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Effects Of Triiodothyronine Administration On Dietary [14C]triolein Partitioning Between Deposition In Adipose Tissue And Oxidation To [14C]CO2 In Ad Libitum-fed Or Food-restricted Rats.

M. L. Cruz, D. Williamson
Published 1993 · Biology, Medicine

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Refeeding a chow meal containing [1-14C]triolein to food-restricted rats results in increased accumulation of [14C]lipid in carcass and epididymal adipose tissue and lower oxidation to [14C]CO2 compared to ad libitum-fed rats (Biochem. J. 285, 773-778, 1992). In the present experiments the effects of treatment with triiodothyronine (T3) for three days on lipid accumulation in refed food-restricted rats has been examined. T3 decreased accumulation of [14C]lipid in carcass and epididymal adipose tissue (32 and 77%, respectively) of food-restricted rats on refeeding the chow-[1-14C]triolein meal. This decreased accumulation of [14C]lipid was accompanied by increased [14C]CO2 production (77%) and decreased heparin-elutable lipoprotein lipase activity in the epididymal fat pad (90%) and subcutaneous adipose tissue (80%). Accumulation of [14C]lipid in the latter did not decrease significantly. In contrast, T3 treatment of ad libitum-fed rats increased [14C]lipid deposition in carcass (44%) and in subcutaneous adipose tissue (240%) on refeeding, when compared to untreated ad libitum rats. Lipoprotein lipase activity in the two adipose tissue depots of the refed ad libitum+T3 rats, however, decreased. Thus, the effects of T3 on [14C]lipid deposition are adipose-tissue-depot-specific and depend on the previous dietary intake (over 14 days) of the rat. T3-treatment increased the lipoprotein lipase activity released from perfused hearts to a similar extent in both food-restricted and ad libitum-fed rats compared to the corresponding untreated groups. The rates of lipogenesis in-vivo in liver, epididymal and subcutaneous adipose tissue of food-restricted rats refed chow were not altered by T3. It is concluded that the increased deposition of dietary lipid in the food-restricted rat can be partially reversed by treatment with T3, suggesting that the low-T3 state associated with this condition may be in part responsible.
This paper references
10.1530/ACTA.0.1240194
Sensitivity of thyrotropin secretion to TSH-releasing hormone in food-restricted rats.
F. Rodríguez (1991)
10.1042/BJ2850773
Refeeding meal-fed rats increases lipoprotein lipase activity and deposition of dietary [14C]lipid in white adipose tissue and decreases oxidation to 14CO2. The role of undernutrition.
M. L. Cruz (1992)
10.2337/diab.34.12.1266
Modulation of Adipose Lipoprotein Lipase by Thyroid Hormone and Diabetes: The Significance of the Low T3 State
L. Gavin (1985)
10.1210/ENDO-104-2-350
Daily rhythms in adrenal responsiveness to adrenocorticotropin are determined primarily by the time of feeding in the rat.
C. Wilkinson (1979)
10.1055/S-0028-1093708
The lipoprotein lipase activity of brown adipose tissue during early post-natal development of the normal and hypothyroid rat.
P. Hémon (1975)
10.1007/BF01117064
Thermogenic and metabolic consequences of thyroid hormone treatment in brown and white adipose tissue
C. Williams (1985)
Relationship of lipoprotein lipase activity to triglyceride uptake in adipose tissue.
A. S. Garfinkel (1967)
10.1159/000122436
Effect of meal feeding on daily rhythms of plasma corticosterone and growth hormone in the rat.
G. Moberg (1975)
10.1042/CS0500213
Effect of nutritional status on rat adipose tissue, muscle and post-heparin plasma clearing factor lipase activities: their relationship to triglyceride fatty acid uptake by fat-cells and to plasma insulin concentrations.
A. Cryer (1976)
10.1016/0005-2760(83)90060-7
Influence of nutritional state on lipoprotein lipase activities in the hypothyroid rat.
P. Hansson (1983)
10.1042/BJ1760343
Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.
A. Robinson (1978)
10.1111/j.1365-2362.1981.tb01758.x
Serum lipoprotein and apolipoprotein concentrations and tissue lipoprotein‐lipase activity in overt and subclinical hypothyroidism: the effect of substitution therapy
H. Lithell (1981)
10.1016/0026-0495(88)90178-3
Regulation of lipoprotein lipase in different rat tissues.
M. Kuwajima (1988)
Effects of thyroid hormones on enzymes involved in fatty acid and glycerolipid synthesis.
D. Roncari (1975)
Regulation of adipose tissue lipoprotein lipase gene expression by thyroid hormone in rats.
B. Saffari (1992)
10.1016/0026-0495(87)90124-7
Brain lipoprotein lipase is responsive to nutritional and hormonal modulation.
L. Gavin (1987)
10.1210/ENDO-115-2-705
The influence of partial food deprivation on the quantity and source of triiodothyronine in several tissues of athyreotic thyroxine-maintained rats.
J. van Doorn (1984)
10.1042/BJ2570607
Comparison of the flux of carbon to hepatic glycogen deposition and fatty acid and cholesterol synthesis on refeeding rats fed ad libitum or meal-fed rats with a chow-diet meal.
F. Pallardó (1989)
10.1210/ENDO-110-3-955
Insulin binding and response to insulin of adipocytes from thyroxine-treated rats.
E. Heise (1982)
10.1042/BJ2100937
Interactions between insulin and thyroid hormone in the control of lipogenesis.
M. Sugden (1983)
10.1055/S-0028-1092790
Effects of hypo- and hyper-thyroidism on in vivo lipogenesis in fed and fasted rats.
M. Llobera (1979)
10.1042/BJ2710421
Glucose utilization by skeletal muscles in vivo in experimental hyperthyroidism in the rat.
M. Sugden (1990)
10.1172/JCI114961
Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat.
J. Oppenheimer (1991)
10.1016/0009-8981(72)90103-9
Rapid determination of lipoprotein lipase activity in human adipose tissue
P. Nilsson-ehle (1972)
10.1097/00000658-198501000-00007
Thyroid hormones in conditions of chronic malnutrition. A study with special reference to cancer cachexia.
H. Persson (1985)
10.1530/ACTA.0.1250186
The role of somatostatin and/or dopamine in basal and TRH-stimulated TSH release in food-restricted rats.
F. Rodríguez (1991)
A stable, radioactive substrate emulsion for assay of lipoprotein lipase.
P. Nilsson-ehle (1976)
10.1152/AJPLEGACY.1971.220.6.1852
Response of lipoprotein lipase in various tissues to cold exposure.
M. Radomski (1971)
10.1042/BJ1600413
Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.
D. Stansbie (1976)
10.1042/BJ2390233
Evidence for conservation of dietary lipid in the rat during lactation and the immediate period after removal of the litter. Decreased oxidation of oral [1-14C]triolein.
C. M. Oller do Nascimento (1986)
10.1210/ENDO-117-6-2307
Protein utilization in growth: effect of lysine deficiency on serum growth hormone, somatomedins, insulin, total thyroxine (T4) and triiodothyronine, free T4 index, and total corticosterone.
T. C. Cree (1985)



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