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Multi-Objective Optimization Design Of Balloon-Expandable Coronary Stent

Xiang Shen, Hongfei Zhu, Jiabao Jiang, Yongquan Deng, Song Ji
Published 2019 · Medicine
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PurposeRecent studies suggested that suboptimal delivery and longitudinal stent deformation can result in in-stent restenosis. Therefore, the purpose of this paper was to study the effect of stent geometry on stent flexibility and longitudinal stiffness (LS) and optimize the two metrics simultaneously. Then, the reliable and accurate relationships between metrics and design variables were established.MethodsA multi-objective optimization method based on finite element analysis was proposed for the investigation and improvement of stent flexibility and LS. The relative influences of design variables on the two metrics were evaluated on the basis of the main effects. Three surrogate models, namely, the response surface model (RSM), radial basis function neural network (RBF), and Kriging were employed and compared.ResultsThe accuracies of the three models in fitting flexibility were nearly similar, although Kriging made more accurate prediction in LS. The link width played important roles in flexibility and LS. Although the flexibility of the optimal stent decreased by 13%, the LS increased by 48.3%.ConclusionsThe obtained results showed that the multi-objective optimization method is efficient in predicting an optimal stent design. The method presented in this paper can be useful in optimizing stent design and improving the comprehensive mechanical properties of stents.
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