Online citations, reference lists, and bibliographies.
← Back to Search

Importance Of Human Gastric Lipase For Intestinal Lipolysis: An In Vitro Study.

Y. Gargouri, G. Piéroni, C. Rivière, P. Lowe, J. Sauniere, L. Sarda, R. Verger
Published 1986 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Using soybean triacylglycerols emulsified with egg lecithin we have studied, in vitro, the influence of substrate prehydrolysis by human gastric lipase upon subsequent degradation by the pancreatic lipase-co-lipase system. Fatty acids liberated by pure human gastric lipase or juice trigger immediate activity of human pancreatic lipase. Gastric lipolysis appears to be of prime importance for dietary lipid digestion in human.
This paper references
10.3109/00365527109180682
The assay of human pancreatic phospholipase A in pancreatic juice and duodenal contents.
C. Figarella (1971)
10.1016/0014-5793(79)80574-8
Evidence for a pancreatic pro‐colipase and its activation by trypsin
B. Borgström (1979)
10.1016/0016-5085(80)90777-5
Importance of phospholipids, pancreatic phospholipase A2, and fatty acid for the digestion of dietary fat: in vitro experiments with the porcine enzymes.
B. Borgström (1980)
10.3109/00365527109180680
Role of duodenum in inhibition of gastric acid secretion. A brohee lecture given at the 4th World Congress of Gastroenterology in Copenhagen 1970.
B. Uvnäs (1971)
10.1016/S0300-9084(81)80216-7
Isolation and properties of prophospholipase A2 from human pancreatic juice.
R. Grataroli (1981)
10.1016/0016-5085(86)90695-5
Kinetic assay of human gastric lipase on short- and long-chain triacylglycerol emulsions.
Y. Gargouri (1986)
10.1016/0024-3205(67)90026-4
The effect of lecithin on the activity of pancreatic lipase.
E. Klein (1967)
10.1172/JCI108019
Pharyngeal lipase and digestion of dietary triglyceride in man.
M. Hamosh (1975)
10.1016/S0016-5085(71)80001-X
Lipolytic activity of human gastric and duodenal juice against medium and long chain triglycerides.
M. Cohen (1971)
10.1016/0009-8981(65)90077-X
THE ACTIVITY OF HUMAN GASTRIC LIPASE TOWARDS P-NITROPHENYL ESTERS.
T. Popiela (1965)
10.1111/j.1651-2227.1973.tb08149.x
GASTRIC LIPOLYSIS OF HUMAN MILK LIPIDS IN INFANTS WITH PYLORIC STENOSIS
T. Olivecrona (1973)
10.1016/0005-2744(68)90248-9
Purification and properties of phospholipase A from porcine pancreas.
G. D. de Haas (1968)
10.1016/S0022-3476(78)80915-9
Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity.
M. Hamosh (1978)
10.1111/J.1748-1716.1946.TB00356.X
The Gastric Lipase in Man
F. Schønheyder (1946)
10.1172/JCI103549
Studies of intestinal digestion and absorption in the human.
B. Borgstrom (1957)
10.1111/J.1699-0463.1956.TB03401.X
Lipase activity of the gastric mucosa of man under pathological conditions.
M. Siurala (1956)
10.1016/0005-2760(82)90299-5
Purification and properties of an acid lipase from human gastric juice.
C. Tiruppathì (1982)



This paper is referenced by
10.1016/S0016-5085(88)80063-5
Gastric lipase: localization in the human stomach.
C. K. Abrams (1988)
10.1016/J.BPG.2004.09.001
Modern, new pharmacotherapy for obesity. A gastrointestinal approach.
L. V. Van Gaal (2004)
10.1146/ANNUREV.NU.13.070193.001245
Biological effects of short-chain fatty acids in nonruminant mammals.
M. Bugaut (1993)
10.1007/s10620-006-9589-z
Human Pancreatic Digestive Enzymes
D. Whitcomb (2006)
10.1007/s11095-014-1532-y
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
Jean-Claude Bakala-N’Goma (2014)
10.1016/S0300-9084(00)01179-2
Digestive lipases: from three-dimensional structure to physiology.
N. Miled (2000)
10.1016/J.COLSURFB.2006.02.013
Scorpion digestive lipase: kinetic study using monomolecular film technique.
N. Zouari (2006)
10.1051/OCL.2010.0318
Gastrointestinal lipolysis of lipid-based excipients intended for the oral drug delivery of poorly water-soluble drugs
Sylvie Fernandez (2010)
PREDUODENAL LIPASES – LIPID DIGESTION IN THE STOMACH
E. Bauer (2005)
10.4155/TDE.11.138
Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems.
J. Bakala N'Goma (2012)
10.1016/0005-2760(88)90029-X
Concerted action of human carboxyl ester lipase and pancreatic lipase during lipid digestion in vitro: importance of the physicochemical state of the substrate.
M. Lindström (1988)
10.1016/0005-2760(88)90036-7
Purification, characterization and kinetic properties of the rabbit gastric lipase.
H. Moreau (1988)
10.1016/0016-5085(95)90125-6
Ontogeny of human gastric lipase and pepsin activities.
D. Ménard (1995)
10.2174/092986610790226049
Structural homologies, importance for catalysis and lipid binding of the N-terminal peptide of a fungal and a pancreatic lipase.
F. Frikha (2010)
10.1007/978-94-009-1249-6_17
Fat Digestion and Solubilisation
B. Borgström (1988)
10.3109/03639045.2012.660949
Role of excipients in successful development of self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS)
Md. Akhlaquer Rahman (2013)
10.1039/c3fo60702j
A standardised static in vitro digestion method suitable for food - an international consensus.
M. Minekus (2014)
10.1016/0005-2760(89)90012-X
Gastric lipases: biochemical and physiological studies.
Y. Gargouri (1989)
10.1016/S1388-1981(00)00033-0
Egg yolk lipoproteins as substrates for lipases.
A. Abousalham (2000)
10.1152/AJPGI.2001.281.1.G16
Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers.
F. Carrière (2001)
10.1016/bs.mie.2016.09.039
Studying Gastric Lipase Adsorption Onto Phospholipid Monolayers by Surface Tensiometry, Ellipsometry, and Atomic Force Microscopy.
A. Bénarouche (2017)
10.1016/0005-2760(89)90113-6
Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase.
S. Bernbäck (1989)
10.1093/JN/120.10.1148
Adaptation of lingual lipase to dietary fat in rats.
M. Armand (1990)
Digestion of dietary fat : gastrointestinal behaviour of emulsions and human physiological responses
A. Helbig (2013)
10.1016/j.bbagrm.2016.02.015
Novel functions of PXR in cardiometabolic disease.
Changcheng Zhou (2016)
10.1038/s41596-018-0119-1
INFOGEST static in vitro simulation of gastrointestinal food digestion
A. Brodkorb (2018)
10.1172/JCI114556
The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase.
S. Bernbäck (1990)
10.1016/0927-7765(94)80069-3
Surface behaviour of human pancreatic and gastric lipases
L. D. L. Fournière (1994)
10.1016/B978-0-7216-9654-6.50118-1
Chapter 115 – Digestion-Absorption Functions in Fetuses, Infants, and Children
O. Koldovský (2004)
10.3109/03639045.2014.972412
In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract
V. Jannin (2015)
10.1016/0005-2760(89)90335-4
Ajoene prevents fat digestion by human gastric lipase in vitro.
Y. Gargouri (1989)
10.1016/j.biochi.2019.11.017
Vegetable lecithins: a review of their compositional diversity, impact on lipid metabolism and potential in cardiometabolic disease prevention.
Chloé Robert (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar