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Synthesis And Antimicrobial Activity Of N-alkyl And N-aryl Piperazine Derivatives.

P. Chaudhary, R. Kumar, A. Verma, D. Singh, V. Yadav, A. K. Chhillar, G. Sharma, R. Chandra
Published 2006 · Medicine, Chemistry

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A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652), and antifungal activity against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds 4d and 6a showed very less toxicity against human erythrocytes.
This paper references
10.1023/B:MYCO.0000020594.35357.b0
Fluconazole and itraconazole susceptibility of vaginal yeast isolates from Slovakia
M. Sojakova (2004)
10.1016/0040-4039(95)01345-I
Asymmetric hydrogenation of tetrahydropyrazines: Synthesis of (S)-piperazine-2-tert-butylcarboxamide, an intermediate in the preparation of the HIV protease inhibitor indinavir
K. Rossen (1995)
10.1021/JM00047A001
L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.
B. Dorsey (1994)
10.1021/JO010842W
Syntheses of optically active tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones and hexahydroimidazo[1,2-a]pyridin-2(3H)-ones.
A. Katritzky (2002)
10.1021/JM9509556
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.
S. J. Brickner (1996)
10.1128/AAC.47.1.34-38.2003
Fluconazole Susceptibility of Vaginal Isolates Obtained from Women with Complicated Candida Vaginitis: Clinical Implications
J. Sobel (2003)
10.2307/3758354
Manual of Clinical Microbiology
J. Jorgensen (2003)
10.1016/S0040-4039(00)75787-X
Highly diastereoselective reaction of a chiral, non-racemic amide enolate with (S)-glycidyl tosylate. Synthesis of the orally active HIV-1 protease inhibitor L-735,524
D. Askin (1994)
10.1016/0005-2736(86)90144-6
Interactions of antibiotics of the iturin group with human erythrocytes.
C. Latoud (1986)
10.1016/S1054-3589(08)60129-5
Clinical pharmacology of systemic antifungal agents: a comprehensive review of agents in clinical use, current investigational compounds, and putative targets for antifungal drug development.
A. Groll (1998)
10.1099/JMM.0.45748-0
A fraction from Escherichia coli with anti-Aspergillus properties.
V. Yadav (2005)
10.1073/PNAS.91.9.4096
L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.
J. Vacca (1994)
10.1021/JM00062A028
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
I. Cliffe (1993)
10.1093/JAC/37.SUPPL_A.41
Pharmacokinetic interactions related to the chemical structures of fluoroquinolones.
Y. Mizuki (1996)
10.1001/archinte.1984.00350150042013
Current Clinical Topics in Infectious Diseases
J. Remington (1980)
10.1055/S-2002-33636
Synthesis of N-substituted thiazolidines and dihydrobenzothiazoles
A. R. Katritzky (2002)
10.1021/CR941170V
Properties and Synthetic Utility of N-Substituted Benzotriazoles.
A. Katritzky (1998)
10.3891/ACTA.CHEM.SCAND.51-0896
Acid-base behavior of quinolones in aqueous acetonitrile mixtures.
V. Sanz-Nebot (1997)
10.1093/OXFORDJOURNALS.JAC.A020889
Quinolone generations: natural history or natural selection?
P. Ball (2000)
10.1021/JO010868N
Convenient syntheses of unsymmetrical imidazolidines.
A. Katritzky (2002)
10.1016/S0960-894X(01)81007-6
Synthesis and structure-activity relationships of a novel series of non-peptide AT2-selective angiotensin II receptor antagonists
M. T. Wu (1993)
10.1016/S0378-8741(02)00036-3
Studies on antimycotic properties of Datura metel.
Rajesh (2002)
10.1007/BF02137246
Acid degradation of erythromycin A and erythromycin B
P. Kurath (2005)
10.1021/JM00401A031
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
J. Kane (1988)
10.1039/P19890000225
The chemistry of N-substituted benzotriazoles. Part 14. Novel routes to secondary and tertiary amines and to N, N-disubstituted hydroxylamines
A. R. Katritzky (1989)
10.1016/S0960-894X(02)00322-0
Novel diphenylalkyl piperazine derivatives with dual calcium antagonistic and antioxidative activities.
M. Kimura (2002)
10.1093/INFDIS/168.1.195
Nosocomial acquisition of Candida albicans: an epidemiologic study.
J. Vázquez (1993)
10.1021/JM00153A010
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
J. P. Yevich (1986)
10.1016/S0960-894X(03)00376-7
Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus.
R. Kerns (2003)
10.1021/JM020960R
Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.
A. Ryckebusch (2003)
10.1021/JM00060A017
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.
M. D. Mullican (1993)
10.1002/j.1875-9114.1990.tb02593.x
Prospective Surveillance of Intravenous Amphotericin B Use Patterns
T. Grasela (1990)
10.1021/JM00027A015
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
J. M. Kane (1994)
10.1016/S0960-894X(02)00656-X
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.
H. Zhao (2002)
10.1021/JM00065A002
1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.
D. Boschelli (1993)
10.1016/J.BMC.2004.02.014
Optically active antifungal azoles: synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-aryl-piperazin-1-yl]-ethyl]-tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol.
R. S. Upadhayaya (2004)
10.1016/0040-4039(95)02162-0
FORMATION OF PHENYLPIPERAZINES BY A NOVEL ALUMINA SUPPORTED BIS-ALKYLATION
E. Mishani (1996)
10.1016/0960-894X(95)00461-2
Cycloalkylpiperazines as HIV-1 protease inhibitors: enhanced oral absorption
B. Kim (1995)
10.1179/joc.2000.12.6.463
Amphotericin B-Induced Nephrotoxicity: A Review
V. Fanos (2000)
10.1016/S0924-8579(00)00192-8
The fluoroquinolone antibacterials: past, present and future perspectives.
P. Appelbaum (2000)



This paper is referenced by
10.1002/ardp.202000208
Synthesis and antimicrobial activity of new 2-piperazin-1-yl-N-1,3-thiazol-2-ylacetamides of cyclopenta[c]pyridines and pyrano[3,4-c]pyridines.
S. Sirakanyan (2020)
10.1016/J.TETLET.2007.04.061
Benzotriazole : an excellent ligand for Cu-catalyzed N-arylation of imidazoles with aryl and heteroaryl halides
A. Verma (2007)
10.1002/JCCS.201000022
Synthesis of New Types of N-Arylpiperazine Phosphoramide Analogues of Chrysin
Xiaolan Chen (2010)
10.2174/157018012803307941
Synthesis, Antibacterial and Antifungal Activities of Novel N,N'-bipyrazole Piperazine Derivatives
Smaail Radi (2012)
10.1016/j.compbiolchem.2018.09.007
2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases: In vitro and in silico studies
M. Abbasi (2018)
10.1038/srep29056
Retraction: Novel piperazine core compound induces death in human liver cancer cells: possible pharmacological properties
N. Samie (2016)
10.1016/j.ejmech.2019.01.062
Design, synthesis and anti-bacterial studies of piperazine derivatives against drug resistant bacteria.
Saba Tahir (2019)
10.1007/S10870-008-9490-Z
Structural Conformation of a Novel 1-Benzhydrylpiperazine Derivative: 1-Benzhydryl-4-(toluene-4-sulfonyl)-piperazine
S. Naveen (2009)
10.1007/s00044-012-0063-5
Synthesis and antimicrobial screening of 4-thiazolidinone and 2-azetidinone derivatives of piperazine
S. Shingade (2012)
10.1080/10426507.2015.1085040
Synthesis and Fungicidal Activities of Novel 1,2,4-Triazole Thione Derivatives Containing 1,2,3-Triazole and Substituted Piperazine Moieties
B. Wang (2016)
10.1107/S1600536813028493
4-Methyl-N-(4-nitrobenzylidene)piperazin-1-amine
C. Kavitha (2013)
10.1007/S11094-020-02247-2
Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors
Muhammad Athar Abbasi (2020)
10.1080/15421400701432396
Synthesis and Crystal Structure of 1-Benzenesulfonyl-4-benzhydryl-piperazine
C. S. Ananda Kumar (2007)
10.1007/s10495-018-1439-x
Piperazine clubbed with 2-azetidinone derivatives suppresses proliferation, migration and induces apoptosis in human cervical cancer HeLa cells through oxidative stress mediated intrinsic mitochondrial pathway
Rashmin Khanam (2018)
10.1016/J.CHERD.2019.01.019
Efficient hybrid modeling of CO2 absorption in aqueous solution of piperazine: Applications to energy and environment
Amir Dashti (2019)
10.1021/acs.jmedchem.5b01219
Indole Based Weapons to Fight Antibiotic Resistance: A Structure-Activity Relationship Study.
S. Lepri (2016)
10.1007/s00044-020-02599-0
Synthesis, characterization, acetylcholinesterase inhibition, and molecular docking studies of new piperazine substituted dihydrofuran compounds
Sait Sari (2020)
10.4314/TJPR.V17I7.25
Synthesis of 3-[4-(2-furoyl)-1-piperazinyl]-N- (substituted)propanamides as promising antibacterial agents with mild cytotoxicity
Ghulam Hussain (2018)
10.1016/J.TETLET.2010.04.054
Efficient synthesis of 1,4-disubstituted polyfunctional piperazines via a sequential one-pot Ugi/nucleophilic addition five-component reaction
Morteza Bararjanian (2010)
10.1016/j.saa.2013.10.102
FT-IR, FT-Raman and DFT quantum chemical study on the molecular conformation, vibrational and electronic transitions of 1-(m-(trifluoromethyl)phenyl)piperazine.
N. Prabavathi (2014)
10.3390/ijms13078071
Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives
M. Yarim (2012)
10.3390/molecules21121684
Design, Synthesis, and Biological Evaluation of Novel Benzofuran Derivatives Bearing N-Aryl Piperazine Moiety
Yulu Ma (2016)
10.1039/C4RA12489H
A highly efficient tandem [3 + 2] “click” cycloaddition/6-exo-cyclization strategy for the construction of triazole fused pyrazines
Biswajit Roy (2014)
10.1155/2013/653962
Virtual Screening and Biological Evaluation of Piperazine Derivatives as Human Acetylcholinesterase Inhibitors
Kavitha Raj Varadaraju (2013)
10.1107/S1600536814011726
4-Acetylpiperazinium picrate
C. Kavitha (2014)
10.1039/C6OB01987K
Phospha-Michael addition reaction of maleimides employing N-heterocyclic phosphine-thiourea as a phosphonylation reagent: synthesis of 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonate derivatives.
Nagaraju Molleti (2016)
10.1021/jo302418p
Electrochemical synthesis based on the oxidation of 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nucleophiles.
A. Amani (2012)
10.1016/j.bmcl.2015.07.052
Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors.
Weijie Si (2016)
SYNTHESIS , CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF SOME N-SUBSTITUTED DERIVATIVES OF 6-FLUORO-1-METHYL-4-OXO-7-( PIPERAZIN-1-YL )-4 H-[ 1 , 3 ] THIAZETO [ 3 , 2-A ] QUINOLINE-3-CARBOXYLIC ACID
Debkiron Mukherjee (2014)
10.5897/AJB10.1040
Organic metabolites produced by Vibrio parahaemolyticus strain An3 isolated from Goan mullet inhibit bacterial fish pathogens
A. Pandey (2010)
10.1016/j.saa.2014.01.045
Spectroscopic (FT-IR, FT-Raman), first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-[3-(4-phenylpiperazin-1-yl)propyl]-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione by density functional methods.
R. Renjith (2014)
10.1107/S1600536813028109
Bis{4-[(1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}methane
C. Kavitha (2013)
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