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PHOTOACTIVE ANTIVIRAL AND CYTOTOXIC ACTIVITIES OF SYNTHETIC THIOPHENES AND THEIR ACETYLENIC DERIVATIVES

J. Hudson, E. Graham, N. Miki, G. Towers, L. Hudson, R. Rossi, A. Carpita, D. Neri
Published 1989 · Chemistry

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Abstract A total of 31 thiophenes were tested for phototoxicity against two membrane-containing viruses, and for cytotoxicity, in comparison with the known potent phototoxic thiophene α-terthienyl. Several compounds were more potent against viruses, but were much less cytotoxic than α-terthienyl. The key structural features of the most active compounds were the possession of a conjugated linear configuration of two or three thiophene rings and a substituent with an acetylenic linkage. Some of these derivatives could constitute useful therapeutic agents against infectious diseases or cancer.
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