Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Phylogenomics Of Caspase-activated DNA Fragmentation Factor.

L. Eckhart, H. Fischer, E. Tschachler
Published 2007 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The degradation of nuclear DNA by DNA fragmentation factor (DFF) is a key step in apoptosis of mammalian cells. Using comparative genomics, we have here determined the evolutionary history of the genes encoding the two DFF subunits, DFFA (also known as ICAD) and DFFB (CAD). Orthologs of DFFA and DFFB were identified in Nematostella vectensis, a representative of the primitive metazoan clade cnidarians, and in various vertebrates and insects, but not in representatives of urochordates, echinoderms, and nematodes. The domains mediating the interaction of DFFA and DFFB, a caspase cleavage site in DFFA, and the amino acid residues critical for endonuclease activity of DFFB were conserved in Nematostella. These findings suggest that DFF has been a part of the primordial apoptosis system of the eumetazoan common ancestor and that the ancient cell death machinery has degenerated in several evolutionary lineages, including the one leading to the prototypical apoptosis model, Caenorhabditis elegans.
This paper references
10.1074/JBC.275.17.12978
A Novel Activation Mechanism of Caspase-activated DNase fromDrosophila melanogaster*
H. Yokoyama (2000)
10.1016/J.YDBIO.2006.08.053
The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus.
A. Robertson (2006)
10.1073/PNAS.0503660102
Origin of the Eumetazoa: testing ecological predictions of molecular clocks against the Proterozoic fossil record.
K. Peterson (2005)
10.1093/nar/gkj020
StellaBase: The Nematostella vectensis Genomics Database
J. C. Sullivan (2006)
10.1074/JBC.M110071200
Co-translational Folding of Caspase-activated DNase with Hsp70, Hsp40, and Inhibitor of Caspase-activated DNase*
H. Sakahira (2002)
10.1074/jbc.274.43.30651
Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation*
Beni B Wolf (1999)
10.1093/nar/gkl776
BeetleBase: the model organism database for Tribolium castaneum
Liangjiang Wang (2007)
10.1101/GR.8.3.163
Phylogenomics: improving functional predictions for uncharacterized genes by evolutionary analysis.
J. Eisen (1998)
10.1093/nar/gkl804
Pristionchus.org: a genome-centric database of the nematode satellite species Pristionchus pacificus
C. Dieterich (2007)
10.1016/S1097-2765(04)00258-8
Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway.
Eui-Jeon Woo (2004)
10.1038/ni881
Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation
K. Kawane (2003)
10.1016/S0022-2836(02)00588-0
Solution structure of the DFF-C domain of DFF45/ICAD. A structural basis for the regulation of apoptotic DNA fragmentation.
K. Fukushima (2002)
10.1038/nrm1715
Trashing the genome: the role of nucleases during apoptosis
K. Samejima (2005)
10.1023/B:BIRE.0000019187.19019.E6
NOBEL LECTURE: Worms, Life and Death
H. Horvitz (2003)
10.1126/SCIENCE.291.5507.1279
Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons.
L. Aravind (2001)
10.1093/nar/gki442
InterProScan: protein domains identifier
Emmanuel Quevillon (2005)
10.1038/34112
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
M. Enari (1998)
10.1093/MOLBEV/MSI111
Multigene analyses of bilaterian animals corroborate the monophyly of Ecdysozoa, Lophotrochozoa, and Protostomia.
H. Philippe (2005)
10.1038/4341076a
Evolutionary biology: Animal roots and shoots
M. Jones (2005)
10.1038/34214
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
H. Sakahira (1998)
10.1073/PNAS.95.11.5857
SMART, a simple modular architecture research tool: identification of signaling domains.
J. Schultz (1998)
10.1074/JBC.M909611199
Identification and Developmental Expression of Inhibitor of Caspase-activated DNase (ICAD) in Drosophila melanogaster*
Naomi Mukae (2000)
10.1073/PNAS.95.16.9123
Molecular cloning and characterization of human caspase-activated DNase.
Naomi Mukae (1998)
10.1073/PNAS.95.21.12480
Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45.
J. Zhang (1998)



This paper is referenced by
10.1093/carcin/bgp319
Gene expression profile in a glioma cell line resistant to cell death induced by the chimeric tumor suppressor-1 (CTS-1), a dominant-positive variant of p53--the role of NFkappaB.
Janina Seznec (2010)
10.1007/s00018-008-8472-9
Roles of the Major Apoptotic Nuclease-DNA Fragmentation Factor-in Biology and Disease
P. Widłak (2008)
10.1186/1471-2148-8-159
Molecular evolution of Cide family proteins: Novel domain formation in early vertebrates and the subsequent divergence
C. Wu (2007)
10.1016/j.fsi.2014.03.006
Cloning and characterization of an apoptosis-related DNA fragmentation factor (DFF) from oyster, Crassostrea hongkongensis.
Zhiming Xiang (2014)
10.1007/s10495-008-0281-y
Fish as model systems for the study of vertebrate apoptosis
G. Krumschnabel (2008)
10.2741/4065
Mechanisms and emerging functions of DNA degradation in the epidermis.
L. Eckhart (2012)
10.1111/j.1365-2583.2011.01131.x
Expression analyses of caspase‐1 and related activities in the midgut of Galleria mellonella during metamorphosis
D. B. Khoa (2012)
10.5897/AJB11.1382
Expression and functional analysis of apoptosis-related gene BmICAD in silkworm, Bombyx mori
W. Yu (2011)
10.1016/j.ejmech.2013.06.038
Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N((i)Pr)CH2CH2OH] for R = Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways.
Nazzatush Shimar Jamaludin (2013)
10.1038/cdd.2008.65
Living with death: the evolution of the mitochondrial pathway of apoptosis in animals
A. Oberst (2008)
Functional analysis of ICAD-S protein and the development of a novel technology for site-specific protein cleavage in vertebrate cells.
A. Ageichik (2007)
10.1016/j.zool.2010.09.004
Evidence for an instructive role of apoptosis during the metamorphosis of Hydractinia echinata (Hydrozoa).
K. Wittig (2011)
10.1371/journal.pone.0061502
Genes of the Mitochondrial Apoptotic Pathway in Mytilus galloprovincialis
Noelia Estévez-Calvar (2013)
10.2307/25470666
Genomic Survey of Candidate Stress-Response Genes in the Estuarine Anemone Nematostella vectensis
A. Reitzel (2008)
10.1371/journal.pone.0170510
The Complete Genome Sequence of a Second Distinct Betabaculovirus from the True Armyworm, Mythimna unipuncta
R. Harrison (2017)
Semantic Scholar Logo Some data provided by SemanticScholar