Chlorogenic Acid Loaded Chitosan Nanoparticles With Sustained Release Property, Retained Antioxidant Activity And Enhanced Bioavailability
Ilaiyaraja Nallamuthu, A. Devi, F. Khanum
Published 2015 · Chemistry
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Abstract In this study, chlorogenic acid (CGA), a phenolic compound widely distributed in fruits and vegetables, was encapsulated into chitosan nanoparticles by ionic gelation method. The particles exhibited the size and zeta potential of 210 nm and 33 mV respectively. A regular, spherical shaped distribution of nanoparticles was observed through scanning electron microscopy (SEM) and the success of entrapment was confirmed by FTIR analysis. The encapsulation efficiency of CGA was at about 59% with the loading efficiency of 5.2%. In vitro ABTS assay indicated that the radical scavenging activity of CAG was retained in the nanostructure and further, the release kinetics study revealed the burst release of 69% CGA from nanoparticles at the end of 100th hours. Pharmacokinetic analysis in rats showed a lower level of C max , longer T max , longer MRT, larger AUC 0–t and AUC 0–∞ for the CGA nanoparticles compared to free CGA. Collectively, these results suggest that the synthesised nanoparticle with sustained release property can therefore ease the fortification of food-matrices targeted for health benefits through effective delivery of CGA in body.
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