Online citations, reference lists, and bibliographies.
← Back to Search

Fast Axonal Transport Of Labeled Protein In Sensory Axons During Regeneration

M. Bisby
Published 1978 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Abstract Fast axonal transport of labeled protein was studied in sensory axons of the rat sciatic nerve at various intervals after crushing the sciatic nerve, and at various times after injection of precursor [ 3 H]leucine into the L5 dorsal root ganglia. The velocity of transport was normal in both intact and regenerated portions of the injured nerve. In response to axotomy there was a short-term decrease in the proportion of ganglion-synthesized labeled protein that was transported, but this returned to normal values as regeneration proceeded. Transported protein accumulated proximal to the site of injury, and regenerated axons distal to the injury became heavily labeled with transported protein. The pattern of labeling of the injured nerve gradually returned to normal during a period of 30 days. Molecular weights were assigned to 23 polypeptides which comprise the major fast-transported protein of normal axons. There were few changes in the relative amounts of the transported polypeptides in regenerating axons. It was concluded that regeneration of sensory axons can be sustained without major changes in those parameters of fast axonal transport which were examined.
This paper references
10.1083/JCB.66.2.351
The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons
P. Hoffman (1975)
10.1002/BJS.18004217505
On the number of branches formed by regenerating nerve‐fibres
G. D. Shawe (1955)
10.1016/0006-8993(77)90193-7
Axonal regeneration in the rat sciatic nerve: Effect of a conditioning lesion and of dbcAMP
I. Mcquarrie (1977)
10.1111/j.1471-4159.1977.tb09624.x
REVERSAL OF AXONAL TRANSPORT AT A NERVE CRUSH 1
M. Bisby (1977)
10.1002/NEU.480050408
Fast axoplasmic transport in nonmyelinated mammalian nerve fibers shown by electron microscopic radioautography.
S. Ochs (1974)
10.1016/0014-4886(69)90093-4
Transport of protein in goldfish optic nerve during regeneration.
B. Grafstein (1969)
10.1111/j.1471-4159.1977.tb07751.x
A COMPARISON OF AXONALLY TRANSPORTED PROTEINS IN THE RAT SCIATIC NERVE BY IN VITRO AND IN VIVO TECHNIQUES
R. Theiler (1977)
10.1016/0006-8993(74)90941-X
The axonal transport of slowly migrating (3H)leucine labelled proteins and the regeneration rate in regenerating hypoglossal and vagus nerves of the rabbit.
M. Frizell (1974)
10.1111/j.1471-4159.1969.tb05941.x
SYNTHESIS OF NUCLEIC ACIDS IN THE SCHWANN CELLS AS THE EARLY CELLULAR RESPONSE TO NERVE INJURY 1
B. Oderfeld-Nowak (1969)
10.1002/NEU.480070407
Fast axonal transport in motor nerve regeneration.
J. Griffin (1976)
10.1111/J.1432-1033.1974.TB03599.X
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.
W. Bonner (1974)
10.1016/0022-510X(75)90167-7
Peripheral nerve regeneration in experimental diabetes
A. Sharma (1975)
10.1016/0014-4886(75)90170-3
The nerve cell body response to axotomy
B. Grafstein (1975)
10.1113/jphysiol.1961.sp006724
Changes in conduction velocity and fibre size proximal to peripheral nerve lesions
B. Cragg (1961)
10.1002/NEU.480080403
Similar polypeptide composition of fast-transported proteins in rat motor and sensory axons.
M. Bisby (1977)
10.1016/S0140-6736(46)90449-7
Mechanical excitability of regenerating nerve-fibres.
J. Konorski (1946)
10.1111/j.1471-4159.1975.tb04372.x
AXOPLASMIC TRANSPORT OF CHOLINE ACETYLTRANSFERASE ACTIVITY IN MICE: EFFECT OF AGE AND NEUROTOMY
C. Jablecki (1975)
10.1111/J.1432-1033.1975.TB02238.X
Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.
R. Laskey (1975)
10.1093/OXFORDJOURNALS.BMB.A070228
THE RATE OF REGENERATION OF NERVE
E. Gutmann (1942)
10.1111/j.1471-4159.1976.tb01563.x
RETROGRADE AXONAL TRANSPORT OF RAPIDLY MIGRATING LABELLED PROTEINS AND GLYCOPROTEINS IN REGENERATING PERIPHERAL NERVES
M. Frizell (1976)
10.1016/0014-4886(77)90071-1
Recovery of peripheral nerve function after axotomy: Effect of triiodothyronine
R. Berenberg (1977)
10.1007/978-3-642-47449-1_9
Changes in axonal flow during regeneration of mammalian motor nerves.
G. Kreutzberg (1971)
10.1113/jphysiol.1972.sp010051
Rate of fast axoplasmic transport in mammalian nerve fibres
S. Ochs (1972)
10.1016/0006-8993(74)90357-6
The axonal transport of (3H)fucose labelled glycoproteins in normal and regenerating peripheral nerves.
M. Frizell (1974)
10.1111/j.1471-4159.1977.tb07737.x
Retrograde axonal transport of endogenous protein: differences between motor and sensory axons
M. Bisby (1977)
10.1113/jphysiol.1976.sp011278
Fast axoplasmic transport in the fibres of chromatolysed neurones.
S. Ochs (1976)
10.1016/0022-510X(71)90131-6
Changes in axonal transport during regeneration of feline ventral roots.
C. Carlsson (1971)
10.1111/j.1471-4159.1974.tb04303.x
TRANSPORT OF PROTEINS, GLYCOPROTEINS AND CHOLINERGIC ENZYMES IN REGENERATING HYPOGLOSSAL NEURONS 1
M. Frizell (1974)



This paper is referenced by
10.1016/0006-8993(80)90144-4
Axonal transport of the cytoskeleton in regenerating motor neurons: constancy and change
P. Hoffman (1980)
10.1016/B978-044482529-2/50035-4
Melanocortins as factors in somatic neuromuscular growth and regrowth.
F. Strand (1994)
10.1016/S0091-679X(08)61434-X
Axonal transport: a cell-biological method for studying proteins that associate with the cytoskeleton.
S. Brady (1982)
10.1016/B978-0-12-137020-6.50010-9
AXONAL TRANSPORT OF MACROMOLECULES
J. Karlsson (1982)
10.1111/j.1471-4159.1988.tb01833.x
Heat Stress Induces Changes in Protein Synthesis and Fast Axonal Transport in Bullfrog Sensory Neurons
G. Stone (1988)
10.1007/978-94-011-2348-8_6
On retrograde signalling and molecular events associated with nerve damage and regeneration
G. W. Perry (1992)
10.1111/j.1460-9568.1996.tb01305.x
Effect of Neonatal Axoplasmic Transport Attenuation in the Infraorbital Nerve on Vibrissae‐related Patterns in the Rat's Brainstem, Thalamus and Cortex
N. Chiaia (1996)
10.1111/j.1471-4159.1983.tb12649.x
Changes in Rapid Transport of Phospholipids in the Rat Sciatic Nerve During Axonal Regeneration
M. Alberghina (1983)
10.1016/0197-0186(89)90054-5
Developments in neurochemistry related to axoplasmic transport
S. Ochs (1989)
10.1016/0014-4886(81)90071-6
Cellular mechanisms for recovery from nervous system injury: A conference report
R. P. Veraa (1981)
10.1111/j.1471-4159.1981.tb01650.x
Reversal of Axonal Transport: Similarity of Proteins Transported in Anterograde and Retrograde Directions
M. Bisby (1981)
10.1002/NEU.480140607
Increased regeneration rate in peripheral nerve axons following double lesions: enhancement of the conditioning lesion phenomenon.
M. Bisby (1983)
10.1016/0006-8993(86)90725-0
Regeneration of primary afferent neurons containing substance P-like immunoreactivity
M. Bisby (1986)
10.1016/0022-510X(79)90222-3
Rate of regeneration of sensory axons in transected rat sciatic nerve repaired with epineurial sutures
D. Forman (1979)
10.1016/0014-4886(79)90053-0
Differences in incorporation of axonally transported protein in regenerating motor and sensory axons
M. Bisby (1979)
10.1002/CNE.903500306
Evidence for survival of the central arbors of trigeminal primary afferents after peripheral neonatal axotomy: Experiments with galanin immunocytochemistry and Di‐I labelling
F. White (1994)
10.1007/978-3-642-85714-0
Axoplasmic Transport in Physiology and Pathology
D. Weiss (1982)
10.1007/978-1-4684-1197-3_12
Effect of a Conditioning Lesion on Axonal Transport During Regeneration
I. Mcquarrie (1984)
10.1523/JNEUROSCI.09-04-01303.1989
Axonal transport and localization of B-50/GAP-43-like immunoreactivity in regenerating sciatic and facial nerves of the rat
W. Tetzlaff (1989)
10.1007/978-3-642-68264-3_21
The Effects on Pain of Reconstructive Neurosurgery in 160 Patients with Traction and/or Crush Injury to the Brachial Plexus
A. Narakas (1981)
10.1083/JCB.87.1.197
Axonal growth during regeneration: a quantitative autoradiographic study
A. Tessler (1980)
10.3109/10409238709083737
Molecular and cellular aspects of nerve regeneration.
M. Schwartz (1987)
10.1002/NEU.480110503
Changes in the composition of labeled protein transported in motor axons during their regeneration.
M. Bisby (1980)
EEEEEEEEEEEEEE EEEEEEEEEEEEEE
E. ()
10.1016/0306-4522(90)90257-5
Expression of β-preprotachykinin mRNA and tachykinins in rat dorsal root ganglion cells following peripheral or central axotomy
D. Henken (1990)
10.1523/JNEUROSCI.11-12-03898.1991
Testosterone differentially regulates the regenerative properties of injured hamster facial motoneurons
K. A. Kujawa (1991)
10.1002/JNR.490240404
Heat stress increases delivery of a unique sub‐population of proteins conveyed by fast axonal transport
G. Stone (1989)
10.1002/CNE.902840206
Death of some dorsal root ganglion neurons and plasticity of others following sciatic nerve section in adult and neonatal rats
B. Himes (1989)
10.1016/0014-4886(87)90144-0
Chronic infusion of agents that increase cyclic AMP concentration enhances the regeneration of mammalian peripheral nerves in vivo
S. Kilmer (1987)
10.1016/0014-4886(81)90039-X
Slow axoplasmic transport in the hibernating and nonhibernating ground squirrel
G. Kemper (1981)
10.1002/CNE.902830307
Junction between parent and daughter axons in regenerating myelinated nerve: Properties of structure and rapid axonal transport
H. Chan (1989)
10.1002/MICR.1920100210
Regeneration of the rat sciatic nerve after different conditioning lesions: Effects of the conditioning interval
C. Arntz (1989)
See more
Semantic Scholar Logo Some data provided by SemanticScholar