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Short-term Electrical Stimulation Alters Tongue Muscle Fibre Type Composition.

E. Pae, Jon-Philippe K. Hyatt, Jennifer Wu, Patricia Chien
Published 2007 · Medicine, Biology

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OBJECTIVE To examine whether short-term exogenous activation of a tongue muscle induced a phenotypic shift from a fast to a slow fibre-type, and thus assess a potential therapeutic avenue to protect against obstructive sleep apnoea (OSA). METHODS New Zealand White rabbit genioglossus (GG) muscle, characteristically a fast muscle, was continuously stimulated at a frequency attributed to slow muscle (10Hz, 3V DC pulses) using an implanted micro-circuit for 7 days. Changes in muscle fibre types and aerobic capacity were assessed between stimulated and un-stimulated (control) groups using immunohistochemistry and electrophoresis for myosin heavy chain (MHC) and assayed for citrate synthase. RESULTS Compared to the un-stimulated control group, stimulated GG muscles had more (approximately 13%) type I MHC (slow-twitch) content; a proportional decrease in type II MHC (fast-twitch) isoform also occurred in the stimulated GG muscle (P<0.05). Electrophoresis analysis on whole muscle and single fibre MHC showed an increased type I expression in the stimulated GG muscle (P<0.01). A commensurate rise in citrate synthase activity, indicating a change in aerobic capacity, was also observed in the stimulated GG muscles. CONCLUSION Together, these results demonstrate a successful alteration in tongue muscle characteristics using exogenous electrical stimulation and perhaps a potential therapeutic application for OSA.
This paper references
10.1016/j.resp.2003.12.001
Tongue mechanical characteristics and genioglossus muscle EMG in obstructive sleep apnoea patients
M. Blumen (2004)
10.1111/J.1525-1594.2005.29034.X
Functional electrical stimulation of denervated muscles: basic issues.
S. Salmons (2005)
10.1113/jphysiol.2005.083659
The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls
R. Fogel (2005)
10.1152/JAPPL.1997.82.4.1319
Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects.
S. Isono (1997)
10.1152/JAPPL.2001.90.5.1909
Induction of a fatigue-resistant phenotype in rabbit fast muscle by small daily amounts of stimulation.
A. López-Guajardo (2001)
10.1002/mus.10271
Plasticity of skeletal muscle phenotype: Mechanical consequences
V. Caiozzo (2002)
10.1111/j.1460-9568.2005.04466.x
Fibre‐type composition of rabbit jaw muscles is related to their daily activity
T. Wessel (2005)
10.1002/PPUL.1950150406
Postnatal expression of myosin lsoforms in the genioglossus and diaphragm muscles.
B. Brozanski (1993)
10.1093/SLEEP/27.2.254
Tongue-muscle training by intraoral electrical neurostimulation in patients with obstructive sleep apnea.
W. Randerath (2004)
10.1152/JAPPL.1993.75.5.2337
Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms.
R. Talmadge (1993)
10.1164/RCCM.2109080
Epidemiology of obstructive sleep apnea: a population health perspective.
T. Young (2002)
10.1007/BF00123364
Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch
S. Yang (2004)
10.1111/J.1432-1033.1997.00030.X
Quantitative analyses of myosin heavy-chain mRNA and protein isoforms in single fibers reveal a pronounced fiber heterogeneity in normal rabbit muscles.
H. Peuker (1997)
10.1164/AJRCCM.159.6.9809052
Patients with obstructive sleep apnea exhibit genioglossus dysfunction that is normalized after treatment with continuous positive airway pressure.
M. Carrera (1999)
10.1007/s004290050268
Origin and development of the avian tongue muscles
R. Huang (1999)
10.1002/(SICI)1097-4598(199812)21:12<1632::AID-MUS3>3.0.CO;2-W
The dose‐related response of rabbit fast muscle to long‐term low‐frequency stimulation
H. Sutherland (1998)
10.1164/AJRCCM/148.1.179
Strength and endurance characteristics of the normal human genioglossus.
A. Scardella (1993)
10.1152/JAPPLPHYSIOL.00394.2005
Effects of inactivity on fiber size and myonuclear number in rat soleus muscle.
H. Zhong (2005)
10.1023/A:1005482132240
Transient expression of myosin heavy chain MHCIα in rabbit muscle during fast-to-slow transition
H. Peuker (2004)
10.1002/mus.10021
Training by low‐frequency stimulation of tibialis anterior in spinal cord–injured men
Stephen D.R. Harridge (2002)
10.1007/s00441-005-0019-x
Embryonic and postnatal development of masticatory and tongue muscles
A. Yamane (2005)
10.1016/j.neulet.2004.10.091
Intermittent hypoxia damages cerebellar cortex and deep nuclei
E. Pae (2005)
10.1164/RCCM.2104120
Adaptation of upper airway muscles to chronic endurance exercise.
H. Vincent (2002)
10.1152/JAPPL.1978.44.6.931
Pathogenesis of upper airway occlusion during sleep
Remmers Je (1978)
10.1007/BF00124241
Differences in capillary supply between human oro-facial, masticatory and limb muscles
P. Stål (2004)
10.1016/J.ARCHORALBIO.2005.10.006
Myosin heavy chain and fibre diameter of extrinsic tongue muscles in rhesus monkey.
J. C. Smith (2006)
10.1172/JCI115751
Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism).
W. Mezzanotte (1992)
10.1016/0301-0082(80)90008-8
The neural regulation of tongue movements
A. Lowe (1980)
10.1378/CHEST.107.1.67
The effect of electrical stimulation on obstructive sleep apnea syndrome.
C. Guilleminault (1995)
10.1023/A:1010353515004
Dynamics of Stimulation-induced Muscle Adaptation: insights from varying the duty cycle
A. López-Guajardo (2004)
10.1016/S0014-5793(96)01325-7
Slow‐to‐fast transitions in myosin expression of rat soleus muscle by phasic high‐frequency stimulation
N. Hämäläinen (1996)
10.1164/AJRCCM.153.6.8665048
Characteristics of the genioglossus and musculus uvulae in sleep apnea hypopnea syndrome and in snorers.
F. Sériès (1996)
10.1002/(SICI)1097-4598(199801)21:1<63::AID-MUS9>3.0.CO;2-E
Training effects on soleus of cats spinal cord transected (T12–13) as adults
R. Roy (1998)
10.1152/JAPPLPHYSIOL.00978.2004
Geniohyoid muscle properties and myosin heavy chain composition are altered after short-term intermittent hypoxic exposure.
E. Pae (2005)
10.1136/thx.49.5.446
Effects of submental stimulation for several consecutive nights in patients with obstructive sleep apnoea.
W. Hida (1994)
10.1007/s00421-003-0792-8
Functional and biochemical properties of chronically stimulated human skeletal muscle
M. Nuhr (2003)
10.1016/S0889-5406(94)70021-4
A cephalometric and electromyographic study of upper airway structures in the upright and supine positions.
E. Pae (1994)
10.1002/mus.10099
Improved viability of latissimus dorsi muscle grafts after electrical prestimulation
E. B. Woo (2002)
10.1016/J.BBAPAP.2005.08.005
Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation.
P. Donoghue (2005)
10.1016/0014-4886(76)90061-3
The human tongue during sleep: Electromyographic activity of the genioglossus muscle
E. Sauerland (1976)
10.1002/(SICI)1097-4598(200003)23:3<416::AID-MUS14>3.0.CO;2-#
Contractile properties of the tongue's genioglossus muscle and motor units in the rat
T. G. Sutlive (2000)
10.1152/JAPPLPHYSIOL.00095.2001
Effects of hypothyroidism on maximum specific force in rat diaphragm muscle fibers.
P. Geiger (2002)
10.1007/s004180100268
Transitions of muscle fiber phenotypic profiles
D. Pette (2001)
10.1046/j.1469-7580.2003.00139.x
The formation of skeletal muscle: from somite to limb
M. Buckingham (2003)
10.1113/jphysiol.2004.073684
‘Fast’ and ‘slow’ muscle fibres in hindlimb muscles of adult rats regenerate from intrinsically different satellite cells
J. Kalhovde (2005)
10.1152/JAPPLPHYSIOL.00203.2003
Upper airway response to electrical stimulation of the genioglossus in obstructive sleep apnea.
A. Oliven (2003)
10.1067/MOD.2001.112667
Changes in orofacial muscle activity in response to changes in respiratory resistance.
H. Song (2001)
10.1016/j.resp.2005.02.016
Phenotype and contractile properties of mammalian tongue muscles innervated by the hypoglossal nerve
J. C. Smith (2005)
10.1164/RCCM.200201-050OC
Brain morphology associated with obstructive sleep apnea.
P. Macey (2002)



This paper is referenced by
10.1517/14728220903005608
Potential therapeutic targets in obstructive sleep apnoea
J. P. Saboisky (2009)
Snoozeal®-Non-Invasive Intraoral Neuromuscular Stimulation Device with Clinically Proven Reduction of Primary Snoring and Mild Obstructive Sleep Apnoea 1 Snoozeal®-Non-Invasive Intraoral Neuromuscular Stimulation Device with Clinically Proven Reduction of Primary Snoring and Mild Obstructive Sleep A
(2020)
NEURAL DRIVE TO HUMAN RESPIRATORY MUSCLES
J. P. Saboisky (2008)
Effects of Age and Exercise on Neuromuscular Junction Plasticity in Muscles of Swallowing and Voice
Aaron M. Johnson (2012)
10.1111/j.1469-7580.2010.01235.x
Adaptation of rat jaw muscle fibers in postnatal development with a different food consistency: an immunohistochemical and electromyographic study
N. Kawai (2010)
10.1002/MUS.25656
Effect of timing of electromyostimulation on denervated skeletal muscle atrophy
E. Koh (2017)
10.1109/BMEI.2010.5639265
The researches of wavelet transform for the sleep apnea syndrome through snoring analysis
Y. Zhang (2010)
10.1002/mus.21819
Effects of electrical stimulation on neuromuscular junction morphology in the aging rat tongue
A. Johnson (2011)
10.1007/s11325-020-02125-x
The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats
R. Cao (2020)
10.1016/J.OTOT.2015.03.011
Physiology of hypoglossal nerve stimulation
M. Gerek (2015)
10.1002/mus.26173
Effect of neuromuscular electrical stimulation frequency on muscles of the tongue
Heidi Kletzien (2018)
10.1016/j.mehy.2009.04.051
Myosin heavy chain proteins are responsible for the development of obstructive sleep apnea syndrome.
Jiří Šedý (2009)
10.1002/mus.23499
Tongue muscle plasticity following hypoglossal nerve stimulation in aged rats
N. Connor (2013)
10.4041/kjod.2012.42.2.64
Response of masticatory muscles to passive stretch stimulus - from perspectives of functional appliances
E. Pae (2012)
10.1002/mus.25656
The effects of electromyostimulation application timing on denervated skeletal muscle atrophy
E. Koh (2017)
10.1111/j.1525-1403.2012.00514.x
Tongue Anatomy and Physiology, the Scientific Basis for a Novel Targeted Neurostimulation System Designed for the Treatment of Obstructive Sleep Apnea
F. Zaidi (2013)
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