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Optimization Of Polyalkylcyanoacrylate Nanoparticle Preparation: Influence Of Sulfur Dioxide And PH On Nanoparticle Characteristics

F. Lescure, C. Zimmer, D. Roy, P. Couvreur
Published 1992 · Chemistry

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Abstract Simultaneous influence of pH and presence of sulfur dioxyde (SO2) on nanoparticle preparation and characteristics have been investigated with poly(isohexylcyanoacrylate) and poly(isobutylcyanoacrylate). Turbidity, nanoparticle size, and molecular weights were followed to understand the exact role of each parameter tested. Results showed the extreme importance of SO2 concentration on nanoparticle characteristics and confirmed its role as a polymerization inhibitor. We also demonstrated that, in certain circumstances, pH could compensate, in a limited way, for the effect of SO2. In fact SO2 was always shown to have such a strong effect on size and molecular weight that reproducible batches could be achieved only with SO2-free monomers. Subsequent work on nanoparticle charges under similar conditions will help to gain a better understanding of SO2 influence.
This paper references
10.1002/JPS.2600781215
New method for the preparation of cyanoacrylic nanoparticles with improved colloidal properties.
V. Lenaerts (1989)
10.1016/0378-5173(83)90166-7
Pharmacokinetics and Distribution of a Biodegradable Drug-carrier
L. Grislain (1983)
10.1016/0378-5173(89)90363-3
Increase of doxorubicin penetration in cultured rat hepatocytes by its binding to polymethacrylic nanoparticles
A. Rolland (1989)
Toxicité des nanosphères à base de polycyanoacrylates d'alkyle
P. Couvreur (1989)
10.1002/PI.4980170404
Molecular weights of poly(butyl 2‐cyanoacrylate) produced during nanoparticle formation
S. J. Douglas (1985)
10.1016/0378-5173(86)90021-9
Biodistribution of poly(butyl 2-cyanoacrylate) nanoparticles in rabbits
S. J. Douglas (1986)
10.1016/0378-5173(90)90248-3
Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticle preparations
L. Marchal-Heussler (1990)
10.1111/J.2042-7158.1978.TB10712.X
IN VITRO DEGRADATION RATES OF BIODEGRADABLE POLY‐N‐ALKYL CYANOACRYLATES
W. R. Vezin (1978)
10.3109/02652048909019899
Development of dehydroemetine nanoparticles for the treatment of visceral leishmaniasis.
M. Fouarge (1989)
10.1111/j.2042-7158.1979.tb13510.x
Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties
P. Couvreur (1979)
10.1016/0021-9797(85)90087-6
Particle size and size distribution of poly(butyl 2-cyanoacrylate) nanoparticles. II. Influence of stabilizers
S. J. Douglas (1985)
10.1089/SCT.1989.5.1
Doxorubicin-loaded nanoparticles: increased efficiency in murine hepatic metastases.
N. Chiannilkulchai (1989)
10.1016/0378-5173(86)90053-0
Enhancement of the myotic response of rabbits with pilocarpine-loaded polybutylcyanoacrylate nanoparticles
T. Harmia (1986)
10.1002/JPS.2600710716
Toxicity of polyalkylcyanoacrylate nanoparticles I: Free nanoparticles.
B. Kante (1982)



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10.1007/s11051-012-0761-4
Folate-decorated chitosan/doxorubicin poly(butyl)cyanoacrylate nanoparticles for tumor-targeted drug delivery
Jinghua Duan (2012)
10.1016/S0142-9612(00)00286-6
Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation.
N. Behan (2001)
10.2174/138161281941131219123329
Current progresses on nanodelivery systems for the treatment of neuropsychiatric diseases: Alzheimer's and schizophrenia.
A. Silva (2013)
10.1016/S0378-5173(99)00311-7
Response surface methodology as a predictive tool for determining the effects of preparation conditions on the physicochemical properties of poly(isobutylcyanoacrylate) nanoparticles.
P. McCarron (1999)
10.1007/978-3-642-13461-6_11
Poly(n-butylcyanoacrylate) Submicron Particles Loaded with Ciprofloxacin for Potential Treatment of Bacterial Infections
G. Yordanov (2010)
10.1007/978-3-642-29265-1_4
Polymeric Nanoparticles, Magnetic Nanoparticles and Quantum Dots: Current and Future Perspectives
J. Ali (2012)
10.1155/2009/149254
Cationic Polybutyl Cyanoacrylate Nanoparticles for DNA Delivery
Jinghua Duan (2009)
10.1016/j.ijpharm.2010.08.033
Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles.
Jinghua Duan (2010)
10.1201/9780203913338-26
From Polymer Chemistry and Physicochemistry to Nanoparticulate Drug Carrier Design and Applications
C. Vauthier (2003)
From Preparation to Real Applications as Drug Delivery Systems
C. Vauthier (2004)
10.1201/B19314-9
Curcumin-Loaded Polymeric Nanoparticle: A Promising Route for the Treatment of Cancer
Chinmayee Saikia (2015)
10.1016/S0169-409X(03)00041-3
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.
C. Vauthier (2003)
10.3109/03639045.2011.563781
Preparation and optimization of doxorubicin-loaded albumin nanoparticles using response surface methodology
L. Li (2011)
10.1007/978-94-011-5512-0_33
Polymer Colloids for Biomedical and Pharmaceutical Applications
C. Pichot (1995)
10.1080/02652040600776424
Alkylcyanoacrylate nanocapsules prepared from mini-emulsions: A comparison with the conventional approach
N. Altinbas (2006)
10.1007/978-1-4899-1207-7
Targeting of Drugs 4
G. Gregoriadis (1994)
10.1016/j.colsurfb.2014.03.017
Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate.
P. Lai (2014)
10.1002/9783527610419.NTLS0255
Polymer Nanoparticles and Their Cellular Interactions
V. Mailaender (2012)
10.1080/03639040500306294
Artificial Neural Networks: Comparison of Two Programs for Modeling a Process of Nanoparticle Preparation
N. Rizkalla (2005)
10.1016/S0378-5173(03)00373-9
Poly(butylcyanoacrylate) nanoparticles for topical delivery of 5-fluorouracil.
M. Simeonova (2003)
10.1002/VNL.21382
Detailed study on fusion characteristics of rigid poly(vinyl chloride) nanocomposites: The comparison of using multiple regression analysis and artificial neural network
M. Moghri (2015)
10.1080/026520400405697
Improved preparation and physical studies of polybutylcyanoacrylate nanocapsules
M. Wohlgemuth, W. MacHtle, C. Mayer (2000)
10.1007/978-94-007-1248-5_9
Poly(Alkyl Cyanoacrylate) Nanosystems
J. Nicolas (2011)
10.1016/J.EJPB.2007.08.003
Biocompatible poly(methylidene malonate)-made materials for pharmaceutical and biomedical applications.
P. Breton (2008)
10.1016/j.ejpb.2010.07.007
Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies.
Shrinidh A Joshi (2010)
Synthesis of poly(alkyl cyanoacrylate)-based colloidal
Patrick Couvreur (2009)
10.1517/17425240902870413
Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?
A. Graf (2009)
10.1016/S0168-3659(98)00065-0
Development of ciprofloxacin-loaded nanoparticles: physicochemical study of the drug carrier.
M. Page-Clisson (1998)
10.1007/978-1-4899-1207-7_15
New Poly(Methylidene Malonate 2.1.2) Nanoparticles: Recent Developments
P. Breton (1994)
Anti-cancer nanoparticulate drug delivery system using biodegradable polymers
Harish Gopinath (2013)
10.1007/S10118-011-1033-Y
Preparation of polyalkylcyanoacrylate nanoparticles with various morphologies
Qing-lin Xu (2011)
10.1007/S00396-010-2226-6
Preparation of poly(butylcyanoacrylate) drug carriers by nanoprecipitation using a pre-synthesized polymer and different colloidal stabilizers
G. Yordanov (2010)
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