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Validated Potentiometric Method For The Determination Of Sulfacetamide Sodium; Application To Its Pharmaceutical Formulations And Spiked Rabbit Aqueous Humor

N. A. Elragehy, M. Hegazy, G. Abdelhamid, Samia A. Tawfik
Published 2018 · Chemistry

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Abstract Specific, accurate and precise electrochemical method was developed and validated for the determination of sulfacetamide sodium in presence of its co-formulated drug (prednisolone acetate) and its pharmacopoeial impurities. The method was based on fabrication of membrane sensor. The characteristics of electrochemical response were estimated, and the proposed sensor displayed excellent characteristics for the determination of sulfacetamide sodium in bulk powder, laboratory prepared mixtures, dosage forms and in spiked biological fluid (Rabbit aqueous humor). The sensor was constructed through the use of tetradodecylammonium bromide (TDB) as an anion exchanger and 2-nitrophenyl octyl ether (NPOE) as a plasticizer in polyvinyl chloride (PVC) matrix. The performance characteristics, sensitivity and selectivity were evaluated according to IUPAC guidelines. Linearity was achieved over the concentration range of 1 × 10−4.5–1 × 10−2 M with Nernstian slope of 51.086 mV/decade over the pH range of 5–7. The sensor showed a rapid response (10–15 s) and good stability (up to 4 weeks). The obtained results were statistically compared with the official methods and no significant difference was found regarding accuracy and precision.
This paper references
Organic Analysis Using Ion-Selective Electrodes
T. Ma (1982)
Spectrophotometric Determinations of Sulfacetamide Following Simple Diazotization and Coupling with Chromotropic Acid
S. A. Darweesh (2017)
10.1016/S0039-9140(02)00309-0
A sulpha-drug sensitive sensor based on ion-pair complex modified PQC resonator.
Jinbin Yuan (2002)
10.1093/chromsci/bmx064
Validated Chromatographic Methods for the Simultaneous Determination of Sulfacetamide Sodium and Prednisolone Acetate in their Ophthalmic Suspension.
N. A. Elragehy (2017)
Schaum's outline of theory and problems of statistics.
M. R. Spiegel (1961)
10.1016/0039-9140(87)80144-3
Sulpha-drug sensitive membrane electrodes and their analytical applications.
S. Yao (1987)
10.1149/2.0921709JES
Green Ion Selective Electrode Potentiometric Application for the Determination of Cinchocaine Hydrochloride in Presence of Its Degradation Products and Betamethasone Valerate: A Comparative Study of Liquid and Solid Inner Contact Ion-Selective Electrode Membranes
Mamdouh R Rezk (2017)
10.1021/ac60344a763
Instrumentation in analytical chemistry
J. Zýka (1991)
10.4152/PEA.201205335
Comparative Study of Different Plasticized Membrane Electrodes for the Stability-indicative Determination of Torsemide
H. E. Zaazaa (2012)
10.1016/S1570-0232(02)00344-6
Determination of voriconazole in aqueous humor by liquid chromatography-electrospray ionization-mass spectrometry.
L. Zhou (2002)
10.1080/02652030701584058
Optimal conditions for determination of zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feed by micellar electrokinetic capillary chromatography
R. Injac (2008)
Comparative study of di ff erent plasticized membrane electrodes for the stability - indicative determination of tor - semide , Portugal
S. Abbas Zaazaa (2012)
10.1016/s0731-7085(02)00666-0
Determination of prednisolone acetate, sulfacetamide and phenylefrine in local pharmaceutical preparations by micellar electrokinetic chromatography.
J. M. Lemus Gallego (2003)
Carbon nanotube embedded poly 1
S. K. Yadav (2014)
10.1002/CHIN.199811318
Carrier-Based Ion-Selective Electrodes and Bulk Optodes. Part 1. General Characteristics
E. Bakker (1998)
Martindale: The Complete Drug Reference
Sean C. Sweetman (1999)
10.1021/jf2005595
Analysis of sulfonamides in animal feeds by liquid chromatography with fluorescence detection.
S. Borràs (2011)
10.1021/CR940394A
Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics.
E. Bakker (1997)
10.1093/MILMED/151.1.386
Goodman and Gilman's the Pharmacological Basis of Therapeutics
W. Stigelman (1986)
10.4103/jpbs.JPBS_184_16
Validation of a Stability-Indicating Spectrometric Method for the Determination of Sulfacetamide Sodium in Pure Form and Ophthalmic Preparations
S. Ahmed (2017)
10.1016/j.saa.2017.03.061
A sensitive method for the determination of Sulfonamides in seawater samples by Solid Phase Extraction and UV-Visible spectrophotometry.
Sophia Ait Errayess (2017)
10.1002/jssc.201100754
Optimization and validation of a fast ultrahigh-pressure liquid chromatographic method for simultaneous determination of selected sulphonamides in water samples using a fully porous sub-2 μm column at elevated temperature.
H. Shaaban (2012)
10.1080/10426919908907570
Principles of Chemical and Biological Sensors
Reviewed by Gang Deng (1999)
10.1016/j.talanta.2013.09.061
Carbon nanotube embedded poly 1,5-diaminonapthalene modified pyrolytic graphite sensor for the determination of sulfacetamide in pharmaceutical formulations.
S. Yadav (2014)
10.1351/PAC200072101851
Potentiometric Selectivity Coefficients of Ion-Selective Electrodes. Part I. Inorganic Cations (Technical Report)
Y. Umezawa (2000)
10.14233/AJCHEM.2017.20301
Spectrophotometric Determination of Sulfacetamide Sodium in Pharmaceutical Preparation Using 8-Hydroxy-7-iodoquinoline-5-sulfonic Acid as Chromogenic Reagent
Wasan A. Al-Uzri (2017)
10.1016/S0731-7085(02)00666-0
Determination of prednisolone acetate, sulfacetamide and phenylefrine in local pharmaceutical preparations by micellar electrokinetic chromatography.
J. M. Gallego (2003)
10.1134/S1061934811070070
Ion-selective electrodes for the determination of closoborate anions
A. Kopytin (2011)
Goodman & Gilman's The Pharmacological Basis of Therapeutics
M. Leider (1985)



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