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Inhibition Of Acute Nociceptive Responses In Rat Spinal Cord By A Bradykinin B1 Receptor Antagonist.

Rachel K Conley, A. Wheeldon, J. Webb, R. M. Dipardo, C. Homnick, Mark G. Bock, T. Chen, R. Chang, D. Pettibone, Susan Boyce
Published 2005 · Medicine

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This study used behavioural and in vivo electrophysiological paradigms to examine the effects of systemic and spinal administration of a bradykinin B1 receptor antagonist, compound X, on acute nociceptive responses in the rat. In behavioural experiments, compound X significantly increased the latency to withdraw the hindpaw from a radiant heat source after both intravenous and intrathecal administration, without affecting motor performance on the rotarod. In electrophysiological experiments, both intravenous and direct spinal administration of compound X attenuated the responses of single dorsal horn neurones to noxious thermal stimulation of the hindpaw. These data show that the antinociceptive effects of a bradykinin B1 receptor antagonist are mediated, at least in part, at the level of the spinal cord and suggest a role for spinal bradykinin B1 receptors in acute nociception.
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