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Patterned Stimulation At The Theta Frequency Is Optimal For The Induction Of Hippocampal Long-term Potentiation

J. Larson, Darryl E. Wong, G. Lynch
Published 1986 · Biology, Medicine

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Short, high frequency stimulation bursts (4 pulses at 100 Hz) were applied to Schaffer/commissural projections to the CA1 field of rat hippocampal slices at 0.1, 0.2, 1.0 or 2.0-s intervals to assess their efficacy in eliciting long-term potentiation (LTP). Bursts repeated at 2-s intervals induced very little LTP; shorter repetition intervals reliably elicited LTP, with the 200-ms repetition interval producing the greatest potentiation. A short-term potentiation effect, which was maximal 20 s after the last burst and decayed within 10 min, was affected differently by the stimulation parameters than was LTP, suggesting that the two phenomena are due to different processes. The results indicate that patterns of stimulation resembling spike discharge patterns of hippocampal neurons in animals in exploratory situations are effective in inducing LTP and suggest temporal constraints on the mechanisms involved in triggering synaptic plasticity.
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This paper is referenced by
Toxin-Induced Models of Neurological Disorders
M. L. Woodruff (1994)
Calcium control of triphasic hippocampal STDP
Daniel Bush (2012)
Frequency‐specific noninvasive modulation of memory retrieval and its relationship with hippocampal network connectivity
Molly S Hermiller (2019)
Theta oscillations reflect a putative neural mechanism for human sensorimotor integration.
Leanna C. Cruikshank (2012)
A distinctive subpopulation of medial septal slow-firing neurons promote hippocampal activation and theta oscillations.
H. Zhang (2011)
Defects in Rho GTPase Signaling to the Spine Actin Cytoskeleton in FMR1 Knockout Mice
J. Lauterborn (2017)
Theta and Learning: Dorsal and Ventral Hippocampal Theta Oscillation Respond Differently to Learning
Gregory N. Newman (2014)
Delta Rhythms: Models and Physiology
R. Traub (2014)
An Investigation of Short-Term Plasticity in Human Motor Cortex
Matthew A. Gannon (2016)
Selegiline reduces N-methyl-D-aspartic acid induced perturbation of neurotransmission but it leaves NMDA receptor dependent long-term potentiation intact in the hippocampus
M. Niittykoski (2003)
Evidence for constitutive protein synthesis in hippocampal LTP stabilization
A. Abbas (2013)
Neuronal plasticity and thalamocortical sleep and waking oscillations.
I. Timofeev (2011)
Synaptic Kainate Receptors in CA1 Interneurons Gate the Threshold of Theta-Frequency-Induced Long-Term Potentiation
V. R. Clarke (2012)
The NMDA receptor as a target for cognitive enhancement
G. Collingridge (2013)
Striking differences in synaptic facilitation along the dorsoventral axis of the hippocampus
C. Papatheodoropoulos (2015)
Hippocampal-amygdala interactions mediate uncertainty-dependent resistance to extinction following fear conditioning
J. Morris (2019)
Brainstem Modulation of the Hippocampus
R. Vertes (1986)
Induction Properties of Synaptic Plasticity in Rat Prefrontal Neurons
S. Otani (2004)
The effects of Morris water maze learning on the number, morphology and molecular composition of rat hippocampal dentate gyrus synapses.
M. Eyre (2002)
Possible involvement of an endogenous benzodiazepine receptor ligand of the inverse agonist type in the regulation of rapid-eye movement (REM) sleep: An hypothesis
L. Wichlinski (1996)
The Use of AF64A (Ethylcholine Aziridinium Ion) to Model Alzheimer's Disease
T. J. Walsh (1994)
Serotonergic regulation of hippocampal rhythmical activity
Robert P Vertes (2020)
Theta burst stimulation to characterize changes in brain plasticity following mild traumatic brain injury: A proof-of-principle study.
S. Tremblay (2015)
Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior
Alex B Kawa (2016)
A Neocortical Delta Rhythm Facilitates Reciprocal Interlaminar Interactions via Nested Theta Rhythms
L. Carracedo (2013)
Functional Brain Connectivity Differences Between Different ADHD Presentations: Impaired Functional Segregation in ADHD-Combined Presentation but not in ADHD-Inattentive Presentation
A. H. Ghaderi (2017)
Réorganisations synaptiques dans l'hippocampe et récupération fonctionnelle après lésion du cortex entorhinal : effets de l'allèle APOE4, du bourgeonnement cholinergique et de la réinnervation glutamatergique
J. Bott (2014)
NMDA receptor-independent control of transcription factors and gene expression
J. P. Adams (2009)
Theogallin and L‐theanine as active ingredients in decaffeinated green tea extract: I. electrophysiological characterization in the rat hippocampus in‐vitro
W. Dimpfel (2007)
Cholinergic modulation of synaptic physiology in deep layer entorhinal cortex of the rat
M. Y. Cheong (2001)
Endogenous acetylcholine enhances synchronized interneuron activity in rat neocortex.
Susanta Bandyopadhyay (2006)
Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: Influence of timing and geometrical parameters and underlying mechanisms
G. Pell (2011)
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