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Fast Axonal Transport Of Labeled Protein In Sensory Axons During Regeneration
Published 1978 · Chemistry, Medicine
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Abstract Fast axonal transport of labeled protein was studied in sensory axons of the rat sciatic nerve at various intervals after crushing the sciatic nerve, and at various times after injection of precursor [ 3 H]leucine into the L5 dorsal root ganglia. The velocity of transport was normal in both intact and regenerated portions of the injured nerve. In response to axotomy there was a short-term decrease in the proportion of ganglion-synthesized labeled protein that was transported, but this returned to normal values as regeneration proceeded. Transported protein accumulated proximal to the site of injury, and regenerated axons distal to the injury became heavily labeled with transported protein. The pattern of labeling of the injured nerve gradually returned to normal during a period of 30 days. Molecular weights were assigned to 23 polypeptides which comprise the major fast-transported protein of normal axons. There were few changes in the relative amounts of the transported polypeptides in regenerating axons. It was concluded that regeneration of sensory axons can be sustained without major changes in those parameters of fast axonal transport which were examined.
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