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Tissue Distribution Of Polybutylcyanoacrylate Nanoparticles Carrying Spin-labelled Nitrosourea

M. Simeonova, T. Ivanova, E. Raikova, M. Georgieva, Z. Raikov
Published 1988 · Chemistry

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The opportunities and advantages of EPR spectroscopy for studying tissue distribution of polyalkylcyanoacrylate nanoparticles are discussed. Tissue distribution of polybutyl-2-cyanoacrylate nanoparticles (PBCN) having diameters of about 100 nm, charged by 1-(2-chloroethyl)-3-(1-oxy-2,2,6,6-tetra-methylpiperidinyl)-1-nitrosourea (spin-labelled nitrosourea, SLCNU) is investigated in C57 Black mice, both healthy and tumor-bearing (subcutaneously implanted Melanom B16). PBCN modifies the tissue distribution profile of SLCNU; the kidney excretion rate is reduced to one third of normal; drug accumulation in the liver and in the brain is also reduced, and drug concentrations are lowered. An increased accumulation of SLCNU loaded PBCN in the tumor tissue is estimated.
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