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Injury Produces Early Rise In Lipoprotein Lipase Activity In Rabbit Aorta.

J. P. Werba, L. Cuniberti, R. Laguens, L. Masnatta, R. Rey, R. Levy, R. Pichel
Published 1996 · Medicine

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The mechanisms following intimal injury predisposing towards atherosclerotic changes have not been fully elucidated. We speculated that a local increase in the enzyme lipoprotein lipase (LPL) might explain a higher susceptibility of the damaged intima to lipid accretion, and so we investigated the effect of balloon endothelial denudation on LPL activity and cholesterol content (LPLa and Cholc, respectively), in aortas from normolipidemic male New Zealand white rabbits. Arteries were obtained from injured and control animals after 2, 6, 8 and 10 weeks to evaluate the shortest period after de-endothelialization necessary to detect LPLa changes. Injury resulted in a 4-fold LPLa rise (P < 0.01), as early as 2 weeks, and the enzymatic activity remained increased throughout the study period. A mild but significant 22% Cholc increase (P < 0.03) was found after 2 weeks of injury, even in this normolipidemic rabbit model. We conclude that physical damage to the intima markedly and soon increases LPLa. This finding might account for the higher lipid accumulation by injured vessels, providing additional support to the hypothesis of LPL as an atherogenic mediator.
This paper references
Effect of improved diabetes control on the expression of lipoprotein lipase in human adipose tissue.
R. Simsolo (1992)
Influence of inflation pressure and balloon size on the development of intimal hyperplasia after balloon angioplasty. A study in the atherosclerotic rabbit.
I. Sarembock (1989)
Atherogenesis: a postprandial phenomenon.
D. B. Zilversmit (1979)
Primer of biostatistics
S. Glantz (1981)
Intimal healing. The pattern of reendothelialization and intimal thickening.
M. Stemerman (1977)
Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy.
A. Martín-Hidalgo (1994)
Effect of cholesterol feeding on arterial lipolytic activity in the rabbit.
J. Corey (1977)
Binding of lipoprotein lipase to heparin. Identification of five critical residues in two distinct segments of the amino-terminal domain.
A. Hata (1993)
A simple method for the isolation and purification of total lipides from animal tissues.
J. Folch (1957)
Can lipoprotein lipase be the culprit in cholesteryl ester accretion in smooth muscle cells in atheroma?
O. Stein (1993)
Lipoprotein lipase (LpL) affects low density lipoprotein (LDL) flux through vascular tissue: evidence that LpL increases LDL accumulation in vascular tissue.
J. Rutledge (1994)
Lipoprotein lipase secretion by human monocytes and rabbit alveolar macrophages in culture.
E. Mahoney (1982)
Coronary atherosclerosis. A multifactorial disease.
J. Badimon (1993)
Lipoprotein lipase-mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages.
S. Rumsey (1992)
Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions.
S. Ylä-Herttuala (1991)
Aortic permeability to LDL as a predictor of aortic cholesterol accumulation in cholesterol-fed rabbits.
L. Nielsen (1992)
Effect of lovastatin on intimal hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit.
J. Gellman (1991)
Structure, function and role of lipoprotein lipase in lipoprotein metabolism.
S. Santamarina-Fojo (1994)
Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques.
K. O'brien (1992)
Glycosaminoglycan distribution in rabbit aortic wall following balloon catheter deendothelialization. An ultrastructural study.
M. Richardson (1980)
High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis.
G. Renier (1993)
A stable, radioactive substrate emulsion for assay of lipoprotein lipase.
P. Nilsson-ehle (1976)
Regulation of lipoprotein lipase in adipose and muscle tissues during fasting.
M. LaDu (1991)
Lipoprotein Lipase in Cultured Pig Aortic Smooth Muscle Cells
J. Vance (1982)
The relation between glycosylation and activity of guinea pig lipoprotein lipase.
H. Semb (1989)
Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases.
R. Eckel (1989)
Lipoprotein lipase domain function.
H. Wong (1994)
Lipoprotein lipase in atherosclerosis: its presence in smooth muscle cells and absence from macrophages.
L. Jonasson (1987)
Apolipoprotein E modulates low density lipoprotein retention by lipoprotein lipase anchored to the subendothelial matrix.
U. Saxena (1993)
Lipoprotein lipase facilitates very low density lipoprotein binding to the subendothelial cell matrix.
U. Saxena (1993)
Molecular Cloning: A Laboratory Manual
J. Sambrook (1983)
Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta.
D. Falcone (1980)
Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation.
J. Ip (1990)
Eine neue Methode zur Erzeugung von Thromben durch gezielte Überdehnung der Gefäßwand
H. Baumgartner (1963)
Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix.
S. Eisenberg (1992)
Human lipoprotein lipase: the loop covering the catalytic site is essential for interaction with lipid substrates.
K. Dugi (1992)

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