← Back to Search
Surface-immobilized Polyethylene Oxide For Bacterial Repellence.
N. Desai, S. Hossainy, J. Hubbell
Published 1992 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
Polyethylene terephthalate films were surface-modified with polyethylene oxide (18,500 g/mol) using a solution technique described previously. These films were investigated for their resistance to bacterial adhesion. Three bacterial strains most commonly associated with implant infections, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, were cultured in tryptic soya broth, human plasma and human serum on the polymeric substrates. Significant reductions (between 70 and 95%) in adherent bacteria were observed on the polyethylene oxide-modified substrates compared to the untreated control polyethylene terephthalate. Surface modification with polyethylene oxide may reduce the risk of implant-associated infections. Plasma fibrinogen was observed to play an important role in the adhesion of all three of these species on both the polyethylene oxide-modified and control polyethylene terephthalate materials.
This paper references
Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices.
G. Christensen (1985)
The microbiology of explanted vascular prostheses.
H. Kaebnick (1987)
Staphylococcus epidermidis: an important pathogen.
R. Forse (1979)
Postmortem microbiological findings of two total artificial heart recipients.
J. J. Dobbins (1988)
Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials.
N. Desai (1991)
Tissue response to intraperitoneal implants of polyethylene oxide-modified polyethylene terephthalate.
N. Desai (1992)
Attachment of staphylococci and streptococci on fibronectin, fibronectin fragments, and fibrinogen bound to a solid phase.
P. Kuusela (1985)
Interactions of Pathogenic Microorganisms with Fibronectin
M. Hoeoek (1989)
Biomaterial-centered infection: microbial adhesion versus tissue integration.
A. Gristina (1987)
Fibronectin, fibrinogen, and laminin act as mediators of adherence of clinical staphylococcal isolates to foreign material.
M. Herrmann (1988)
Binding sites for streptococci and staphylococci in fibronectin.
P. Kuusela (1984)
Specific attachment of Staphylococcus aureus to immobilized fibronectin.
I. Maxe (1986)
The role of bacterial hydrophobicity in infection: bacterial adhesion and phagocytic ingestion.
D. Absolom (1988)
Surface physical interpenetrating networks of poly(ethylene terephthalate) and poly(ethylene oxide) with biomedical applications
N. Desai (1992)
In vitro and in vivo comparative colonization of Staphylococcus aureus and Staphylococcus epidermidis on orthopaedic implant materials.
E. Barth (1989)
Adhesive colonization of biomaterials and antibiotic resistance.
A. Gristina (1987)
Adhesion of coagulase-negative staphylococci to methacrylate polymers and copolymers.
A. H. Hogt (1986)
This paper is referenced by
Biomimetic polymers to control cell adhesion
T. Reintjes (2008)
Bacterial adhesion onto azidated poly(vinyl chloride) surfaces.
S. Lakshmi (2002)
Effects of surface-coupled polyethylene oxide on human macrophage adhesion and foreign body giant cell formation in vitro.
C. R. Jenney (1999)
In vivo and in vitro responses to poly(ethylene terephthalate-co-diethylene glycol terephthalate) and polyethylene oxide blends.
I. O. Barcellos (1998)
Amphiphilic Copolymer Coatings via Plasma Polymerisation Process: Switching and Anti‐Biofouling Characteristics
Virendra Kumar (2011)
Hierarchical Self-Assembly of Microgel-Modified Biomaterials Surfaces
Yong Wu (2014)
Busscher the Surface Biomaterial-Associated Infection : Locating the Finish Line in the Race for
H. Busscher (2018)
Staphylococci and implant surfaces: a review.
L. Harris (2006)
RF Plasma Deposited PEO-Like Films: Surface Characterization and Inhibition of Pseudomonas Aeruginosa Accumulation
E. Johnston (1997)
The production and engineering of antimicrobial peptides and their application in the coating of urinary catheters
X. Li (2013)
Microbial adhesion to poly(ethylene oxide) brushes: influence of polymer chain length and temperature.
A. Roosjen (2004)
Biomimetic Adhesives and Coatings Based on Mussel Adhesive Proteins
Yuan Liu (2016)
A brief review of recent developments in the designs that prevent bio-fouling on silicon and silicon-based materials
X. Zhang (2017)
S. epidermidis biofilm formation: effects of biomaterial surface chemistry and serum proteins.
Jasmine D. Patel (2007)
Microencapsulation of islets in PEG-amine modified alginate-poly(l-lysine)-alginate microcapsules for constructing bioartificial pancreas
J. Chen (1998)
Cell-Synthetic Surface Interactions
A. L. Koenig (2002)
Bacterial factors influencing adhesion of Pseudomonas aeruginosa strains to a poly(ethylene oxide) brush.
A. Roosjen (2006)
New Approaches in Gastritis Treatment
G. Marcial (2011)
Microbial adhesion to biomaterials and infections of the urogenital tract
G. Reid (1994)
Anti-adhesive and Antibacterial Polymer Brushes
K. Neoh (2013)
Phage Device Coatings
J. R. A. J. NiCastro (2016)
Surfactant polymers designed to suppress bacterial (Staphylococcus epidermidis) adhesion on biomaterials.
K. Vacheethasanee (2000)
Synthesis and characterization of polysaccharide-based antimicrobial materials.
P. Li (2012)
Coating of Poly ( ethylene glycol ) for Prevention of Biofilm Formation on the Surface of Polyethylene Ventilation Devices
Bum-Chul Kim (2013)
Chapter 8 – Bacterial Interactions with Polyaryletheretherketone
Edward T. J. Rochford (2012)
Modern Strategies in the Prevention of Implant-Associated Infections
C. von Eiff (2005)
A Fibrinogen-Binding Protein ofStaphylococcus epidermidis
M. Nilsson (1998)
Studying Bacterial Adhesion to Irregular or Porous Surfaces
L. Montanaro (2000)
Study of Antibacterial Efficacy of Hybrid Chitosan-Silver Nanoparticles for Prevention of Specific Biofilm and Water Purification
Somnath Ghosh (2011)
Morphological assessment of HEMA-MMA microcapsules for liver cell transplantation
J. Babensee (1996)
Surface characteristics and biocompatibility of lactide-based poly(ethylene glycol) scaffolds for tissue engineering.
D. Han (1998)
Biofilms and the technological implications of microbial cell adhesion
J. Bryers (1994)See more