← Back to Search
Olfactory Experience Modulates Apoptosis In The Developing Olfactory Bulb
J. Najbauer, M. Leon
Published 1995 · Biology, Medicine
Download PDFAnalyze on Scholarcy
Early sensory stimulation plays a key role in shaping the structure and function of the developing olfactory system. Here, we provide the first direct evidence for apoptotic cell death in the olfactory bulbs of rat pups during normal development and we also demonstrate that olfactory deprivation by unilateral naris occlusion causes a dramatic increase in apoptotic cell death in the glomerular and granule cell layers of the deprived bulb. The accessory olfactory bulbs displayed a remarkably high basal level of apoptosis but the occluded accessory bulb did not differ in that regard from the control accessory bulb. These results suggest that apoptosis may be an important mechanism by which the olfactory system can adjust its cell numbers in response in sensory stimuli experienced in early life, thereby underlying one form of plasticity in the developing olfactory system.
This paper references
Early unilateral deprivation modifies olfactory bulb function
K. Guthrie (1990)
The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
T. Allsopp (1993)
Increase in a focal population of juxtaglomerular cells in the olfactory bulb associated with early learning
C. Woo (1991)
Early olfactory deprivation and the mitral cells of the olfactory bulb: A Golgi study
E. Meisami (1986)
Early postnatal differentiation of granule cell dendrites in the olfactory bulbs of normal and unilaterally odor-deprived rats.
L. Frazier-Cierpial (1989)
Cell death during development of the nervous system.
R. Oppenheim (1991)
Rapid changes in 2-deoxyglucose uptake and amino acid incorporation following unilateral odor deprivation: a laminar analysis.
D. Korol (1990)
Molecular regulation of apoptosis: Genetic controls on cell death
G. Williams (1993)
Neural growth and differentiation
E. Meisami (1979)
Functional consequences of unilateral olfactory deprivation: Time-course and age sensitivity
D. A. Wilson (1992)
Effects of sensory deprivation on the developing mouse olfactory system: a light and electron microscopic, morphometric analysis
T. E. Benson (1984)
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
D. Hockenbery (1993)
Autoradiographic study of histogenesis in the mouse olfactory bulb. II. Cell proliferation and migration
J. W. Hinds (1968)
Unilateral naris closure and olfactory system development
P. Brunjes (1994)
Mechanisms and functions of cell death.
R. Ellis (1991)
Toward an understanding of the molecular mechanisms of physiological cell death.
D. Vaux (1993)
Olfactory recognition: a simple memory system.
P. Brennan (1990)
Programmed cell death and the control of cell survival: lessons from the nervous system.
M. Raff (1993)
Evidence for olfactory function in utero.
P. Pedersen (1983)
bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.
D. Merry (1994)
Cell death genes: Drosophila enters the field.
M. Raff (1994)
Apoptosis: The Molecular Basis of Cell Death
L. D. Tomei (1991)
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
Y. Gavrieli (1992)
Unilateral odor deprivation: Early postnatal changes in olfactory bulb cell density and number
L. L. Frazier (1988)
Afferent regulation of neurons in the brain stem auditory system.
E. Rubel (1990)
The development of ocular dominance columns in normal and visually deprived monkeys
S. Le Vay (1980)
Lasting effects of early olfactory deprivation on the growth, DNA, RNA and protein content, and Na-K-ATPase and AchE activity of the rat olfactory bulb.
E. Meisami (1981)
Rapid increase in mitochondrial volume in nucleus magnocellularis neurons following cochlea removal
G. E. Hyde (1994)
Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene.
I. García (1992)
Maturation and plasticity in the olfactory system of vertebrates
P. Brunjes (1986)
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
J. Kerr (1972)
Effects of olfactory deprivation on postnatal growth of the rat olfactory bulb utilizing a new method for production of neonatal unilateral anosmia
E. Meisami (1976)
Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
J. Altman (1969)
Enriched neonatal odor exposure leads to increased numbers of olfactory bulb mitral and granule cells.
L. Rosselli-Austin (1990)
Unilateral odor deprivation: Time course of changes in laminar volume
P. Brunjes (1985)
Ablation of the olfactory bulb up-regulates the rate of neurogenesis and induces precocious cell death in olfactory epithelium
Virginia McM. Carr (1992)
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
D. J. Kane (1993)
Developmental studies on the rat vomeronasal organ: vascular pattern and neuroepithelial differentiation. I. Light microscopy.
K. Szabó (1988)
Somatosensory Cortex: Structural Alterations following Early Injury to Sense Organs
H. Van der Loos (1973)
bcl-2 inhibits death of central neural cells induced by multiple agents.
L. Zhong (1993)
A quantitative study of the effects of early unilateral olfactory deprivation on the number and distribution of mitral and tufted cells and of glomeruli in the rat olfactory bulb
E. Meisami (1981)
Retinal ganglion cell loss is size dependent in experimental glaucoma.
Y. Glovinsky (1991)
THE DEVELOPMENTAL NEUROPSYCHOLOGY OF SENSORY DEPRIVATION
A. Riesen (1977)
Olfactory deprivation increases dopamine D2 receptor density in the rat olfactory bulb
K. Guthrie (1991)
Unilateral, neonatal olfactory deprivation alters tyrosine hydroxylase expression but not aromatic amino acid decarboxylase or gaba immunoreactivity
H. Baker (1990)
Molecular mechanisms of developmental neuronal death.
E. Johnson (1993)
Early postnatal cellular proliferation and survival in the olfactory bulb and rostral migratory stream of normal and unilaterally odor‐deprived rats
L. Frazier-Cierpial (1989)
This paper is referenced by
A leucine‐rich repeat membrane protein, 5T4, is expressed by a subtype of granule cells with dendritic arbors in specific strata of the mouse olfactory bulb
F. Imamura (2006)
Activity-Dependent Adjustments of the Inhibitory Network in the Olfactory Bulb following Early Postnatal Deprivation
A. Saghatelyan (2005)
Widespread Defects in the Primary Olfactory Pathway Caused by Loss of Mash1 Function
R. Murray (2003)
Handbook of Parenting. Volume 2: Biology and Ecology of Parenting.
M. Bornstein (1996)
Neurogenesis in the central olfactory pathway of the adult shore crab Carcinus maenas is controlled by sensory afferents
A. Hansen (2001)
Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: Partial colocalization with mature interneuron markers
K. Xiong (2008)
Characterization of perinatally born glutamatergic neurons of the mouse olfactory bulb based on NeuroD6 expression reveals their resistance to sensory deprivation
A. Angelova (2019)
Effects of Sensory Ablation on the Young and Aged Ventriculo-Olfactory Neurogenic System
Jessica Clark (2013)
Expression of active caspase‐3 in mitotic and postmitotic cells of the rat forebrain
X. X. Yan (2001)
Plasticity in the Olfactory System: Lessons for the Neurobiology of Memory
D. Wilson (2004)
Learning and memory: Traditional and systems approaches
Y. Aleksandrov (2006)
Neonatal olfactory sensory deprivation decreases BDNF in the olfactory bulb of the rat.
J. H. McLean (2001)
Sensory deafferentation transsynaptically alters neuronal GluR1 expression in the external plexiform layer of the adult mouse main olfactory bulb.
K. Hamilton (2008)
Exposure to a broad range of odorants decreases cell mortality in the olfactory bulb
C. Woo (2006)
Activity‐dependent Extrinsic Regulation of Adult Olfactory Bulb and Hippocampal Neurogenesis
Dengke K. Ma (2009)
Patterns of olfactory bulb neurogenesis in the adult zebrafish are altered following reversible deafferentation
Darcy M. Trimpe (2016)
Intergenerational effects of complete maternal deprivation and replacement stimulation on maternal behavior and emotionality in female rats.
A. González (2001)
Neurobiology of mother – infant interactions : experience and central nervous system plasticity across development and generations
A. S. Fleminga (1999)
In situ detection of apoptotic cells by TUNEL in the gill epithelium of the developing brown trout (Salmo trutta)
M. C. Rojo (1998)
6 Neurochemistry of the Main Olfactory System
M. Ennis (2007)
GABAergic Input From the Basal Forebrain Promotes the Survival of Adult-Born Neurons in the Mouse Olfactory Bulb
E. Hanson (2020)
ncreased apoptosis and different regulation of pro-apoptosis protein bax and nti-apoptosis protein bcl-2 in the olfactory bulb of a rat model of depression
eyu Yanga (2011)
Enriched Odor Exposure Increases the Number of Newborn Neurons in the Adult Olfactory Bulb and Improves Odor Memory
C. Rochefort (2002)
Regulation of Neural Stem Cell Death
R. S. Akhtar (2006)
Group I metabotropic glutamate receptors are differentially expressed by two populations of olfactory bulb granule cells.
T. Heinbockel (2007)
The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.
S. Latchney (2014)
NEURAL MECHANISMS OF MAMMALIAN OLFACTORY LEARNING
P. Brennan (1997)
Bidirectional influences between neurons and glial cells in the developing olfactory system
L. Tolbert (2004)
Transient increase of TUNEL-positive cells on postnatal day 20 in the developing rat olfactory bulb
K. Saito (2004)
Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb
M. Lemasson (2005)
The Type 3 Adenylyl Cyclase Is Required for the Survival and Maturation of Newly Generated Granule Cells in the Olfactory Bulb
J. Luo (2015)
Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment
G. Singhal (2014)See more