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Nanobiomaterials Set To Revolutionize Drug-delivery Systems For The Treatment Of Diabetes: State-of-the-art

A. Yazdanpanah, Z. Rezvani, Arash Ramedani, M. Gholipourmalekabadi, N. S. Chauhan, Sina Moztarzadeh, A. Urbanska, M. Mozafari
Published 2016 · Medicine

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Abstract Diabetes can result when the accurate control of insulin levels fails in the body. As a result, insulin has been conventionally administered for the treatment of diabetes mainly through subcutaneous injection. There have been several attempts to administer insulin orally. However, the oral bioavailability of insulin is strictly limited, mainly by low permeability across biological membranes. Advances in biotechnology and nanotechnology have recently led to the discovery of several new approaches for the delivery of drugs. In this concept, nanobiomaterials have been shown to be promising candidates for oral insulin delivery. This chapter describes the recent advances and future prospects of using nanobiomaterials for innovative drug-delivery systems.
This paper references
10.1016/j.ijpharm.2011.04.003
Facilitated nanoscale delivery of insulin across intestinal membrane models.
Camile B. Woitiski (2011)
10.1016/S0142-9612(02)00578-1
The production and characteristics of solid lipid nanoparticles (SLNs).
DongZhi Hou (2003)
10.1016/J.EJPB.2007.01.017
The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats.
A. Dahan (2007)
10.1016/J.PROGPOLYMSCI.2012.03.002
Electrospraying of polymers with therapeutic molecules: State of the art
Nathalie Bock (2012)
10.1080/10601320903458556
Designing Gelatin Nanocarriers as a Swellable System for Controlled Release of Insulin: An In-Vitro Kinetic Study
Shilpi Goswami (2009)
10.1016/J.CERAMINT.2013.10.115
Synthesis, characterization and biocompatibility evaluation of sol–gel derived bioactive glass scaffolds prepared by freeze casting method
M. Mozafari (2014)
10.1016/j.ijpharm.2008.01.045
Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation.
C. Puglia (2008)
10.1016/j.ejpb.2009.12.008
Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics.
C. Chen (2010)
10.1021/CR000700M
Peroral route: an opportunity for protein and peptide drug delivery.
A. Sood (2001)
10.1016/B978-012088394-3/50067-2
CHAPTER 64 – Sugar Absorption
E. Wright (2006)
Properties of tolmetin-loaded Eudragit RL100 and Eudragit RS100 microparticles prepared by different techniques
R. Pignatello (1997)
10.3109/03639040903241817
Electrospray technique for solid lipid-based particle production
M. Trotta (2010)
10.1016/j.nano.2008.01.003
Preparation and characterization of insulin nanoparticles using chitosan and its quaternized derivatives.
A. Bayat (2008)
10.1016/S0032-5910(02)00045-1
Micronisation and microencapsulation of pharmaceuticals using a carbon dioxide antisolvent
L.Sze Tu (2002)
10.1677/JOE.0.1640001
Orally administered, insulin-loaded amidated pectin hydrogel beads sustain plasma concentrations of insulin in streptozotocin-diabetic rats.
C. Musabayane (2000)
10.1007/BF02209146
Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters
J. Pappenheimer (2005)
10.1016/j.ijpharm.2011.01.062
Beads made of cyclodextrin and oil for the oral delivery of lipophilic drugs: in vitro studies in simulated gastro-intestinal fluids.
M. Hamoudi (2011)
10.1080/02652040400008473
Formulation and evaluation of novel tableted chitosan microparticles for the controlled release of clozapine
S. Agnihotri (2004)
10.1016/S0378-5173(98)00129-X
Investigation of pectin as a carrier for oral delivery of proteins using calcium pectinate gel beads
P. Sriamornsak (1998)
10.1002/jbm.b.31241
Synthesis and characterization of PEGylated calcium phosphate nanoparticles for oral insulin delivery.
Rukmani Ramachandran (2009)
10.1208/pt030432
The effect of cosolvents on the formulation of nanoparticles from low-molecular-weight poly(I)lactide
L. Peltonen (2008)
10.3844/AJBBSP.2006.41.48
Nanoceramic Matrices: Biomedical Applications
W. Paul (2006)
10.1016/J.JCONREL.2006.10.023
Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats.
C. Damgé (2007)
Oral insulin delivery by means of solid lipid nanoparticles
B. Sarmento (2007)
10.1023/A:1024470508758
Visualization of Insulin-Loaded Nanocapsules: In Vitro and in Vivo Studies After Oral Administration to Rats
H. Pinto-Alphandary (2004)
10.4103/0250-474X.42967
Protein and Peptide Drug Delivery: Oral Approaches
J. Shaji (2008)
10.4103/2229-5178.120635
Nanocarriers and nanoparticles for skin care and dermatological treatments
S. Gupta (2013)
10.1016/0378-5173(95)00002-Z
Biodegradable submicron carriers for peptide drugs : Preparation of DL-lactide/glycolide copolymer(PLGA)nanospheres with nafarelin acetate by a novel emulsion-phase separation method in an oil system.
Toshiyuki (1995)
10.1016/j.tibtech.2009.07.009
Therapeutic application of peptides and proteins: parenteral forever?
Zuzana Antošová (2009)
10.1016/J.TCM.2005.07.003
Tiny solutions for giant cardiac problems.
D. Kong (2005)
10.1179/030801800679206
Drug delivery systems
S. Davis (1983)
10.1016/j.ejpb.2009.06.002
Design for optimization of nanoparticles integrating biomaterials for orally dosed insulin.
Camile B. Woitiski (2009)
10.1016/j.ejpb.2008.03.004
Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells.
A. Sadeghi (2008)
10.1517/17425247.3.6.763
Non-invasive routes for insulin administration: current state and perspectives
C. González (2006)
10.1177/0883911507088276
Preparation and in vitro Evaluation of Linear and Star-branched PLGA Nanoparticles for Insulin Delivery
S. Davaran (2008)
10.1021/IE300173J
Fabrication and Characterization of PLLA/Chitosan/Nano Calcium Phosphate Scaffolds by Freeze-Casting Technique
M. Jafarkhani (2012)
10.1016/S0939-6411(00)00087-4
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
10.1016/S0168-3659(02)00066-4
Sustained release of etanidazole from spray dried microspheres prepared by non-halogenated solvents.
F. J. Wang (2002)
10.1021/JS980235X
Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin.
K. Iwanaga (1999)
10.1016/J.CARBPOL.2006.02.008
Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies
B. Sarmento (2006)
10.1016/S0169-409X(00)00123-X
Polysaccharide colloidal particles as delivery systems for macromolecules.
K. Janes (2001)
10.1016/S0168-3659(03)00126-3
Chitosan-based gastrointestinal delivery systems.
Radi Hejazi (2003)
10.1038/nature05062
Control and detection of chemical reactions in microfluidic systems
A. deMello (2006)
10.1155/2014/879645
Characterization of Individuals with Sacroiliac Joint Bridging in a Skeletal Population: Analysis of Degenerative Changes in Spinal Vertebrae
T. Imamura (2014)
10.1016/J.JCONREL.2006.12.003
A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin.
K. Chalasani (2007)
10.2165/00003088-199733040-00004
Pharmacokinetic Considerations of New Insulin Formulations and Routes of Administration
A. Hoffman (1997)
10.1111/J.1744-7402.2009.02442.X
Fatty Acid Conjugated Calcium Phosphate Nanoparticles for Protein Delivery
W. Paul (2010)
10.1163/1568562041753098
Design and characterisation of new nanoparticulate polymer blends for drug delivery
N. Csaba (2004)
10.1016/j.ijpharm.2009.09.018
The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin--towards oral insulin delivery.
C. Thompson (2010)
10.1016/J.JCONREL.2006.05.013
Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation.
F. Cui (2006)
10.1016/J.ADDR.2007.08.019
Current challenges in non-invasive insulin delivery systems: a comparative review.
E. Khafagy (2007)
10.1016/S0169-409X(98)00039-8
Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics.
Allémann (1998)
10.1016/J.IJPHARM.2004.05.003
β-Cyclodextrin as a suitable solubilizing agent for in situ absorption study of poorly water-soluble drugs
M. Oda (2004)
10.1016/j.addr.2009.11.009
Chitosan-based delivery systems for protein therapeutics and antigens.
M. Amidi (2010)
10.1016/j.biomaterials.2010.12.011
Drug permeation across intestinal epithelial cells using porous silicon nanoparticles.
Luis M Bimbo (2011)
10.1016/J.JCONREL.2007.04.004
Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery.
X. Y. Xiong (2007)
Synthesis and Characterization of Polylactic Acid Tubular Scaffolds with Improved Mechanical Properties for Vascular Tissue Engineering
A. Yazdanpanah (2014)
10.1002/bab.1119
Characteristics improvement of calcium hydroxide dental cement by hydroxyapatite nanoparticles. Part 1: Formulation and microstructure
M. Yasaei (2013)
10.1111/j.2042-7158.2010.01030.x
Pharmaceutical applications of cyclodextrins: basic science and product development
T. Loftsson (2010)
10.2174/187221109787158346
Chitosan and its use in design of insulin delivery system.
T. Wong (2009)
10.1016/S0169-409X(01)00180-6
Chitosan and its derivatives as intestinal absorption enhancers.
M. Thanou (2001)
10.1016/j.ijpharm.2010.04.006
Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles.
N. Zhang (2010)
10.1002/smll.201300427
Dual growth factor delivery using biocompatible core-shell microcapsules for angiogenesis.
D. Choi (2013)
10.1007/s11095-010-0345-x
Uptake and Transport of Novel Amphiphilic Polyelectrolyte-Insulin Nanocomplexes by Caco-2 Cells—Towards Oral Insulin
C. Thompson (2010)
10.1016/J.COLSURFB.2006.09.012
Development and characterization of new insulin containing polysaccharide nanoparticles.
B. Sarmento (2006)
10.1023/A:1011494008729
Design of a Self-Regulated Drug Delivery Device
Xia Cao (2001)
10.1080/713840322
Delivery of Didanosine from Enteric-Coated, Sustained-Release Bioadhesive Formulation
D. Deshmukh (2003)
10.1136/gut.6.3.225
Number, size, and distribution of Peyer's patches in the human small intestine
J. S. Cornes (1965)
10.1016/J.IJPHARM.2003.07.015
Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin.
T. Morçöl (2004)
10.1002/jps.21347
Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response.
C. Reis (2008)
10.1016/j.ijpharm.2009.04.014
The complexation between novel comb shaped amphiphilic polyallylamine and insulin: towards oral insulin delivery.
C. Thompson (2009)
10.1016/J.CERAMINT.2012.02.097
Enhancement of fracture toughness in bioactive glass-based nanocomposites with nanocrystalline forsterite as advanced biomaterials for bone tissue engineering applications
Abolfazl Yazdanpanah (2012)
10.1016/j.ijpharm.2009.02.005
Genipin-crosslinked casein hydrogels for controlled drug delivery.
Fei Song (2009)
10.1016/J.JCONREL.2006.04.017
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
M. George (2006)
10.3390/molecules14072602
Polymeric Plant-derived Excipients in Drug Delivery
Carien E. Beneke (2009)
10.1023/B:PHAM.0000016283.87709.a9
Drug Solubilization Behavior During in Vitro Digestion of Suspension Formulations of Poorly Water-Soluble Drugs in Triglyceride Lipids
A. Kaukonen (2004)
10.1016/S0378-5173(96)04731-X
Biodegradation of solid lipid nanoparticles as a function of lipase incubation time
R. Mueller (1996)
10.1016/J.PROGPOLYMSCI.2006.06.001
Chitin and chitosan: Properties and applications
M. Rinaudo (2006)
10.3109/03639049209046327
The spray drying of pharmaceuticals
J. Broadhead (1992)
10.1016/j.jconrel.2009.08.010
Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis.
E. Roger (2009)
10.1016/S0169-409X(02)00228-4
Biodegradable nanoparticles for drug and gene delivery to cells and tissue.
J. Panyam (2003)
10.1016/j.ejpb.2013.01.005
Spray-dried casein-based micelles as a vehicle for solubilization and controlled delivery of flutamide: formulation, characterization, and in vivo pharmacokinetics.
Ahmed O Elzoghby (2013)
10.1002/AJA.1001410407
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types.
H. Cheng (1974)
10.1081/DDC-120018199
New Developments in Insulin Delivery
N. Ghilzai (2003)
10.1055/S-2007-1001766
Improving Insulin Therapy: Achievements and Challenges
Galloway Ja (1994)
Porous Hydroxyapatite Nanoparticles for Intestinal Delivery of Insulin
W. Paul (2001)
10.1021/BC0255586
Plasmid DNA-entrapped nanoparticles engineered from microemulsion precursors: in vitro and in vivo evaluation.
Z. Cui (2002)
10.1007/s13167-010-0001-x
Drug delivery systems: Advanced technologies potentially applicable in personalized treatments
J. Coelho (2010)
10.1016/J.JOPR.2013.06.015
Lactose coated ceramic nanoparticles for oral drug delivery
Pavani Vengala (2013)
10.1016/S0928-0987(99)00010-X
Effect of calcium concentration, hardening agent and drying condition on release characteristics of oral proteins from calcium pectinate gel beads.
P. Sriamornsak (1999)
10.1016/J.BIOMATERIALS.2003.10.036
Pectin/poly(lactide-co-glycolide) composite matrices for biomedical applications.
L. Liu (2004)
10.1081/DDC-120030930
Insulin‐Loaded Calcium Pectinate Nanoparticles: Effects of Pectin Molecular Weight and Formulation pH
K. Cheng (2004)
10.1002/PPSC.201200044
Elaborate Design Strategies Toward Novel Microcarriers for Controlled Encapsulation and Release
Tae Soup Shim (2013)
10.1016/S0896-8446(98)00129-6
SUPERCRITICAL ANTISOLVENT PRECIPITATION OF MICRO- AND NANO-PARTICLES
E. Reverchon (1999)
10.1016/J.JCONREL.2007.05.019
Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles.
K. Chalasani (2007)
10.1533/9781845699802.2.204
Inorganic nanoparticles for targeted drug delivery
W. Paul (2010)
10.1016/J.CARBPOL.2007.05.027
Atomic force microscopy imaging of novel self-assembling pectin–liposome nanocomplexes
P. Sriamornsak (2008)
10.1016/S0168-3659(00)00339-4
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
10.1016/0142-9612(96)81411-6
Preparation and characterization of polyethyl-2-cyanoacrylate nanocapsules containing antiepileptic drugs.
M. Fresta (1996)
10.1002/JPS.20875
Role of nanotechnology in pharmaceutical product development.
H. Devalapally (2007)
10.1016/S0169-409X(02)00044-3
Nanoparticles in cancer therapy and diagnosis.
I. Brigger (2002)
10.1517/17425247.2012.745848
Ceramic nanocarriers: versatile nanosystem for protein and peptide delivery
D. Singh (2013)
10.1016/0378-5173(96)04539-5
Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles
R. Mueller (1996)
Spray-drying as a preparation method of microparticulate drug delivery systems: an overview
P. Giunchedi (1995)
10.1016/j.jconrel.2012.01.004
Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled β-casein micelles.
Michal Bachar (2012)
10.1021/JS970124I
Poly(alkyl cyanoacrylate) nanospheres for oral administration of insulin.
C. Damgé (1997)
10.1146/ANNUREV.ME.41.020190.002141
Intestinal barriers to bacteria and their toxins.
R. I. Walker (1990)
10.1002/(SICI)1097-4628(20000228)75:9<1089::AID-APP1>3.0.CO;2-5
Beta cyclodextrin-insulin-encapsulated chitosan/alginate matrix : Oral delivery system
L. Moses (2000)
10.1038/nrn1827
Neuroscience nanotechnology: progress, opportunities and challenges
G. Silva (2006)
10.1016/J.IJPHARM.2006.06.019
Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery.
S. Sajeesh (2006)
10.1016/0378-5173(92)90249-2
Preparation of aqueous polymeric nanodispersions by a reversible salting-out process : influence of process parameters on particle size
E. Allémann (1992)
Nanoparticle characterization : a comprehensive physicochemical approach
B. Magenheim (1991)
10.1021/JS980084Y
Nanoparticle technology for delivery of drugs across the blood-brain barrier.
U. Schroeder (1998)
10.1211/jpp.58.3.0003
Chitosan nanoparticles encapsulated vesicular systems for oral immunization: preparation, in‐vitro and in‐vivo characterization
S. Jain (2006)
10.1211/0022357022476
The potential of chitosan in ocular drug delivery
M. Alonso (2003)
10.1021/bc800076n
Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation.
F. Mi (2008)
10.1016/0378-5173(86)90236-X
Development of a new process for the manufacture of polyisobutylcyanoacrylate nanocapsules
N. A. K. Fallouh (1986)
10.1016/S0169-409X(98)00057-X
Cyclodextrins in peptide and protein delivery.
Irie. (1999)
10.1016/S0378-5173(02)00176-X
Spray dried Eudragit microparticles as encapsulation devices for vitamin C.
E. Esposito (2002)
10.1016/0378-5173(92)90303-J
Preparation of submicron drug particles in lecithin-stabilized o/w emulsions I. Model studies of the precipitation of cholesteryl acetate
B. Sjoestroem (1992)
10.1016/j.jcis.2010.08.030
Controllable synthesis, characterization and optical properties of colloidal PbS/gelatin core-shell nanocrystals.
M. Mozafari (2010)
10.1016/J.JCONREL.2005.02.002
Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery.
Jung-hwan Park (2005)
10.1007/BF02627733
Enteral absorption of water-in-oil-in-water insulin emulsions in rabbits
M. Shichiri (2007)
10.1016/j.ejps.2010.08.009
Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles.
Camile B. Woitiski (2010)
10.1111/j.2042-7158.1988.tb05166.x
Preparation of Biodegradable Poly(±)lactide Microparticles Using a Spray‐Drying Technique
R. Bodmeier (1988)
10.1016/J.JLUMIN.2011.12.054
Self-assembly of PbS hollow sphere quantum dots via gas–bubble technique for early cancer diagnosis
M. Mozafari (2013)
10.1016/j.addr.2012.10.003
Advanced materials and processing for drug delivery: the past and the future.
Y. Zhang (2013)
Nanodermatology: a bright glimpse just beyond the horizon - part I.
A. Nasir (2010)
10.1002/JPS.2600750408
Physicochemical and morphological characterization of polyisobutyl cyanoacrylate nanocapsules.
J. Rollot (1986)
10.1248/BPB.29.1790
Nanocarriers: promising vehicle for bioactive drugs.
M. Rawat (2006)
10.1111/j.1749-6632.2009.04027.x
Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function
A. Watson (2009)
10.1007/s11095-012-0897-z
Novel Spray-Dried Genipin-Crosslinked Casein Nanoparticles for Prolonged Release of Alfuzosin Hydrochloride
Ahmed O Elzoghby (2012)
10.1016/j.ijpharm.2013.02.050
Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations.
Jianfeng Guo (2013)
10.1016/J.CES.2005.06.019
Inorganic nanoparticles as carriers for efficient cellular delivery
Z. P. Xu (2006)
10.1016/B978-012088394-3/50014-3
CHAPTER 11 – Physiology of Gastrointestinal Stem Cells
A. Vidrich (2006)
10.1016/J.DRUDIS.2006.10.013
Blood-brain barrier delivery.
W. Pardridge (2007)
10.1002/JPS.20750
Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery.
F. Cui (2007)
10.1016/j.addr.2012.01.003
Engineering nanomedicines using stimuli-responsive biomaterials.
Y. Wang (2012)
10.1016/S0169-409X(00)00117-4
Panoparticulate systems for improved drug delivery.
Y. Kawashima (2001)
10.1016/0021-8502(91)90013-8
Particle formation with supercritical fluids—a review
J. Tom (1991)
10.1016/J.CERAMINT.2010.07.010
Development of macroporous nanocomposite scaffolds of gelatin/bioactive glass prepared through layer solvent casting combined with lamination technique for bone tissue engineering
M. Mozafari (2010)
10.1016/0378-5173(95)00122-Y
Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
G. Liversidge (1995)
10.1210/ENDO-90-5-1220
Studies on the Mode of Action of Insulin: Properties and Biological Activity of an Insulin-Dextran Complex
F. Suzuki (1972)
10.1163/156856207779996931
Nanostructured materials for applications in drug delivery and tissue engineering
M. Goldberg (2007)
10.1016/j.ejps.2008.12.017
Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimisation and in vivo evaluation.
A. Graf (2009)
10.1007/s11095-007-9367-4
Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery
B. Sarmento (2007)
10.2147/NANO.2006.1.2.117
Chitosan nanoparticles for oral drug and gene delivery
Katherine Bowman (2006)
10.1111/J.2042-7158.1978.TB13402.X
Increased intestinal absorption of insulin: an insulin suppository
M. Shichiri (1978)
10.1002/jps.21434
Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process.
S. Salmaso (2009)
10.1002/jps.21874
Poly(epsilon-caprolactone)/eudragit nanoparticles for oral delivery of aspart-insulin in the treatment of diabetes.
C. Damgé (2010)
10.1038/nrc1958
Polymer conjugates as anticancer nanomedicines
R. Duncan (2006)
10.2174/157341309788921516
Lipid Matrix Nanoparticles: Pharmacokinetics and Biopharmaceutics
S. Doktorovová (2009)
10.1177/096369351001900204
Development of 3D Bioactive Nanocomposite Scaffolds Made from Gelatin and Nano Bioactive Glass for Biomedical Applications
M. Mozafari (2010)
10.1023/A:1011957512347
Phase Behavioral Effects on Particle Formation Processes Using Supercritical Fluids
S. Palakodaty (2004)
10.1016/J.CERAMINT.2013.05.071
Calcium hydroxide-modified zinc polycarboxylate dental cements
Ali Zamanian (2013)
Drug loaded poly(lactic acid) nanoparticles produced by a reversible salting-out process : purification of an injectable dosage form
E. Allémann (1993)
10.1111/j.1463-1326.2011.01546.x
Preparation, characterization and in vivo evaluation of pH‐sensitive oral insulin‐loaded poly(lactic‐co‐glycolicacid) nanoparticles
J. Yang (2012)
10.1016/J.IJPHARM.2006.07.026
Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin.
N. Zhang (2006)
10.1016/j.msec.2012.09.001
Oral insulin delivery by self-assembled chitosan nanoparticles: in vitro and in vivo studies in diabetic animal model.
Piyasi Mukhopadhyay (2013)
10.1002/POLA.26860
pH‐responsive polymer core–shell nanospheres for drug delivery
H. Wang (2013)
10.1016/J.APSUSC.2010.09.008
Biomimetic formation of apatite on the surface of porous gelatin/bioactive glass nanocomposite scaffolds
M. Mozafari (2010)
10.1002/jbm.a.32490
Starch-based polymeric carriers for oral-insulin delivery.
M. Mahkam (2010)
10.1517/17425247.5.1.45
Nanoparticle strategies for the oral delivery of insulin
C. Damgé (2008)
Nanoparticles and nanocapsules--new dosage forms in the nanometer size range.
J. Kreuter (1978)
10.1016/j.biomaterials.2010.05.042
Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-responsive nanoparticles vs. subcutaneous injection.
K. Sonaje (2010)
10.1016/S1359-6446(01)01962-6
Insulin therapies - past, present and future.
O. Pillai (2001)
10.4172/2157-7439.S4-007
Oral nano-insulin therapy: current progress on nanoparticle-based devices for intestinal epithelium-targeted insulin delivery
A. Ahmad (2011)
10.3390/ijms9122376
Improving the Stability of Insulin in Solutions Containing Intestinal Proteases in Vitro
Liefeng Zhang (2008)
10.1007/s11095-010-0174-y
Transdermal Delivery of Macromolecules Using Solid-State Biodegradable Microstructures
Janet R Wendorf (2010)
10.1179/174367510X12753884125488
Green synthesis and characterisation of spherical PbS luminescent micro‐ and nanoparticles via wet chemical technique
M. Mozafari (2011)
Drug-loaded nanoparticles – preparation methods and drug targeting issues
E. Alleman (1993)
10.2165/00003495-198734030-00003
Human Insulin
R. Brogden (2012)
10.1016/j.addr.2013.07.003
BioMEMS in drug delivery.
E. Nuxoll (2013)
10.1016/S0016-5085(70)80092-0
Surface structure of intestinal epithelium.
S. Balcerzak (1970)
10.1155/2014/898930
Synthesis and Characterization of Poly(lactic-co-glycolic) Acid Nanoparticles-Loaded Chitosan/Bioactive Glass Scaffolds as a Localized Delivery System in the Bone Defects
K. Nazemi (2014)
10.1088/0022-3727/40/19/R01
Microfluidic methods for generating continuous droplet streams
G. Christopher (2007)
10.1016/B978-012088394-3/50018-0
CHAPTER 15 – Regulation of Gastrointestinal Normal Cell Growth
M. R. Hellmich (2006)
10.1002/JPS.2600651217
Polymerized micelles and their use as adjuvants in immunology.
G. Birrenbach (1976)
10.1007/BF00400466
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man
S. Prato (2004)
10.1038/sj.gt.3301318
Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles
H. Cohen (2000)
10.1248/CPB.58.1423
Chitosan nanoparticles: a promising system in novel drug delivery.
K. Nagpal (2010)
10.1109/JMEMS.2007.899339
Integrated Lithographic Molding for Microneedle-Based Devices
R. Luttge (2007)
10.1021/BC00031A600
Synthesis of LHRH antagonists suitable for oral administration via the vitamin B12 uptake system.
G. J. Russell-Jones (1995)
10.1038/nnano.2012.168
Microfluidic technologies for accelerating the clinical translation of nanoparticles.
P. Valencia (2012)
10.1038/nrc1566
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
10.1016/J.NANO.2006.04.009
Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems.
C. Reis (2006)
10.1049/iet-nbt.2013.0053
Synthesis and characterisation of poly(lactide-co-glycolide) nanospheres using vitamin E emulsifier prepared through one-step oil-in-water emulsion and solvent evaporation techniques.
M. Mozafari (2014)



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