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Chitosan/cyclodextrin Nanoparticles As Macromolecular Drug Delivery System.
A. Krauland, M. Alonso
Published 2007 · Chemistry, Medicine
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The aim of this study was to generate a new type of nanoparticles made of chitosan (CS) and carboxymethyl-beta-cyclodextrin (CM-beta-CD) and to evaluate their potential for the association and delivery of macromolecular drugs. CS and CM-beta-CD or mixtures of CM-beta-CD/tripolyphosphate (TPP) were processed to nanoparticles via the ionotropic gelation technique. The resulting nanoparticles were in the size range of 231-383 nm and showed a positive zeta potential ranging from +20.6 to +39.7 mV. These nanoparticles were stable in simulated intestinal fluid pH 6.8 at 37 degrees C for at least 4h. Elemental analysis studies revealed the actual integration of CM-beta-CD to CS nanoparticles. Insulin and heparin used as macromolecular model drugs, could be incorporated into the different nanocarriers with association efficiencies of 85.5-93.3 and 69.3-70.6%, respectively. The association of these compounds led to an increase of the size of the nanoparticles (366-613 nm), with no significant modification of their zeta potentials (+23.3 to +37.1 mV). The release profiles of the associated macromolecules were highly dependent on the type of molecule and its interaction with the nanomatrix: insulin was very fast released (84-97% insulin within 15 min) whereas heparin remained highly associated to the nanoparticles for several hours (8.3-9.1% heparin within 8h). In summary, CS-CD (cyclodextrin) nanoparticles may be considered as nanocarriers for the fast or slow delivery of macromolecules.
This paper references
Chitosan drug binding by ionic interaction.
Yaowalak Boonsongrit (2006)
Cyclodextrins as Nasal Absorption Promoters of Insulin: Mechanistic Evaluations
Z. Shao (2004)
Formulation pH modulates the interaction of insulin with chitosan nanoparticles.
Zengshuan Ma (2002)
Chitosan microspheres with hydrocortisone and hydrocortisone-hydroxypropyl-beta-cyclodextrin inclusion complex.
J. Filipović‐Grčić (2000)
Cyclodextrins in Nasal Delivery of Low-Molecular-Weight Heparins: In Vivo and in Vitro Studies
T. Yang (2004)
Influence of cyclodextrins on the stability of the peptide salmon calcitonin in aqueous solution.
J. F. Sigurjónsdóttir (1999)
Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration
R. Fernández-Urrusuno (1999)
Varying effects of cyclodextrin derivatives on aggregation and thermal behavior of insulin in aqueous solution.
K. Tokihiro (1997)
The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
M. P. Desai (2004)
Protection Afforded by Maltosyl-β-cyclodextrin Against α-Chymotrypsin-Catalyzed Hydrolysis of a Luteinizing Hormone-Releasing Hormone Agonist, Buserelin Acetate
Kazutaka Matsubara (2004)
Cyclodextrin-enhanced solubilization of pentachlorophenol in water.
K. Hanna (2004)
Preparation and In Vitro Evaluation of Heparin-Loaded Polymeric Nanoparticles
Y. Jiao (2001)
Cyclodextrins in peptide and protein delivery.
Nasal delivery. The use of animal models to predict performance in man.
L. Illum (1996)
In Vitro and In Vivo Evaluation of Oral Heparin–Loaded Polymeric Nanoparticles in Rabbits
Y. Jiao (2002)
A new drug nanocarrier consisting of chitosan and hydoxypropylcyclodextrin.
F. Maestrelli (2006)
Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles
R. Fernández-Urrusuno (2004)
Kinetic degradation study of insulin complexed with methyl-beta cyclodextrin. Confirmation of complexation with electrospray mass spectrometry and (1)H NMR.
Y. Dotsikas (2002)
Evaluation of the clearance characteristics of bioadhesive systems in humans.
R. Soane (1999)
Chitosan and its use as a pharmaceutical excipient.
L. Illum (1998)
Separation of 3'-azido-2',3'-dideoxythymidine pronucleotide diastereoisomers in biological samples by CZE with cyclodextrin addition.
C. Perrin (2006)
Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers
P. Calvo (1997)
Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro.
M. Marschütz (2000)
Nasal administration of glucagon combined with dimethyl-β-cyclodextrin: Comparison of pharmacokinetics and pharmacodynamics of spray and powder formulations
F. Sakr (1996)
Structural background of cyclodextrin-protein interactions.
F. Aachmann (2003)
Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice.
A. Vila (2004)
Absorption Enhancing Effect of Cyclodextrins on Intranasally Administered Insulin in Rats
F. H. H. M. Merkus (2004)
Transmucosal macromolecular drug delivery.
C. Prego (2005)
Chiral separation of pharmacologically active dihydropyrimidinones with carboxymethyl‐ β‐cyclodextrin
O. Lecnik (2001)
Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
P. Jani (1990)
This paper is referenced by
1 Chitosan Derivatives : Introducing New 2 Functionalities with a Controlled Molecular 3 Architecture for Innovative Materials † 4
W. Argüelles-Monal (2018)
Theoretical investigation on insulin dimer-β-cyclodextrin interactions using docking and molecular dynamics simulation
Erma Fatiha Muhammad (2015)
Preparation and characterization of Berberine Hydrochloride and Trimethoprim Chitosan/ SBE7-β-CD microspheres
Qingping Tong (2018)
Sulfobutylether-β-cyclodextrin/chitosan nano- and microparticles and their physicochemical characteristics.
Zoltán Fülöp (2014)
Host-guest interaction and structural ordering in polymeric nanoassemblies: Influence of molecular design.
I. Antoniuk (2017)
Synthesis and characterization of a novel hydroxypropyl chitosan-graft-β-Cyclodextrin copolymer as potential drug carrier
J. Xie (2019)
Nasal Delivery of High Molecular Weight Drugs
Y. Ozsoy (2009)
Formulation of chitosan-TPP-pDNA nanocapsules for gene therapy applications.
V. Gaspar (2011)
GEMCITABINE LOADED PLGA NANOPARTICLES -AN APPROACH FOR COLORECTAL CANCER
Sutar Ps (2013)
Chitosan/sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for ocular drug delivery.
Azza A. Mahmoud (2011)
Application of chitosan and chitosan derivatives as biomaterials
C. Choi (2016)
Thermoreversible in situ gelling poloxamer-based systems with chitosan nanocomplexes for prolonged subcutaneous delivery of heparin: design and in vitro evaluation.
M. Radivojša (2013)
Systems for Drug Delivery: Safety, Animal, and Microbial Polysaccharides
Saurabh Bhatia (2016)
Analytical characterization of chitosan nanoparticles for peptide drug delivery applications
E. Ieva (2009)
Chitosan/sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for tea polyphenol encapsulation
F. Liu (2016)
Cyclodextrins as “smart” components of polymer nanoparticles
R. Gref (2012)
A vision for cyclodextrin nanoparticles in drug delivery systems and pharmaceutical applications.
Jaya R. Lakkakula (2014)
Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin.
S. Mao (2006)
Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents
Anumita Chaudhury (2010)
Preparation of novel dual-site drug delivery system based on hydroxypropyl methyl cyclodextrin.
Xi-qing Yan (2017)
Conventional and novel approaches for colon specific drug delivery
P. D. Kothawade (2015)
Chitosan–Cyclodextrin Complexes: Gene–Drug Delivery
Shahrouz Taranejoo (2015)
Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing.
Gina S. El-Feky (2017)
Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide Nanoparticles for Diabetes Treatment
Chun Y Wong (2020)
Current trends in molecular modeling methods applied to the study of cyclodextrin complexes
M. A. Quevedo (2017)
Chitosan‐Based Systems for Mucosal Delivery of Biopharmaceuticals
S. Al-Qadi (2012)
β-Cyclodextrin derivatives hybrid Fe3O4 magnetic nanoparticles as the drug delivery for ketoprofen
L. Huang (2014)
Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system
Haibo Yan (2008)
Preparation of chitosan nanoparticles using methacrylic acid.
M. R. de Moura (2008)
Polymers for targeted and/or sustained drug delivery
Joseph Jagur-Grodzinski (2009)
Polymer Scaffolds for Bone Tissue Regeneration
R. Dorati (2011)
Strategy of oral vaccination by polymeric nanoparticles : M cell targeting or bioadhesion
Laurence Plapied (2011)See more