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Recent Advances On The Use Of Biodegradable Microparticles And Nanoparticles In Controlled Drug Delivery

L. Brannon-Peppas
Published 1995 · Chemistry

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Abstract The possibility of using biodegradable polymers as drug carriers was brought to the attention of many scientists when bioresorbable sutures entered the market two decades ago. Since that time, researchers in pharmacy, chemical engineering, and other disciplines have striven to design biodegradable polymers with desired degradation mechanisms and mechanical properties. Biodegradable polymers have advantages over other carrier systems in that they need not be surgically removed when drug delivery is completed and that they can provide direct drug delivery to the systemic circulation. The drug and polymer may be combined in a number of different ways depending upon the application of interest. Microparticulate formulations have the widest applicability to the widest variety of formulation needs: oral delivery, intramuscular injection, subcutaneous injection, and targeted delivery. This review addresses recent work utilizing biodegradable polymers for controlled drug delivery, focusing on micro- and nanoparticulate delivery systems containing poly(lactic acid), poly(glycolic acid) or their copolymers.
This paper references
10.1023/A:1018942118148
Determinants of Release Rate of Tetanus Vaccine from Polyester Microspheres
M. Alonso (2004)
10.1016/0142-9612(93)90066-B
Poly(L-lactide): a long-term degradation study in vivo. I. Biological results.
H. Pistner (1993)
10.1007/978-3-642-74529-4_6
Biodegradable microspheres: vaccine delivery system for oral immunization.
J. Eldridge (1989)
10.1016/0168-3659(93)90003-N
Gentamycin/poly(lactic acid) blends aimed at sustained release local antibiotic therapy administered per-operatively. II. The case of gentamycin sulfate in high molecular weight poly(dl-lactic acid) and poly(l-lactic acid)
J. Mauduit (1993)
10.1038/NBT0890-755
Controlled Release of Interleukin-2 from Biodegradable Microspheres
M. Hora (1990)
Biodegradable microparticles as controlled release antigen delivery systems.
D. O'hagan (1991)
10.1016/0168-3659(92)90171-M
Poly (glycolic acid-co-dl-lactic acid): diffusion or degradation controlled drug delivery?
Subodh Shah (1992)
10.1023/A:1018967424392
The Influence of Polymer Glass Transition Temperature and Molecular Weight on Drug Release from Tablets Containing Poly(DL-lactic Acid)
M. O. Omelczuk (2004)
10.1016/0142-9612(92)90189-U
Controlled cisplatin delivery system using poly(D,L-lactic acid).
O. Ike (1992)
10.3109/10611869308998764
Analysis of drug release kinetics from degradable polymeric devices.
F. Fischel-Ghodsian (1993)
10.1007/BF00701240
Bioresorbability and biocompatibility of aliphatic polyesters
M. Vert (1992)
10.1016/0161-5890(91)90076-V
Biodegradable microspheres as a vaccine delivery system.
J. Eldridge (1991)
10.1002/JPS.2600810817
In vitro and in vivo release of poly(DL-lactic acid) microspheres containing neurotensin analogue prepared by novel oil-in-water solvent evaporation method.
I. Yamakawa (1992)
Drug loaded poly(lactic acid) nanoparticles produced by a reversible salting-out process : purification of an injectable dosage form
E. Allémann (1993)
Delivery of antisense oligonucleotides from photopolymerized hydrogels
J. L. Hill-West (1993)
10.1002/JBM.820221104
Biodegradable PEO/PLA block copolymers.
D. Cohn (1988)
10.1016/0168-3659(92)90122-8
Design and mathematical analysis of controlled release from microsphere-containing polymeric implants
L. Brannon-Peppas (1992)
10.1016/0142-9612(93)90047-6
Biodegradable poly(DL-lactic acid) formulations in a calcitonin delivery system.
M. Asano (1993)
10.1163/156856294X00068
Controlled release of beta-estradiol from biodegradable microparticles within a silicone matrix.
L. Brannon-Peppas (1994)
10.1002/APP.1990.070390101
Preparation, characterization, and properties of polylactide (PLA)–poly(ethylene glycol) (PEG) copolymers: A potential drug carrier
K. J. Zhu (1990)
10.1023/A:1018924219540
Influence of Poly(DL-Lactide) Nanocapsules on the Biliary Clearance and Enterohepatic Circulation of Indomethacin in the Rabbit
F. Fawaz (2004)
10.1016/0168-3659(93)90169-6
In vivo biocompatibility studies of medisorb® 65/35 D,L-lactide/glycolide copolymer microspheres
Kazuhiro Yamaguchi (1993)
10.1016/0168-3659(93)90095-M
Controlled release of albumin from biodegradable poly(DL-lactide) cylinders
X. Zhang (1993)
10.1016/0168-3659(93)90093-K
Gentamycin/poly (lactic acid) blends aimed at sustained release local antibiotic therapy administered per-operatively. III. The case of gentamycin sulfate in films prepared from high and low molecular weight poly (DL-lactic acids)
J. Mauduit (1993)
10.3109/10731199309118298
Preparation and Evaluation in Vitro and Vivo of Copoly (lactic/glycolic) acid Microspheres Containing Norethisterone
Zhou Zhifang (1993)
10.1016/0168-3659(85)90044-6
Controlled delivery of an LHRH analogue from biodegradable injectable microspheres
L. M. Sanders (1985)
10.1016/0168-3659(93)90002-M
Gentamycin/poly(lactic acid) blends aimed at sustained release local antibiotic therapy administered per-operatively. I. The case of gentamycin base and gentamycin sulfate in poly(dl-lactic acid) oligomers
J. Mauduit (1993)
10.1016/0168-3659(93)90103-C
The preparation of sub-200 nm poly(lactide-co-glycolide) microspheres for site-specific drug delivery
P. Scholes (1993)
10.1002/JBM.820260405
Preparation of poly (D,L) lactide microspheres by emulsion-solvent evaporation, and their clinical applications as a convenient embolic material.
C. Grandfils (1992)
10.1002/JBM.820270807
Adsorption/desorption of human serum albumin at the surface of poly(lactic acid) nanoparticles prepared by a solvent evaporation process.
T. Verrecchia (1993)
Controlled release of bioactive agents from lactide/glycolide polymers
D. Lewis (1990)
10.1016/0169-409X(93)90005-O
The conjugation of proteins with polyethylene glycol and other polymers: Altering properties of proteins to enhance their therapeutic potential
N. Katre (1993)
10.1016/0730-725X(94)00083-F
Controlled delivery of Gd-containing liposomes to lymph nodes: surface modification may enhance MRI contrast properties.
V. Trubetskoy (1995)
10.1016/0168-3659(93)90097-O
Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D, L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior.
T. Niwa (1993)
10.1177/088391158800300203
Lactic Acid Oligomer Microspheres Containing an Anticancer Agent for Selective Lymphatic Delivery: I. In Vitro Studies
R. Wada (1988)



This paper is referenced by
10.1002/TERM.2
Materials in particulate form for tissue engineering. 1. Basic concepts
G. A. Silva (2007)
10.1016/j.jconrel.2014.04.009
Nanostructured drug delivery for better management of tuberculosis.
I. P. Kaur (2014)
10.23860/diss-jain-rajeev-1998
Controlled drug delivery from a novel injectable in situ formed biodegradable PLGA microsphere system
R. A. Jain (1998)
10.1016/S0168-3659(99)00207-2
Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(epsilon-caprolactone) (PCL) amphiphilic block copolymeric nanospheres. II. Thermo-responsive drug release behaviors.
S. Kim (2000)
10.1080/02652040210162612
Microsphere entrapped bee-venom phospholipase A2 retains specific IgE binding capacity: a possible use for oral specific immunotherapy
V. Guérin (2002)
10.1002/APP.10661
In vitro release modulation of hemoglobin from a ternary polymeric delivery vehicle
A. Bajpai (2002)
10.1615/CRITREVTHERDRUGCARRIERSYST.V22.I3.10
Optimizing drug delivery systems using systematic "design of experiments." Part II: retrospect and prospects.
B. Singh (2005)
Oral Mucoadhesive Sustained Release Nanoparticle Coated Probiotic Nanofood
D. Kim (2007)
10.1002/JBM.A.31108
In vitro studies of platelet adhesion, activation, and protein adsorption on curcumin-eluting biodegradable stent materials.
C. J. Pan (2007)
Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis
Daniela Filipa (2012)
10.1590/S1984-82502012000400014
Biodegradable microparticulate drug delivery system of diltiazem HCl
Manish Kumar Gupta (2012)
10.1002/9783527648047.CH3
Applications of Small‐Molecule Gels – Drug Delivery
Lifeng Kang (2013)
10.1081/E-ENN3-120042105
Biomaterials: Mechanical Characterization
E. P. S. Tan (2014)
10.1063/1.4941486
Polylactide nanocomposites for packaging materials: A review
Indah Widiastuti (2016)
10.3109/10837450.2010.531735
Characterization of nano oxaliplatin prepared by novel Fat Employing Supercritical Nano System, the FESNS®
Seung-Jae Lee (2012)
Développement de Polymères à Empreintes Moléculaires pour la Libération Controlée de la Ribavirine et de l'Adénosine -5'-monosphosphate
M. Ayari (2018)
10.1016/0378-5173(95)04135-4
Primaquine-loaded poly(lactide) nanoparticles : physicochemical study and acute tolerance in mice
J. M. Rodrigues (1995)
10.1080/026520400417658
Biodegradable nanoparticles as a delivery system for cyclosporine: preparation and characterization.
J. Molpeceres (2000)
10.1007/BF02976496
Albumin release from biodegradable hydrogels composed of dextran and poly(ethylene glycol) macromer
I. Kim (2001)
10.1016/J.CARBPOL.2006.12.007
Nanoscale structures of dextran esters
S. Hornig (2007)
10.1533/9781845694210.2.251
10 – Food-protein-derived materials and their use as carriers and delivery systems for active food components
M. Subirade (2008)
10.1088/0957-4484/21/6/065104
Preparation, characterization and in silico modeling of biodegradable nanoparticles containing cyclosporine A and coenzyme Q10.
D. D. Ankola (2010)
10.1016/j.foodchem.2012.01.049
Preparation and in vitro evaluation of calcium-induced soy protein isolate nanoparticles and their formation mechanism study.
J. Zhang (2012)
11-18-2013 68 Ga-NOTA-CHSg and 99 mTc-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning
Alejandro Amor-Coarasa (2017)
Pramlintide (25,28,29-pro-h-amylin) is the synthetic analog of human amylin, which is a 37-amino acid peptide related to calcitonin gene-related peptide (CGRP) and calcitonin, and is co-secreted with insulin in response to elevated plasma glucose concentrations from pancreatic β-cells
Vivek Patel (2012)
10.1177/2041731413503357
Silica-based mesoporous nanoparticles for controlled drug delivery
Sooyeon Kwon (2013)
Alpha-tocopherol: extraction from rice bran by microwave-assisted method, and entrapment and release from polymeric nanoparticles
Imola G. Zigoneanu (2006)
10.1016/S0168-3659(97)00124-7
METHOXY POLY(ETHYLENE GLYCOL) AND CAPROLACTONE AMPHIPHILIC BLOCK CO POLYMERIC MICELLE CONTAINING INDOMETHACIN. II: MICELLE FORMATION AND DRUG RELEASE BEHAVIORS
S. Kim (1998)
10.1016/S0065-2318(00)55005-7
Synthesis of chiral polyamides from carbohydrate-derived monomers
Ó. Varela (2000)
10.1163/15685620360511155
Molecular weight distribution changes during degradation and release of PLGA nanoparticles containing epirubicin HCl
D. Birnbaum (2003)
10.1002/JSSC.200301516
Sedimentation field-flow fractionation and granulometric analysis of PLGA microspheres
N. Faisant (2003)
10.1016/J.IJPHARM.2006.09.052
Novel self-assembling nanogels: stability and lyophilisation studies.
S. Daoud-Mahammed (2007)
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