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Modified Curcumin With Hyaluronic Acid: Combination Of Pro-drug And Nano-micelle Strategy To Address The Curcumin Challenge
J. Li, G. H. Shin, Xiguang Chen, H. Park
Published 2015 · Chemistry
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Abstract Curcumin is well known for its pleiotropic activities such as anti-oxidant, anti-inflammatory and anti-tumor properties. But curcumin has extremely low solubility in aqueous medium which limits its potential applications in food and pharmaceutical industries. In this study, the combined pro-drug and nano-micelle strategy was attempted to address the limitation. We modified curcumin with hyaluronic acid (HA) based on the understanding that the hydrophilic polymer facilitates dissolution of curcumin in water. The amphiphilic curcumin derivative self-assembled into nano-micelle in water with the size around 100 nm and low PDI (
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