← Back to Search
Preparation Of Injectable Controlled-release Microcapsules By A Solvent-evaporation Process
Published 1985 · Chemistry
Abstract The solvent-evaporation microencapsulation process can be used to prepare high-quality, injectable, controlled-release microcapsules containing as little as 1 wt.% drug to as much as 90 wt.% drug. This process is useful for the microencapsulation of water-soluble and water-insoluble drugs. When the process conditions are optimized, the process affords good yields of a free-flowing powder comprising smooth spherical particles. Using this process, a batch of microcapsules can be made to have a wide or narrow size distribution. The micro-capsules can have diameters from less than 1 μm to as large as 250 μm. During the early stages of a microcapsule development project, problems can often arise, and high-quality microcapsules are difficult to fabricate. Some of these problems and how to remedy them with respect to the solvent-evaporation process are discussed.