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Successful Adenovirus-mediated Gene Transfer In An In Vivo Model Of Human Malignant Mesothelioma.

W. Smythe, L. Kaiser, H. Hwang, K. Amin, J. Pilewski, S. Eck, J. Wilson, S. Albelda
Published 1994 · Medicine

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Malignant mesothelioma remains a frustrating clinical problem with uniformly poor responses to current therapeutic regimens. However, the localized nature of the disease, the potential accessibility of the tumor, and the relative lack of distant metastases make it a particularly attractive candidate for somatic gene therapy. The purpose of this study was to evaluate the ability of an adenoviral vector system to transfer genetic material to human mesothelioma cells in vitro and in vivo. Using a replication-deficient recombinant adenovirus carrying the Escherichia coli lacZ marker gene, we found that human mesothelioma cell lines were susceptible to adenovirus infection. Furthermore, surprisingly effective gene transfer was accomplished within tumor implants of human mesothelioma growing within the peritoneal cavity of immunodeficient mice after intraperitoneal administration of virus. These studies demonstrate that adenoviral vectors hold promise as vehicles to deliver gene therapy in human malignant mesothelioma.
This paper references
10.1016/0304-3835(92)90051-V
Multiple transduction as a means of preserving ganciclovir chemosensitivity in sarcoma cells carrying retrovirally transduced herpes thymidine kinase genes.
F. S. Moolten (1992)
Quantitative comparison between the transplantability of human and murine tumors into the subcutaneous tissue of NCr/Sed-nu/nu nude and severe combined immunodeficient mice.
A. Taghian (1993)
10.1016/0959-437X(93)90126-A
Gene therapy: adenovirus vectors.
K. Kozarsky (1993)
10.1016/S0022-5223(19)36577-8
The role of extrapleural pneumonectomy in malignant pleural mesothelioma. A Lung Cancer Study Group trial.
V. Rusch (1991)
10.1038/ng0593-27
Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses
J. Engelhardt (1993)
10.1093/NAR/21.7.1607
Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA.
S. Erzurum (1993)
Characterization of a human malignant mesothelioma cell line (H-MESO-1): a biphasic solid and ascitic tumor model.
Frank R. Reale (1987)
10.1096/fasebj.2.1.3275560
Interactions of cancer cells with the microvasculature during metastasis 1 2
L. Weiss (1988)
10.1038/NG0893-415
The Wilms tumour gene WT1 is expressed in murine mesoderm–derived tissues and mutated in a human mesothelioma
S. Park (1993)
10.1378/CHEST.96.1_SUPPLEMENT.92S
The epidemiology and pathogenesis of malignant mesothelioma.
J. Craighead (1989)
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
Z. Ram (1993)
10.1093/JNCI/82.4.297
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
F. Moolten (1990)
10.1093/OXFORDJOURNALS.AJE.A121306
Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines.
F. Top (1971)
Development of adenovirus vectors for the expression of heterologous genes.
Berkner Kl (1988)
10.1126/SCIENCE.8493530
The basic science of gene therapy.
R. Mulligan (1993)
10.1016/S0022-5223(19)36578-X
Extrapleural pneumonectomy, chemotherapy, and radiotherapy in the treatment of diffuse malignant pleural mesothelioma.
D. Sugarbaker (1991)



This paper is referenced by
10.1007/s001090000092
Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer
J. Bennett (2000)
10.1016/S0168-7069(01)05016-9
Adenovirus cancer gene therapy
M. Powell (2001)
10.1038/sj.cgt.7700059
The evaluation of adenoviral p53-mediated bystander effect in gene therapy of cancer
N. Rizk (1999)
10.1201/B13502-52
Gene therapy in pleural diseases
S. Albelda (2008)
10.1158/1078-0432.CCR-12-0628
CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma
Z. Rivera (2012)
10.1016/S0002-9378(96)70038-8
Adenovirus-mediated gene therapy of ovarian cancer in a mouse model.
K. Behbakht (1996)
10.1371/journal.pone.0150044
Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma
D. Barbone (2016)
10.1016/B978-012437551-2/50033-1
CHAPTER 32 – Treatment of Mesothelioma Using Adenoviral-Mediated Delivery of Herpes Simplex Virus Thymidine Kinase Gene in Combination with Ganciclovir
D. Sterman (2002)
10.1089/HUM.1996.7.2-141
Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene.
A. Elshami (1996)
10.1016/S0022-5223(96)70422-1
Cardiac gene transfer by intracoronary infusion of adenovirus vector-mediated reporter gene in the transplanted mouse heart.
J. Lee (1996)
10.1371/journal.pone.0052753
Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression
D. Barbone (2012)
10.1016/S0029-7844(96)00296-7
GENE THERAPY AND OVARIAN CANCER: A REVIEW
M. Barnes (1997)
10.1089/HUM.1996.7.10-1251
Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.
D. Yee (1996)
10.1097/JTO.0b013e3182a0840a
ZIC1 Is Silenced and Has Tumor Suppressor Function in Malignant Pleural Mesothelioma
Y. Cheng (2013)
Single-Dose Intrapleural IFN-B GeneTransfer forMalignant PleuralMesotheliomaandMetastatic Pleural Effusions : HighRate ofAntitumor ImmuneResponses
D. Sterman (2007)
10.1016/J.JTCVS.2003.08.034
Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma.
Robert J Kruklitis (2004)
10.1089/hum.2016.152
Genetic Modification of the Lung Directed Toward Treatment of Human Disease.
D. Sondhi (2017)
10.1089/HUM.1996.7.16-2047
Treatment of advanced mesothelioma with the recombinant adenovirus H5.010RSVTK: a phase 1 trial (BB-IND 6274).
J. Treat (1996)
10.1378/CHEST.116.2.504
Advances in the treatment of malignant pleural mesothelioma.
D. Sterman (1999)
10.1038/oncsis.2013.32
Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo
A. G. Manente (2013)
10.1038/sj.cgt.7700589
Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing
R. Wiewrodt (2003)
10.1016/S0003-4975(01)03625-6
Gene therapy for thoracic disease: practice, promise, and pragmatism.
W. Smythe (2002)
10.1371/journal.pone.0065489
BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma
S. Busacca (2013)
10.1038/sj.gt.3300516
Long-term survival of immunocompetent rats with intraperitoneal colon carcinoma tumors using herpes simplex thymidine kinase/ganciclovir and IL-2 treatments
J.-L. Coll (1997)
10.1517/14712598.5.8.1039
Gene therapy of mesothelioma
D. Nelson (2005)
10.1016/S1054-3589(08)60140-4
Human adenovirus vectors for gene transfer into mammalian cells.
M. M. Hitt (1997)
10.1016/S1010-7940(96)01008-1
Pleurectomy/decortication for palliation in malignant pleural mesothelioma: results of surgery.
O. Soysal (1997)
10.1158/1078-0432.CCR-07-0403
A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses
D. Sterman (2007)
10.1038/sj.gt.3300520
HSV-1 thymidine kinase gene therapy for colorectal adenocarcinoma-derived peritoneal carcinomatosis
C. Lechanteur (1997)
Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir.
M. E. Rosenfeld (1995)
Cancer Therapy : Preclinical CSPG 4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma
Zeyana Rivera (2012)
10.1158/0008-5472.CAN-18-0655
A Polysome-Based microRNA Screen Identifies miR-24-3p as a Novel Promigratory miRNA in Mesothelioma.
Stefania Oliveto (2018)
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