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Substance P And Peripheral Inflammatory Hyperalgesia

M. Nakamura-Craig, T. Smith
Published 1989 · Medicine

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&NA; The hyperalgesic effect of substance P (SP) is usually described as presenting short latency. We now report that multiple injections of sub‐threshold doses of SP into the foot pad of a hind paw of rats pre‐treated with indomethacin induced a long‐lasting hyperalgesia, sensitizing the paw to further challenges with small doses of SP, dopamine or prostacyclin. The sensitizing process also occurred after multiple injections of prostacyclin or prostaglandin E2. The sensitizing effect induced by SP, prostaglandin E2 or prostacyclin is inhibited by pre‐treatment with the SP antagonist (d‐Arg1, d‐Pro2, d‐Trp7,9, Leu11)‐SP. We suggest that SP has an important role as a modulator in peripheral inflammatory pain by sensitizing nociceptors to its own action and to the action of different mediators. This sensitizing process could also be associated with chronic inflammatory pain.
This paper references
10.1016/0028-3908(85)90027-9
Characterization of the hyperalgesic effect induced by intrathecal injection of substance P
H. Matsumura (1985)
10.1111/J.1748-1716.1987.TB08039.X
D-Arg1, D-Trp7,9, Leu11-substance P (spantide) does not antagonize substance P-induced hyperexcitability of the nociceptive flexion withdrawal reflex in the rat.
Z. Wiesenfeld‐Hallin (1987)
10.1139/Y86-224
Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation.
M. Sweeney (1986)
DuaI actions of substance P on nociception: possible role of endogenous
Frederickson (1978)
10.1126/SCIENCE.6171882
Sensory and motor functions of spinal cord substance P.
M. Piercey (1981)
10.1016/0006-8993(81)91110-0
Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats
V. Kayser (1981)
10.1254/JJP.41.427
Interaction of bradykinin with substance P on vascular permeability and pain response.
M. Shibata (1986)
Does dipyrone block the peripheral memory of pain
S. H. Ferreira (1987)
10.1016/0304-3959(87)91114-6
Does dypirone block the peripheral memory of pain? Clinical and exterimental evidence
S. Ferreira (1987)
10.1159/000135431
CONTRIBUTION TO THE THEORY THAT SUBSTANCE P HAS A TRANSMITTER ROLE IN SENSITIVE PATHWAY.
I. Gasparovic (1964)
10.1016/0304-3959(88)90019-X
Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis
H. Vaerøy (1988)
10.1002/9780470720738.CH9
Biosynthesis, axonal transport and turnover of neuronal substance P.
P. Keen (1982)
10.1038/270741a0
Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
G. Jancsó (1977)
10.1016/0361-9230(84)90043-1
Substance p anatogue blocks sp-induced facilitation of a spinal nociceptive reflex
K. Yashpal (1984)
Ocular responses evoked by capsaicin and prostaglandin E 2 are inhibited by a substance P
G. Bynke (1983)
10.1016/0304-3959(82)90096-3
Substance P reduces tail-flick latency: Implications for chronic pain syndromes
Kiran Yasphal (1982)
10.1016/0014-2999(78)90265-0
Central and peripheral antialgesic action of aspirin-like drugs.
S. Ferreira (1978)
M.S.A., The hyperaIgesic effects of prostacychn and prostagIandin
S. H. Ferreira (1978)
Neurotoxic action of caps&in on spinal substance
T. D. Rusine (1980)
10.1098/RSTB.1985.0039
Future trends in pain research.
P. Wall (1985)
10.1016/0014-2999(87)90606-6
A peripheral sympathetic component in inflammatory hyperalgesia.
Masato Nakamura (1987)
Sensory and motor functions of spinal cord substance
M. F. Piercey (1981)
10.1016/0006-8993(78)90146-4
Capsaicin-induced depletion of substance P from primary sensory neurones
T. Jessell (1978)
10.1111/J.1476-5381.1967.TB01984.X
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin.
N. Jancsó (1967)
10.1016/0014-2999(85)90081-0
Behavioural and antinociceptive effects of intrathecally injected substance P analogues in mice.
C. Post (1985)
10.1111/J.1748-1716.1982.TB07036.X
Intrathecal (D-Pro2, D-Trp7,9)-SP elicits hypoalgesia and motor blockade in the rat and antagonizes noxious responses induced by substance P.
B. Akerman (1982)
10.1007/978-1-4613-3515-3_1
Substance P in the Nervous System
T. Jessell (1983)
10.1016/0090-6980(82)90021-1
Prostaglandin hyperalgesia, V: a peripheral analgesic receptor for opiates.
S. Ferreira (1982)
10.1126/SCIENCE.204012
Dual actions of substance P on nociception: possible role of endogenous opioids
R. Frederickson (1978)
In the eye (D-P&, D-T~~‘,~)-SP is a substance P agonist which modified the responses to substance P, prostaghurdin E, and antidromic trigeminal nerve stimulation
A. MandahI (1983)
10.1016/0014-2999(84)90428-X
Is methylnalorphinium the prototype of an ideal peripheral analgesic?
S. Ferreira (1984)
10.1111/J.1748-1716.1983.TB07188.X
In the eye (D-Pro2, D-Trp7,9)-SP is a substance P agonist, which modifies the responses to substance P, prostaglandin E1 and antidromic trigeminal nerve stimulation.
A. Mandahl (1983)
10.1016/0006-8993(80)90369-8
Effects of capsaicin on nociceptive heat, pressure and chemical thresholds and on substance P levels in the rat
A. Hayes (1980)
10.1016/0006-8993(79)91062-X
Substance P-induced analgesia in the rat
J. Mohrland (1979)
10.1002/9780470720738.CH3
Role of substance P as a sensory transmitter in spinal cord and sympathetic ganglia.
M. Otsuka (1982)
Prostaglandin hyperaIgesia. V. A peripheral analgesic receptor for opiates, Prostaglandins
S. H. Ferreira (1982)
10.1002/9780470720738.CH12
Relation of substance P to pain transmission: neurophysiological evidence.
J. Henry (1982)
10.1016/0304-3940(85)90056-4
Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration
C. Post (1985)
10.1038/264083A0
Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat
M. Otsuka (1976)
F.M.A., Central and peripheral antialgic action of aspirin-like drugs
S. H. Fetreira (1978)
10.1254/JJP.43.113
Peripheral transmission in primary sensory nerves.
I. Muramatsu (1987)
10.1007/BF00500282
Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
F. Lembeck (2004)
10.1016/0014-2999(78)90329-1
Behavioural depressant and antinociceptive properties of substance P in the mouse: possible implication of brain monoamines.
M. Starr (1978)
10.1016/0304-3940(83)90444-5
Neural actions of several substance P antagonists in the rat spinal cord
L. Stoppini (1983)
10.1126/SCIENCE.6154313
Substance P: does it produce analgesia or hyperalgesia?
P. Oehme (1980)
10.1016/0006-8993(86)91549-0
Analgesic activities of spinal cord substance P antagonists implicate substance P as a neurotransmitter of pain sensation
M. Piercey (1986)
10.1111/j.1476-5381.1984.tb10773.x
Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization
S. Moochhala (1984)
10.1016/0006-8993(80)90987-7
Neurotoxic action of capsaicin on spinal substance P neurons
J. Nagy (1980)
Elevated cerebrospinal fluid substance P in arachnoiditis is reduced by systemic administration of morphine.
Y. Hosobuchi (1982)
10.1016/0028-3908(87)90089-X
Behavioural characterization of substance P-induced nociceptive response in mice
K. Takahasi (1987)
The role of substance P as a central nervous system transmitter
M. F. Piercey (1985)
10.1002/9780470720738.CH14
If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function?
P. Wall (1982)
Future trends in pain research, Phil
P. D. Wall (1985)
10.1016/0304-3940(81)90321-9
Identification of the unmyelinated sensory nerves which evoke plasma extravasation in response to antidromic stimulation
P. Kenins (1981)
Antinociceptive models displaying peripheral opioid activity.
Smith Tw (1985)
10.1016/0090-6980(78)90199-5
The hyperalgesic effects of prostacyclin and prostaglandin E2.
S. Ferreira (1978)
10.1016/0014-2999(83)90317-5
Local inhibition of inflammatory pain by naloxone and its N-methyl quaternary analogue.
L. Rios (1983)
10.1038/262784a0
Substance P and analgesia
John M. Stewart (1976)
10.1111/j.1476-5381.1988.tb11408.x
Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions
R. L. Follenfant (1988)
10.1016/0024-3205(78)90518-0
Analgesic activity of substance P following intracerebral administration in rats.
J. Malick (1978)



This paper is referenced by
10.1007/1-84628-050-8_27
Tendon Innervation and Neuronal Response After Injury
P. Ackermann (2005)
10.1097/00007632-200406010-00005
Demonstration of Substance P, Calcitonin Gene-Related Peptide, and Protein Gene Product 9.5 Containing Nerve Fibers in Human Cervical Facet Joint Capsules
S. Kallakuri (2004)
10.1002/JCB.240520112
Signal transduction mechanisms of recombinant bovine neurokinin‐2 receptor stably expressed in Baby hamster kidney cells
H. R. Eistetter (1993)
10.1016/0006-8993(92)90168-9
Hyperemia of injured peripheral nerve: sensitivity to CGRP antagonism
D. Zochodne (1992)
10.1159/000370301
Sudden Sensorineural Hearing Loss Associated with Tension-Type Headache: A Population-Based Study
Po-Chou Hsiao (2015)
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version
M. G. Pshennikova (2006)
10.1016/S0301-0082(96)00055-X
NEUROIMMUNOMODULATION VIA LIMBIC STRUCTURES — THE NEUROANATOMY OF PSYCHOIMMUNOLOGY
H. Haas (1997)
CHAPTER FOR THE BOOK ON TENDONS Title : TENDON INNERVATION AND NEURONAL RESPONSE AFTER INJURY
P. Ackermann (2014)
10.3171/SPI.2005.3.6.0471
Localized cervical facet joint kinematics under physiological and whiplash loading.
B. Stemper (2005)
10.1007/978-3-642-97649-0_5
Zusammenfassung: Spinale Schmerzverarbeitung
H. Waldvogel (1996)
10.1007/978-90-313-7316-1_149
Nociceptie van cardiale pijn
G. Horst (2004)
10.1007/978-3-0348-8753-3_8
Inflammatory pain and the joint
D. Mcqueen (1999)
The primary afferent nociceptor and neuropeptide gene expression : importance in experimental arthritis
L. Donaldson (1994)
10.1053/eujp.2000.0222
The neurokinin‐1 receptor antagonist RP 67580 reduces the sensitization of primary afferents by substance P in the rat
M. Pawlak (2001)
10.1007/s000110050754
Sensitisation of group III articular afferents to mechanical stimuli by substance P
M. Herbert (2001)
10.1177/0333102410362927
Stress and tension-type headache mechanisms
S. Cathcart (2010)
10.1016/0306-4522(92)90395-I
Inflammatory mediators and nociception in the joint: Excitation and sensitization of slowly conducting afferent fibers of cat's knee by prostaglandin I2
K. Schepelmann (1992)
10.17140/DOJ-5-138
Frequency of Post-Instrumentation Symptoms Using Hand Files Versus Rotary Protapers
A. J. Mirza (2018)
10.3344/KJP.2006.19.2.168
Detection of Substance P, Calcitonin Gene-Related Peptide and Prostaglandin E2 in Human Epidural Space
S. H. Paek (2006)
10.1002/MED.2610120505
Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation
A. Barber (1992)
10.1007/978-3-642-75319-0_11
Peptidergic Innervation in Chronic Pancreatitis
E. Weihe (1990)
10.1152/JN.1990.64.1.273
Ionic mechanism of substance P actions on neurons in trigeminal root ganglia.
I. Spigelman (1990)
10.1016/S0306-4522(99)00102-5
Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons
K. McCarson (1999)
10.1016/B978-0-12-198875-3.50009-8
3 – Biological Properties of Cyclooxygenase Products
J. Vane (1994)
10.1017/S0317167100047466
Epineurial peptides: a role in neuropathic pain?
D. Zochodne (1993)
10.1016/0306-4522(94)90527-4
Behavioural effects of intraplantar injection of inflammatory mediators in the rat
Y. Hong (1994)
10.1111/j.1476-5381.1996.tb15664.x
Substance P and capsaicin‐induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors
A. Davis (1996)
10.1111/j.1476-5381.1995.tb16359.x
Central versus peripheral site of action of the tachykinin NK1‐antagonist RP 67580 in inhibiting chemonociception
U. Holzer-Petsche (1995)
10.1038/sj.bjp.0704434
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing
A. S. Souza (2002)
10.1111/ijd.14389
Longitudinal progress of transepidermal water loss, color, and sensory elements in split‐thickness skin graft donor sites in East Asians
J. Kim (2019)
10.1038/sj.bjp.0701379
The effect of 15‐HPETE on airway responsiveness and pulmonary cell recruitment in rabbits
M. Riccio (1997)
10.2106/JBJS.D.01850
Tendon injury and tendinopathy: healing and repair.
Pankaj Sharma (2005)
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