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Development Of A Rabies Vaccine In Cell Culture For Veterinary Use In The Lyophilized Form

Matheus Gonçalves Severo
Published 2013 · Biology

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Rabies is a viral zoonosis with 61,000 estimated deaths per year. The rabies vaccine is the best treatment before and after exposure and the virus can be produced in animal cells for veterinary use. Lyophilization has permitted the development of vaccines that would otherwise be too unstable for effective use, including a rabies vaccine that has improved stability when freeze-dried. This chapter is divided into two parts: a review of the rabies virus, viral vaccines, and lyophilization; and a case of study of infected rabies cells kinetics and vaccine freeze-drying with different cryoprotectors. The experiment tested three viral inocula in baby hamster kidney-21 cells growing in 1.5-L spinner flasks, comparing kinetics and virus titration to determine the best inoculum. Harvests of the best inoculum were inactivated and 12 formulations of excipients were made and freeze-dried, comparing visual aspects and residual moisture to select the best formulations.
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