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Enhancement Of The Myotic Response Of Rabbits With Pilocarpine-loaded Polybutylcyanoacrylate Nanoparticles

T. Harmia, J. Kreuter, P. Speiser, T. Boye, R. Gurny, A. Kubi
Published 1986 · Chemistry

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Abstract In vivo studies of pilocarpine loaded to polybutylcyanoacrylate nanoparticles were carried out with albino rabbits. A prolonged pilocarpine-induced myosis was achieved with pilocarpine-nanoparticle adsorbates compared to a commercial pilocarpine solution. With nanoparticles containing incorporated drug no significant prolongation of the myotic effect was observed. A two-chamber diffusion cell with a cellophane membrane was found to be unsuitable for in vitro release studies.
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