Online citations, reference lists, and bibliographies.
← Back to Search

Effective Gene Delivery With Novel Liposomal Bubbles And Ultrasonic Destruction Technology.

R. Suzuki, T. Takizawa, Y. Negishi, N. Utoguchi, K. Maruyama
Published 2008 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
From the viewpoint of safety, non-viral vector systems represent an attractive gene delivery system for gene therapy. However, the transfection efficiency of non-viral vectors in vivo is generally very low. Previously, it was reported that microbubbles, utilized as imaging agents for diagnostic echocardiography, could promote gene delivery into cells when combined with ultrasound exposure. We therefore developed novel liposomal bubbles (Bubble liposomes) containing the lipid nanobubbles of perfluoropropane which is used as ultrasound imaging agent. These Bubble liposomes were smaller in diameter than conventional microbubbles and induced cavitation upon exposure to ultrasound. These results suggested that cavitation of these Bubble liposomes could be an efficient approach for delivering plasmid DNA into cells. In addition, in in vivo gene delivery, the combination of Bubble liposomes and ultrasound provided more effective gene delivery than conventional lipofection methods, further suggesting that Bubble liposomes could be effective as a non-viral vector system in in vivo gene delivery. In this review, we discuss the characteristics of Bubble liposomes and their potential utility as a gene delivery tool in vitro and in vivo.
This paper references
10.1023/A:1022983907223
Sonoporation: Mechanical DNA Delivery by Ultrasonic Cavitation
D. Miller (2002)
10.1016/J.BBRC.2005.08.052
Sonoporation using microbubble BR14 promotes pDNA/siRNA transduction to murine heart.
S. Tsunoda (2005)
10.1016/J.JCONREL.2006.02.013
The effects of albumin-coated microbubbles in DNA delivery mediated by therapeutic ultrasound.
M. Duvshani-Eshet (2006)
10.1073/PNAS.0602921103
Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.
S. Chen (2006)
10.1148/RADIOL.2292020500
Gene transfer with echo-enhanced contrast agents: comparison between Albunex, Optison, and Levovist in mice--initial results.
Tieli Li (2003)
10.1016/J.JCONREL.2005.08.025
Therapeutic ultrasound optimization for gene delivery: a key factor achieving nuclear DNA localization.
M. Duvshani-Eshet (2005)
10.1016/J.EXER.2007.08.006
A novel bubble liposome and ultrasound-mediated gene transfer to ocular surface: RC-1 cells in vitro and conjunctiva in vivo.
T. Yamashita (2007)
10.1016/S0301-5629(03)00899-8
Bioeffects caused by changes in acoustic cavitation bubble density and cell concentration: a unified explanation based on cell-to-bubble ratio and blast radius.
H. R. Guzmán (2003)
10.1016/J.JCONREL.2004.04.018
Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT).
K. Maruyama (2004)
CD 19-targeting liposomes containing imatinib efficiently kill Philadelphia chromosome – positive acute lymphoblastic leukemia cells
M. Harata (2004)
Tumor necrosis factor alpha-mediated tumor regression by the in vivo transfer of genes into the artery that leads to tumors.
H. Mizuguchi (1998)
10.1016/J.APRADISO.2004.03.109
Accumulation of boron compounds to tumor with polyethylene-glycol binding liposome by using neutron capture autoradiography.
Hironobu Yanagië (2004)
10.1016/J.JCONREL.2006.09.008
Gene delivery by combination of novel liposomal bubbles with perfluoropropane and ultrasound.
R. Suzuki (2007)
10.1167/IOVS.05-0889
Gene transfer to corneal epithelium and keratocytes mediated by ultrasound with microbubbles.
S. Sonoda (2006)
10.1016/J.BIOPHA.2005.05.011
Application of boron-entrapped stealth liposomes to inhibition of growth of tumour cells in the in vivo boron neutron-capture therapy model.
H. Yanagie (2006)
10.1006/BBRC.1997.6578
Selective clinical ultrasound signals mediate differential gene transfer and expression in two human prostate cancer cell lines: LnCap and PC-3.
D. Tata (1997)
10.1182/BLOOD-2004-02-0588
CD19-targeting liposomes containing imatinib efficiently kill Philadelphia chromosome-positive acute lymphoblastic leukemia cells.
M. Harata (2004)
10.1016/0301-5629(90)90105-L
Protein synthesis stimulated in sonicated sugar beet cells and protoplasts.
M. Joersbo (1990)
10.1038/sj.gt.3301678
Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle
Y. Taniyama (2002)
Intracellu - lar targeting of sodium mercaptoundecahydrododecaborate ( BSH ) to solid tumors by transferrinPEG liposomes , for boron neutroncapture therapy ( BNCT )
K. aruyama (2004)
10.1016/J.JCONREL.2006.10.026
Spinal gene transfer using ultrasound and microbubbles.
M. Takahashi (2007)
10.1089/HUM.1996.7.11-1339
Ultrasound-mediated transfection of mammalian cells.
H. Kim (1996)
10.1016/0022-1759(83)90303-4
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
T. Mosmann (1983)
10.1016/J.JCONREL.2007.02.010
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
Xinyu Wang (2007)
10.1007/s11095-005-2586-7
Intracellular Delivery of Bak BH3 Peptide by Microbubble-Enhanced Ultrasound
M. Kinoshita (2005)
Optimal drug and gene delivery in cancer cells by ultrasound-induced cavitation.
I. Larina (2005)
10.1080/10611860701499789
Effective gene delivery with liposomal bubbles and ultrasound as novel non-viral system
R. Suzuki (2007)
10.7863/jum.2004.23.12.1569
Bioeffects of Low‐Frequency Ultrasonic Gene Delivery and Safety on Cell Membrane Permeability Control
W. Wei (2004)
10.1016/J.JCONREL.2007.08.025
Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles.
R. Suzuki (2008)
10.1073/PNAS.87.15.5744
Lipid composition is important for highly efficient target binding and retention of immunoliposomes.
K. Maruyama (1990)
10.1161/HC1002.105228
Local Delivery of Plasmid DNA Into Rat Carotid Artery Using Ultrasound
Y. Taniyama (2002)
10.1016/J.BBRC.2005.07.101
A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound.
M. Kinoshita (2005)
10.1097/01.cji.0000190169.61416.f5
Dendritic Cells That Endocytosed Antigen-Containing IgG-Liposomes Elicit Effective Antitumor Immunity
K. Kawamura (2006)
10.1016/J.JCONREL.2006.08.001
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.
T. Ishida (2006)
10.1161/01.CIR.0000044916.05919.8B
Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to &agr;v-Integrins
H. Leong-Poi (2003)
10.1016/S0301-5629(98)00003-9
Artificial cavitation nuclei significantly enhance acoustically induced cell transfection.
W. J. Greenleaf (1998)
10.1016/S0301-5629(96)00089-0
A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective.
M. Miller (1996)
10.1161/01.CIR.92.5.1148
Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis.
K. Tachibana (1995)
10.1161/01.CIR.101.22.2554
Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium.
R. Shohet (2000)
10.1023/A:1010960900254
Liposomes Bearing Polyethyleneglycol-Coupled Transferrin with Intracellular Targeting Property to the Solid Tumors In Vivo
O. Ishida (2004)
10.1038/nrd1417
Microbubbles in medical imaging: current applications and future directions
J. Lindner (2004)
10.1038/sj.gt.3302843
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
H. Hatakeyama (2007)
Tumor necrosis factor alphamediated tumor regression by the in Pharmaceutics 354 ( 2008 ) 49 – 55 55 vivo transfer of genes into the artery that leads to tumors
H. izuguchi (1998)
10.1073/PNAS.84.23.8463
Transfection of mammalian cells with plasmid DNA by scrape loading and sonication loading.
M. Fechheimer (1987)



This paper is referenced by
10.1038/srep03883
Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia
Y. Endo-Takahashi (2014)
10.1016/J.PROGPOLYMSCI.2010.04.006
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—A review
Joaquim M. Oliveira (2010)
10.1002/dta.52
The hunt for gene dopers.
M. Mansour (2009)
10.1117/12.877565
The art and science of low-energy applications in medicine: pathology perspectives
Sharon L. Thomsen (2011)
10.1007/s10565-009-9144-8
Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo
D. Wells (2009)
10.1021/mp200554c
Systemic delivery systems of angiogenic gene by novel bubble liposomes containing cationic lipid and ultrasound exposure.
Y. Negishi (2012)
10.3179/JJMU.38.221
Recent progress in molecular bioeffects of ultrasound : from apoptosis to gene response
Takashi Kondo (2011)
Effect of magnetic field on the radial pulsations of a gas bubble in a non-Newtonian fluid
S. Behniaa (2015)
10.1016/J.SUPFLU.2011.01.006
Preparation of liposomes using the supercritical anti-solvent (SAS) process and comparison with a conventional method
L. Lesoin (2011)
10.1016/j.ijpharm.2013.08.041
Micro- and nanobubbles: a versatile non-viral platform for gene delivery.
Roberta Cavalli (2013)
Chapter 2 Nanoparticles Types , Classifi cation , Characterization , Fabrication Methods and Drug Delivery Applications
(2020)
10.1016/J.COLSURFA.2011.01.027
CO2/water/surfactant ternary systems and liposome formation using supercritical CO2: a review
L. Lesoin (2011)
10.3892/mmr.2012.1100
Optimization of transfection parameters for ultrasound/SonoVue microbubble-mediated hAng-1 gene delivery in vitro.
Q. Zhou (2012)
10.1002/bip.22246
Ultrasound-mediated gene delivery systems by AG73-modified Bubble liposomes.
Yoichi Negishi (2013)
10.1007/978-981-287-470-2_25-1
Bioeffects of Ultrasound and Its Therapeutic Application
Ryohei Ogawa (2015)
10.1016/j.drudis.2020.09.026
Recent advances in ultrasound-triggered drug delivery through lipid-based nanomaterials.
A. Ahmadi (2020)
10.1002/anie.201505817
Stable Encapsulated Air Nanobubbles in Water.
Y. Wang (2015)
10.1016/j.ultrasmedbio.2011.05.012
Ultrasound-triggered drug release and enhanced anticancer effect of doxorubicin-loaded poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) nanodroplets.
L. Du (2011)
10.4238/2013.April.25.3
Enhancement of recombinant adeno-associated virus mediated transgene expression by targeted echo-contrast agent.
S. Yang (2013)
10.1248/bpb.b15-00994
Preparation of Angiopep-2 Peptide-Modified Bubble Liposomes for Delivery to the Brain.
Y. Endo-Takahashi (2016)
10.1016/j.ultras.2012.05.006
Fluorescent microscope system to monitor real-time interactions between focused ultrasound, echogenic drug delivery vehicles, and live cell membranes.
S. Ibsen (2013)
10.2745/DDS.25.466
Drug delivery system utilized bubble liposome
K. Hirata (2010)
10.1021/acsami.5b02832
Ultrasound-Triggered Phase-Transition Cationic Nanodroplets for Enhanced Gene Delivery.
Di Gao (2015)
10.1371/journal.pone.0178305
Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina
Sachin S Thakur (2017)
10.1016/j.addr.2008.03.003
Liposomes in ultrasonic drug and gene delivery.
Shao-ling Huang (2008)
10.1152/ajpheart.00265.2012
Ultrasound-mediated targeted drug delivery: recent success and remaining challenges.
Jason Castle (2013)
10.1016/j.colsurfb.2014.07.051
Ultrasonically triggered drug delivery: breaking the barrier.
G. Husseini (2014)
10.1007/978-3-319-25427-2_8
Stem Cell Secretome and Paracrine Activity
F. Engel (2016)
10.1080/10717544.2017.1319433
Effective intraperitoneal gene transfection system using nanobubbles and ultrasound irradiation
Koyo Nishimura (2017)
10.1016/j.jconrel.2012.04.018
In vivo temperature controlled ultrasound-mediated intracellular delivery of cell-impermeable compounds.
A. Yudina (2012)
10.1007/978-3-642-34303-2_9
Other Molecular Imaging Technology
Xin Yang (2013)
10.1016/j.yjmcc.2010.06.007
Gene therapy for ischemic heart disease.
Madhav Lavu (2011)
See more
Semantic Scholar Logo Some data provided by SemanticScholar