← Back to Search
Synthesis, Characterization And MRI Application Of Dextran-coated Fe3O4 Magnetic Nanoparticles
R. Hong, R. Hong, B. Feng, L. Chen, G. H. Liu, Hailong Li, Y. Zheng, D. G. Wei
Published 2008 · Chemistry
Save to my Library
Download PDFAnalyze on Scholarcy
Biocompatible ferrofluid based on dextran-coated Fe3O4 magnetic nanoparticles (MNPs) was prepared through a one-step method. In contrast to the conventional co-precipitation method, hydrazine hydrate was added as reducing agent and precipitator in the present investigation. The effects of hydrazine hydrate, the weight ratio of dextran to MNPs and the molecular weight of dextran on the dispersibility of MNPs in water were investigated. Also, the particles size of modified MNP and coating efficiency of dextran on MNPs were measured. In addition, biocompatible ferrofluid was intravenously injected into rabbits, the iron content in blood and organs at different times were measured by atomic absorption spectrometer, and the bio-distribution and the bio-transportation of ferrofluid in organs was examined. Then, the magnetic resonance (MR) images of liver, marrow and lymph were acquired by MRI experiments before and after intravenous injection of ferrofluid. Image analysis revealed that the MR signal intensity of these organs notably decreased after intensified by ferrofluid. However, when there existed tumors in organs, the signal intensity of tumor did not change after injection. From that the tumor can easily be identified, which indicated a potential application of the as-prepared MNP in functional molecular imaging for biomedical research and clinical diagnosis.
This paper references
Maghemite nanoparticles protectively coated with poly(ethylene imine) and poly(ethylene oxide)-block-poly(glutamic acid).
A. Thünemann (2006)
Biomolecular reactions studied using changes in Brownian rotation dynamics of magnetic particles.
Andrea Prieto Astalan (2004)
Starch-Coated Superparamagnetic Nanoparticles as MR Contrast Agents
D. Kim (2003)
Ferrite particles as an MR contrast agent.
S. Saini (1988)
Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study.
Towards oriented assembly of proteins onto magnetic nanoparticles
Chi-Wei Hung (2008)
Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors.
B. Chertok (2008)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
Clinical results with Resovist: a phase 2 clinical trial.
P. Reimer (1995)
One‐Pot Reaction to Synthesize Biocompatible Magnetite Nanoparticles
Zhen Li (2005)
Magnetic resonance imaging of focal liver lesions. Comparison of the superparamagnetic iron oxide resovist versus gadolinium-DTPA in the same patient.
T. Vogl (1996)
Nantotechniques and approaches in biotechnology.
A. Curtis (2001)
Hyaluronic acid interaction with chitosan-conjugated magnetite particles and its purification
Pei-Fen Yang (2007)
Iron Oxides in the Laboratory: Preparation and Characterization
U. Schwertmann (1991)
Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.
R. Weissleder (1990)
Nanotechnology applications in medicine.
J. Wilkinson (2003)
Magnetic resonance of a dextran-coated magnetic fluid intravenously administered in mice.
L. Lacava (2001)
Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging.
O. Bomatí-Miguel (2005)
Relaxometry of magnetic resonance imaging contrast agents.
Koenig Sh (1987)
Iron oxide-enhanced MR lymphography: initial experience.
M. F. Bellin (2000)
Long-circulating and target-specific nanoparticles: theory to practice.
S. Moghimi (2001)
A Novel Formulation for Superparamagnetic Iron Oxide (SPIO) Particles Enhancing MR Lymphography: Comparison of Physicochemical Properties and The In Vivo Behaviour
K. Lind (2002)
Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors.
P. Hahn (1990)
Immobilization of Pycnoporus sanguineus laccase on magnetic chitosan microspheres
Desheng Jiang (2005)
Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating.
C. Wilhelm (2003)
Biodegradable nanoparticles for drug and gene delivery to cells and tissue.
J. Panyam (2003)
Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.
D. Stark (1988)
Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution.
C. Chouly (1996)
Application of magnetite ferrofluids for hyperthermia
R. Hiergeist (1999)
This paper is referenced by
Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups
Seong Cheol Hong (2011)
The effect of poly(ethylene glycol) coating on colloidal stability of superparamagnetic iron oxide nanoparticles as potential MRI contrast agent.
A. Masoudi (2012)
Rapid surface-biostructure interaction analysis using strong metal-based nanomagnets.
A. Rotzetter (2013)
Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles
G. Iglesias (2018)
Synthesis and Gas-Expanded Liquid (GXL) Processing of Metal and Metal Oxide Nanoparticles: Fundamentals and Application
Pranav S. Vengsarkar (2015)
Positron annihilation spectroscopy in tomorrow's material defect studies
A. N. Singh (2016)
Fabrication of magnetic phase change n-eicosane @ Fe3O4/SiO2 microcapsules on wood surface via sol-gel method
Temeng Qian (2019)
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Xiang-hong Peng (2008)
Biomimetically Synthesized Aqueous Ferrofluids Having Antibacterial and Anticancer Properties
L. Sheikh (2015)
Synthesis and characterization of dextran-coated iron oxide nanoparticles
A. Predescu (2018)
Magnetite nanoparticle coated with amphiphilic bilayer surfactant of polysiloxane and poly(poly(ethylene glycol) methacrylate)
Bandit Thong-On (2012)
The heating effect of iron-cobalt magnetic nanofluids in an alternating magnetic field: application in magnetic hyperthermia treatment
A. Shokuhfar (2013)
Effects of organic polymer addition in magnetite synthesis on the crystalline structure
Yoshimitsu Kuwahara (2014)
COMPARATIVE STUDY FOR THE PREPARATION OF SUPERPARAMAGNETIC-CITRIC COATED MAGNETIC NANOPARTICLE AND FO-DESALINATION APPLICATION
Photochemical preparation of magnetic chitosan beads for immobilization of pullulanase
L. Zhang (2009)
Experimental Design Optimization of Castor Oil, Phthalic Anhydride, and Glycerin Magnetic Nanocomposites Useful as Oil Spill Cleanup Tool
Magnovaldo Carvalho Lopes (2018)
A magnetic polypeptide nanocomposite with pH and near-infrared dual responsiveness for cancer therapy
Jie Zhang (2017)
The effect of stabilizer addition and sonication on nanoparticle agglomeration in a confined impinging jet reactor
S. W. Siddiqui (2009)
Magnetic nanoparticles in biomedicine: synthesis, functionalization and applications.
R. Frimpong (2010)
Dextran and Polymer Polyethylene Glycol (PEG) Coating Reduce Both 5 and 30 nm Iron Oxide Nanoparticle Cytotoxicity in 2D and 3D Cell Culture
M. Yu (2012)
Magnetite-loaded fluorine-containing polymeric micelles for magnetic resonance imaging and drug delivery.
X. Li (2012)
Influence of intrinsic parameters on the particle size of magnetic spinel nanoparticles synthesized by wet chemical methods
H. Shokrollahi (2016)
Espumados magnetizáveis úteis em processos de recuperação ambiental
M. C. Lopes (2010)
Recent research progress on the preparation and application of magnetic nanospheres
Yulei Tai (2011)
Synthesis, Surface Modification and Characterisation of Biocompatible Magnetic Iron Oxide Nanoparticles for Biomedical Applications
Mahnaz Mahdavi (2013)
Synthesis and characterization of Fe3O4 nanoparticles coated with fucan polysaccharides
V. B. Silva (2013)
Long-term investigation on the phase stability, magnetic behavior, toxicity, and MRI characteristics of superparamagnetic Fe/Fe-oxide core/shell nanoparticles.
A. Masoudi (2012)
Interaction between novel porphyrin-dextran nanoparticles and human serum albumin
Z. Zhang (2010)
Halloysite Nanotubes, a Multifunctional Nanovehicle for Anticancer Drug Delivery
Mingyi Guo (2012)
Screening of serine protease inhibitors with antimicrobial activity using iron oxide nanoparticles functionalized with dextran conjugated trypsin and in silico analyses of bacterial serine protease inhibition.
S. Mandal (2014)
Iron oxide nanoparticles for targeted cancer imaging and diagnostics.
Joshua E. Rosen (2012)
Magnetic nanoparticles for biocatalysis and bioseparation
Sara D F Santana (2011)See more