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Polyphenols Based On Isoflavones As Inhibitors Of Helicobacter Pylori Urease.

Zhu-Ping Xiao, D. Shi, Huan-qiu Li, Li-Na Zhang, C. Xu, Hai-Liang Zhu
Published 2007 · Chemistry, Medicine

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Twenty polyphenols were synthesized and evaluated for their effect on Helicobacter pylori urease. Among these compounds, 4-(p-hydroxyphenethyl)pyrogallol (15) (IC(50)=0.03 mM) and 7,8,4'-trihydroxyisoflavone (19) (IC(50)=0.14 mM) showed potent inhibitory activities, and inhibited Helicobacter pylori urease in a time-dependent manner. The structure-activity relationship of these polyphenols revealed: the two ortho hydroxyl groups were essential for inhibitory activity of polyphenol. When the C-ring of isoflavone was broken, the inhibitory activity markedly decreased. As for deoxybenzoin, the carboxyl group was clearly detrimental.
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