Online citations, reference lists, and bibliographies.
← Back to Search

Polymer Microspheres For Controlled Drug Release.

S. Freiberg, X. Zhu
Published 2004 · Materials Science, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Polymer microspheres can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. Since the rate of drug release is controlled by these two factors, it is important to understand the physical and chemical properties of the releasing medium. This review presents the methods used in the preparation of microspheres from monomers or from linear polymers and discusses the physio-chemical properties that affect the formation, structure, and morphology of the spheres. Topics including the effects of molecular weight, blended spheres, crystallinity, drug distribution, porosity, and sphere size are discussed in relation to the characteristics of the release process. Added control over release profiles can be obtained by the employment of core-shell systems and pH-sensitive spheres; the enhancements presented by such systems are discussed through literature examples.
This paper references
10.3109/02652049809006833
Incorporation and release of vancomycin from poly(D,L-lactide-co-glycolide) microspheres.
T. Atkins (1998)
10.1016/S0022-4804(64)80040-8
THE USE OF SILICONE RUBBER AS A CARRIER FOR PROLONGED DRUG THERAPY.
J. Folkman (1964)
10.1016/S0378-5173(98)00387-1
Silicone microspheres for pH-controlled gastrointestinal drug delivery.
V. Carelli (1999)
10.1016/S0378-5173(97)00116-6
Preparation and characterisation of poly (D,L-lactic-co-glycolic acid) microspheres containing desferrioxamine
E. Schlicher (1997)
10.1016/0168-3659(94)90263-1
Degradation of poly(d,l-lactic acid) microspheres: effect of molecular weight
T. Park (1994)
10.1016/0378-5173(96)04560-7
Interaction between nicardipine hydrochloride and polymeric microspheres for a controlled release system
N. Yuksel (1996)
10.1016/S0168-3659(02)00491-1
POE/PLGA composite microspheres: formation and in vitro behavior of double walled microspheres.
Yi-Yan Yang (2003)
10.1126/science.274.5289.959
Thermally Switchable Periodicities and Diffraction from Mesoscopically Ordered Materials
J. Weissman (1996)
10.1016/0168-3659(88)90082-X
A one-week subdermal delivery system for l-methadone based on biodegradable microcapsules
Ying Cha (1988)
10.1016/0378-5173(94)90300-X
Preparation and characterization of bupivacaine-loaded polylactide and polylactide-co-glycolide microspheres
P. Corre (1994)
10.1016/S0378-5173(00)00574-3
Effects of the rate of solvent evaporation on the characteristics of drug loaded PLLA and PDLLA microspheres.
T. Chung (2001)
10.1016/S0009-2509(99)00503-5
Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method
Y. Yang (2000)
10.1016/0168-3659(95)00125-5
Effect of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery
R. Jeyanthi (1996)
10.1002/APP.10327
Investigation on preparation and protein release of biodegradable polymer microspheres as drug‐delivery system
S. Zhou (2002)
10.1016/0378-5173(95)04369-1
In vitro and in vivo evaluation of PLAGA (50/50) microspheres containing 5-fluorouracil prepared by a solvent evaporation method
K. Çiftçi (1996)
10.1002/(SICI)1097-0290(19970120)53:2<232::AID-BIT15>3.0.CO;2-M
Production of micronic particles of biocompatible polymer using supercritical carbon dioxide.
L. Benedetti (1997)
10.1002/JPS.2600650612
In vivo and in vitro evaluation of a microencapsulated narcotic antagonist.
N. Mason (1976)
10.1002/APP.1257
Effect of polymer compositions on the fabrication of poly(ortho‐ester) microspheres for controlled release of protein
Xin-Lai Bai (2001)
10.1016/S0168-3659(02)00493-5
Double walled POE/PLGA microspheres: encapsulation of water-soluble and water-insoluble proteins and their release properties.
M. Shi (2003)
10.1016/S0142-9612(02)00084-4
Chitin/PLGA blend microspheres as a biodegradable drug-delivery system: phase-separation, degradation and release behavior.
F. Mi (2002)
10.3109/02652049309015325
Evaluation of spray drying as a method for polylactide and polylactide-co-glycolide microsphere preparation.
F. Pavanetto (1993)
10.1016/s0169-409x(00)00133-2
Key issues in non-viral gene delivery.
Pouton (1998)
10.1016/S0142-9612(98)00108-2
Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. I. In vitro degradation.
K. Leach (1998)
10.1007/3-540-68442-5_3
Polymerizations in Liquid and Supercritical Carbon Dioxide
D. Canelas (1997)
10.1016/S0168-3659(96)01502-7
Iron(III)-carboxymethylchitin microsphere for the pH-sensitive release of 6-mercaptopurine
F. L. Mi (1997)
10.1016/S0264-410X(02)00613-8
Oral immunization of adult volunteers with microencapsulated enterotoxigenic Escherichia coli (ETEC) CS6 antigen.
D. E. Katz (2003)
10.1016/0168-3659(95)00077-1
Kinetic and thermodynamic modeling of the formation of polymeric microspheres using solvent extraction/evaporation method
Wen-I Li (1995)
10.1002/cncr.11388
Therapeutic effectiveness of novel 5‐fluorouracil‐loaded poly(methylidene malonate 2.1.2)‐based microspheres on F98 glioma‐bearing rats
E. Fournier (2003)
10.1016/S0168-3659(02)00136-0
Precise control of PLG microsphere size provides enhanced control of drug release rate.
C. Berkland (2002)
10.1038/NMAT1075
Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines
C. Wang (2004)
10.1016/S0169-409X(00)00118-6
Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future.
R. Mueller (2001)
10.1016/S0378-5173(99)00394-4
Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and in vitro/in vivo evaluation.
M. Tunçay (2000)
10.1002/(SICI)1097-4628(19960912)61:11<1949::AID-APP9>3.0.CO;2-J
Preparation and characteristics of polymer-based large adsorbent particles
E. Ruckenstein (1996)
10.1016/S0939-6411(00)00099-0
Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres.
H. Ravivarapu (2000)
10.1016/S0168-3659(96)01469-1
In vitro evaluation of the hydrolytic degradation of dispersed and aggregated poly(dl-lactide-co-glycolide) microspheres
P. Sansdrap (1997)
10.1002/JPS.2600740407
Bioadhesive polymers as platforms for oral controlled drug delivery II: synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers.
H. S. Ch'ng (1985)
10.3109/02652049009028421
Microencapsulation using poly (L-lactic acid) II: Preparative variables affecting microcapsule properties.
R. Jalil (1990)
10.1002/JPS.2600731215
Characterization of drug-loaded poly(d,l-lactide) microspheres.
S. Benita (1984)
10.1016/S0376-7388(96)00269-4
The limitations of using Flory-Huggins equation for the states of solutions during asymmetric hollow-fiber formation
T. Chung (1997)
10.1007/S00396-001-0634-3
A thermosensitive amphoteric microsphere and its potential application as a biological carrier
Shi-jiang Fang (2002)
10.1016/S0168-3659(01)00289-9
Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions.
C. Berkland (2001)
10.3109/10611860008997909
Site-Specific Administration of Antisense Oligonucleotides using Biodegradable Polymer Microspheres Provides Sustained Delivery and Improved Subcellular Biodistribution in the Neostriatum of the Rat Brain
A. Khan (2000)
10.1016/S0168-3659(99)00008-5
Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: influence of encapsulation technique and polymer composition on particle characteristics.
K. F. Pistel (1999)
10.1016/S0927-7765(00)00148-X
Pulsatile drug release from poly (lactide-co-glycolide) microspheres: how does the composition of the polymer matrices affect the time interval between the initial burst and the pulsatile release of drugs?
K. Makino (2000)
10.1080/02652040010019587
The in-vitro and in-vivo characterization of PLGA:L-PLA microspheres containing dexamethasone sodium phosphate.
H. Eroğlu (2001)
10.1002/ADMA.19940060916
One-step preparation of double-walled microspheres†
K. Pekarek (1994)
10.1016/0378-5173(86)90106-7
A physicochemical study of the morphology of progesterone-loaded poly (d,l-lactide) microspheres
J. Benoît (1986)
10.1002/JPS.2600731004
Novel approach to zero-order drug delivery via immobilized nonuniform drug distribution in glassy hydrogels.
P. Lee (1984)
10.1016/S0378-5173(98)00253-1
Nifedipine loaded-polymeric microspheres: preparation and physical characteristics
M. Guyot (1998)
10.1016/S0079-6700(00)00024-1
Functional polymer microspheres
H. Kawaguchi (2000)
10.1016/S0169-409X(02)00222-3
Biomedical micro- and nano-technology
D. Grainger (2003)
10.3109/02652049709015336
In vitro controlled release kinetics of local anaesthetics from poly(D,L-lactide) and poly(lactide-co-glycolide) microspheres.
P. Le Corre (1997)
10.1211/0022357011776126
Triton‐X‐100‐modified polymer and microspheres for reversal of multidrug resistance
Z. Liu (2001)
10.1016/0142-9612(95)93575-X
Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition.
T. Park (1995)
10.1038/367258A0
Double-walled polymer microspheres for controlled drug release
K. Pekarek (1994)
10.1016/S0378-5173(96)04685-6
Gelatin microsphere cocktails of different sizes for the controlled release of anticancer drugs
R. Narayani (1996)
10.1002/(SICI)1099-0518(19990615)37:12<1877::AID-POLA17>3.0.CO;2-4
Novel drug delivery microspheres from poly(1,5-dioxepan-2-one-co-L-lactide)
U. Edlund (1999)
10.1016/0378-5173(91)90247-L
Preparation and characterization of a new controlled release ibuprofen suspension for improving suspendability
Y. Kawashima (1991)
10.1006/JCIS.1993.1075
Poly(N-isopropylacrylamide) Latices Prepared with Sodium Dodecyl Sulfate
W. Mcphee (1993)
10.1023/A:1011968707321
The Production of Uniformly Sized Polymer Microspheres
B. Amsden (2004)
10.3109/02652049009028423
Microencapsulation using poly(L-lactic acid) IV: Release properties of microcapsules containing phenobarbitone.
R. Jalil (1990)
10.1211/0022357011776469
Application of Eudragit P‐4135F for the delivery of ellagic acid to the rat lower small intestine
Young‐Il Jeong (2001)
10.1007/BF00689098
Intratumoural administration of cisplatin in slow-release devices
M. J. Deurloo (2004)
10.1016/0378-5173(95)04297-0
In vitro evaluation of a pH-sensitive hydrogel for control of GI drug delivery from silicone-based matrices
A. Bilia (1996)
10.1016/S0168-3659(97)00188-0
Influence of the microencapsulation method and peptide loading on poly(lactic acid) and poly(lactic-co-glycolic acid) degradation during in vitro testing.
C. Witschi (1998)
10.1016/0168-3659(94)90159-7
Drug delivery using biodegradable microspheres
Okada Hiroaki (1994)
10.1007/3-540-45734-8_3
Degradable polymer microspheres for controlled drug delivery
U. Edlund (2002)
10.1016/S0168-3659(99)00085-1
Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine serum albumin release.
B. Bittner (1999)
10.1002/JPS.2600541012
Investigation of factors influencing release of solid drug dispersed in inert matrices.
S. J. Desai (1965)
10.3109/02652049409040439
Controlled release of anticancer drug methotrexate from biodegradable gelatin microspheres.
R. Narayani (1994)
10.1016/S0378-5173(97)04887-4
Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradable polymer microspheres
S. Akhtar (1997)
10.1016/S0378-5173(97)00154-3
Drug release from PLA/PEG microparticulates
Y. Huang (1997)
Encyclopedia of polymer science and engineering
H. F. Mark (1985)
10.3109/10717549709052017
Carboplatin-Loaded PLGA Microspheres for Intracerebral Implantation: In Vivo Characterization.
W. Chen (1997)
10.1016/S0378-5173(99)00060-5
A method using biodegradable polylactides/polyethylene glycol for drug release with reduced initial burst.
Y. Huang (1999)
10.1002/APP.1995.070581014
pH‐responsive gelatin microspheres for oral delivery of anticancer drug methotrexate
R. Narayani (1995)
10.1023/A:1015168301339
In Vitro Characterization and in Vivo Testosterone Suppression of 6-Month Release Poly(D,L-Lactide) Leuprolide Microspheres
Byung Ho Woo (2004)
10.1016/S0378-5173(96)04856-9
Poly(palmitoyl-l-hydroxyproline ester) microspheres as potential oral controlled drug delivery system
A. Kumar (1997)
10.3109/02652048909031167
Microencapsulation using poly(L-lactic acid). I: Microcapsule properties affected by the preparative technique.
R. Jalil (1989)
10.1016/S0168-3659(00)00212-1
Microspheres for protein delivery prepared from amphiphilic multiblock copolymers. 2. Modulation of release rate.
J. Bezemer (2000)
10.1080/026520499289040
Preparation of spray-dried microspheres of indomethacin and examination of the effects of coating on dissolution rates.
D. Ermiş (1999)
10.1016/S0168-3659(98)00123-0
Conjugation of drug to poly(D,L-lactic-co-glycolic acid) for controlled release from biodegradable microspheres.
J. Oh (1999)
10.1016/S0378-5173(97)00212-3
Entrapment of drug-loaded ion-exchange particles within polymeric microparticles
M. Sriwongjanya (1997)
10.1016/0168-3659(91)90071-K
Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate
S. Izumikawa (1991)
10.3109/02652049709006813
Development of a microencapsulated form of cefuroxime axetil using pH-sensitive acrylic polymers.
M. L. Lorenzo-Lamosa (1997)
10.1016/S0142-9612(97)00188-9
Preparation and characterization of pH-sensitive proteinoid microspheres for the oral delivery of methotrexate
A. Kumar (1998)
10.1021/MA001398M
Synthesis and Characterization of Multiresponsive Core−Shell Microgels
Clinton D. Jones and (2000)
10.3109/02652049709015330
Effect of processing parameters on the properties of peptide-containing PLGA microspheres.
R. Jeyanthi (1997)
10.3109/02652049709015333
The encapsulation of a model protein in poly (D, L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility.
J. P. Mcgee (1997)
10.1016/S0378-5173(03)00087-5
Bioadhesive microspheres as a controlled drug delivery system.
Jaspreet K. Vasir (2003)
10.1016/S0168-3659(02)00235-3
Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies.
T. H. Lee (2002)
10.1006/JCIS.2000.7190
Synthesis of Highly Charged, Monodisperse Polystyrene Colloidal Particles for the Fabrication of Photonic Crystals.
Reese (2000)
10.1016/S0378-5173(96)04793-X
Evaluation of a pH-sensitive semi-interpenetrating polymer network for control of GI drug delivery
M. Buonaguidi (1997)
10.1016/S0927-7765(99)00105-8
Sustained release of 17β-estradiol from poly (lactide-co-glycolide) microspheres in vitro and in vivo
Takao Mogi (2000)
10.1016/S0939-6411(02)00035-8
A novel approach for the preparation of highly loaded polymeric controlled release dosage forms of diltiazem HCl and diclofenac sodium.
Hanan F Kakish (2002)
10.3109/02652049009021842
Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties.
R. Jalil (1990)
10.1002/1521-3935(200207)203:10/11<1364::AID-MACP1364>3.0.CO;2-6
Core–shell microspheres by dispersion polymerization as drug delivery systems
K. Sparnacci (2002)
10.1002/(SICI)1099-0518(20000301)38:5<786::AID-POLA2>3.0.CO;2-7
Morphology engineering of a novel poly(L-lactide)/poly(1,5-dioxepan-2-one) microsphere system for controlled drug delivery
U. Edlund (2000)
10.1016/0378-5173(88)90073-7
Solvent selection in the preparation of poly(dl-lactide) microspheres prepared by the solvent evaporation method
R. Bodmeier (1988)
10.1016/0168-3659(85)90051-3
Kinetics of drug release from hydrogel matrices
P. Lee (1985)
10.1016/0168-3659(86)90027-1
Initial concentration distribution as a mechanism for regulating drug release from diffusion controlled and surface erosion controlled matrix systems
P. Lee (1986)
10.1016/0168-3659(89)90047-3
The acceleration of degradation-controlled drug delivery from polyester microspheres
Y. Cha (1989)
10.1016/S0169-409X(98)00048-9
Key issues in non-viral gene delivery.
C. Pouton (2001)
Nifedipine-loaded PLGA microspheres: In vitro / in vivo comparison of drug release and polymer degradation
P. Sansdrap (1999)
10.1016/0378-5173(84)90091-7
A comparative study of the gastrointestinal transit of a pellet and tablet formulation
S. Davis (1984)
Dispersion polymerization in organic media
K. E. Barrett (1974)
10.1016/0168-3659(95)00076-3
Prediction of solvent removal profile and effect on properties for peptide-loaded PLGA microspheres prepared by solvent extraction/ evaporation method
Wen-I Li (1995)
10.1080/026520400288517
Studies on microencapsulation of 5-fluorouracil with poly(ortho ester) polymers.
Y. H. Lin (2000)
10.1016/0168-3659(94)90161-9
pH/temperature-sensitive polymers for macromolecular drug loading and release
Y. Kim (1994)
10.1016/0168-3659(94)90233-X
Characterization and morphological analysis of protein-loaded poly(lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique
C. Yan (1994)
10.1023/A:1017976014534
pH dependent hydrolysis and drug release behavior of chitosan/poly(ethylene glycol) polymer network microspheres
K. Gupta (2001)
10.1002/1521-3773(20010504)40:9<1707::AID-ANIE17070>3.0.CO;2-F
pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH**
D. Lynn (2001)
10.1016/0378-5173(96)04639-X
Effect of preparative parameters on the characteristics of poly d,l-lactide-co-glycolide)microspheres made by the double emulsion method
R. Ghaderi (1996)
10.1016/S0168-3659(97)00203-4
Design of microencapsulated chitosan microspheres for colonic drug delivery.
M. L. Lorenzo-Lamosa (1998)
10.1016/0168-3659(95)00010-6
Preparation of porous and nonporous biodegradable polymeric hollow microspheres
G. Crotts (1995)
10.1016/S0142-9612(00)00439-7
Polymeric microspheres composed of pH/temperature-sensitive polymer complex.
E. Kim (2001)



This paper is referenced by
10.1515/epoly-2014-0025
Swelling characterization of photo-cross-linked gelatin methacrylate spherical microgels for bioencapsulation
J. Jung (2014)
MANNHEIMIA HAEMOLYTICA LEUKOTOXIN - HOST CELL RECEPTOR INTERACTIONS
S. Shanthalingam (2010)
10.1002/APP.29319
Preparation, characterization, and salicylic acid release behavior of chitosan/poly(vinyl alcohol) blend microspheres
O. Şanlı (2009)
10.2478/s11696-012-0191-x
Ethylcellulose, polycaprolactone, and eudragit matrices for controlled release of piroxicam from tablets and microspheres
Kheira Diaf (2012)
10.1039/c0cp02615h
Effect of surface chemical composition on the surface potential and iso-electric point of silicon substrates modified with self-assembled monolayers.
Che-Hung Kuo (2011)
10.1016/J.ADDR.2005.04.007
Biofilms and antibiotic therapy: is there a role for combating bacterial resistance by the use of novel drug delivery systems?
A. W. Smith (2005)
In-situ Formed Bioactive Stem Cell Hydrogel Dressings from PEG-based Multifunctional Copolymers for Wound Healing
Yixiao Dong (2013)
10.1080/14787210.2017.1372192
Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis
C. Ford (2017)
10.13005/OJC/300108
Biodegradable Poly(D,L-Lactide)/Lipid Blend Microparticles Prepared by Oil-in-Water Emulsion Method for Controlled Release Drug Delivery
Y. Srisuwan (2014)
10.3109/02652048.2013.834992
Microencapsulation of mildronate in biodegradable and non-biodegradable polymers
Dagnija Loča (2014)
10.1002/psc.2491
Biodegradable paclitaxel‐loaded microparticles prepared from novel block copolymers: influence of polymer composition on drug encapsulation and release
S. Sartori (2013)
10.1109/MEMSYS.2016.7421594
Patterned soft-micropolyhedra by self-folding and molding
S. Pandey (2016)
10.1002/9781118229347.CH5
Nanotechnology‐Enabled Delivery Systems for Food Functionalization and Fortification
R. Tiwari (2012)
10.1089/ten.TEB.2011.0184
The use of micro- and nanospheres as functional components for bone tissue regeneration.
H. Wang (2012)
10.1021/la2036746
Controlled-release system mediated by a retro Diels-Alder reaction induced by the photothermal effect of gold nanorods.
S. Yamashita (2011)
PREPARATION AND CHARACTERIZATION OF NICORANDIL MICROSPHERES
Keyur S. Patel (2013)
Development and in vitro characterization of 5-flurouracil-loaded , colon-targeted drug delivery system
Hina Raza (2018)
10.3109/02652048.2011.576785
Paclitaxel-loaded polyester nanoparticles prepared by spray-drying technology: in vitro bioactivity evaluation
P. López-Gasco (2011)
10.1007/s10965-019-1872-8
pH-responsive smart gels of block copolymer [pluronic F127-co-poly(acrylic acid)] for controlled delivery of Ivabradine hydrochloride: its toxicological evaluation
N. Nasir (2019)
10.1016/J.SUPFLU.2006.01.013
Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery
A. Duarte (2006)
10.1016/j.carbpol.2019.01.001
Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation.
S. Trombino (2019)
10.15171/apb.2019.012
Development of Theophylline Microbeads Using Pregelatinized Breadfruit Starch (Artocarpus altilis) as a Novel Co-polymer for Controlled Release
A. Okunlola (2019)
10.1208/s12249-017-0720-6
Development and Evaluation of Buccal Films Based on Chitosan for the Potential Treatment of Oral Candidiasis
G. Tejada (2017)
10.1016/j.actbio.2019.01.044
Porous PolyHIPE microspheres for protein delivery from an injectable bone graft.
M. Whitely (2019)
10.1016/j.ijbiomac.2020.04.083
Alginate microbeads with internal microvoids for the sustained release of drugs.
S. Boi (2020)
10.1016/j.colsurfb.2012.05.024
Tetracycline adsorption on chitosan: a mechanistic description based on mass uptake and zeta potential measurements.
A. Caroni (2012)
10.1201/B19242-13
Polymer processing using supercritical fluid based technologies for drug delivery and tissue engineering applications
A. Duarte (2015)
10.1016/j.msec.2013.01.051
Synthesis of aligned porous poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite microspheres.
M. J. Kim (2013)
10.1016/j.addr.2018.01.016
Improving long‐term subcutaneous drug delivery by regulating material‐bioenvironment interaction☆
W. Chen (2018)
10.11648/J.PST.20160101.11
Multiparticulate Carriers for Controlled Oral Drug Delivery
R. Kamel (2016)
10.1002/PPAP.201300087
Atmospheric Plasma Surface Modification of PMMA and PP Micro‐Particles
M. Gilliam (2014)
10.1080/10601325.2012.728464
Study on Controlled Release of 5-Fluorouracil from Gelatin/Chitosan Microspheres
Z. Zhou (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar