Rheological Properties Of Chitosan–tripolyphosphate Complexes: From Suspensions To Microgels
Ji Li, Qingrong Huang
Published 2012 · Chemistry
Download PDFAnalyze on Scholarcy
Complex fluids formed by crosslinking of chitosan (CS, 330 kDa) with sodium tripolyphosphate (TPP) have been studied by dynamic light scattering (DLS), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and rheology. The effects of chitosan/TPP ratios, initial chitosan or TPP concentrations, and ultrasonication time on the chitosan–TPP complex formation have been investigated. It was found that the optimum condition for CS–TPP nanoparticle formation occurred at CS/TPP mass ratio of 3.75 and with 9 min sonication treatment (energy output 3.75 W/mL). At the same initial chitosan concentration, small particle sizes (i.e., particle size < 300 nm) resulted in the formation of CS–TPP nanoparticle suspensions, which showed a lower viscosity than pure chitosan solutions, and their viscosities increased as the CS–TPP nanoparticles sizes increased. Centrifugation of CS–TPP particles of larger particle sizes (i.e., 360–870 nm) at 11,000 × g caused the formation of CS–TPP microgels. Dynamic rheological studies indicated that both storage modulus (G′) and loss modulus (G″) increased with particle sizes. During centrifugation processing, strong centrifugal force surmounted the electrostatic repulsion between CS–TPP particles and caused particles to stick with each other to form CS–TPP microgels. The water contents of microgels negligibly depended on particle size, suggesting that the free volumes of microgels were not affected by particle size, therefore supporting our pseudo-hard sphere assumption for CS–TPP nanoparticles.
This paper references
Gum arabic-chitosan complex coacervation.
Hugo Espinosa-Andrews (2007)
Biodegradable interpolyelectrolyte complexes based on methoxy poly(ethylene glycol)-b-poly(alpha,L-glutamic acid) and chitosan.
K. Luo (2008)
Composition, secondary structure, and self-assembly of oat protein isolate.
Gang Liu (2009)
Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions
A. Chenite (2001)
Chitosan-dibasic orthophosphate hydrogel: a potential drug delivery system.
Hang T Ta (2009)
Preparation and characterization of nanoparticles containing trypsin based on hydrophobically modified chitosan.
C. Liu (2005)
Structure and self-assembly properties of a new chitosan-based amphiphile.
Yuping Huang (2010)
Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines
P. Calvo (2004)
Effects of pH on the interactions and conformation of bovine serum albumin: comparison between chemical force microscopy and small-angle neutron scattering.
Yunqi Li (2008)
Biocompatible and biodegradable ultrafine fibrillar scaffold materials for tissue engineering by facile grafting of L-lactide onto chitosan.
M. Skotak (2008)
A series of novel chitosan derivatives: Synthesis, characterization and micellar solubilization of paclitaxel
Zhong Yao (2007)
Polysaccharide colloidal particles as delivery systems for macromolecules.
K. Janes (2001)
Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics.
H. Zhang (2006)
Carbon nanotube-chitosan system for electrochemical sensing based on dehydrogenase enzymes.
Maogen Zhang (2004)
Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions.
Xiaoyong Wang (2008)
Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA.
S. Richardson (1999)
Novel injectable neutral solutions of chitosan form biodegradable gels in situ.
A. Chenite (2000)
Composition and structure of whey protein/gum arabic coacervates.
F. Weinbreck (2004)
Chitosan nanoparticle as protein delivery carrier--systematic examination of fabrication conditions for efficient loading and release.
Quan Gan (2007)
Influence of wine pectic polysaccharides on the interactions between condensed tannins and salivary proteins.
E. Carvalho (2006)
Stability of chitosan nanoparticles for L-ascorbic acid during heat treatment in aqueous solution.
Keum-il Jang (2008)
Preparation and characterization of chitosan microparticles intended for controlled drug delivery.
J. A. Ko (2002)
Unique rheological behavior of chitosan-modified nanoclay at highly hydrated state.
Songmiao Liang (2009)
Chitosan nanofibers from an easily electrospinnable UHMWPEO-doped chitosan solution system.
Y. Zhang (2008)
Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate.
Yan Wu (2005)
Effects of urea and trimethylamine-N-oxide (TMAO) on the interactions of lysozyme in solution.
M. Niebuhr (2005)
Biofabrication with chitosan.
H. Yi (2005)
Polymers and Neutron Scattering
J. S. Higgins (1997)
Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers
P. Calvo (1997)
Optimization of fabrication parameters to produce chitosan-tripolyphosphate nanoparticles for delivery of tea catechins.
B. Hu (2008)
Polymers in drug delivery.
O. Pillai (2001)
Hybrid material based on chitosan and layered double hydroxides: characterization and application to the design of amperometric phenol biosensor.
E. Han (2007)
Why is chitosan mucoadhesive?
Ioannis A Sogias (2008)
This paper is referenced by
Formulation and Characterization of Chondroitin Sulfate Nanoparticle with Chitosan as Polymer and Kappa Carrageenan as Crosslinker Using the Ionic Gelation Method
Danni Ramdhani (2017)
In vitro SPF and Photostability Assays of Emulsion Containing Nanoparticles with Vegetable Extracts Rich in Flavonoids
L. C. Cefali (2018)
Pitfalls in Analyzing Release from Chitosan/Tripolyphosphate Micro- and Nanoparticles.
Yuhang Cai (2019)
Synthesis, characterization and evaluation of antioxidant properties of catechin hydrate nanoparticles
Ramneek Kaur (2017)
The effect of NaCl on the rheological properties of suspension containing spray dried starch nanoparticles.
Ai-min Shi (2012)
Characterization of the interaction between chitosan and inorganic sodium phosphates by means of rheological and optical microscopy studies.
L. Casettari (2013)
Fabrication of β-chitosan nanoparticles and its anticancer potential against human hepatoma cells.
Namasivayam Subhapradha (2017)
Distilled pyroligneous liquor obtained from Eucalyptus grandis and chitosan: physicochemical properties of the solution and films
Fabiane Grecco da Silva Porto (2018)
Fabrication of polymeric nanocapsules from curcumin-loaded nanoemulsion templates by self-assembly.
Shabbar Abbas (2015)
About the Sterilization of Chitosan Hydrogel Nanoparticles
Raquel Manozzo Galante (2016)
Development of chitosan-sodium phytate nanoparticles as a potent antibacterial agent.
J. Yang (2017)
Rheological properties of suspensions containing cross-linked starch nanoparticles prepared by spray and vacuum freeze drying methods.
A. Shi (2012)
Biomedical Application of Soft Nano-/Microparticles
Jie Wu (2015)
Effect of Chitosan and Chitosan-Nanoparticles as Active Coating on Microbiological Characteristics of Fish Fingers
Entsar S. Abdou (2012)
Suspensions of vacuum-freeze dried starch nanoparticles: influence of NaCl on their rheological properties.
Ai-min Shi (2013)
Modified chitosan thermosensitive hydrogel enables sustained and efficient anti-tumor therapy via intratumoral injection.
Yingchun Jiang (2016)
Characterization of emulsion stabilization properties of quince seed extract as a new source of hydrocolloid.
Emrah Kirtil (2016)
Tuneable Chitosan Particles with Potential Forensic and Pharmaceutical Applications
Ezzeddin M A Hejjaji (2018)
Enhanced cytotoxic activity of curcumin on cancer cell lines by incorporating into gold/chitosan nanogels
N. Amanlou (2019)
Designing chitosan-tripolyphosphate microparticles with desired size for specific pharmaceutical or forensic applications.
Ezzeddin M A Hejjaji (2017)
Micro- and Nanogel Formation through the Ionic Crosslinking of Polyelectrolytes
Yan Huang (2014)
Protein-free cress seed (Lepidium sativum) gum: Physicochemical characterization and rheological properties.
Somayeh Razmkhah (2016)
Edible coating from citrus essential oil-loaded nanoemulsions: physicochemical characterization and preservation performance
Chunhua Wu (2016)
Therapeutic Management of Pulmonary Tuberculosis by Mannosylated Chitosan Ascorbate Microspheres: Preparation and Characterization
Archana Bagre (2019)
A novel water-based chitosan-La pesticide nanocarrier enhancing defense responses in rice (Oryza sativa L) growth.
Wenlong Liang (2018)
Salt-assisted mechanistic analysis of chitosan/tripolyphosphate micro- and nanogel formation.
Yan Huang (2012)
Chitosan Nanoparticle Penetration into Shrimp Muscle and its Effects on the Microbial Quality
Alexander Chouljenko (2016)
Combined effects of two kinds of essential oils on physical, mechanical and structural properties of chitosan films
Yong Peng (2014)
Fabrication and Characterization of chitosan based polymeric Escitalopram nanoparticles
Rashi Rajput (2016)
Rheological properties and microstructure characterization of normal and waxy corn starch dry heated with soy protein isolate
C. Qiu (2015)
Properties and energetics for design and characterization of chitosan nanoparticles used for drug encapsulation
E. Koukaras (2014)
Chitosan/titanium dioxide nanocomposite coatings: Rheological behavior and surface application to cellulosic paper.
Y. Tang (2016)See more