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The Release Of Prostaglandin E2 From A Novel Crystalline-rubbery Poly (ethylene Oxide) Network Crosslinked By 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate)☆

N. B. Graham, M. Mcneill, A. Rashid
Published 1985 · Chemistry

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Abstract The synthesis and aqueous swelling properties of a new family of crystalline-rubbery hydrogels based on poly (ethylene glycols) (PEG) and 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate) are described. Their use as monolithic delivery systems for prostaglandin E 2 (PGE 2 ) is presented and compared with the delivery of PGE 2 from urethane crystalline-rubbery poly (ethylene oxide) (PEO) hydrogels of similar crystal-linity and swelling. The fractional-release/time plots for PGE 2 from devices of identical geometry and drug loading, but based on the two different crosslinking structures were essentially superimposable.
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