Online citations, reference lists, and bibliographies.
← Back to Search

Microemulsion-based Hydrogel Formulation Of Ibuprofen For Topical Delivery.

Huabing Chen, Xueling Chang, Danrong Du, J. Li, H. Xu, X. Yang
Published 2006 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The purpose of this study was to construct microemulsion-base hydrogel formulation for topical delivery of ibuprofen. Ethyl oleate (EO) was screened as the oil phase of microemulsions, due to a good solubilizing capacity of the microemulison systems and excellent skin permeation rate of ibuprofen. The pseudo-ternary phase diagrams for microemulsion regions were constructed using ethyl oleate as the oil, Tween 80 as the surfactant, propylene glycol as the cosurfactant. Various microemulsion formulations were prepared and the abilities of various microemulsions to deliver ibuprofen through the skin were evaluated in vitro using Franz diffusion cells fitted with porcine skins. The in vitro permeation data showed that microemulsions increased the permeation rate of ibuprofen 5.72-30.0 times over the saturated solution. The optimum formulation consisted of 3% ibuprofen, 6% EO, 30% Tween 80/PG (2:1) and water, showed a high permeation rate of 38.06 microg cm(-2) h(-1). Xanthan gum as a gel matrix was used to construct the microemulsion-based hydrogel for improving the viscosity of microemulsion for topical administration. The studied microemulsion-based hydrogel showed a good stability. These results indicate that the studied microemulsion-based hydrogel may be a promising vehicle for topical delivery of ibuprofen.
This paper references
10.1016/S0168-3659(97)00153-3
Transdermal delivery from eutectic systems: enhanced permeation of a model drug, ibuprofen.
P. W. Stott (1998)
10.1615/CRITREVTHERDRUGCARRIERSYST.V16.I5.20
Microemulsions: an overview and pharmaceutical applications.
S. Tenjarla (1999)
10.1016/J.JCONREL.2004.06.001
A study of microemulsion systems for transdermal delivery of triptolide.
Huabing Chen (2004)
10.1016/0024-3205(86)90195-5
Skin permeability of various non-steroidal anti-inflammatory drugs in man.
T. Yano (1986)
10.1016/J.IJPHARM.2004.11.033
Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle.
D. Gulsen (2005)
10.1016/S0378-5173(03)00297-7
The in vitro delivery of NSAIDs across skin was in proportion to the delivery of essential fatty acids in the vehicle--evidence that solutes permeate skin associated with their solvation cages?
C. Heard (2003)
10.1007/S003970000151
Effects of polymer addition on the rheology of o/w microemulsions
R. Lapasin (2001)
10.1016/S1350-9462(01)00017-9
Microemulsions as ocular drug delivery systems: recent developments and future challenges
T. Vandamme (2002)
10.1016/S0378-5173(00)00402-6
pH, pK(a) and dermal delivery.
J. Hadgraft (2000)
Physical Chemical analysis of Percutaneous Absorption Process from Creams and Ointments
T. Higuchi (1960)
10.1016/j.addr.2012.09.018
Microemulsion-based media as novel drug delivery systems.
M. Lawrence (2000)
10.1016/S0378-5173(00)00559-7
Enhancing effect of polyoxyethylene alkyl ethers on the skin permeation of ibuprofen.
E. Park (2000)
10.1016/S0378-5122(98)00009-7
Comparison of the transdermal delivery of estradiol from two gel formulations.
K. Walters (1998)
10.1016/S0378-5173(99)00029-0
Preparation and evaluation of flurbiprofen-loaded microemulsion for parenteral delivery.
K. Park (1999)
10.1016/J.JCONREL.2003.11.020
Influence of carrageenan on the rheology and skin permeation of microemulsion formulations.
C. Valenta (2004)
10.1016/S0378-5173(03)00063-2
Sodium ascorbyl phosphate in topical microemulsions.
P. Spiclin (2003)
10.1016/J.IJPHARM.2005.06.023
The effect of internal structure of selected water-Tween 40-Imwitor 308-IPM microemulsions on ketoprofene release.
F. Podlogar (2005)
10.1016/S0378-5173(02)00632-4
Microemulsions for topical delivery of estradiol.
S. Peltola (2003)
10.1016/J.JCONREL.2004.06.005
Development of mucoadhesive patches for buccal administration of ibuprofen.
L. Perioli (2004)
10.1016/J.JCONREL.2003.11.004
New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo.
A. Sintov (2004)
10.1016/S0378-5173(00)00603-7
Penetration enhancement of ibuprofen from supersaturated solutions through human skin.
M. Iervolino (2001)



This paper is referenced by
10.1063/1.5064097
Solubilization of gliclazide in microemulsion stabilized using saponin-based surfactants from leaf extract of Orthosiphonaristatus (Blume) Miq
M. Abbas (2018)
10.1016/j.colsurfb.2019.110632
Lidocaine tripotassium phosphate complex laden microemulsion for prolonged local anaesthesia: In vitro and in vivo studies.
Furqan A. Maulvi (2019)
10.1002/CHIN.201208274
Bioavailability enhancement of poorly water soluble drugs: A review
A. Gupta (2011)
10.1155/2017/4654958
Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
F. Ali (2017)
10.1007/s40005-014-0119-2
Formulation and ex-vivo evaluation of metronidazole microemulsion loaded hydrogel for prevention of periodontitis
S. Pandey (2014)
10.3109/10717544.2014.898713
Preparation and evaluation of dl-praeruptorin A microemulsion based hydrogel for dermal delivery
Xianhua Zhang (2015)
10.3109/03639045.2015.1066799
Rheological and textural properties of microemulsion-based polymer gels with indomethacin
A. Froelich (2016)
10.20959/WJPR20178-8962
FORMULATION AND EVALUATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR RESVERATROL
M. Sharma (2017)
10.3109/10717544.2013.859186
Formulation development, in vitro and in vivo evaluation of microemulsion-based gel loaded with ketoprofen
Kishor V Nikumbh (2015)
10.7324/JAPS.2012.2803
Controlled Drug Delivery Approaches for Rheumatoid Arthritis
Amandeep Kaur (2012)
10.1080/02652048.2019.1637474
Tamanu oil potentiated novel sericin emulgel of levocetirizine: repurposing for topical delivery against DNCB-induced atopic dermatitis, QbD based development and in vivo evaluation
Ravi Raj Pal (2019)
10.1007/s13346-012-0109-8
Microemulsion-based antifungal gel delivery to nail for the treatment of onychomycosis: formulation, optimization, and efficacy studies
B. Barot (2012)
10.1016/j.ijpharm.2011.06.026
Evaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulations.
Neslihan Ustündağ Okur (2011)
10.1208/s12249-013-9993-6
RETRACTED ARTICLE: Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus
M. Nirmala (2013)
10.1016/j.biopha.2018.07.027
Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: An overview.
Sourav Thakur (2018)
10.1208/s12249-014-0091-1
Retraction Note: Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus
M. Nirmala (2014)
10.1016/j.ijpharm.2017.06.059
Developments of Polysorbate (Tween) based microemulsions: Preclinical drug delivery, toxicity and antimicrobial applications.
G. Kaur (2017)
10.2174/157018012799859891
Enhancement of Skin Permeation and Anti-Inflammatory Effect of Indomethacin Using Nanoemulsuion
N. Barakat (2012)
10.1016/j.ejps.2016.05.005
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats.
Ljiljana Djekic (2016)
In Vitro and In Vivo Evaluation of Diclofenac Sodium Gel Prepared with Cellulose Ether and Carbopol 934 P
Dheeraj T. Baviskar (2013)
A NOVEL APPROACH OF ENTERIC COATED PELLETS FOR IMMEDIATE RELEASE BY USING EXTRUSION-SPHERONIZATION TECHNIQUE
Bipin Bholani (2017)
Impact of Ibuprofen at Skin Level - an in vitro and in vivo Study
Lavinia Vlaia (2014)
REVIEW ON MICROEMULSION AS FUTURISTIC DRUG DELIVERY
Faizi Mu Zaffar (2013)
10.1016/j.ijpharm.2012.04.070
Investigation of surfactant/cosurfactant synergism impact on ibuprofen solubilization capacity and drug release characteristics of nonionic microemulsions.
Ljiljana Djekic (2012)
10.4314/TJPR.V12I4.7
In Vitro and In Vivo Evaluation of Diclofenac Sodium Gel Prepared with Cellulose Ether and Carbopol 934P
D. Baviskar (2013)
10.22159/AJPCR.2017.V10I8.19510
FORMULATION AND OPTIMIZATION OF CELECOXIB NANOEMULGEL
Sankha Bhattacharya (2017)
DETERMINATION OF A POORLY SOLUBLE DRUG, IBUPROFEN IN RAT PLASMA BY A SIMPLE HPLC ANALYSIS AND ITS APPLICATION IN PHARMACOKINETIC STUDY
A. Nurfazreen (2014)
10.3109/10717544.2014.898111
Cationic polymer-based micro-emulgel with self-preserving ability for transdermal delivery of diclofenac sodium
C. Yang (2015)
10.1016/j.msec.2018.12.075
Key characteristics and modelling of bigels systems: A review.
A. Shakeel (2019)
10.2147/DDDT.S111351
In situ delivery of thermosensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer
L. Wang (2016)
10.1016/j.colsurfb.2014.01.014
Amphotericin B topical microemulsion: formulation, characterization and evaluation.
Dhruv Butani (2014)
OPTIMIZATION BY 32 FACTORIAL DESIGN AND COMPONENT SCREENING OF MICONAZOLE NITRATE NANOEMULSION.
P. Shinde (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar