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Mechanical Characterization Of Pharmaceutical Solids: A Comparison Between Rheological Tests Performed Under Static And Dynamic Porosity Conditions.

G. Bonacucina, M. Cespi, Monica Misici-Falzi, G. Palmieri
Published 2007 · Materials Science, Medicine

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The aim of this work was to verify how and to what extent rheological tests, carried out under dynamic (Heckel) and static (creep, stress/strain) porosity conditions, may serve as a valuable complement to the classic Heckel tests in the characterization of viscoelastic and densification properties of solid materials for pharmaceutical use. Six different modified (pregelatinized) starches were compressed in a rotary tablet machine equipped to measure force and punch displacement. Tablets were obtained using flat-faced 6mm diameter punches at different compression pressures. Compression cycles performed at the maximal pressure of 200MPa were used to build the Heckel plots. Ejected tablets at the 10%, 20%, 30%, and 40% porosity levels were used for the stress/strain and creep tests. Parameters obtained with both types of tests were consistent with each other. In particular, among the six starches, lower viscosity values corresponded to lower P(Y) values, and lower elastic modulus values corresponded to lower elastic recovery of the tablet. Mechanical properties of materials can be better characterized if viscoelastic tests performed under dynamic porosity conditions (Heckel analysis) are supported by classical viscoelastic tests carried out under conditions of static porosity.
This paper references
Compression and recovery behaviour of compacts using extended Heckel plots
K. D. Tsardaka (1988)
An analysis of powder compaction phenomena
R. W. Heckel (1961)
10.1016/0032-5910(89)80011-7
Creep compliance behaviour of direct compression excipients
J. Staniforth (1989)
Some effects of moisture on the viscoelastic behaviour of modified starch during powder compaction
J. E. Rees (1994)
10.3109/03639049609043873
The Viscoelastic Deformation of Some Tableting Materials as Assessed by Indentation Rheology
M. Celik (1996)
Apparent viscosity of particulate solids determined using creep analysis , Powder Technol
J. E. Rees K. D. Tsardaka (1990)
10.1016/S1461-5347(98)00111-4
Mechanical properties of powders for compaction and tableting: an overview.
Jain (1999)
10.1016/J.IJPHARM.2003.12.030
Application of dynamic mechanical analysis (DMA) to the determination of the mechanical properties of coated pellets.
Abraham B Bashaiwoldu (2004)
10.1002/JPS.3030431007
The physics of tablet compression. IV. Relationship of ejection, and upper and lower punch forces during compressional process: application of measurements to comparison of tablet lubricants.
E. Nelson (1954)
Plastic deformation and retarded elastic deformation of particulate solids using creep experiments
K. D. Tsardaka (1989)
10.1016/0378-5173(93)90271-G
Viscoelastic properties of some pharmaceutical powders compared using creep compliance, extended Heckel analysis and tablet strength measurements
S. Malamataris (1993)
The physics of tablet compression
E. Nelson (1955)
10.1016/0378-5173(89)90297-4
Characterization of the viscoelastic properties of compacted pharmaceutical powders by a novel nondestructive technique
G. W. Radebaugh (1989)
Effects of true density
C.M.D. Gabaude (1999)
10.1002/JPS.3030440413
The physics of tablet compression. VII. Determination of energy expenditure in the tablet compression process.
E. Nelson (1955)
Powder technology and pharmaceutical processes
D. Chulia (1994)
10.1111/j.2042-7158.1990.tb14450.x
RELATIONS BETWEEN VISCOELASTIC PARAMETERS AND COMPACTION PROPERTIES OF TWO MODIFIED STARCHES
K. D. Tsardaka (1990)
10.1016/J.IJPHARM.2005.04.033
Differences between eccentric and rotary tablet machines in the evaluation of powder densification behaviour.
G. Palmieri (2005)
10.1016/S0032-5910(05)80030-0
Apparent viscosity of particulate solids determined using creepanalysis
K. D. Tsardaka (1993)
Assessment of powder compaction
E. Doelker (1994)
10.1111/J.1151-2916.1961.TB11671.X
Expression for Effect of Porosity on Elastic Modulus of Polycrystalline Refractory Materials, Particularly Aluminum Oxide
R. Spriggs (1961)
10.1023/A:1018968502586
Evaluation of Preflo® Modified Starches as New Direct Compression Excipients. I. Tabletting Characteristics
Pradeepkumar P. Sanghvi (2004)
10.1021/JS9803050
Effects of true density, compacted mass, compression speed, and punch deformation on the mean yield pressure.
C. Gabaude (1999)
10.1016/0378-5173(90)90178-7
YOUNG'S MODULUS OF POWDERS USED AS PHARMACEUTICAL EXCIPIENTS
F. Bassam (1990)



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