Online citations, reference lists, and bibliographies.
← Back to Search

Recent Advancements In Oral Delivery Of Insulin: From Challenges To Solutions

Raje Chouhan, Shilpi Goswami, A. Bajpai
Published 2017 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract The attempt to design oral formulations of insulin has been a cutting-edge area of interdisciplinary research where chemical, pharmaceutical, and biological sciences have joined hands to provide a sustainable solution to diabetic patients. This chapter presents an overview of diabetes highlighting various aspects of insulin therapy, including insulin analogs, oral delivery of insulin, mechanistic action of insulin, challenges of oral administration of insulin and breakthroughs in insulin delivery at the global level. This chapter also provides an account of commercialization level of insulin.
This paper references
A BRIEF OVERVIEW OF DIABETES
M. Shivashankar (2011)
10.1016/j.jconrel.2014.09.031
Targeting of gastrointestinal tract for amended delivery of protein/peptide therapeutics: strategies and industrial perspectives.
V. Pawar (2014)
10.4239/wjd.v4.i1.1
Insulin therapies: Current and future trends at dawn.
S. Yaturu (2013)
10.1002/mabi.201000388
Advances in mucoadhesion and mucoadhesive polymers.
V. Khutoryanskiy (2011)
10.1039/C3BM60064E
COMPETING PROPERTIES OF MUCOADHESIVE FILMS DESIGNED FOR LOCALIZED DELIVERY OF IMIQUIMOD.
Sandeep Ramineni (2013)
10.1038/nrendo.2011.183
The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives
L. Chen (2012)
10.1007/S12257-009-3058-4
Strategies for oral delivery of macromolecule drugs
J. Park (2010)
10.4103/0253-7613.91879
Evaluation of an oral insulin formulation in normal and diabetic rats
H. Najafzadeh (2012)
10.1016/j.ejmech.2014.04.084
Solid lipid nanoparticles for hydrophilic biotech drugs: optimization and cell viability studies (Caco-2 & HEPG-2 cell lines).
P. Severino (2014)
10.1016/j.nano.2014.02.014
Intestinal absorption of insulin nanoparticles: contribution of M cells.
M. A. Lopes (2014)
10.1016/S0165-0327(12)70004-6
Epidemiology of depression and diabetes: a systematic review.
T. Roy (2012)
10.4172/2157-7064.1000E114
Overview on Diabetes Mellitus (Type 2)
Bassam Hassan (2013)
10.1210/jc.2011-1927
Update in the CNS response to hypoglycemia.
R. McCrimmon (2012)
10.1186/s12951-015-0136-y
Nanoparticle based insulin delivery system: the next generation efficient therapy for Type 1 diabetes
G. Sharma (2015)
10.1021/acsnano.5b00028
Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin.
Wei Shan (2015)
10.1517/17425247.2012.735658
Liposomal delivery of proteins and peptides
Janani Swaminathan (2012)
10.1016/j.addr.2012.10.007
Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery.
Yeonhee Yun (2013)
10.4155/TDE.12.40
Polymer-based oral peptide nanomedicines.
E. P. Herrero (2012)
10.2174/092986712799945003
Converting peptides into drug leads by lipidation.
L. Zhang (2012)
10.15272/AJBPS.V4I40.645
Diabetes mellitus ? a devastating metabolic disorder
Piero Mn (2015)
10.3390/molecules18066734
Eudragit® L100/N-Trimethylchitosan Chloride Microspheres for Oral Insulin Delivery
E. Marais (2013)
10.1016/j.jconrel.2010.02.001
A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa.
Abdallah Makhlof (2011)
10.5897/JPAP2013.0001
The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus
Ozougwu Ozougwu (2013)
Novel Approaches for Oral Delivery of Insulin and Current Status of Oral Insulin Products
P KineshV. (2010)
10.4061/2010/823710
Peyer's Patches: The Immune Sensors of the Intestine
C. Jung (2010)
10.1007/978-1-60761-609-2_11
Polymeric nanoparticles for drug delivery.
J. M. Chan (2010)
10.1016/j.jsps.2014.06.004
A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
Abdul Muheem (2016)
10.1016/j.biomaterials.2011.08.087
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery.
M. Chen (2011)
10.1371/journal.pone.0059524
Glucose-Reducing Effect of the ORMD-0801 Oral Insulin Preparation in Patients with Uncontrolled Type 1 Diabetes: A Pilot Study
R. Eldor (2013)
10.1111/j.1463-1326.2009.01146.x
The glucose lowering effect of an oral insulin (Capsulin) during an isoglycaemic clamp study in persons with type 2 diabetes
S. Luzio (2010)
10.1016/j.addr.2011.12.009
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
Laura M Ensign (2012)
10.1517/17425247.2011.539200
Vitamin B12 in drug delivery: breaking through the barriers to a B12 bioconjugate pharmaceutical
Susan M. Clardy (2011)
10.3390/ma3031928
Targeted Delivery of Protein Drugs by Nanocarriers
R. Solaro (2010)
10.1016/J.PROGPOLYMSCI.2014.07.010
Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review
A. Sosnik (2014)
10.1517/17425247.2013.745509
Paracellular drug absorption enhancement through tight junction modulation
H. R. Lemmer (2013)
10.1016/j.biomaterials.2011.10.021
Preactivated thiomers as mucoadhesive polymers for drug delivery
J. Iqbal (2012)
10.1016/j.biotechadv.2014.07.006
A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules.
Bibi F Choonara (2014)
10.1016/j.addr.2013.01.003
In vitro and in vivo models for the study of oral delivery of nanoparticles.
J. Gamboa (2013)
10.1111/cbdd.12318
Retracted: Synthesis, Characterization, and In vitro Studies of PLGA–PEG Nanoparticles for Oral Insulin Delivery
S. Hosseininasab (2014)
10.1016/j.bbrc.2010.03.041
Investigation of archaeosomes as carriers for oral delivery of peptides.
Z. Li (2010)
10.4172/2157-7439.S4-007
Oral nano-insulin therapy: current progress on nanoparticle-based devices for intestinal epithelium-targeted insulin delivery
A. Ahmad (2011)
RECENT ADVANCES IN PULMONARY DRUG DELIVERY SYSTEM
C. Rahul (2013)
10.22377/AJP.V8I3.353
Novel noninvasive techniques in management of diabetes
Nadaf Sameer (2014)
10.1186/s12951-014-0062-4
The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types
Paul Schlinkert (2015)
10.5798/DICLEMEDJ.0921.2012.02.0149
Insulin hormone: Mechanism and effects on the body and relationship with central nervous system
D. Unal (2012)
10.4155/TDE.11.114
Oral peptide delivery: prioritizing the leading technologies.
D. Brayden (2011)
10.1016/J.PROGPOLYMSCI.2012.04.004
Strategies for effective oral insulin delivery with modified chitosan nanoparticles: A review
Piyasi Mukhopadhyay (2012)
10.19070/2167-910X-1300015
A Description on Study of Intestinal Barrier, Drug Permeability and Permeation Enhancers
Sanjar Alam (2013)
10.1016/j.biomaterials.2011.12.038
Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery.
Fang-Yi Su (2012)
EUDRAGIT POLYMERS IN COLON TARGETED ORAL DELIVERY OF INSULIN
R. Kumar (2014)
10.7150/ijms.10001
Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention
Y. Wu (2014)
A REVIEW ON ORAL INSULIN
Aarti Khulbe (2015)
10.1002/mabi.201000464
Surface modification to control protein/surface interactions.
L. Yuan (2011)
10.1016/c2013-0-18177-9
Oral Delivery of Insulin
C. P. Sharma (2014)
10.1016/j.ijpharm.2011.12.055
HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin.
Z. M. Wu (2012)
10.1016/j.jfda.2015.01.007
Application of polymeric nanoparticles and micelles in insulin oral delivery.
M. Alai (2015)
10.1152/physrev.00019.2012
Claudins and the modulation of tight junction permeability.
D. Günzel (2013)
10.1016/j.ddtec.2012.04.005
Insight of current technologies for oral delivery of proteins and peptides.
J. Chin (2012)
Non invasive insulins: advanced insulin therapy over this decade
T. Rajeswari (2011)
10.4155/TDE.11.132
Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET).
E. Walsh (2011)
10.1016/j.ijpharm.2013.02.030
Approaches for enhancing oral bioavailability of peptides and proteins.
J. Renukuntla (2013)
10.1208/s12248-011-9307-4
Absorption Enhancers: Applications and Advances
B. Aungst (2011)
10.4103/2249-4855.118669
Storage of insulin in rural areas
S. Kalra (2012)
10.1155/2014/378048
Emerging Trends in Noninvasive Insulin Delivery
A. Verma (2014)
10.2337/dc11-0523
Long-Term Outcome of Individuals Treated With Oral Insulin
K. Vehik (2011)
10.1016/j.ddtec.2011.11.006
Overcoming poor permeability: translating permeation enhancers for oral peptide delivery.
S. Maher (2012)
10.1016/j.jconrel.2012.11.005
Polymeric hydrogels for oral insulin delivery.
K. Chaturvedi (2013)
10.1016/j.ghir.2011.12.002
The effect of polyethylene glycol recombinant human growth hormone on growth and glucose metabolism in hypophysectomized rats.
Zhi xin Zhang (2012)
Microspheres - An Overview
Akash Chakraborthy Moy (2011)
10.1177/193229681300700228
Oral Insulin Delivery: How Far are We?
P. Fonte (2013)
10.2147/DDDT.S79383
Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery
K. Song (2015)
10.1111/j.1463-1326.2009.01150.x
Oral insulin – a review of current status
H. Iyer (2010)
10.1002/9783527636730.CH3
Oral Peptide Drug Delivery: Strategies to Overcome Challenges
J. Hamman (2011)
10.1007/s40265-014-0226-4
The Evolution of Insulin Glargine and its Continuing Contribution to Diabetes Care
R. Hilgenfeld (2014)
10.1016/J.REACTFUNCTPOLYM.2010.10.002
Oral protein delivery: Current status and future prospect
K. Park (2011)
Current Status of Diabetes in India and Need for Novel Therapeutic Agents
A. Ramachandran (2010)
10.1530/ERC-12-0026
Insulin and its analogues and their affinities for the IGF1 receptor.
A. Varewijck (2012)
10.1155/2013/591751
Development and Evaluation of Insulin Incorporated Nanoparticles for Oral Administration
A. K. Prusty (2013)
10.2174/1389200211309010004
Models to predict intestinal absorption of therapeutic peptides and proteins.
Filipa Antunes (2013)
10.1016/j.cgh.2014.06.018
Polymeric nanoparticle technologies for oral drug delivery.
Eric M. Pridgen (2014)
10.1208/s12249-010-9563-0
Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery
S. Das (2010)
10.4103/0975-7406.76478
Mucoadhesive drug delivery systems
Rahamatullah Shaikh (2011)
10.1002/9781118540398
Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists.
R. A. Copeland (2005)
10.1210/jc.2012-1179
Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression.
S. Tuvia (2012)
10.1177/193229681200600630
Oral Delivery of Glucagon-like Peptide-1 and Analogs: Alternatives for Diabetes Control?
F. Araújo (2012)
10.1016/j.ijpharm.2010.03.061
Silica nanoparticle coated liposomes: a new type of hybrid nanocapsule for proteins.
Vellore J. Mohanraj (2010)
10.17221/7495-CJAS
Oral delivery of insulin-loaded nanoparticles in diabetic rabbits and in sheep
S. Olya (2018)
AN OVERVIEW: STORAGE OF PHARMACEUTICAL PRODUCTS
Kausar Shafaat (2013)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar