Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Evidence That Brain-derived Neurotrophic Factor Is A Trophic Factor For Motor Neurons In Vivo

V. Koliatsos, R. Clatterbuck, J. Winslow, M. Cayouette, Donald L. Prices
Published 1993 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) act upon populations of neurons that express specific receptors. The present study demonstrates that BDNF rescues motor neurons from degeneration and may also play a role in the normal physiology of these cells. BDNF is expressed in the local environment and in muscle targets of motor neurons; muscle expression is up-regulated by denervation. The alpha motor neurons express the gene encoding p145trkB, a receptor involved in BDNF signal transduction, whereas a subset of motor neurons express p75NGFR. BDNF is transported selectively to alpha motor neurons from skeletal muscles. Finally, BDNF prevents motor neuron death in the axotomized facial nucleus of the neonatal rat. The effects of BDNF on motor neurons raise the possibility that some neurotrophins may be useful in treating patients with motor neuropathies and amyotrophic lateral sclerosis.
This paper references
10.1136/jnnp.40.5.464
Preservation of a certain motoneurone group of the sacral cord in amyotrophic lateral sclerosis: its clinical significance.
T. Mannen (1977)
10.1002/CNE.902240206
Motoneuron death after sciatic nerve section in newborn rats
H. Schmalbruch (1984)
10.1016/0012-1606(86)90089-8
Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture.
U. Dohrmann (1986)
10.1016/0006-8993(91)90471-7
Axotomy induces nerve growth factor receptor immunoreactivity in spinal motor neurons
V. Koliatsos (1991)
10.1016/0896-6273(91)90265-2
Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF
A. Acheson (1991)
10.1111/j.1460-9568.1991.tb00082.x
Absence of Nerve – muscle Interaction Influences the Survival of Developing Motoneurons
A. Burls (1991)
10.1016/0012-1606(87)90467-2
Distinct neurotrophic factors from skeletal muscle and the central nervous system interact synergistically to support the survival of cultured embryonic spinal motor neurons.
U. Dohrmann (1987)
10.1038/345440A0
Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
M. Sendtner (1990)
10.1016/0896-6273(92)90040-K
Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero
S. Carroll (1992)
10.1016/0006-8993(86)90198-8
Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats
U. E. Gasser (1986)
10.1002/ANA.410040309
Sparing of the onufrowicz nucleus in sacral anterior horn lesions
M. Iwata (1978)
10.1097/00005072-199105000-00002
A New Mouse Mutant with Progressive Motor Neuronopathy
H. Schmalbruch (1991)
10.1002/CNE.902100208
Cell death of motoneurons in the chick embryo spinal cord. VI. Reduction of naturally occurring cell death in the thoracolumbar column of terni by nerve growth factor
R. Oppenheim (1982)
10.1073/PNAS.70.12.3884
Properties of the β Nerve Growth Factor Receptor of Avian Dorsal Root Ganglia
K. Herrup (1973)
10.1042/BJ1130299
An enzymic method for the trace iodination of immunoglobulins and other proteins.
J. Marchalonis (1969)
10.1002/j.1460-2075.1987.tb04835.x
Cellular localization of nerve growth factor synthesis by in situ hybridization.
C. Bandtlow (1987)
10.1016/0896-6273(92)90023-7
Neurotrophin receptors: A window into neuronal differentiation
M. Chao (1992)
10.1016/0092-8674(91)90395-F
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
S. Squinto (1991)
10.1016/S0079-6123(08)62484-X
Muscle-derived trophic factors influencing cholinergic neurons in vitro and in vivo.
S. Appel (1989)
10.1016/0896-6273(89)90049-4
Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons
P. Ernfors (1989)
10.1016/0014-4886(90)90039-U
Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells
B. Knüsel (1990)
10.1016/0006-8993(79)90303-2
Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra
M. Schwab (1979)
10.1016/0896-6273(91)90287-A
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB
L. Berkemeier (1991)
10.1038/326353A0
Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor
A. Davies (1987)
10.1113/jphysiol.1974.sp010670
The formation of synapses in striated muscle during development
M. Bennett (1974)
10.1523/JNEUROSCI.06-08-02155.1986
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
F. Hefti (1986)
10.1126/SCIENCE.2011743
Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor.
R. Oppenheim (1991)
10.1016/0006-8993(84)90646-2
Motor neuron survival and neuritic extension from spinal cord explants induced by factors released from denervated muscle
V. Nurcombe (1984)
10.1097/00005072-197905000-00002
HEREDITARY CANINE SPINAL MUSCULAR ATROPHY
L. Cork (1979)
10.1073/PNAS.89.7.3060
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
N. Ip (1992)
10.1523/JNEUROSCI.06-07-02012.1986
Effects of nerve growth factor on the survival and synaptic function of Ia sensory neurons axotomized in neonatal rats
Y. Miyata (1986)
10.1038/302538a0
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor
J. Scott (1983)
10.1073/PNAS.83.8.2714
Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.
D. Shelton (1986)
10.1016/0896-6273(92)90213-W
The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons
P. Distefano (1992)
10.1016/0092-8674(91)90628-C
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
R. Klein (1991)
10.1016/0092-8674(91)90396-G
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
D. Soppet (1991)
10.1113/jphysiol.1976.sp011565
Polyneuronal innervation of skeletal muscle in new‐born rats and its elimination during maturation.
M. C. Brown (1976)
10.1002/j.1460-2075.1987.tb02354.x
The internalization of nerve growth factor by high‐affinity receptors on pheochromocytoma PC12 cells.
M. Hosang (1987)
10.1016/0092-8674(92)90286-L
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
Kuo-Fen Lee (1992)
10.1016/0003-2697(87)90021-2
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
P. Chomczyński (1987)
10.1016/0896-6273(90)90203-R
Primary structure and biological activity of a novel human neurotrophic factor
A. Rosenthal (1990)
10.1002/CNE.902790312
Target dependence of hypoglossal motor neurons during development and in maturity
W. Snider (1989)
10.1016/s0021-9258(17)42578-6
Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.
P. Bernd (1984)
10.1210/ENDO-129-3-1289
Primary structure and biological activity of human brain-derived neurotrophic factor.
A. Rosenthal (1991)
10.1523/JNEUROSCI.06-02-00439.1986
Selective effects of skeletal muscle extract fractions on motoneuron development in vitro
R. Smith (1986)
10.1523/JNEUROSCI.08-09-03481.1988
An immunohistochemical study of the nerve growth factor receptor in developing rats
Q. Yan (1988)
10.1126/SCIENCE.1850551
Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation.
H. Yan (1991)
10.1016/0896-6273(88)90082-7
Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects
Q. Van (1988)
10.1016/0092-8674(92)90413-7
Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product
C. Ibáñez (1992)
10.1038/350678A0
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
B. Hempstead (1991)



This paper is referenced by
10.1055/s-0037-1606539
The Effect of Split Nerve on Electromyography Signal Pattern in a Rat Model
M. Deslivia (2018)
10.1007/s00418-001-0349-z
Ultrastructural localisation of intramuscular expression of BDNF mRNA by silver-gold intensified non-radioactive in situ hybridisation
R. Liem (2001)
10.1111/nyas.12052
Axon regeneration and exercise‐dependent plasticity after spinal cord injury
J. Houlé (2013)
10.1016/J.PMR.2005.08.002
Neurotrophic factors in neuromuscular disease.
B. Distad (2005)
10.1002/NEU.1059
Ovariectomy attenuates dendritic growth in hormone-sensitive spinal motoneurons.
S. L. Hebbeler (2001)
10.1142/S0218957709002353
QUANTIFICATION OF NEUROTROPHINS IN SKELETAL MUSCLE FOLLOWING NERVE INJURY: COMPARISON BETWEEN SPINAL CORD INJURY AND PERIPHERAL NERVE INJURY
Y. Morisawa (2009)
10.1016/S1566-0702(01)00358-7
Neuronal cell death, nerve growth factor and neurotrophic models: 50 years on
M. R. Bennett (2002)
10.1097/00004311-200604420-00004
Neurotrophin and Trk-mediated Signaling in the Neuromuscular System
Elizabeth Vernon Pitts (2006)
10.1006/mcne.2001.1001
Neuromuscular Junction Disassembly and Muscle Fatigue in Mice Lacking Neurotrophin-4
N. Belluardo (2001)
10.1523/JNEUROSCI.23-12-05050.2003
Differential Effects of Neurotrophins and Schwann Cell-Derived Signals on Neuronal Survival/Growth and Synaptogenesis
H. Peng (2003)
10.1523/JNEUROSCI.15-02-01044.1995
BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons
B. Friedman (1995)
10.1523/JNEUROSCI.17-18-06999.1997
Endogenous Ciliary Neurotrophic Factor Is a Lesion Factor for Axotomized Motoneurons in Adult Mice
M. Sendtner (1997)
10.1002/(SICI)1097-4547(19960415)44:2<133::AID-JNR5>3.0.CO;2-E
Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro
A. Zurn (1996)
10.1016/0166-2236(93)90104-T
On neuronal health
O. Isacson (1993)
10.1016/0169-328X(94)00241-6
Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration.
S. Kiryu (1995)
10.1016/S0165-5728(02)00017-6
Brain-derived neurotrophic factor in experimental autoimmune neuritis
P. Felts (2002)
10.1523/JNEUROSCI.22-23-10201.2002
Glial Cell Line-Derived Neurotrophic Factor and Target-Dependent Regulation of Large-Conductance KCaChannels in Developing Chick Lumbar Motoneurons
Miguel Martin-Caraballo (2002)
10.1002/cne.1380
GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia
A. Josephson (2001)
10.1016/S0079-6123(00)27025-8
Chapter 24 Spinal cord motoneuron maintenance, injury and repair
T. Carlstedt (2000)
10.1006/exnr.1999.7306
Contraction-Induced Muscle Fiber Damage Is Increased in Soleus Muscle of Streptozotocin-Diabetic Rats and Is Associated with Elevated Expression of Brain-Derived Neurotrophic Factor mRNA in Muscle Fibers and Activated Satellite Cells
S. Copray (2000)
10.1007/BF02256573
Neural progenitors isolated from newborn rat spinal cords differentiate into neurons and astroglia.
Shun-Fen Tzeng (2002)
10.1093/jnen/nlv002
Neuropathological Characteristics of Brachial Plexus Avulsion Injury With and Without Concomitant Spinal Cord Injury
Zarina S. Ali (2016)
10.1001/ARCHOTOL.126.4.501
Delayed repair of transected nerves: effect of brain-derived neurotrophic factor.
M. Moir (2000)
10.1111/j.1460-9568.2000.01341.x
Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons
A. Al-Majed (2000)
10.1201/9781420008661.ch19
Snake venom nerve growth factors.
M. Lavin (2009)
10.3389/fnins.2017.00399
Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems
R. Hernández (2017)
10.1523/JNEUROSCI.17-01-00470.1997
Adult Mammalian Sensory and Motor Neurons: Roles of Endogenous Neurotrophins and Rescue by Exogenous Neurotrophins after Axotomy
J. Munson (1997)
10.1016/S0896-6273(00)80282-2
Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development
T. Michaelidis (1996)
10.1523/JNEUROSCI.5398-05.2006
BDNF Is Expressed in Skeletal Muscle Satellite Cells and Inhibits Myogenic Differentiation
K. Mousavi (2006)
10.1093/JNEN/62.2.162
Oxidized Galectin‐1 Stimulates the Migration of Schwann Cells from Both Proximal and Distal Stumps of Transected Nerves and Promotes Axonal Regeneration after Peripheral Nerve Injury
Kenji Fukaya (2003)
10.1002/glia.23949
YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration
Haley Jeanette (2020)
10.1016/j.pneurobio.2008.09.006
Driving GDNF expression: The green and the red traffic lights
A. Saavedra (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar