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CHAPTER 2 – Translation And Posttranslational Processing Of Gastrointestinal Peptides
C. Gariepy, C. J. Dickinson
Published 2006 · Chemistry
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PC8 [corrected], a new member of the convertase family.
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Proteolytic processing of pro-ACTH/endorphin begins in the Golgi complex of pituitary corticotropes and AtT-20 cells.
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Molecular dissection of the secretory pathway
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Growth-promoting effects of glycine-extended progastrin.
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Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: Analysis of biochemical mutants of SRP
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Neither glycine-extended gastrin nor the 1-13 fragment of gastrin 17 influences gastric acid secretion in humans.
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From precursor to final peptides: a statistical sequence-based approach to predicting prohormone processing.
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Defective Prodynorphin Processing in Mice Lacking Prohormone Convertase PC2
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Clathrin-immunoreactive sites in the Golgi apparatus are concentrated at the trans pole in polypeptide hormone-secreting cells.
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A protein-conducting channel in the endoplasmic reticulum
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Mechanism of C-terminal amide formation by pituitary enzymes
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Glycoprotein Hormone Assembly in the Endoplasmic Reticulum
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Yeast KEX1 protease cleaves a prohormone processing intermediate in mammalian cells.
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Gastrin biosynthesis in canine G cells.
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Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum
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Peptide processing and targeting in the neuronal secretory pathway.
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The processing of peptide precursors
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Catalysis of Slow C‐Terminal Processing Reactions by Carboxypeptidase H
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COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum
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Characterization of a peptide alpha-amidation activity in human plasma and tissues.
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The organization of endoplasmic reticulum export complexes
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Mutations in Translation Initiation Factors Lead to Increased Rates of Deadenylation and Decapping of mRNAs inSaccharomyces cerevisiae
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Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases
B. Lamphear (1995)
Tyrosine sulfation and the secretory pathway.
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Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.
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Phospholipid is required for the processing of presecretory proteins by detergent-solubilized canine pancreatic signal peptidase.
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Subcellular fractionation studies on the post-translational processing of pro-adrenocorticotropic hormone/endorphin in rat intermediate pituitary.
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A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase.
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Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network
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Discrimination between temperature- and brefeldin A-sensitive steps in the sulfation, phosphorylation, and cleavage of progastrin and its derivatives.
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Rapid assay and purification of a unique signal peptidase that processes the prolipoprotein from Escherichia coli B.
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Mechanism of the Facilitation of PC2 Maturation by 7B2: Involvement in ProPC2 Transport and Activation but Not Folding
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Diminished prohormone convertase 3 expression (PC1/PC3) inhibits progastrin post-translational processing
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Species variation in the tyrosine sulfation of mammalian gastrins.
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The Yeast SPC22/23 Homolog Spc3p Is Essential for Signal Peptidase Activity*
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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
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An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.
W. Busby (1987)
Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.
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Post-translational processing of progastrin: inhibition of cleavage, phosphorylation and sulphation by brefeldin A.
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SEC11 is required for signal peptide processing and yeast cell growth
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Identification and characterization of glycine-extended post-translational processing intermediates of progastrin in porcine stomach.
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Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
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IV. Wilson's disease and Menkes disease.
M. Schaefer (1999)
Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins
R. B. Freedman (1989)
Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme.
V. Hook (1990)
Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals
J. Rehfeld (2002)
Progastrin processing in primary antral G-cells is mediated by prohormone convertase (PC) 2
V. Stepan (1998)
The β-Subunit of the Protein-conducting Channel of the Endoplasmic Reticulum Functions as the Guanine Nucleotide Exchange Factor for the β-Subunit of the Signal Recognition Particle Receptor*
Jurgen Helmers (2003)
Phosphorylation state of pro-atrial natriuretic factor in rat atrial secretory granules.
G. Wildey (1990)
The Biology and Enzymology of Protein Tyrosine O-Sulfation*
K. Moore (2003)
Processing and proliferative effects of human progastrin in transgenic mice.
T. Wang (1996)
Amino-terminal sequences of prosomatostatin direct intracellular targeting but not processing specificity
K. Sevarino (1989)
Efficient in vitro translocation into Escherichia coli membrane vesicles of a protein carrying an uncleavable signal peptide. Characterization of the translocation process.
K. Yamane (1988)
Molecular analysis of dibasic endoproteolytic cleavage signals.
C. Dickinson (1992)
Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA.
C. A. Beelman (1994)
Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer.
S. Watson (1996)
Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA*
V. Kolupaeva (1998)
Protein hormone storage in secretory granules: mechanisms for concentration and sorting.
P. Dannies (1999)
Dynorphin converting enzyme with unusual specificity from rat brain.
L. Devi (1984)
Protein folding and quality control in the endoplasmic reticulum.
B. Kleizen (2004)
Amino acid sequence and heterogeneity of gastric inhibitory polypeptide (GIP)
H. Jörnvall (1981)
Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.
P. Halban (2003)
Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum.
M. G. Pollard (1998)
Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones.
R. Skidgel (1989)
Purification and characterization of peptidylglycine alpha-amidating monooxygenase from bovine neurointermediate pituitary.
A. Murthy (1986)
Assembly and function of RNA silencing complexes
E. Sontheimer (2005)
The β-Subunit of the Signal Recognition Particle Receptor Is a Novel GTP-binding Protein without Intrinsic GTPase Activity*
K. R. Legate (2003)
The role of the hydroxy amino acid in the triplet sequence Asn-Xaa-Thr(Ser) for the N-glycosylation step during glycoprotein biosynthesis.
E. Bause (1981)
Menkes protein contributes to the function of peptidylglycine α-amidating monooxygenase
Tami C. Steveson (2003)
Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.
D. Rajan (1999)
Signal-mediated sorting of neuropeptides and prohormones: secretory granule biogenesis revisited.
M. Glombik (2000)
Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review)
J. Holthuis (2003)
Evolutionary conserved close linkage of the c‐fes/fps proto‐oncogene and genetic sequences encoding a receptor‐like protein.
A. Roebroek (1986)
The methionine‐rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.
D. Zopf (1990)
A microRNA in a Multiple-Turnover RNAi Enzyme Complex
G. Hutvágner (2002)
The methionine‐rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences.
H. Lütcke (1992)
Precursors for peptide hormones share common secondary structures forming features at the proteolytic processing sites
M. Rholam (1986)
CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses
L. Wu (1998)
ProSAAS and prohormone convertase 1 are broadly expressed during mouse development.
Y. Feng (2002)
MicroRNA Pathways in Flies and Worms Growth, Death, Fat, Stress, and Timing
V. Ambros (2003)
Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.
A. Nakamura (2004)
Biological activity of progastrin posttranslational processing intermediates.
M. Matsumoto (1987)
Pathways for protein disulphide bond formation.
A. Frand (2000)
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.
Z. Mourelatos (2002)
Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins.
Y. Ouyang (1998)
Severe Defect in Proglucagon Processing in Islet A-cells of Prohormone Convertase 2 Null Mice*
M. Furuta (2001)
Lipid Raft Association of Carboxypeptidase E Is Necessary for Its Function as a Regulated Secretory Pathway Sorting Receptor*
S. Dhanvantari (2000)
Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export.
Krysten J. Palmer (2004)
Development of gastrin synthesis and posttranslational processing mechanisms in rats.
L. Marino (1988)
Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites.
N. Cole (1996)
Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.
L. Bishop (1998)
Protein translocation across membranes.
K. Verner (1988)
Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer.
J. Smith (1988)
Peptide-binding specificity of the molecular chaperone BiP
G. Flynn (1991)
Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.
D. Constam (2000)
Activation of the furin endoprotease is a multiple‐step process: requirements for acidification and internal propeptide cleavage
E. D. Anderson (1997)
A structural step into the SRP cycle
K. Wild (2004)
Characterization of peptide alpha-amidation activity in human cerebrospinal fluid and central nervous system tissue.
G. Wand (1985)
Structural characterization of the rat carboxypeptidase-E gene.
Y. K. Jung (1991)
Specific Interaction of Eukaryotic Translation Initiation Factor 3 with the 5′ Nontranslated Regions of Hepatitis C Virus and Classical Swine Fever Virus RNAs
D. V. Sizova (1998)
Stimulation of growth of a colon cancer cell line by gastrin.
C. Kusyk (1986)
Reflex Splanchnic Nerve Stimulation Increases Levels of Carboxypeptidase E mRNA and Enzymatic Activity in the Rat Adrenal Medulla
Lloyd D. Flicker (1990)
Signal peptides open protein-conducting channels in E. coli
S. Simon (1992)
A motif found in propeptides and prohormones that may target them to secretory vesicles.
J. S. Kizer (1991)
Gastrin and Glycine-extended Progastrin Processing Intermediates Induce Different Programs of Early Gene Activation (*)
A. Todisco (1995)
(Glu62, Ala30, Tyr8)n serves as high-affinity substrate for tyrosylprotein sulfotransferase: a Golgi enzyme.
R. Lee (1985)
Effects of propeptide deletion on human renin secretion from mouse pituitary AtT‐20 cells
M. Nagahama (1990)
Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism
I. E. Clark (2000)
Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes.
V. Lingappa (1984)
Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene.
D. Drucker (1986)
Measurement of delta pH and membrane potential in secretory vesicles isolated from bovine pituitary intermediate lobe.
Y. P. Loh (1984)
Expression of porcine cholecystokinin cDNA in a murine neuroendocrine cell line. Proteolytic processing, sulfation, and regulated secretion of cholecystokinin peptides.
W. Lapps (1988)
Molecular Cloning and Expression of Human and Mouse Tyrosylprotein Sulfotransferase-2 and a Tyrosylprotein Sulfotransferase Homologue in Caenorhabditis elegans *
Y. Ouyang (1998)
Biosynthesis of gastrin. Localization of the precursor and peptide products using electron microscopic-immunogold methods.
J. Rahier (1987)
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
E. Manser (1990)
Novel Gastrin Receptors Mediate Mitogenic Effects of Gastrin and Processing Intermediates of Gastrin on Swiss 3T3 Fibroblasts
P. Singh (1995)
Secretory protein translocation across membranes—the role of the ‘docking protein’
D. I. Meyer (1982)
A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus
A. Nakano (1989)
Partial purification of microsomal signal peptidase from hen oviduct
Robert K. Baker (1986)
Isolation and characterization of the intact gastrin precursor from a gastrinoma
H. Desmond (1987)
In Vitro Copper Stimulation of Plasma Peptidylglycineα-Amidating Monooxygenase in Menkes Disease Variant with Occipital Horns
J. Prohaska (1997)
Direct identification of prohormone conversion site in insulin-secreting cells
L. Orci (1985)
The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins
L. Orci (1987)
Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and α-factor precursor processing
A. Dmochowska (1987)
Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants
R. Gilmore (1985)
Activation and membrane binding of carboxypeptidase E
L. Fricker (1988)
Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2
P. Eck (2004)
Sequence of the leader peptidase gene of Escherichia coli and the orientation of leader peptidase in the bacterial envelope.
P. Wolfe (1983)
The isolation and chemical characterization of phosphorylated enkephalin-containing peptides from bovine adrenal medulla.
A. Watkinson (1989)
Stimulation of DNA synthesis by big and little gastrin (G-34 and G-17).
L. Johnson (1976)
Signal peptide fragments of preprolactin and HIV‐1 p‐gp160 interact with calmodulin
B. Martoglio (1997)
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide
T. Connolly (1989)
Iron regulatory protein prevents binding of the 43S translation pre‐initiation complex to ferritin and eALAS mRNAs.
N. K. Gray (1994)
Assembly of influenza hemagglutinin trimers and its role in intracellular transport
C. S. Copeland (1986)
Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin-releasing factor.
C. Rodríguez (1989)
Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA "footprinting".
V. Siegel (1988)
Immunocytochemical Localization of the Menkes Copper Transport Protein (ATP7A) to the Trans-Golgi Network
H. Dierick (1997)
Formation of an intrachain disulfide bond on nascent immunoglobulin light chains.
L. W. Bergman (1979)
Role and regulation of the ER chaperone BiP.
M. J. Gething (1999)
Targeting of proteins into the eukaryotic secretory pathway: Signal peptide structure/function relationships
S. Nothwehr (1990)
Messenger-RNA-binding proteins and the messages they carry
G. Dreyfuss (2002)
Intramembrane proteolysis and post-targeting functions of signal peptides.
B. Martoglio (2003)
Involvement of GTP-binding “G” proteins in transport through the Golgi stack
P. Melançon (1987)
Stepwise cleavage of the pro part of promelittin by dipeptidylpeptidase IV. Evidence for a new type of precursor--product conversion.
G. Kreil (1980)
The role of ascorbate in the biosynthesis of neuroendocrine peptides.
B. Eipper (1991)
Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.
D. Andres (1990)
A subunit of mammalian signal peptidase is homologous to yeast SEC11 protein.
G. Greenburg (1989)
Residues flanking the COOH-terminal C-region of a model eukaryotic signal peptide influence the site of its cleavage by signal peptidase and the extent of coupling of its co-translational translocation and proteolytic processing in vitro.
S. Nothwehr (1990)
Interchain disulfide bond formation in types I and II procollagen. Evidence for a protein disulfide isomerase catalyzing bond formation.
J. Koivu (1987)
Acetylation of alpha-melanotropin and beta-endorphin in the rat intermediate pituitary. Subcellular localization.
C. Glembotski (1982)
Studies on the reduction and re-formation of protein disulfide bonds.
C. Anfinsen (1961)
Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation.
D. Stoffers (1991)
Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit.
K. R. Legate (2000)
Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin.
K. Iwase (1997)
Sorting Ourselves Out: Seeking Consensus on Trafficking in the Beta‐Cell
P. Arvan (2004)
SRP meets the ribosome
K. Wild (2004)
Identification of Drosophila MicroRNA Targets
A. Stark (2003)
Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase.
I. Song (1994)
Trafficking of Mutant Carboxypeptidase E to Secretory Granules in a β-Cell Line Derived from Cpefat/Cpefat Mice
N. Cawley (2003)
Cholesterol is Required for the Formation of Regulated and Constitutive Secretory Vesicles from the trans‐Golgi Network
Yanzhuang Wang (2000)
beta-Endorphin and related peptides in pituitary, brain, pancreas and antrum.
D. Smyth (1983)
Involvement of the membrane lipid bilayer in sorting prohormone convertase 2 into the regulated secretory pathway.
M. Blázquez (2000)
Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein.
C. Chang (1978)
Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase.
S. Prigge (1997)
Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site
J. Hwang (2001)
Proteolysis in neuropeptide processing and other neural functions.
Y. P. Loh (1984)
Peptide binding and release by proteins implicated as catalysts of protein assembly.
G. Flynn (1989)
Molecular cloning and nucleotide sequence of full-length of cDNA coding for porcine gastrin.
O. Yoo (1982)
Purification and properties of human serum dopamine-β -hydroxylase
T. Ikeno (2004)
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
Mario Halic (2004)
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor
T. Connolly (1991)
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.
S. Molloy (1992)
Characterization of the peptide acetyltransferase activity in bovine and rat intermediate pituitaries responsible for the acetylation of beta-endorphin and alpha-melanotropin.
C. Glembotski (1982)
Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase
D. Julius (1983)
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.
R. Carroll (1988)
Investigation of a possible role of the amino-terminal pro-region of proopiomelanocortin in its processing and targeting to secretory granules
P. Roy (1991)
Circularization of mRNA by eukaryotic translation initiation factors.
S. Wells (1998)
Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue
R. Gregory (1969)
Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation.
L. Scopsi (1995)
Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice.
L. Friis-Hansen (2001)
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
N. Brakch (1995)
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle
R. Gilmore (1982)
 Derivatives of glutamine in peptides☆
B. Blombäck (1967)
Peptidyl-Gly cine α-Amidation Activity in Tissues and Serum of the Adult Rat*
B. Eipper (1985)
Processing of human prosomatostatin in AtT-20 cells: S-28 and S-14 are generated in different secretory pathways.
N. Brakch (1994)
Clathrin, cages, and coated vesicles
S. Harrison (1983)
Purified yeast aspartic protease 3 cleaves anglerfish pro‐somatostatin I and II at di‐ and monobasic sites to generate somatostatin‐14 and ‐28
N. Cawley (1993)
Enzymatic sulfation of gastrin in rat gastric mucosa.
L. J. Chen (1990)
The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane
J. D. Miller (1995)
Binary specification of nonsense codons by splicing and cytoplasmic translation
R. Thermann (1998)
The action of gastrin and cholecystokinin-related peptides on pancreatic secretion in the rat.
Dockray Gj (1973)
Genetic Complementation in Yeast Reveals Functional Similarities between the Catalytic Subunits of Mammalian Signal Peptidase Complex*
H. Liang (2003)
A C-terminal signal prevents secretion of luminal ER proteins
S. Munro (1987)
Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi.
S. Pfeffer (1987)
Translational repression by a complex between the iron‐responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position‐dependent in vivo.
B. Goossen (1990)
A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein β-adaptin
T. Serafini (1991)
The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells
E. Snapp (2004)
70K heat shock related proteins stimulate protein translocation into microsomes
W. Chirico (1988)
Carboxypeptidase E is a sorting receptor for prohormones: Binding and kinetic studies
D. Cool (1998)
Initiation of Protein Synthesis from the A Site of the Ribosome
J. E. Wilson (2000)
Transfer to proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components
G. Blobel (1975)
Protein secretion: Puzzling receptors
C. Thiele (1997)
KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene
M. Rose (1989)
Brefeldin A: insights into the control of membrane traffic and organelle structure
R. Klausner (1992)
Evidence that luminal ER proteins are sorted from secreted proteins in a post‐ER compartment.
H. Pelham (1988)
Translocons, thermodynamics, and the folding of membrane proteins
S. White (2003)
Enkephalin convertase: a specific enkephalin synthesizing carboxypeptidase in adrenal chromaffin granules, brain, and pituitary gland.
L. Fricker (1982)
Impaired Prohormone Convertases inCpe fat/Cpe fat Mice*
Y. Berman (2001)
Reevaluation of the determinants of tyrosine sulfation
H. B. Nicholas (2007)
Impaired fertility in mice deficient for the testicular germ-cell protease PC4.
M. Mbikay (1997)
Splicing and 3′ end formation in the definition of nonsense‐mediated decay‐competent human β‐globin mRNPs
G. Neu-Yilik (2001)
Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo.
S. López de Quinto (2000)
COP and clathrin-coated vesicle budding: different pathways, common approaches.
H. McMahon (2004)
Small GTP-binding proteins in vesicular transport.
W. Balch (1990)
Cholecystokinin-associated COOH-terminal peptides are fully sulfated in pig brain.
J. Eng (1986)
A Posttermination Ribosomal Complex Is the Guanine Nucleotide Exchange Factor for Peptide Release Factor RF3
A. Zavialov (2001)
Chemical determination of polypeptide hormones.
K. Tatemoto (1978)
Topogenesis of membrane proteins at the endoplasmic reticulum.
Marie Higy (2004)
Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells.
P. Singh (1996)
Characterization of the carboxyl-terminal sequences responsible for protein retention in the endoplasmic reticulum.
D. Andres (1991)
Structural properties of homogeneous protein disulphide-isomerase from bovine liver purified by a rapid high-yielding procedure.
N. Lambert (1983)
An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N‐terminal arginine from β‐lipotropin60–65
H. Gainer (1984)
Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication.
E. Boel (1983)
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
I. De Bie (1996)
Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study
J. R. Peinado (2003)
Structural insights into the signal recognition particle.
J. Doudna (2004)
LIVER DISEASE IN ANTI-HBe POSITIVE CHRONIC HBsAg CARRIERS AND HEPATITIS C VIRUS
G. Fattovich (1989)
Glycine-Extended Gastrin Exerts Growth-Promoting Effects on Human Colon Cancer Cells
V. Stepan (1999)
Topology of signal recognition particle receptor in endoplasmic reticulum membrane
L. Lauffer (1985)
Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis
M. Waters (1986)
The signal recognition particle receptor is a complex that contains two distinct polypeptide chains
S. Tajima (1986)
SRP-mediated protein targeting: structure and function revisited.
J. Luirink (2004)
A signal sequence is sufficient for green fluorescent protein to be routed to regulated secretory granules.
R. El Meskini (2001)
Primary structure and functional expression of a glutaminyl cyclase.
T. Pohl (1991)
The effect of gastrin on growth of human stomach cancer cells.
J. Ishizuka (1992)
Four basic characteristics of the gastrin-cholecystokinin system.
J. Rehfeld (1981)
Impaired α‐carboxyamidation of gastrin in vitamin C‐deficient guinea pigs
L. Hilsted (1986)
Isolation of a cDNA clone encoding pancreatic polypeptide.
T. Takeuchi (1985)
Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme.
S. Strittmatter (1986)
Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice.
D Chen (2000)
Isolation and characterization of corticotropin- and melanotropin-related peptides from the neurointermediary lobe of the rat pituitary by reversed-phase liquid chromatography.
C. A. Browne (1981)
Processing of the gastrin precursor. Modulation of phosphorylated, sulfated, and amidated products.
A. Varró (1990)
cDNA-derived primary structure of the glycoprotein component of canine microsomal signal peptidase complex.
G. Shelness (1988)
Proatrial natriuretic factor is phosphorylated by rat cardiocytes in culture.
K. Bloch (1987)
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
Y. Zeng (2003)
Trophic effects of pentagastrin on gastrointestinal tract in fed and fasted rats.
T. Solomon (1986)
Is adrenal proenkephalin glcosylated
D. L. Kilpatrick (1983)
Misplacement of the amino-terminal positive charge in the prepro-alpha-factor signal peptide disrupts membrane translocation in vivo.
R. Green (1989)
Glycosylation and posttranslational processing of thyroid-stimulating hormone: clinical implications.
B. Weintraub (1985)
Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization
M. Maccumber (1990)
A human homologue of the yeast HDEL receptor
M. Lewis (1990)
Molecular structure of the Menkes disease gene (ATP7A).
H. Dierick (1995)
 Rat pituitary Nα-acetyltransferase
J. Dixon (1984)
Sequence of the cDNA encoding rat furin, a possible propeptide-processing endoprotease.
Y. Misumi (1990)
Cisternal maturation and vesicle transport: join the band wagon! (Review)
M. Elsner (2003)
In Addition to SEC11, a Newly Identified Gene,SPC3, Is Essential for Signal Peptidase Activity in the Yeast Endoplasmic Reticulum*
H. Fang (1997)
ER-to-Golgi transport: COP I and COP II function (Review)
R. Duden (2003)
Consensus sequence for processing of peptide precursors at monobasic sites
L. Devi (1991)
Machine learning approaches for the prediction of signal peptides and other protein sorting signals.
H. Nielsen (1999)
Large aqueous channels in membrane vesicles derived from the rough endoplasmic reticulum of canine pancreas or the plasma membrane of Escherichia coli.
S. Simon (1989)
Purification and characterization of a peptidyl glycine monooxygenase from porcine pituitary.
J. S. Kizer (1986)
Isolation and characterization of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites.
Y. Bourbonnais (1993)
Multiple targets for brefeldin A
H. Pelham (1991)
Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts.
C. Zhang (2003)
Protein folding and translocation across the endoplasmic reticulum membrane (Review)
E. Swanton (2003)
Protein translocation across the endoplasmic reticulum
P. Walter (1984)
Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA.
F. Gebauer (2003)
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
M. Furuta (1997)
Effects of mutations at glycine residues in the hydrophobic region of the Escherichia coli prolipoprotein signal peptide on the secretion across the membrane.
S. Inouye (1984)
Processing of Wild-type and Mutant Proinsulin-like Growth Factor-IA by Subtilisin-related Proprotein Convertases*
S. J. Duguay (1997)
IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.
M. Muckenthaler (1998)
Comparison of the regulation of carboxypeptidase E and prolactin in GH4C1 cells, a rat pituitary cell line.
L. Fricker (1990)
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast
S. Bednarek (1995)
Substrate specificity of eukaryotic signal peptidase. Site-saturation mutagenesis at position -1 regulates cleavage between multiple sites in human pre (delta pro) apolipoprotein A-II.
R. Folz (1988)
ER-to-Golgi transport visualized in living cells
J. Presley (1997)
Membrane Dynamics at the Endoplasmic Reticulum–Golgi Interface
S. Bannykh (1997)
Purification and cDNA cloning of Xenopus laevis skin peptidylhydroxyglycine N-C lyase, catalyzing the second reaction of C-terminal alpha-amidation.
Y. Iwasaki (1991)
Purification and characterization of hen oviduct microsomal signal peptidase.
Robert K. Baker (1987)
The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation.
H. Gerdes (1989)
Purification and structural characterization of progastrin-derived peptides from a human gastrinoma.
V. Huebner (1991)
Monensin and brefeldin A differentially affect the phosphorylation and sulfation of secretory proteins.
P. Rosa (1992)
Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase
C. Vulpe (1993)
Brefeldin A-induced prosomatostatin N-glycosylation in AtT20 cells.
Philippe Daull (2002)
Models of intracellular transport and evolution of the Golgi complex
G. Beznoussenko (2002)
Living with clathrin: its role in intracellular membrane traffic.
F. Brodsky (1988)
Processing and Sorting of the Prohormone Convertase 2 Propeptide*
L. Muller (2000)
Evidence for the presence of a secondary structure at the dibasic processing site of prohormone: the pro‐ocytocin model.
L. Paolillo (1992)
Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance.
J. Cheng (1994)
Translational control of gene expression and disease.
C. Calkhoven (2002)
Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein
J. Chelly (1993)
Tyrosine O‐sulfation promotes proteolytic processing of progastrin.
J. R. Bundgaard (1995)
A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides.
D. Perlman (1983)
Amino acid sequences of three bombesin-like peptides from canine intestine extracts.
J. Reeve (1983)
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins.
K. Nakayama (1997)
The Role of Dibasic Residues in Prohormone Sorting to the Regulated Secretory Pathway
S. Feliciangeli (2001)
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This paper is referenced by
Post-translational Processing of Gastrointestinal Peptides
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