Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Modified Curcumin With Hyaluronic Acid: Combination Of Pro-drug And Nano-micelle Strategy To Address The Curcumin Challenge

J. Li, G. H. Shin, Xiguang Chen, H. Park
Published 2015 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Abstract Curcumin is well known for its pleiotropic activities such as anti-oxidant, anti-inflammatory and anti-tumor properties. But curcumin has extremely low solubility in aqueous medium which limits its potential applications in food and pharmaceutical industries. In this study, the combined pro-drug and nano-micelle strategy was attempted to address the limitation. We modified curcumin with hyaluronic acid (HA) based on the understanding that the hydrophilic polymer facilitates dissolution of curcumin in water. The amphiphilic curcumin derivative self-assembled into nano-micelle in water with the size around 100 nm and low PDI (
This paper references
10.1021/jf9024807
Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers.
V. Gota (2010)
10.1021/jf4035404
Preparation of chitosan-coated nanoliposomes for improving the mucoadhesive property of curcumin using the ethanol injection method.
G. H. Shin (2013)
10.1016/j.foodchem.2008.01.038
Structural and antioxidant properties of gamma irradiated hyaluronic acid.
J. K. Kim (2008)
10.1021/mp400101k
Synergistic interaction of paclitaxel and curcumin with cyclodextrin polymer complexation in human cancer cells.
Ali O Boztas (2013)
10.1002/APP.34191
Encapsulation of curcumin by methoxy poly(ethylene glycol‐b‐aromatic anhydride) micelles
Ding-Wei Hong (2011)
10.1002/STAR.19900420507
DETERMINATION OF DEGREE OF SUBSTITUTION OF EXTRUDED BENZYLATED STARCH BY H-NMR AND UV SPECTROMETRY
J. H. Marsman (1990)
10.1016/j.ijpharm.2012.03.003
Lyophilised ready-to-use formulations of PEG-PCL-PEI nano-carriers for siRNA delivery.
Thomas Endres (2012)
10.1089/ADT.2007.064
Improving the solubility and pharmacological efficacy of curcumin by heat treatment.
B. Kurien (2007)
10.1016/j.jcis.2011.03.071
Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability.
S. Man-ju (2011)
10.5264/EIYOGAKUZASHI.44.307
Studies on products of browning reaction--antioxidative activities of products of browning reaction prepared from glucosamine
M. Oyaizu (1986)
10.1016/J.JCONREL.2007.05.015
PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner.
T. Ishida (2007)
10.1007/s00709-013-0516-9
A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke
Niyaz Ahmad (2013)
10.1016/j.biomaterials.2013.12.090
Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment.
Ornchuma Naksuriya (2014)
10.1016/J.COLSURFA.2010.09.011
Nanosized magnetofluorescent Fe3O4-curcumin conjugate for multimodal monitoring and drug targeting
L. Tran (2010)
10.1002/jps.21964
Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability.
S. Onoue (2010)
Total Phenol Analysis: Automation and Comparison with Manual Methods
K. Slinkard (1977)
10.1016/j.reprotox.2012.04.005
Reproductive effects of a pegylated curcumin.
C. J. Murphy (2012)
10.1016/J.IJPHARM.2007.01.013
Studies on curcumin and curcuminoids XXXI. Symmetric and asymmetric curcuminoids: stability, activity and complexation with cyclodextrin.
M. A. Tomren (2007)
10.1158/1940-6207.CAPR-10-0006
Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention
Shyam S. Bansal (2011)
Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells.
R. E. Eliaz (2001)
10.1016/j.ijpharm.2012.12.032
Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis.
L. Liu (2013)
10.1016/J.FOODRES.2012.12.027
Fate of curcumin encapsulated in silica nanoparticle stabilized Pickering emulsion during storage and simulated digestion
Rohan V Tikekar (2013)
10.1111/j.1742-4658.2011.08071.x
Hyaluronan–CD44 interactions as potential targets for cancer therapy
S. Misra (2011)
10.1096/fasebj.6.9.1612287
Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues
J. Scott (1992)
10.1002/mnfr.201000310
Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin.
V. Kakkar (2011)
10.1021/jf305143k
Curcumin and genistein coloaded nanostructured lipid carriers: in vitro digestion and antiprostate cancer activity.
N. P. Aditya (2013)
10.1007/978-0-387-46401-5
The molecular targets and therapeutic uses of curcumin in health and disease
B. Aggarwal (2007)
10.1016/j.drudis.2011.09.009
Curcumin nanoformulations: a future nanomedicine for cancer.
Murali M Yallapu (2012)
10.1016/j.carbpol.2013.08.067
Conjugation of curcumin onto alginate enhances aqueous solubility and stability of curcumin.
S. Dey (2014)
10.1016/j.colsurfb.2012.04.017
Curcumin loaded mixed micelles composed of Pluronic P123 and F68: preparation, optimization and in vitro characterization.
L. Zhao (2012)
10.1007/3-540-32112-8
Esterification of Polysaccharides
T. Heinze (2006)
10.1016/S0927-7757(98)00620-7
Flocculation and coalescence of micron-size emulsion droplets
I. Ivanov (1999)
10.1016/S0925-4439(96)00032-4
Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells.
M. Kuo (1996)
10.1007/978-0-387-46401-5_5
Cancer chemopreventive effects of curcumin.
Y. Surh (2007)
10.1016/J.CARBPOL.2010.08.001
Design and investigation of nanoemulsified carrier based on amphiphile-modified hyaluronic acid
M. Kong (2011)



This paper is referenced by
10.3390/molecules25092244
Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin
Abdelkader Hassani (2020)
10.1080/10408398.2019.1604490
The nanotech potential of turmeric (Curcuma longa L.) in food technology: A review
A. S. Serpa Guerra (2019)
10.1080/01480545.2018.1504058
Effect of curcumin nanoparticles on the cisplatin-induced neurotoxicity in rat
Y. Khadrawy (2019)
10.1016/J.DYEPIG.2016.07.016
Modification of curcumin with a reactive UV absorber and its dyeing and functional properties for silk
Yuyang Zhou (2016)
10.1021/acsami.7b01087
d-α-Tocopheryl Succinate/Phosphatidyl Ethanolamine Conjugated Amphiphilic Polymer-Based Nanomicellar System for the Efficient Delivery of Curcumin and To Overcome Multiple Drug Resistance in Cancer.
Omkara Swami Muddineti (2017)
10.1080/21691401.2017.1358731
Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation
M. Sharma (2018)
10.1002/jcp.25961
Therapeutic potential of novel formulated forms of curcumin in the treatment of breast cancer by the targeting of cellular and physiological dysregulated pathways
A. Tajbakhsh (2018)
10.1080/00405000.2016.1219447
Influence of fixing treatment on the color fastness and bioactivities of silk fabric dyed with curcumin
Y. Zhou (2017)
10.1111/IJFS.12916
The influence of different water types and brewing durations on the colloidal properties of green tea infusion
J. Li (2015)
10.1515/jcim-2017-0117
Neuroprotective effect of curcumin nanoparticles against rat model of status epilepticus induced by pilocarpine
Y. Khadrawy (2018)
10.1007/s00210-020-01888-0
Curcumin nanoparticles ameliorate hepatotoxicity and nephrotoxicity induced by cisplatin in rats
Mayada M El-Gizawy (2020)
10.1016/j.ijbiomac.2017.05.170
Enhancement in in vitro anti-angiogenesis activity and cytotoxicity in lung cancer cell by pectin-PVP based curcumin particulates.
D. Gaikwad (2017)
10.1007/s13318-016-0377-7
Enhancement of Curcumin Bioavailability Via the Prodrug Approach: Challenges and Prospects
Pahweenvaj Ratnatilaka Na Bhuket (2016)
10.1016/j.nano.2019.102105
Desirable PEGylation for improving tumor selectivity of hyaluronic acid-based nanoparticles via low hepatic captured, long circulation times and CD44 receptor-mediated tumor targeting.
Chao Teng (2019)
10.1016/J.LWT.2016.01.012
Calcium-alginate beads loaded with gallic acid: Preparation and characterization
J. Li (2016)
10.1016/J.FOODHYD.2018.10.027
Fabrication of ovalbumin/κ-carrageenan complex nanoparticles as a novel carrier for curcumin delivery
Hujun Xie (2019)
10.1111/1750-3841.13224
Development of Food-Grade Curcumin Nanoemulsion and its Potential Application to Food Beverage System: Antioxidant Property and In Vitro Digestion.
H. Joung (2016)
10.1142/S0218625X19501063
FILMS SPIN-COATED WITH GALLIC ACID AND THE DETECTION OF SPUN FILMS AGAINST VOLATILE ORGANIC COMPOUNDS
S. Şen (2020)
10.1016/j.colsurfb.2018.02.016
The effect of the molecular weight of hyaluronic acid on the physicochemical characterization of hyaluronic acid-curcumin conjugates and in vitro evaluation in glioma cells.
Cihui Tian (2018)
10.1016/j.foodres.2018.02.055
In vitro digestion models suitable for foods: Opportunities for new fields of application and challenges.
R. Lucas-González (2018)
10.1016/j.ejpb.2015.06.002
Curcumin-Eudragit® E PO solid dispersion: A simple and potent method to solve the problems of curcumin.
J. Li (2015)
10.1016/j.foodhyd.2020.106390
Characterization of ferulic acid encapsulation complexes with maltodextrin and hydroxypropyl methylcellulose
Ji Young Yu (2021)
10.3390/molecules23123291
Formation and Characterization of Lactoferrin-Hyaluronic Acid Conjugates and Their Effects on the Storage Stability of Sesamol Emulsions
Runhua Liu (2018)
10.5935/2446-4775.20140006
Biodisponibilidade de compostos fenólicos: um importante desafio para o desenvolvimento de fármacos?
Jacqueline Souza (2014)
10.1016/j.xphs.2018.07.009
Sustained-Release Curcumin Microparticles for Effective Prophylactic Treatment of Exocrine Dysfunction of Pancreas: A Preclinical Study on Cerulein-Induced Acute Pancreatitis.
Pratibha Anchi (2018)
10.1016/j.ijbiomac.2017.03.005
Structural characterization and bioavailability of ternary nanoparticles consisting of amylose, α-linoleic acid and β-lactoglobulin complexed with naringin.
Tao Feng (2017)
10.1016/J.MOLLIQ.2016.04.126
Physicochemical study of curcumin in oil driven nanoemulsions with surfactants
Parth Malik (2016)
10.3389/fbioe.2020.00050
Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model
Zeynep Busra Bolat (2020)
10.3390/ma13163476
Curcumin/Usnic Acid-Loaded Electrospun Nanofibers Based on Hyaluronic Acid
P. Snetkov (2020)
10.1016/j.carbpol.2020.116195
Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material.
Yumeng Duan (2020)
10.1111/1750-3841.13208
Enhancement of Curcumin Solubility by Phase Change from Crystalline to Amorphous in Cur-TPGS Nanosuspension.
G. H. Shin (2016)
10.3390/ph13010002
Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy
M. Curcio (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar