
B. Straub (2008)
10.1247/CSF.22.487
Extension of long cellular processes of hepatic stellate cells cultured on extracellular type I collagen gel by microtubule assembly: observation utilizing time-lapse video-microscopy.
M. Miura (1997)
10.1006/BBRC.2002.6385
Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.
K. Kon (2002)
10.1152/AJPGI.1997.272.3.G589
Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis.
M. Ohata (1997)
10.1002/hep.21768
Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future
Anna Wieckowska (2007)
10.1007/s004410051181
Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases
H. Heid (1998)
10.1002/hep.21477
Bone marrow–derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice
R. Higashiyama (2007)
10.1002/HEP.1840070609
Biochemical characteristics of isolated rat liver stellate cells
M. Yamada (1987)
10.1097/01.LAB.0000101911.53973.90
Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis
A. Desmoulière (2003)
10.1006/EXCR.1995.1065
Regulation of differentiated phenotype of rat hepatic lipocytes by retinoids in primary culture.
T. Sato (1995)
10.1091/MBC.E02-08-0493
Dendritic fibroblasts in three-dimensional collagen matrices.
F. Grinnell (2003)
10.1111/j.1478-3231.2004.0977.x
Hydrodynamic‐based in vivo transfection of retinoic X receptor‐α gene can enhance vitamin A‐induced attenuation of liver fibrosis in mice
Chen Chen (2004)
10.1074/jbc.M303136200
Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR*
M. Tabb (2003)
10.1002/hep.21991
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate–activated protein kinase
M. Adachi (2008)
10.1016/S0168-8278(01)00260-4
Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers.
D. Cassiman (2002)
10.1074/jbc.274.34.23695
Distinct Roles for Cellular Retinoic Acid-binding Proteins I and II in Regulating Signaling by Retinoic Acid*
D. Dong (1999)
10.1007/BF00222231
Fine structure and cytochemistry of lysosomes in the Ito cells of the rat liver
K. Yamamoto (2004)
10.1016/0270-9139(95)95194-6
Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells.
V. Carloni (1996)
Pancreatic stellate
MV Apte (1999)
10.1164/AJRCCM.154.5.8912761
Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages.
C. Redlich (1996)
10.1152/AJPGI.00337.2005
[Ca2+]i-independent contractile force generation by rat hepatic stellate cells in response to endothelin-1.
A. Melton (2006)
10.1002/HEP.1840150635
Extracellular matrix gradients in the space of disse: Relevance to liver biology
L. Reid (1992)
10.5694/j.1326-5377.1956.tb57052.x
An Outline of the Cytology and Pathology of the Reticular Tissue
A. Liebow (1956)
10.1002/HEP.510290232
Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells
Toshiro Niki (1999)
10.1002/hep.22316
Retinol‐binding protein 4: A new marker of virus‐induced steatosis in patients infected with hepatitis c virus genotype 1
S. Petta (2008)
10.1172/JCI200524282C1
Erratum: Liver fibrosis (Journal of Clinical Investigation (2005) 115 (209-218) DOI:10.1172/JCI200524282)
R. Bataller (2005)
Polar bears and PCBs
C Holden (1998)
10.1111/j.1478-3231.2009.02070.x
Active matrix metalloproteinase‐2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N‐cadherin
Stephen N. Hartland (2009)
10.1172/JCI1018
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
J. Iredale (1998)
10.1053/GAST.2000.9365
Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells.
F. Marra (2000)
10.1247/CSF.25.329
Adhesion between cells and extracellular matrix with special reference to hepatic stellate cell adhesion to three-dimensional collagen fibers.
K. Imai (2000)
10.1034/J.1600-0676.2000.020003191.X
The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease.
L. Everett (2000)
10.1136/GUT.48.4.548
Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors.
R. Issa (2001)
10.1194/jlr.M700263-JLR200
Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells Published, JLR Papers in Press, August 2, 2007.
Alexandrine During (2007)
10.1247/CSF.24.255
Regulatory role of extracellular matrix components in expression of matrix metalloproteinases in cultured hepatic stellate cells.
Y. Li (1999)
10.1002/hep.25757
The basic helix‐loop‐helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver
C. Yin (2012)
10.1006/cbir.1996.0009
WHERE AM I? HOW A CELL RECOGNIZES ITS POSITIONAL INFORMATION DURING MORPHOGENESIS
R. Hata (1996)
10.3748/WJG.V13.I39.5208
CTGF, intestinal stellate cells and carcinoid fibrogenesis.
M. Kidd (2007)
10.1111/j.1440-1827.1978.tb00891.x
FLUORESCENCE AND ELECTRON MICROSCOPIC STUDIES ON THE PERIVASCULAR MESENCHYMAL CELLS AND FIBROBLASTS AFTER VITAMIN A ADMINISTRATION
M. Yamamoto (1978)
10.1093/AJCN/69.5.931
Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein.
H. Biesalski (1999)
10.1002/ar.21151
Onset of Apoptosis in the Cystic Duct During Metamorphosis of a Japanese Lamprey, Lethenteron reissneri
M. Morii (2010)
10.1002/jcb.10373
Changes of sphingolipid species in the phenotype conversion from myofibroblasts to lipocytes in hepatic stellate cells
Cláudia M B Andrade (2003)
10.1056/NEJME068091
Retinol-binding protein 4, insulin resistance, and type 2 diabetes.
K. Polonsky (2006)
10.1016/j.bbalip.2008.11.001
Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage.
W. Blaner (2009)
10.1016/J.DIABRES.2007.08.016
Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus.
H. Wu (2008)
Expression of muscle-associated cytoskeletal proteins by human sinusoidal liver cells
Q Aimed (1991)
10.1016/J.HEPRES.2006.08.010
The liver as a target organ of retinoids.
G. Shiota (2006)
Hepatic stellate cells (vitamin A-storing cells) change their cytoskeleton structure by extracellular matrix through signal transduction system
N Kojima (1998)
Menger MD (2002a) High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis
B Vollmar (2002)
10.1152/AJPGI.00212.2007
Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1.
S. Radaeva (2007)
10.1016/0003-9861(91)90227-A
Fatty acyl CoA-dependent and -independent retinol esterification by rat liver and lactating mammary gland microsomes.
R. Randolph (1991)
10.3177/JNSV.38.SPECIAL_327
Cellular uptake of vitamin A.
R. Blomhoff (1992)
10.1152/ajpendo.90464.2008
Cellular retinol-binding protein type III is a PPARgamma target gene and plays a role in lipid metabolism.
C. Zizola (2008)
10.1007/BF02977740
Ueber intravasculäre Zellen in den Blutcapillaren der Leberacini
Browicz (1898)
Harrison's Principles of Internal Medicine
Eugene Braunwald (1950)
10.1002/hep.21988
Diacylglycerol acyltranferase 1 anti‐sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis
K. Yamaguchi (2008)
10.1053/JHEP.2003.50005
Foxf1 +/− mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury
V. Kalinichenko (2003)
10.1679/AOHC.70.95
Characterization of vitamin A-storing cells in mouse fibrous kidneys using Cygb/STAP as a marker of activated stellate cells.
Y. Kida (2007)
10.1016/J.CBPC.2004.07.014
Retinal is the essential form of retinoid for storage and transport in the adult of the ascidian Halocynthia roretzi.
Toshiaki Irie (2004)
10.1016/s0021-9258(18)81686-6
Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix.
S. Friedman (1989)
10.1016/s0021-9258(18)60905-6
Liver takes up retinol-binding protein from plasma.
T. Gjøen (1987)
10.1002/HEP.1840150226
Ito cell expression of a nuclear retinoic acid receptor
F. R. Weiner (1992)
10.1111/J.1753-4887.1987.TB02696.X
Hepatic retinol metabolism: role of the various cell types.
R. Blomhoff (1987)
10.1053/JHEP.2000.9322
Proteome analysis of rat hepatic stellate cells
Dan Bach Kristensen (2000)
10.1002/HEP.1840210418
Interferon alfa and gamma inhibit proliferation and collagen synthesis of human ito cells in culture
A. Mallat (1995)
10.1042/BJ3050419
Tissue distribution of the receptor for plasma retinol-binding protein.
S. Smeland (1995)
10.1136/gut.44.1.127
Inhibitory effect of oestradiol on activation of rat hepatic stellate cells in vivo and in vitro
I. Shimizu (1999)
10.1126/SCIENCE.7716514
Integrins and signal transduction pathways: the road taken.
E. Clark (1995)
10.1097/00007890-198408000-00016
PHENOTYPE AND HISTOLOGICAL DISTRIBUTION OF INTERSTITIAL DENDRITIC CELLS IN THE RAT PANCREAS, LIVER, HEART, AND KIDNEY
B. Steiniger (1984)
10.1074/jbc.M605621200
Impaired Proteolysis of Collagen I Inhibits Proliferation of Hepatic Stellate Cells
X. Zhou (2006)
10.1002/HEP.1840200433
Hepatic ito cells contain calcium channels: Increases with transforming growth factor‐β 1
H. Oide (1994)
10.1136/gut.49.5.713
Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells
K. J. Vincent (2001)
10.1111/J.1600-0676.1998.TB00120.X
Signal transduction in hepatic stellate cells.
M. Pinzani (1998)
10.1007/BF00215511
Stellate cells storing retinol in the liver of adult lamprey, Lampetra japonica
K. Wake (2004)
10.1016/S0168-8278(99)80006-3
Differential expression of prostanoid receptors in hepatocytes, Kupffer cells, sinusoidal endothelial cells and stellate cells of rat liver.
A. Fennekohl (1999)
10.1136/GUT.2005.053278
Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells.
T. Itagaki (2005)
10.1002/hep.20015
Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
K. Hellemans (2004)
10.1016/J.ABB.2007.04.016
NOX in liver fibrosis.
S. de Minicis (2007)
10.1124/JPET.105.085597
Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis
S. Fiorucci (2005)
10.1006/EXCR.1996.0174
Interactions of human skin fibroblasts with monomeric or fibrillar collagens induce different organization of the cytoskeleton.
I. Mercier (1996)
10.1074/jbc.M101840200
JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells*
D. Smart (2001)
10.1053/J.GASTRO.2005.03.025
Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells.
K. Shimizu (2005)
H2O2 and cyclooxygenase-2
T Niki (1996)
Elongation of long, multipolar processes in hepatic stellate cell culture on type I collagen gel by microtubule assembly: observation utilizing time-lapse video-microscopy
M Miura (1999)
Hepatic stellate cells and extrahepatic stellate cells (extrahepatic vitamin A-storing cells)
Y Matano (1999)
Hepatic uptake
R 150194–204 Blomhoff (1985)
10.1002/JCP.1041360323
Transforming growth factor β responsiveness is modulated by the extracellular collagen matrix during hepatic ito cell culture
B. H. Davis (1988)
10.1126/SCIENCE.294.5548.1866
Nuclear receptors and lipid physiology: opening the X-files.
A. Chawla (2001)
10.1074/JBC.M410078200
Adipogenic Transcriptional Regulation of Hepatic Stellate Cells*
H. She (2005)
Fat-storing cells
S Bronfenmajer (1966)
10.1016/0014-5793(90)81336-M
Distribution of lecithin‐retinol acyltransferase activity in different types of rat liver cells and subcellular fractions
W. Blaner (1990)
10.1073/PNAS.79.23.7326
In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells.
R. Blomhoff (1982)
Retinol Esterification by Rat Liver Microsomes EVIDENCE FOR A FATTY ACYL COENZYME A : RETINOL ACYLTRANSFERASE *
A. Catharine (2001)
10.1016/S0014-5793(02)03276-3
p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF‐α and TGF‐β in a cell line of rat hepatic stellate cells 1
M. Varela-Rey (2002)
10.1080/01926230390183643
Mast Cell Density, Hepatic Stellate Cell Activation and TGF-β1 Transcripts in the Aging Sprague-Dawley Rat During Early Acute Liver Injury
F. Grizzi (2003)
10.1016/S0168-8278(99)80262-1
Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo.
M. Okuno (1999)
10.1016/s0021-9258(19)38241-9
Purification and crystallization of a retinoic acid-binding protein from rat epididymis. Identity with the major androgen-dependent epididymal proteins.
M. Newcomer (1990)
Transcriptional regulation of stellate cell activation
SL Friedman (2006)
Regulation of cultured rat hepatocyte proliferation by stellate cells
宇山 直樹 (2002)
10.1002/HEP.1840190224
Ito cell heterogeneity: Desmin‐negative ito cells in normal rat liver
G. Ballardini (1994)
Hepatic stellate cells--from the viewpoint of retinoid handling and function of the extracellular matrix.
H. Senoo (1997)
10.1038/71397
Complexity and specificity of integrin signalling
F. Giancotti (2000)
Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis.
A. M. Gressner (1990)
10.1021/BC00011A013
Nuclear targeting of a viral-cointernalized protein by a short signal sequence from human retinoic acid receptors.
F. Hamy (1991)
10.1056/NEJM199306243282508
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies
S. Friedman (1993)
Histologic distribution of vitamin A in human organs under normal and under pathologic conditions.
H. Popper (1941)
10.1053/JHEP.2001.27828
Oxidized low‐density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis
W. Schneiderhan (2001)
10.1074/JBC.M209673200
Stimulation of Proliferation of Rat Hepatic Stellate Cells by Galectin-1 and Galectin-3 through Different Intracellular Signaling Pathways*
N. Maeda (2003)
10.1074/jbc.m207712200
The Surface of Lipid Droplets Is a Phospholipid Monolayer with a Unique Fatty Acid Composition*
Kumi Tauchi-Sato (2002)
10.1002/HEP.510290234
Nestin in the liver—lessons from the brain
A. Messing (1999)
10.1073/PNAS.86.24.9906
The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others.
M. J. Elices (1989)
10.1152/AJPGI.1992.263.2.G139
The liver as a stem cell and lineage system.
S. Sigal (1992)
10.1152/AJPGI.2000.279.2.G245
Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis.
M. J. Arthur (2000)
10.1002/AR.A.10345
Vitamin A distribution and content in tissues of the lamprey, Lampetra japonica.
H. L. Wold (2004)
10.1038/318670A0
Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product
C. Weinberger (1985)
10.1007/bf02890417
The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver
G. Ramadori (1991)
10.1053/JHEP.2001.23937
Morphologic and functional characterization of caveolae in rat liver hepatocytes
M. Calvo (2001)
Cooperation of Ito cells and hepatocytes in the deposition of an extracellular matrix in vitro.
O. Loréal (1993)
10.1016/S0016-5085(98)70216-1
Pancreatic stellate cells: the new stars of chronic pancreatitis?
R. Wells (1998)
10.1111/j.1478-3231.2008.01773.x
Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver
K. Nagatsuma (2009)
Inhibitory effect of acyclic (polyprenoic acid) on hepatic fibrosis
M Okuno (1990)
10.1042/BST0341119
The impact of pregnane X receptor activation on liver fibrosis.
M. Wright (2006)
1975a) One hundred years of the stellate cells of von Kupffer
K Wake (1975)
The role of focal adhesion
DA (2003)
10.1038/nbt1396
Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone
Y. Sato (2008)
Stellate cell-endothelial cell interactions
H Senoo (2007)
Ueber das Verhaeltnis der Kupfferschen Sternzellen zum Endothel der Leberkapillaren beim Menschen
K W Zimmerman (1928)
Localization of retinol-binding protein in several tissues
SB Porter (1983)
10.4183/AEB.2005.499
Harrison's Principles of Internal Medicine 16th ed
C. Badiu (2005)
10.1152/PHYSREV.1991.71.4.951
Vitamin A metabolism: new perspectives on absorption, transport, and storage.
R. Blomhoff (1991)
10.1152/ajpgi.1998.275.2.G269
Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells.
C. Hellerbrand (1998)
10.1007/BF00410656
Evidence of species differences in the ultrastructure of the Hepatic sinusoid
R. L. Wood (2004)
Fatstoring (Ito) cell biology
A Geerts (1994)
10.1210/ER.2000-0035
Bile acid regulation of gene expression: roles of nuclear hormone receptors.
J. Chiang (2002)
10.1007/BF00482963
Immunogold localization of procollagen III, fibronectin and heparan sulfate proteoglycan on ultrathin frozen sections of the normal rat liver
A. Geerts (2004)
10.1128/MCB.00813-07
Vitamin K Induces Osteoblast Differentiation through Pregnane X Receptor-Mediated Transcriptional Control of the Msx2 Gene
M. Igarashi (2007)
10.1242/jcs.03191
Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis
H. Robenek (2006)
10.1136/gut.2005.088690
Emerging insights into Transforming growth factor β Smad signal in hepatic fibrogenesis
Y. Inagaki (2007)
10.1002/HEP.1840080416
The effect of retinol on ito cell proliferation in vitro
B. H. Davis (1988)
10.1111/J.1530-0277.1997.TB04439.X
Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen.
X. Ma (1997)
10.1016/J.GDE.2005.01.005
The key to development: interpreting the histone code?
R. Margueron (2005)
10.1038/SJ.JID.5700327
Molecular screening for GS2 lipase regulators: inhibition of keratinocyte retinylester hydrolysis by TIP47.
J. Gao (2006)
10.1002/HEP.1840040425
Immunocytochemical Detection of Desmin in Fat‐Storing Cells (Ito Cells)
Y. Yokoi (1984)
10.1002/hep.24119
Septum transversum‐derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
K. Asahina (2011)
10.1002/j.1460-2075.1992.tb05453.x
Cooperation of proto‐signals for nuclear accumulation of estrogen and progesterone receptors.
T. Ylikomi (1992)
10.1111/j.1478-3231.2009.01979.x
Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium
B. Smedsrød (2009)
10.1042/BJ20041598
Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.
C. J. Marek (2005)
10.1074/jbc.M700194200
Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition*
M. Zeisberg (2007)
10.1097/01.LAB.0000069036.63405.5C
Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic
A. Canbay (2003)
10.1002/JCP.1041180203
In vitro characteristics of the lipid‐filled interstitial cell associated with postnatal lung growth: Evidence for fibroblast heterogeneity
H. J. Maksvytis (1984)
10.1053/J.GASTRO.2004.07.007
Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2.
X. Wang (2004)
10.1016/S0002-9440(10)65501-0
Synaptophysin: A novel marker for human and rat hepatic stellate cells.
D. Cassiman (1999)
10.1124/JPET.105.084905
A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes Resolution of Liver Fibrosis
S. Fiorucci (2005)
10.1042/BJ3000793
Characterization of liver stellate cell retinyl ester storage.
G. Trøen (1994)
10.1136/gut.2005.085399
Thiazolidinediones and hepatic fibrosis: don’t wait too long
F. Marra (2006)
10.1042/0264-6021:3480481
Retinoid-binding proteins: mediators of retinoid action.
N. Noy (2000)
Retinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells.
W. Blaner (1985)
10.1016/S0174-173X(82)80031-9
The extracellular matrix of the liver.
M. Rojkind (1982)
10.1016/J.BBADIS.2006.08.009
Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice.
L. Wang (2007)
10.1053/GAST.2002.33367
Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C.
M. J. Arthur (2002)
10.1247/CSF.25.161
Immunocytochemical localization of bovine serum albumin (BSA) in the liver and testis of rats injected with testosterone-BSA, hydrocortisone-BSA or corticosterone-BSA.
T. Nishimura (2000)
Newly administered
R Blomhoff (1988)
b-Carotene storage, conversion to retinoic acid, and induction of the lipocyte phenotype in hepatic stellate cells
EB Martucci (2004)
Structure of the sinusoidal wall in the liver
K Wake (1995)
MAPK mediates the regulation of a1(I) procollagen mRNA levels by TNF-a and TGF-b in a cell line of rat hepatic stellate cells
M Varela-Rey (2002)
The stellate cell of the liver
K Wake (1975)
Ueber Sternzellen der Leber. Briefliche Mitteilung an Prof. Waldeyer
C. Kupffer (1876)
10.1146/ANNUREV.NU.12.070192.000345
Vitamin A: physiological and biochemical processing.
R. Blomhoff (1992)
10.1007/s10555-005-5127-2
Integrin Signaling
R. Juliano (2005)
10.1007/s11626-005-0002-6
Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells
M. Fukushima (2005)
Cytoskeletal Control of Gene Expression : Depolymerization of Microtubules Activates NF-xB
(2002)
10.1038/labinvest.2008.20
Activation of peroxisome proliferator-activated receptor-γ by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells
Jianguo Lin (2008)
10.1016/s0021-9258(17)38759-8
Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells.
R. Blomhoff (1985)
10.1016/s0021-9258(18)99168-4
Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets.
A. Greenberg (1991)
Morphology and function of Ito cell (fat-storing cell) in the liver
M Yamamoto (1975)
10.1126/SCIENCE.1064829
Taking Cell-Matrix Adhesions to the Third Dimension
E. Cukierman (2001)
10.3109/01902148309055012
Induction of lipid droplets in fibroblasts of the hamster lung by a diet high in vitamin A.
B. J. Spit (1983)
10.1126/SCIENCE.3029866
Molecular cloning of complementary DNA encoding the avian receptor for vitamin D.
D. McDonnell (1987)
10.1053/J.GASTRO.2003.11.018
Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells.
R. Bataller (2004)
10.1073/PNAS.95.16.9500
Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.
V. Ratziu (1998)
Vitamin sources in Arctic regions
K. Rodahl (1949)
10.1634/stemcells.2008-0115
Fate‐Mapping Evidence That Hepatic Stellate Cells Are Epithelial Progenitors in Adult Mouse Livers
L. Yang (2008)
10.1002/HEP.1840160224
Small cell colonies appear in the primary culture of adult rat hepatocytes in the presence of nicotinamide and epidermal growth factor
T. Mitaka (1992)
10.1002/HEP.1840200122
Prostaglandin F2α and D2 release from primary ito cell cultures after stimulation with noradrenaline and ATP but not adenosine
A. Athari (1994)
10.1073/PNAS.89.17.7856
Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein.
H. Jiang (1992)
10.1021/ES00033A009
Global distribution of tris(4-chlorophenyl)methanol in high tropic level birds and mammals
W. Jarman (1992)
10.3892/IJMM.19.1.105
Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.
Alain da Silva Morais (2007)
10.1002/HEP.1840140520
Dexamethasone modulates α2‐macroglobulin and apolipoprotein E gene expression in cultured rat liver fat‐storing (Ito) cells
G. Ramadori (1991)
10.1034/J.1600-0676.2001.01631.X
In vivo quantification of ageing changes in the rat liver from early juvenile to senescent life.
B. Vollmar (2002)
The hepatic extracellular matrix. I. Components and distribution in normal liver
A Martinez-Hernandez (1993)
Moellendorff’s Handbuch der mikroskopishen Anatomie des Menscen
W Pfuhl (1932)
Role of NFjB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-a in human hepatic stellate cells
C Gallois (1998)
Uptake of collagen into hepatic stellate cells
SA Mousavi (2005)
10.1007/978-94-011-4932-7_20
Hepatic stellate cells.
S. Friedman (1996)
Absorption, transport, and storage of retinyl-15-14C palmitate-9,10-3H in the rat.
C. Lawrence (1966)
10.1016/S0987-7053(99)80055-0
Harrison's principles of internal medicine
J. M. Guérit (1999)
10.1002/AR.1091910106
Intrahepatic distribution of nerves in the rat
F. Reilly (1978)
10.1073/PNAS.80.21.6586
Localization of cellular retinol-binding protein in several rat tissues.
S. B. Porter (1983)
10.1007/BF00221510
Primary cultures of endothelial cells of the rat liver
A. D. Leeuw (2004)
So-called Kupffer cells and hepatic stellate cells
K Wake (1980)
10.1016/s0021-9258(17)38761-6
Hepatic uptake of [3H]retinol bound to the serum retinol binding protein involves both parenchymal and perisinusoidal stellate cells.
R. Blomhoff (1985)
10.1016/S0968-0004(98)01349-8
Mechanisms of lipid-body formation.
D. Murphy (1999)
10.1152/AJPLUNG.1992.262.5.L517
The lungs and vitamin A.
F. Chytil (1992)
10.1038/164530A0
Toxicity of Polar Bear Liver
K. Rodahl (1949)
10.1074/jbc.M006577200
Peroxisome Proliferator-activated Receptors and Hepatic Stellate Cell Activation*
T. Miyahara (2000)
10.1016/J.CMET.2007.02.006
STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens.
W. Blaner (2007)
10.1002/HEP.1840030101
Hepatic Fibrosis After Long‐Term Administration of Ethanol and Moderate Vitamin A Supplementation in the Rat
M. Leo (1983)
10.1016/J.JHEP.2003.12.006
On the origin of stellate cells: mesodermal, endodermal or neuro-ectodermal?
A. Geerts (2004)
10.1016/0167-4889(89)90055-4
Modulation of vitamin A metabolism during hepatic and intestinal cell culture.
B. H. Davis (1989)
10.1016/S0168-8278(02)00263-5
Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research.
D. Cassiman (2002)
Reversible regulation of hepatic stellate cell functions by three-dimensional structure of extracellular matrix
N. Kojima (1997)
10.1046/j.1440-1711.2002.01063.x
Hepatoimmunology: A perspective
I. Mackay (2002)
10.1053/GAST.2002.33023
Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C.
T. Poynard (2002)
10.1002/AR.A.20230
Vitamin A storage in hepatic stellate cells in the regenerating rat liver: with special reference to zonal heterogeneity.
N. Higashi (2005)
10.1002/HEP.510290333
Control of the tissue inhibitor of metalloproteinases‐1 promoter in culture‐activated rat hepatic stellate cells: Regulation by activator protein‐1 DNA binding proteins
M. Bahr (1999)
10.1152/AJPGI.00537.2005
Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells.
P. Sancho-Bru (2006)
Isolation and serum free culture of stellate cells
H Senoo (1991)
Cells in and around the hepatic sinusoid: past, present and future. In: Motta PM (ed) Recent advances in microscopy of cells, tissues and organs
K Wake (1997)
10.1196/annals.1377.010
Cytoplasmic Lipid Droplets
T. Fujimoto (2006)
10.1111/j.1749-6632.1980.tb21314.x
PLASMA RETINOL‐BINDING PROTEIN *
D. S. Goodman (1980)
10.2307/3868324
Polar Bears and PCBs
Nancy Bazilchuk (2004)
10.1007/BF02593544
Der feinere Bau der Blutcapillaren
K. Zimmermann (2007)
10.1002/AR.A.20091
Control of hepatocyte metabolism by sympathetic and parasympathetic hepatic nerves.
G. Püschel (2004)
Expression of intercellular adhesion molecule 1 by activated hepatic stellate cells
Lu Lun (1998)
10.1152/AJPGI.00411.2003
Tumor necrosis factor-α inhibits peroxisome proliferator-activated receptor γ activity at a posttranslational level in hepatic stellate cells
C. Sung (2004)
Morphological aspects of the differentiation of stellate cell line in the vertebrates
K. Wake (1986)
10.1002/hep.21093
Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
Shan-Shan Zhan (2006)
10.1016/S1357-2725(01)00066-8
Retinol mobilization from cultured rat hepatic stellate cells does not require retinol binding protein synthesis and secretion.
P. Sauvant (2001)
10.1016/0014-4827(77)90011-8
Isolation and characterization of Kupffer and endothelial cells from the rat liver.
D. Knook (1977)
10.1016/J.BCP.2003.11.013
Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase(PI3-kinase) pathway.
J. McCarroll (2004)
10.1186/1476-5926-2-S1-S18
Decreased Capacity for Vitamin A Storage in Hepatic Stellate Cells for Arctic Animals
H. Senoo (2004)
10.1038/NEWBIO243186A0
Cytological studies of fat-storing cells in the liver of rats given large doses of vitamin A.
K. Kobayashi (1973)
10.1002/j.1460-2075.1986.tb04300.x
The chicken oestrogen receptor sequence: homology with v‐erbA and the human oestrogen and glucocorticoid receptors.
A. Krust (1986)
Complement C4 protein expression by rat hepatic stellate cells.
C. Fimmel (1996)
10.1016/J.JHEP.2003.09.026
Corticosteroids stimulate selectively transforming growth factor (TGF)-beta receptor type III expression in transdifferentiating hepatic stellate cells.
L. Wickert (2004)
10.1007/s00441-005-0028-9
Transdifferentiation of vocal-fold stellate cells and all-trans retinol-induced deactivation
Tannin J. Fuja (2005)
10.1136/gut.45.1.134
All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially
K. Hellemans (1999)
10.1111/j.1440-1746.2006.04659.x
Molecular mechanisms of hepatic fibrogenesis
C. J. Parsons (2007)
10.3892/ijmm.2011.809
Elevated expression of transforming growth factor β3 in carbon tetrachloride-treated rat liver and involvement of retinoid signaling.
Y. Mezaki (2012)
Electron microscopic observation on the sinusoid of the normal rabbit liver.
T. Horiuchi (1960)
10.1016/0092-8674(92)90115-S
Integrins: Versatility, modulation, and signaling in cell adhesion
R. Hynes (1992)
10.1016/j.exger.2005.06.012
Hepatic pseudocapillarization in aged mice
A. Warren (2005)
10.20632/VSO.59.4_184_2
THE NAME OF THE PERISINUSOIDAL STELLATE CELLS, FAT STORING CELLS, ITO CELLS, PERICYTES, VITAMIN A STORING CELLS OF THE LIVER.
R. K. Norum (1985)
10.1053/JHEP.2003.50002
Activated stellate cells express the TRAIL receptor‐2/death receptor‐5 and undergo TRAIL‐mediated apoptosis
P. Taimr (2003)
Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair.
T. Knittel (1996)
10.1016/S0168-8278(00)80514-0
Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors.
D. Cassiman (2001)
10.1002/HEP.510240137
Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance
D. Rockey (1996)
10.7589/0090-3558-34.4.792
FEMALE PSEUDOHERMAPHRODITE POLAR BEARS AT SVALBARD
Ø. Wiig (1998)
10.1172/JCI30542
Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ.
J. Iredale (2007)
10.1002/(SICI)1097-0185(20000401)258:4<338::AID-AR2>3.0.CO;2-G
Storage of lipid droplets in and production of extracellular matrix by hepatic stellate cells (vitamin A‐storing cells) in Long‐Evans cinnamon‐like colored (LEC) rats
K. Imai (2000)
Die Bindegewebeszellen des Dissesch en Raumes in der menschlichten Leber bei Normafaellen und pathologischen Zustaenden
H Schnack (1966)
The Sternzellen of von Kupffer-after 106 years. In: Knook DL, Wisse E (eds) Sinusoidal liver cells
K Wake (1982)
10.1053/J.GASTRO.2007.02.033
Gene expression profiles during hepatic stellate cell activation in culture and in vivo.
S. de Minicis (2007)
Vitamin A-storing cell (stellate cell) system. In: Loessing IT (ed) Vitamin A: new research
H Senoo (2007)
10.1016/S0344-0338(11)80990-8
Regulation of proteoglycan expression in fibrotic liver and cultured fat-storing cells.
A. M. Gressner (1994)
10.1152/ajpgi.1998.275.2.g269
Cytokines induce NF-κB in activated but not in quiescent rat hepatic stellate cells.
C. Hellerbrand (1998)
Intracellular signaling for process elongation in cultured hepatic stellate cells on type I collagen gel
M Sato (1999)
10.1016/S0945-053X(96)90015-3
Promotion of fibroblast adhesion by triple-helical peptide models of type I collagen-derived sequences.
B. Grab (1996)
10.1016/S0098-2997(03)00038-4
Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models.
L. Quadro (2003)
10.1016/0014-5793(89)81804-6
Transforming growth factors (TGFα and TGFβH) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells
M. Bachem (1989)
10.1016/J.JHEP.2004.02.005
Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat.
A. Mabuchi (2004)
10.1083/JCB.132.6.1133
Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium
G. Block (1996)
10.1097/00000441-194911000-00016
A Textbook of Histology
Alexander A. Maximow (1935)
10.1016/s0021-9258(18)50052-1
Characterization of a plasma retinol-binding protein membrane receptor expressed in the retinal pigment epithelium.
C. Bavik (1992)
10.1074/JBC.273.6.3336
The Transfer of Retinol from Serum Retinol-binding Protein to Cellular Retinol-binding Protein Is Mediated by a Membrane Receptor*
M. Sundaram (1998)
Kupffer’s original article of discovery of the stellate cell in liver
K Wake (1978)
Cellular retinol-binding protein. Quantitation and distribution.
U. Eriksson (1984)
10.1247/CSF.26.71
Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in Arctic animals.
M. Sato (2001)
10.1053/J.GASTRO.2004.08.028
From quiescence to activation: Gene regulation in hepatic stellate cells.
R. Rippe (2004)
10.1042/BJ2850367
Eicosanoid-mediated contractility of hepatic stellate cells.
N. Kawada (1992)
10.1126/SCIENCE.3353727
Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
D. Lubahn (1988)
10.1182/BLOOD-2007-07-101261
Hematopoietic origin of hepatic stellate cells in the adult liver.
E. Miyata (2008)
10.1074/jbc.273.1.302
Expression of Interleukin-10 by in Vitro and in Vivo Activated Hepatic Stellate Cells*
S. C. Wang (1998)
10.1006/BBRC.1994.1331
Regulation of undulin synthesis and gene expression in human fat-storing cells by acetaldehyde and transforming growth factor-beta 1: comparison with fibronectin.
A. Casini (1994)
10.1111/J.1530-0277.1979.TB05287.X
Alterations in zinc, vitamin A, and retinol-binding protein in chronic alcoholics: a possible mechanism for night blindness and hypogonadism.
C. McClain (1979)
10.1080/01926230309803
Mast cell density, hepatic stellate cell activation and TGF-b1 transcript in aging rat during early acute liver injury
F. Grizzi (2003)
10.1016/0012-1606(82)90155-5
Collagen modulates cell shape and cytoskeleton of embryonic corneal and fibroma fibroblasts: distribution of actin, alpha-actinin, and myosin.
J. Tomasek (1982)
10.1002/HEP.1840120209
Collagen type I and III occur together in hybrid fibrils in the space of disse of normal rat liver
A. Geerts (1990)
10.1002/HEP.510300327
Persistent activation of nuclear factor‐κB in cultured rat hepatic stellate cells involves the induction of potentially novel rel‐like factors and prolonged changes in the expression of IκB family proteins
A. Elsharkawy (1999)
10.1111/j.1440-1746.2006.04584.x
Hepatic stellate cells and the reversal of fibrosis
T. Kisseleva (2006)
Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis.
S. Vyalov (1993)
10.1002/ar.22555
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators
H. Senoo (2012)
Extracellular matrix regulates cell morphology, proliferation, and tissue formation.
H. Senoo (1994)
10.1016/J.BBALIP.2005.09.003
Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1.
Michael D Orland (2005)
Differentiation of hepatocytes into type I collagen producing cells during primary culture in the presence of aphidicolin (inhibitor of DNA polymerase alpha)
R Hata (1980)
Induction of cellular process elongation mediated by microtubule-associated protein 2 in hepatic stellate cells cultured
M Sato (2001)
10.1097/00002480-199510000-00003
Artificial liver. Evolution and future perspectives.
J. Rozga (1995)
A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix
S Fiorucci (2005)
Rat pancreatic stellate cells secrete
PA Phillips (2003)
Population expansion, clonal division, and specific differentiation patterns in primary cultures of hepatocytes by HGF/SF, EGF, and TGFa in a chemically defined (HGM) medium
GD Block (1996)
Distribution of retinol in rat
R Blomhoff (1988)
Three-dimensional structure of extracellular matrix regulates gene expression in cultured stellate cells to induce process elongation
M Sato (2004)
10.1002/cbin.10140
Uptake and storage of vitamin A as lipid droplets in the cytoplasm of cells in the lamina propria mucosae of the rat intestine
H. Senoo (2013)
10.1016/S0002-9440(10)65595-2
Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia.
G. Ramm (1998)
10.1016/S0161-4754(03)00102-7
The Developing Human: Clinically Oriented Embryology, 7th ed.
B. W. Bakkum (2003)
The Developing Human: Clinically Oriented Embryology
K. Moore (1973)
10.1242/jcs.01005
Fibroblast heterogeneity: more than skin deep
J. Sorrell (2004)
10.1016/s0021-9258(18)33451-3
Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium.
J. Saari (1982)
10.1016/s0021-9258(18)53092-1
Cellular retinol-binding proteins are determinants of retinol uptake and metabolism in stably transfected Caco-2 cells.
M. Levin (1993)
10.1080/009841001459397
Relationships Between Plasma Levels of Organochlorines, Retinol and Thyroid Hormones from Polar Bears (Ursus maritimus) at Svalbard
J. U. Skaare (2001)
10.1016/S0165-5728(85)80073-4
Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver
A. L. Gard (1985)
10.1097/00000478-197912000-00006
The story of the myofibroblasts
G. Majno (1979)
10.1152/ajpendo.1977.232.5.e471
Vitamin A1 intestinal absorption in vivo: influence of luminal factors on transport.
D. Hollander (1977)
10.1152/ajpgi.90356.2008
Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer.
A. Masamune (2008)
10.1172/JCI114362
Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.
S. Friedman (1989)
10.1111/J.1432-1033.1987.TB11058.X
Studies on the in vivo transfer of retinoids from parenchymal to stellate cells in rat liver.
W. Blaner (1987)
10.3109/10520298609109937
Improved Kupffer's gold chloride method for demonstrating the stellate cells storing retinol (vitamin A) in the liver and extrahepatic organs of vertebrates.
K. Wake (1986)
10.1210/EDRV-10-3-308
Retinol-binding protein: the serum transport protein for vitamin A.
W. Blaner (1989)
10.1016/S0003-9861(02)00058-9
Regulation of the murine α2(I) collagen promoter by retinoic acid and retinoid X receptors
L. Wang (2002)
10.1016/0016-5085(88)90625-7
Characteristics of alcohol dehydrogenase in fat-storing (Ito) cells of rat liver.
M. Yamauchi (1988)
10.1016/S0006-291X(88)80818-0
A lecithin:retinol acyltransferase activity in human and rat liver.
P. MacDonald (1988)
10.1016/0006-291X(91)91234-4
Tissue distribution of the 1,25-dihydroxyvitamin D3 receptor in the male rat.
M. E. Sandgren (1991)
10.1002/HEP.1840040307
Purified Rat Liver Fat‐Storing Cells in Culture Divide and Contain Collagen
A. De Margreet Leeuw (1984)
10.2302/KJM.54.190
Fat paradox in liver disease.
H. Tsukamoto (2005)
10.1177/40.12.1333502
Cytoskeletal features of alveolar myofibroblasts and pericytes in normal human and rat lung.
Y. Kapanci (1992)
10.1038/32588
Dendritic cells and the control of immunity
J. Banchereau (1998)
Population kinetics of GFAP-positive cells following experimental acute liver injury
CL Dack (1997)
Kupffer cells
J Armendariz-Borunda (1989)
Fatty acyl CoA
RK 153527–535 Randolph (1991)
Biosynthesis and metabolism of retinoic acid: roles of CRBP and CRABP in retinoic acid homeostasis
JL Napoli (1993)
One hundred years of the stellate cells of von Kupffer
K Wake
Hepatic stellate cell (vitamin Astoring cell) and its relative
H Senoo (2011)
Transforming growth factor-b1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells
T Reimann (1997)
Peroxisome proliferator-activated receptor c induces a phenotypic switch from activated to quiescent hepatic stellate cells
S Hazra (2004)
10.5152/tjg.2018.17330
Liver fibrosis.
M. M. Aydin (2018)
10.1096/fasebj.5.3.2001786
Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis
R. Blomhoff (1991)
Suppression of experimental hepatic fibrosis by administration of vitamin A.
H. Senoo (1985)
10.1038/labinvest.3700013
Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis
Kazuki Nakatani (2004)
10.1002/jcb.20073
β‐Carotene storage, conversion to retinoic acid, and induction of the lipocyte phenotype in hepatic stellate cells
R. Martucci (2004)
10.1002/HEP.1840190415
α‐Smooth muscle actin–positive perisinusoidal stromal cells in human hepatocellular carcinoma
H. Enzan (1994)
10.1111/J.1432-1033.1988.TB13782.X
Distributions of retinoids, retinoid-binding proteins and related parameters in different types of liver cells isolated from young and old rats.
H. F. Hendriks (1988)
10.1016/0304-4165(77)90150-7
Uptake and degdradation of formaldehyde-treated 125I-labeled human serum albumin in rat liver cells in vivo and in vitro
Margareta Nilsson (1977)
10.1007/BF01701981
High levels of PCBs in breast milk of inuit women from arctic quebec
É. Dewailly (1989)
10.1016/j.mehy.2013.04.045
The role of retinoic acid receptors in activated hepatic stellate cells.
Y. Mezaki (2013)
Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43.
P. Greenwel (1993)
10.1016/0016-5085(92)91515-6
Bromobenzene accelerates hepatocyte streaming in rats.
N. Arber (1992)
10.1038/320134A0
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
S. Green (1986)
10.1053/JHEP.2002.30083
Differential regulation of TGF‐β signal in hepatic stellate cells between acute and chronic rat liver injury
Y. Tahashi (2002)
10.1016/S0168-8278(96)80269-8
Glial fibrillary acidic protein--a cell type specific marker for Ito cells in vivo and in vitro.
K. Neubauer (1996)
10.1186/1476-5926-2-S1-S29
Role of Hepatic Stellate Cells in the Early Phase of Liver Regeneration in Rat: Formation of Tight Adhesion to Parenchymal Cells
A. Mabuchi (2004)
10.1136/gut.50.6.891
Transcriptional regulation of hepatic stellate cell activation
D. Mann (2002)
10.1002/AR.A.20200
Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.
N. Higashi (2005)
10.1247/CSF.24.111
Retinol esterification activity contributes to retinol transport in stellate cells.
T. Matsuura (1999)
10.1016/S0002-9440(10)63544-4
Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis.
F. Oakley (2003)
10.11418/JTCA1981.11.3_337
EXTRACELLULAR MATRIX SYSTEM REGULATES CELL GROWTH, TISSUE FORMATION, AND CELLULAR FUNCTIONS
R. Hata (1992)
10.1016/S0016-5085(97)70107-0
Extracellular matrix is reduced by inhibition of transforming growth factor beta1 in pancreatitis in the rat.
A. Menke (1997)
10.1016/S0083-6729(06)75006-3
Vitamin A-storing cells (stellate cells).
H. Senoo (2007)
10.3892/ijmm.2015.2066
Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.
Taku Hebiguchi (2015)
10.1096/FASEBJ.7.2.8440409
Cellular metabolism and activation of retinoids: roles of cellular retinoid-binding proteins.
A. C. Ross (1993)
10.1167/IOVS.06-0768
All-trans-retinol generated by rhodopsin photobleaching induces rapid recruitment of TIP47 to lipid droplets in the retinal pigment epithelium.
E. Tsuiki (2007)
10.1046/j.1440-1746.2002.02831.x
Three‐dimensional examination of hepatic stellate cells in rat liver and response to endothelin‐1 using confocal laser scanning microscopy
H. Oikawa (2002)
10.1016/J.TRSL.2006.03.007
Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats.
G. Fujisawa (2006)
10.1038/262316a0
Native collagen formation by liver parenchymal cells in culture
K. Sakakibara (1976)
10.1369/jhc.2009.953208
Insoluble, Speckled Cytosolic Distribution of Retinoic Acid Receptor Alpha Protein as a Marker of Hepatic Stellate Cell Activation In Vitro
Y. Mezaki (2009)
10.1016/S0168-8278(01)00122-2
Alpha B-crystallin expression in human and rat hepatic stellate cells.
D. Cassiman (2001)
10.1016/S1357-2725(96)00068-4
Retinyl ester storage is altered in liver stellate cells and in HL60 cells transfected with cellular retinol-binding protein type I.
Å. Nilsson (1997)
Cytological studies on stellate cells of Kupffer and fatstoring cells in the capillary wall of the human liver
T Ito (1951)
10.1074/JBC.M507924200
Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT)*
S. M. O'Byrne (2005)
10.1042/CBI20100321
Hepatic stellate cell (vitamin A‐storing cell) and its relative – past, present and future
H. Senoo (2010)
Morphology of sites of adhesion between extracellular matrix and hepatic stellate cells
K Imai (2000)
Peroxisome proliferator-activated receptor c suppresses proximal a1(I) collagen promoter via inhibition of p300facilitated NF-I binding to DNA in hepatic stellate cells
S Yavrom (2005)
Uptake of collagen into hepatic stellate cells: evidence of the involvement of urokinase plasminogen activator associated protein/Endo 180
S A Mousavi (2005)
Identification of a tetrapeptide recognition sequence for the a2b1 integrin in collagen
WD Staatz (1991)
Induction of cellular process elongation mediated by microtubule-associated protein 2 in hepatic stellate cells cultured on type I collagen gel
M Sato (2001)
Vitamin A-storing cell (stellate cell) system
H Senoo (2007)
10.1053/GAST.2002.33666
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
A. Galli (2002)
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein.
D. Brasaemle (1997)
Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.
W. Staatz (1991)
10.1186/1476-5926-2-S1-S4
3-D structure of extracellular matrix regulates gene expression in cultured hepatic stellate cells to induce process elongation
M. Sato (2004)
10.1093/jn/123.suppl_2.362
Biosynthesis and metabolism of retinoic acid: roles of CRBP and CRABP in retinoic acid: roles of CRBP and CRABP in retinoic acid homeostasis.
J. Napoli (1993)
Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway inactivation
F Jiang (2006)
10.1002/hep.22426
Does retinol‐binding protein 4 cause or reflect fatty liver disease?
M. Blüher (2008)
Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.
E. J. Blanchette-Mackie (1995)
10.1016/J.BBRC.2007.06.189
Expression and function of fibroblast growth factor (FGF) 9 in hepatic stellate cells and its role in toxic liver injury.
M. Antoine (2007)
10.1002/(SICI)1097-0029(19971115)39:4<336::AID-JEMT4>3.0.CO;2-F
Development of hepatic sinusoidal structure with special reference to the Ito cells
H. Enzan (1997)
[Browicz's phagocytic cells and Kupffer's 'so-called stellate cells'].
K. Wake (2009)
10.1038/mt.2016.127
MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice.
Y. Matsumoto (2016)
10.1126/science.1161431
Generation and Regeneration of Cells of the Liver and Pancreas
K. Zaret (2008)
10.1074/jbc.M409444200
The Role of p70S6K in Hepatic Stellate Cell Collagen Gene Expression and Cell Proliferation*
E. Gäbele (2005)
10.1172/JCI114363
Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.
M. Pinzani (1989)
10.1002/hep.21107
Mechanisms of alcohol‐induced hepatic fibrosis: A summary of the Ron Thurman Symposium
V. Purohit (2006)
10.1016/0014-5793(95)01261-0
Involvement of phosphatidylinositol 3‐kinase in the activation of extracellular signal‐regulated kinase by PDGF in hepatic stellate cells
F. Marra (1995)
10.1152/AJPGI.1993.264.5.G947
Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF.
S. Friedman (1993)
10.1073/PNAS.90.24.12035
Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes.
A. Greenberg (1993)
The stellate cell (vitamin A-storing cell) system
H Senoo (2014)
Alteration in distribution of focal adhesion components by signaling inhibitors in hepatic stellate cells and fibroblasts cultured on type I collagen gel
N Kojima (1999)
Regulation of vitamin A homeostasis by the stellate cell (vitamin A-storing cell) system. In: Lucas P (ed) Vitamin A: nutrition, side effects and supplements nutrition and diet research progress
H Senoo (2011)
10.1267/AHC.10.253
A NOTE ON AUTORADIOGRAPHY; AN INTRODUCTION OF VITAMIN A-STORING CELLS
K. Hirosawa (1977)
Morphology and function of Ito cell (fat-storing cell) in the liver
M Yamamoto (1975)
10.1002/(SICI)1097-0185(199804)250:4<430::AID-AR6>3.0.CO;2-0
Morphology of sites of adhesion between hepatic stellate cells (vitamin A‐storing cells) and a three‐dimensional extracellular matrix
K. Imai (1998)
Evidence of species difference in the ultrastructure of the hepatic sinusoids
RL Wood (1963)
Expression of the integrin a8b1
D Levine (2000)
Peroxisome proliferator-activated receptor c transcriptional regulation is involved in platelet-derived growth factorinduced proliferation of human hepatic stellate cells
A Galli (2000)
10.1074/JBC.M001422200
Ethanol and Arachidonic Acid Increase α2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1
N. Nieto (2000)
10.1136/gut.52.5.677
Cell migration: a novel aspect of pancreatic stellate cell biology
P. Phillips (2003)
10.1038/labinvest.3780456
Cellular Retinol-Binding Protein-1 Expression and Modulation during In Vivo and In Vitro Myofibroblastic Differentiation of Rat Hepatic Stellate Cells and Portal Fibroblasts
K. Uchio (2002)
10.1006/BBRC.2001.5479
Hepatic Stellate Cells Contain the Functional Estrogen Receptor β but Not the Estrogen Receptor α in Male and Female Rats
Yajun Zhou (2001)
10.1002/HEP.510240333
Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells
C. Hellerbrand (1996)
10.3748/WJG.V11.I30.4735
Effect of ligand of peroxisome proliferator-activated receptor gamma on the biological characters of hepatic stellate cells.
Y. Guo (2005)
10.1016/S0955-2863(01)00179-6
Acyl-CoA: retinol acyltransferase (ARAT) and lecithin:retinol acyltransferase (LRAT) activation during the lipocyte phenotype induction in hepatic stellate cells.
V. Fortuna (2001)
10.1006/ABBI.1997.0209
Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoids.
T. Shimada (1997)
10.1172/JCI106741
The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma.
F. Smith (1971)
10.1016/0168-8278(90)90080-B
Nerves and perisinusoidal cells in human liver.
P. Bioulac-Sage (1990)
10.1247/CSF.1.201
The Possible Existence of a Vitamin A-storing Cell System
E. Yamada (1976)
10.1002/AR.A.20092
Innervation of the sinusoidal wall: regulation of the sinusoidal diameter.
T. Ueno (2004)
10.1053/J.GASTRO.2005.01.007
Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor.
G. Svegliati-Baroni (2005)
10.1074/JBC.M005118200
Characterization of a New Member of the Fatty Acid-binding Protein Family That Binds All-trans-retinol*
S. Vogel (2001)
10.1194/JLR.R100015-JLR200
Gene expression regulation by retinoic acid Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.R100015-JLR200
J. Balmer (2002)
10.1001/jama.1995.03530040080050
Bloom and Fawcett: A Textbook of Histology
C. Cross (1995)
10.1016/S0955-0674(99)00067-8
Focal adhesions - the cytoskeletal connection.
D. Critchley (2000)
10.1053/GAST.2003.50012
Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors.
Chang-qing Yang (2003)
10.1111/J.1600-0676.1988.TB00995.X
The streaming liver. III. Littoral cells accompany the streaming hepatocyte.
G. Zajicek (1988)
10.1016/s0021-9258(18)34945-7
Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase.
A. C. Ross (1982)
10.1055/S-2001-17554
Cytokine receptors and signaling in hepatic stellate cells.
M. Pinzani (2001)
10.1053/JHEP.2002.32524
Hypoxia‐induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
C. Corpechot (2002)
10.1016/S0002-9440(10)64994-2
Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation.
N. Trim (2000)
10.1016/J.DLD.2004.07.002
Therapies for hepatic fibrosis: real hope or just academic exercise?
M. Pinzani (2004)
10.1111/j.1440-1681.1992.tb00501.x
AGEING HAS NO EFFECT ON THE VOLUME DENSITY OF HEPATOCYTES, RETICULOENDOTHELIAL CELLS OR THE EXTRACELLULAR SPACE IN LIVERS OF FEMALE SPRAGUE‐DAWLEY RATS
G. Martín (1992)
10.1038/318635A0
Primary structure and expression of a functional human glucocorticoid receptor cDNA
S. M. Hollenberg (1985)
10.1016/S0168-8278(02)00429-4
Liver fibrosis -- from bench to bedside.
S. Friedman (2003)
10.1007/BF00194608
Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver
H. Enzan (2004)
10.1002/hep.20054
PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation
S. Fiorucci (2004)
10.1016/J.JHEP.2004.04.003
The role of hepatic stellate cells in liver regeneration.
C. Balabaud (2004)
10.1074/JBC.M312410200
Lecithin-retinol Acyltransferase Is Essential for Accumulation of All-trans-Retinyl Esters in the Eye and in the Liver*
Matthew L Batten (2004)
10.1016/J.JHEP.2004.12.008
Fibrosis in chronic liver diseases: diagnosis and management.
M. Pinzani (2005)
Histochemical studies of vitamin A
K Tanaka (1955)
Three-dimensional morphological changes in cultured hepatic stellate cells by type I collagen fibers
K Imai (1997)
CCl4-induced fibrotic rat livers
T Niki (1999)
10.1016/0076-6879(90)90009-P
Isolation and cultivation of rat liver stellate cells.
R. Blomhoff (1990)
10.1002/HEP.1840160325
Inhibition of rat hepatic lipocyte activation in culture by interferon‐γ
D. Rockey (1992)
Absorption of vitamin A in the rat.
H. Popper (1944)
Adipose differentiation-related protein
EJ (1997)
Primary culture of endothelial cells of the rat liver. A model for ultrastructural and functional studies
AM de Leeuw (1982)
A hierarchy of ECMmediated signaling regulates tissue-specific gene expression
CD Roskelley (1995)
Uptake and degradation of formaldehyde-treated 125I-labelled human serum albumin in rat liver cells in vivo and in vitro.
M. Nilsson (1977)
10.1111/J.1600-0676.1985.TB00252.X
[The streaming liver].
N. Arber (1991)
10.1016/0014-4827(84)90713-4
Newly administered [3H]retinol is transferred from hepatocytes to stellate cells in liver for storage.
R. Blomhoff (1984)
10.1007/BF02933897
Ueber Sternzellen der Leber
C. Kupffer (1876)
10.1006/BBRC.1996.0636
Retinoic acid-stimulated liver stellate cells suppress the production of albumin from parenchymal cells via TGF-beta.
H. Koda (1996)
10.1083/JCB.128.6.1111
Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B
C. Rosette (1995)
10.2220/BIOMEDRES.7.311
ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE
H. Senoo (1986)
10.1016/J.JHEP.2006.03.016
Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation.
F. Jiang (2006)
10.1016/J.BBRC.2006.09.069
PPARγ Agonists Prevent TGFβ1/Smad3-Signaling in Human Hepatic Stellate Cells
Caiyan Zhao (2006)
10.1007/s004180050273
Hepatic stellate cells (vitamin A-storing cells) change their cytoskeleton structure by extracellular matrix components through a signal transduction system
N. Kojima (1998)
10.1074/JBC.M310284200
Peroxisome Proliferator-activated Receptor γ Induces a Phenotypic Switch from Activated to Quiescent Hepatic Stellate Cells*
S. Hazra (2004)
10.1074/JBC.271.19.11039
Raf and Mitogen-activated Protein Kinase Regulate Stellate Cell Collagen Gene Expression (*)
B. H. Davis (1996)
10.1016/s0021-9258(18)98574-1
Identification and partial characterization of a retinal pigment epithelial membrane receptor for plasma retinol-binding protein.
C. Bavik (1991)
10.1016/S1388-1981(99)00117-1
Interactions of retinoid binding proteins and enzymes in retinoid metabolism.
J. Napoli (1999)
10.1002/j.1460-2075.1987.tb02654.x
Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor.
D. Picard (1987)
10.1016/J.JHEP.2003.10.020
Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytes.
Y. Gnainsky (2004)
10.1634/stemcells.2006-0316
Identification and Characterization of Vitamin A‐Storing Cells in Fetal Liver: Implications for Functional Importance of Hepatic Stellate Cells in Liver Development and Hematopoiesis
H. Kubota (2007)
10.1002/hep.20427
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations
S. Magness (2004)
10.1016/J.JHEP.2006.04.014
Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.
T. Kisseleva (2006)
10.1016/0167-4889(89)90069-4
Retinoid-mediated induction of the fat-storing phenotype in a liver connective tissue cell line (GRX).
R. Margis (1989)
10.1002/hep.20425
Antifibrotic effects of a tissue inhibitor of metalloproteinase‐1 antibody on established liver fibrosis in rats
C. J. Parsons (2004)
10.5772/35813
How Do Lampreys Avoid Cholestasis After Bile Duct Degeneration
M. Morii (2012)
10.2183/PJAB.54.391
Active Synthesis of Collagen by Albumin-Producing Liver Parenchymal Cell Clones in Culture
R. Hata (1978)
10.1016/J.ABB.2007.06.024
Rat hepatic stellate cells acquire retinoid responsiveness after activation in vitro by post-transcriptional regulation of retinoic acid receptor alpha gene expression.
Y. Mezaki (2007)
10.1056/NEJMOA054862
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
T. Graham (2006)
10.1016/S0167-4838(00)00156-4
Epididymal retinoic acid-binding protein.
D. Ong (2000)
Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets.
H. Moriwaki (1988)
10.1679/AOHC.74.59
Histology of the hepatopancreas of puffer fish (Takifugu rubripes) in relation to the localization of tetrodotoxin
M. Miura (2013)
10.1073/PNAS.95.22.13018
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
S. Cases (1998)
10.1016/J.JHEP.2005.09.023
Hepatic stellate cells do not derive from the neural crest.
D. Cassiman (2006)
10.1016/0014-4827(85)90243-5
Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver.
H. F. Hendriks (1985)
10.1152/AJPLUNG.00140.2003
Lung retinol storing cells synthesize and secrete retinoic acid, an inducer of alveolus formation.
G. Dirami (2004)
10.1016/0048-9697(92)90246-O
Arctic marine ecosystem contamination.
D. Muir (1992)
10.1152/AJPGI.00474.2002
Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth.
J. Xu (2003)
10.1002/HEP.510280115
Collagen XVIII is localized in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver
O. Musso (1998)
10.1247/CSF.28.105
Hepatic stellate cells: unique characteristics in cell biology and phenotype.
M. Sato (2003)
10.1002/HEP.1840110119
Ito‐cell gene expression and collagen regulation
F. R. Weiner (1990)
10.1042/BJ20040928
Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro.
Shizhong Zheng (2004)
10.1016/0167-4889(94)90181-3
Prostaglandin E suppression of platelet-derived-growth-factor-induced Ito cell mitogenesis occurs independent of raf perinuclear translocation and nuclear proto-oncogene expression.
D. W. Beno (1994)
[One hundred years of sinusoidal cells in the liver].
K. Wake (1997)
10.1006/BBRC.1994.1549
Extracellular matrix regulates and L-ascorbic acid 2-phosphate further modulates morphology, proliferation, and collagen synthesis of perisinusoidal stellate cells.
H. Senoo (1994)
10.1002/AJA.1001330106
A morphological study of the development of the human liver. II. Establishment of liver parenchyma, extrahepatic ducts and associated venous channels.
C. Severn (1972)
10.1016/S1097-2765(00)80003-9
The discoidin domain receptor tyrosine kinases are activated by collagen.
W. Vogel (1997)
Vitamin A-storing system in mammals and birds in Arctic area—a study in the Svalbard
H Senoo (1999)
Cytochemistry of the lipid droplets containing vitamin A in the liver
K Wake (1973)
Tissue formation and extracellular matrix system—cellular devices for adhesion to extracellular matrix
H Senoo (1993)
American Association of Anatomists SeventySeventh Session University of Colorado
J Rhodin (1964)
10.1038/ng1089
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
R. Jaenisch (2003)
Hepatic stellate cells contain the functional estrogen receptor b but not the estrogen receptor a in male and female rats
Y Zhou (2001)
Isolation and cultivation of rat liver
R New York Blomhoff (1990)
PEG-FIBROSIS Project Group (2002) Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis
T Poynard (2002)
PPARc agonists prevent TGFb1/Smad3-signaling in human hepatic stellate cells
C Zhao (2006)
The intestinal absorption and metabolism of vitamin A and b-carotene in man
DS Goodman (1966)
Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1a-mediated stellate cell activation
F Hong (2009)
10.1016/S0002-9440(10)65066-3
Expression of the Integrin α8β1 during Pulmonary and Hepatic Fibrosis
D. Lévine (2000)
The retinal pigment epithelial membrane receptor for plasma retinol-binding protein. Isolation and cDNA cloning of the 63-kDa protein.
C. Bavik (1993)
10.1016/B978-1-4832-2824-2.50007-8
CHAPTER 1 – THE EMBRYONIC LIVER
A. M. Bois (1963)
10.1016/B978-0-12-658102-7.50008-7
8 – Plasma Retinol-Binding Protein
D. S. Goodman (1984)
10.2957/KANZO.32.169
A simple method for the isolation of human ito cells (fat-storing cells).
M. Nakagawa (1991)
10.1053/J.GASTRO.2007.01.033
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.
M. Adachi (2007)
10.2183/PJAB.82.155
Hepatic stellate cells: Three-dimensional structure, localization, heterogeneity and development
K. Wake (2006)
The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver.
A. Martinez-Hernandez (1984)
10.1021/BI00542A026
Biosynthesis of interstitial types of collagen by albumin-producing rat liver parenchymal cell (hepatocyte) clones in culture.
R. Hata (1980)
10.1002/hep.20170
Administration of the potent PPARα agonist, Wy‐14,643, reverses nutritional fibrosis and steatohepatitis in mice
Emilia Ip (2004)
10.1006/cbir.1996.0065
THREE‐DIMENSIONAL STRUCTURE OF EXTRACELLULAR MATRIX REVERSIBLY REGULATES MORPHOLOGY, PROLIFERATION AND COLLAGEN METABOLISM OF PERISINUSOIDAL STELLATE CELLS (VITAMIN A‐STORING CELLS)
H. Senoo (1996)
A silver impregnation method in histology
K Suzuki (1958)
10.1093/AJCN/69.5.829
Mutations in the gene encoding retinol binding protein and retinol deficiency: is there compensation by retinyl esters and retinoic acid?
A. C. Ross (1999)
10.1074/jbc.275.4.2247
Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury*
S. Friedman (2000)
Reversing hepatic fibrosis
SL Friedman (2002)
Liver fat-storing cell clones
P Greenwel (1993)
Cytokines and peroxisome proliferator-activated receptor c ligand regulate phagocytosis bypancreatic stellate cells.Gastroenterology128:2105–2118
K Shimizu (2005)
The retinal pigment epithelial membrane receptor for plasma retinolbinding protein
CO Båvik (1993)
10.1111/j.1478-3231.2007.01578.x
Hepatic stellate cell line modulates lipogenic transcription factors
E. L. Guimarães (2007)
High circulating retinolbinding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
N Stefan (2007)
10.1136/gut.44.4.534
Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis
M. Apte (1999)
10.1016/S0022-5320(70)90150-4
An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids.
E. Wisse (1970)
10.1002/JCP.1041380103
L‐ascorbic acid 2‐phosphate stimulates collagen accumulation, cell proliferation, and formation of a three‐dimensional tissuelike substance by skin fibroblasts
R. Hata (1989)
Absorption of vitamin A.
D. Ong (1994)
10.1055/S-2007-967918
Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4.
E. Yagmur (2007)
10.1002/HEP.1840380418
Human hepatic stellate cells show features of antigen‐presenting cells and stimulate lymphocyte proliferation
O. Vińas (2003)
10.1016/S1357-2725(96)00118-5
Tissue inhibitors of metalloproteinases in liver fibrosis.
J. Iredale (1997)
10.1016/J.BBRC.2004.02.147
Induction of cell death in activated hepatic stellate cells by targeted gene expression of the thymidine kinase/ganciclovir system.
Nora Janoschek (2004)
10.1126/SCIENCE.1136244
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
R. Kawaguchi (2007)
10.1136/bmj.327.7407.143
Cirrhosis: new research provides a basis for rational and targeted treatments
J. Iredale (2003)
10.1016/S0168-8278(99)80192-5
Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells.
A. Desmoulière (1999)
10.1002/JCB.240370406
Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA‐2 and VLA‐3 in the VLA family of heterodimers
Y. Takada (1988)
10.1084/jem.20051775
Complete differentiation of CD8+ T cells activated locally within the transplanted liver
I. Klein (2006)
10.1053/J.GASTRO.2004.11.065
Intercellular communication via gap junctions in activated rat hepatic stellate cells.
R. Fischer (2005)
Establishment of a new human cell line, LI90, exhibiting characteristics of hepatic Ito (fat-storing) cells.
K. Murakami (1995)
10.1007/BF01919862
Extravascular cells within the perisinusoidal space of the avian liver
M. Purton (2005)
10.1152/AJPLUNG.00383.2004
PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis
Heather A Burgess (2005)
10.1074/jbc.M204410200
Functional Conservation for Lipid Storage Droplet Association among Perilipin, ADRP, and TIP47 (PAT)-related Proteins in Mammals,Drosophila, and Dictyostelium *
S. Miura (2002)
10.1038/sj.cdd.4401979
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis
J. Mann (2007)
10.1016/J.JHEP.2004.01.008
Cellular retinol-binding protein-1 expression in normal and fibrotic/cirrhotic human liver: different patterns of expression in hepatic stellate cells and (myo)fibroblast subpopulations.
S. Lepreux (2004)
Fat-storing cells and myofibroblasts are involved in the initial phase of carbon tetrachloride-induced hepatic fibrosis in BN/BiRij rats.
W. Seifert (1994)
10.1002/HEP.1840150211
Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture
S. Friedman (1992)
10.1007/BF01915363
Lamprey biliary atresia: First model system for the human condition?
J. Youson (2005)
10.1267/ahc.13007
Differential Increases in the Expression of Intermediate Filament Proteins and Concomitant Morphological Changes of Transdifferentiating Rat Hepatic Stellate Cells Observed In Vitro
Y. Mezaki (2013)
Regulation of gene expression and cell function by extracellular matrix.
P. Jones (1993)
10.1152/AJPGI.1994.266.4.G624
Endothelin-1 induces direct constriction of hepatic sinusoids.
J. Zhang (1994)
10.1016/S0076-6879(82)81112-9
Isolation and characterization of serum retinol-binding protein.
Y. Muto (1982)
10.1152/AJPGI.00450.2005
Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor.
Shizhong Zheng (2006)
10.1136/GUT.44.4.451
New kids on the block: pancreatic stellate cells enter the fibrogenesis world
M. Pinzani (1999)
10.1152/PHYSREV.1944.24.2.205
DISTRIBUTION OF VITAMIN A IN TISSUE AS VISUALIZED BY FLUORESCENCE MICROSCOPY
H. Popper (1944)
10.1002/hep.510260417
Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF‐β in liver stellate cells
M. Okuno (1997)
10.1016/S0168-8278(02)00427-0
The management of alcoholic liver disease.
S. Stewart (2003)
10.1136/gut.43.1.128
Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture
M. Apte (1998)
Retinol transport in cultured fat-storing cells of rat liver. Quantitative analysis by anchored cell analysis and sorting system.
T. Matsuura (1989)
Hepatic induction in the avian embryo: specificity of reactive endoderm and inductive mesoderm.
S. Fukuda-Taira (1981)
10.1016/J.MATBIO.2005.08.005
Changes in expression of extracellular matrix genes, fibrogenic factors, and actin cytoskeletal organization in retinol treated and untreated vocal fold stellate cells.
Tannin J. Fuja (2006)
10.1267/AHC1960.1964.103
Distribution of Vitamin A in the Liver
K. Wake (1964)
10.1053/JHEP.2003.50224
Regulating hepatic inflammation: Pathogen‐associated molecular patterns take their toll
J. Iredale (2003)
10.1002/HEP.510290149
Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor
G. Michalopoulos (1999)
Vitamin A storing cell in mouse urinary bladder—an autoradiographic study
H Yorifuji (1980)
Newly administered
R Blomhoff (1984)
Intracellular signaling for process elongation in cultured hepatic stellate cells on type I collagen
M Sato (1999)
10.1136/bmj.1.3884.1208
OBSERVATIONS ON THE ABSORPTION OF CAROTENE AND VITAMIN A
J. Drummond (1935)
10.1111/j.1440-1746.2006.04585.x
Transcriptional regulation of stellate cell activation
S. Friedman (2006)
2016) MiR-29a assists in preventing the activation of human stellate cells and promotes recovery from liver fibrosis in mice
Y Matsumoto (2016)
Inhibitory effect of acyclic (polyprenoic acid) on hepatic fibrosis in CCl 4 -treated rats
M Okuno (1990)
A (2003a) Peroxisome proliferator-activated receptor-b signaling contributes to enhanced proliferation of hepatic stellate cells
K Hellemans (2003)
10.1002/ar.20663
The Hepatic Microvascular System in Health and Its Response to Toxicants
R. S. McCuskey (2008)
[Mechanisms of hepatic fibrogenesis].
T. Lamireau (2002)
10.1152/AJPGI.1995.269.4.G532
Vitamin A-poor lipocytes: a novel desmin-negative lipocyte subpopulation, which can be activated to myofibroblasts.
G. Ramm (1995)
10.1097/00007890-198811000-00024
Characterization of interstitial dendritic cells in human liver.
T. Prickett (1988)
10.1126/SCIENCE.2581314
Identification of human glucocorticoid receptor complementary DNA clones by epitope selection.
C. Weinberger (1985)
10.1002/HEP.510310117
Peroxisome proliferator‐activated receptor γ transcriptional regulation is involved in platelet‐derived growth factor–induced proliferation of human hepatic stellate cells
A. Galli (2000)
Fatty acyl CoA
RK 153527–535 Randolph (1991)
10.1159/000201257
Molecular mechanisms of liver fibrogenesis--a homage to the role of activated fat-storing cells.
A. M. Gressner (1995)
10.1002/HEP.510310122
Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells
V. Ankoma-Sey (2000)
10.1679/AOHC1950.33.421
Effect of the administration of large doses of vitamin A on the fine structure of rat liver with special reference to changes in the fat-storing cell.
K. Kobayashi (1971)
10.1074/JBC.270.26.15686
Retinol-binding Protein and Asialo-orosomucoid Are Taken Up by Different Pathways in Liver Cells (*)
L. Malaba (1995)
10.1126/science.2426779
Molecular cloning of the chicken progesterone receptor
O. Conneely (1986)
10.1111/J.1432-1033.1993.TB17824.X
The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus.
N. Kawada (1993)
10.1006/EXCR.1993.1126
Retinol transport in cultured stellate cells of rat liver: studies by light and electron microscope autoradiography.
T. Matsuura (1993)
10.1152/AJPCELL.2001.281.2.C532
Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells.
E. Schneider (2001)
10.1016/0309-1651(89)90066-0
Co-culture of fibroblasts and hepatic parenchymal cells induces metabolic changes and formation of a three-dimensional structure.
H. Senoo (1989)
10.1002/AR.1092100302
Freeze‐replica study of lipid droplets in the ito cells of rat liver
K. Yamamoto (1984)
10.1136/gut.2005.079194
Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats
I. Leclercq (2006)
10.1016/S0002-9440(10)65211-X
Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis.
P. Haber (1999)
10.1002/AJA.1001320404
"Sternzellen" in the liver: perisinusoidal cells with special reference to storage of vitamin A.
K. Wake (1971)
10.1679/AOHC1950.40.121
Vitamin A uptake cells distributed in the liver and other organs of the rat.
Y. Kusumoto (1977)
10.1126/SCIENCE.3037703
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.
J. Arriza (1987)
10.1093/oxfordjournals.jmicro.a050691
Fine structure of intestinal fibroblasts: autoradiographic and three-dimensional studies.
K. Hirosawa (1988)
10.1016/0014-4827(84)90673-6
Isolation and characterization of vitamin-A-storing lung cells.
T. Okabe (1984)
Purification and Crystallization of a Retinoic Acid-binding Protein from Rat Epididymis
Márcia (2001)
Isolation of perisinusoidal stellate cells (vitamin A-storing cells, fat-storing cells) of the rat liver
H Senoo (1993)
Some observations on perisinusoidal lipocyte (Ito cell) of Carassius auratus liver as revealed by electron microscopy.
Y. C. Shin (1981)
Norum KR (1988c) Transfer of retinol
R 60233–239 Blomhoff (1988)
The Sternzellen of von Kupffer-after 106 years
K Wake (1982)
Studies in the histology of the liver. III. The perivascular cell of the rabbits liver
H J Berkley
The hepatic extracellular matrix. II. Ontogenesis, regeneration and cirrhosis
A Martinez-Hernandez (1993)
A (2003b) PPARb regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation
K Hellemans (2003)
An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoid
E Wisse (1970)
10.1007/BF00121914
Localization of messenger RNA for tissue inhibitor of metalloproteinases-1 and type IV collagenases/gelatinases in monkey hepatocellular carcinomas
C. Lindsay (2004)
10.1093/emboj/18.18.4903
Cellular retinol‐binding protein I is essential for vitamin A homeostasis
N. Ghyselinck (1999)
10.1073/PNAS.85.10.3455
Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol-binding protein.
R. Blomhoff (1988)
10.1002/hep.20691
Embryonic development of the liver
Roong Zhao (2005)
10.1002/HEP.1840190129
Vitamin A deficiency potentiates carbon tetrachloride‐induced liver fibrosis in rats
W. Seifert (1994)
10.1194/JLR.M200376-JLR200
PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.
K. Hellemans (2003)
10.1152/AJPCELL.1997.272.6.C1980
Confocal imaging analysis of ATP-induced Ca2+ response in individual endothelial cells of the artery in situ.
H. Ohata (1997)
10.1053/GAST.2003.50015
Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.
K. Hellemans (2003)
10.1002/HEP.1840060212
Cell types involved in collagen and fibronectin production in normal and fibrotic human liver
B. Clement (1986)
10.1111/j.1440-1746.2006.04658.x
Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis
T. Kisseleva (2007)
10.1073/PNAS.90.8.3616
Transfer of retinol-binding protein from HepG2 human hepatoma cells to cocultured rat stellate cells.
H. Senoo (1993)
10.1016/s0021-9258(18)60635-0
Esterification of retinol in rat liver. Possible participation by cellular retinol-binding protein and cellular retinol-binding protein II.
D. Ong (1988)



This paper is referenced by
10.29011/2688-6421.100013
the possible protective effect of propolis against aluminum chloride induced hepatic injury in adult male rats histological study
M. Raafat (2019)
10.3390/ijms20030581
High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway
Hyuk Moon (2019)
10.3390/jdb7020010
Retinoids in Stellate Cells: Development, Repair, and Regeneration
R. Carmona (2019)
Interacción colesterol-gangliósido GD3 en la fibrosis hepática
Vallejo Valdivia (2017)
10.3390/ijms19103043
Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation
Kunihiro Saga (2018)
10.1016/j.nano.2017.08.017
Development of a peptide-modified siRNA nanocomplex for hepatic stellate cells.
Z. Zhao (2018)
10.3389/fphys.2018.00754
A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells
Ran Xue (2018)
10.1080/17474124.2019.1543588
Vitamin A and inflammatory bowel diseases: from cellular studies and animal models to human disease
S. M. Barbalho (2019)
10.1093/jn/nxz036
Carrot Leaves Maintain Liver Vitamin A Concentrations in Male Mongolian Gerbils Regardless of the Ratio of α- to β-Carotene When β-Carotene Equivalents Are Equalized.
T. J. Titcomb (2019)
10.1016/j.bbagen.2020.129559
Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices.
Cristina Zivko (2020)
10.3390/nu11081876
Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
L. Norsa (2019)
10.4103/sjg.SJG_470_17
Pokeweed antiviral protein attenuates liver fibrosis in mice through regulating Wnt/Jnk mediated glucose metabolism
Y. Zhang (2018)
10.1016/j.lfs.2019.116934
Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells.
Z. Zhang (2019)
10.1080/14737159.2020.1814746
Advances in the clinical use of collagen as biomarker of liver fibrosis
S. Meurer (2020)
10.1016/j.fct.2019.02.023
In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring.
J. Esteban (2019)
10.1016/j.pathophys.2017.06.003
A novel Golgi-Cox staining method for detecting and characterizing roles of the hepatic stellate cells in liver injury.
Ma de Jesús Gómez Villalobos (2017)
10.1016/j.molmet.2020.101025
Dynamics of vitamin A uptake, storage, and utilization in vocal fold mucosa
Kohei Nishimoto (2020)
10.1007/978-3-319-96400-3_3
The Anatomy and Histology of the Liver and Biliary Tract
Maria Guido (2019)
10.3390/ijms19123715
Liver-Derived Exosomes and Their Implications in Liver Pathobiology
Sumi Sung (2018)
10.1074/jbc.TM118.002812
Roles of the endoplasmic reticulum–resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease
S. Ito (2018)
10.1038/s41598-020-77411-5
Absence of CD36 alters systemic vitamin A homeostasis
M. Trites (2020)
10.1016/j.jcmgh.2020.07.006
Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes
Ali Saeed (2020)
10.1111/liv.13753
Autofluorescence‐based optical biopsy: An effective diagnostic tool in hepatology
A. C. Croce (2018)
10.3389/fphar.2018.00709
Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats
Masatsugu Ohara (2018)
10.1016/j.nut.2020.110984
Association between serum β-carotene-to-retinol ratio and severity of hepatic steatosis in non-alcoholic fatty liver disease in Japan: A cross-sectional study.
M. Kimura (2020)
Semantic Scholar Logo Some data provided by SemanticScholar