← Back to Search
Dose-volume Histogram Analysis As Predictor Of Radiation Pneumonitis In Primary Lung Cancer Patients Treated With Radiotherapy.
M. Fay, A. Tan, R. Fisher, M. M. Mac Manus, A. Wirth, D. Ball
Published 2005 · Medicine
Download PDFAnalyze on Scholarcy
PURPOSE To determine the relationship between various parameters derived from lung dose-volume histogram analysis and the risk of symptomatic radiation pneumonitis (RP) in patients undergoing radical radiotherapy for primary lung cancer. METHODS AND MATERIALS The records of 156 patients with lung cancer who had been treated with radical radiotherapy (>/=45 Gy) and for whom dose-volume histogram data were available were reviewed. The incidence of symptomatic RP was correlated with a variety of parameters derived from the dose-volume histogram data, including the volume of lung receiving 10 Gy (V(10)) through 50 Gy (V(50)) and the mean lung dose (MLD). RESULTS The rate of RP at 6 months was 15% (95% confidence interval 9-22%). On univariate analysis, only V(30) (p = 0.036) and MLD (p = 0.043) were statistically significantly related to RP. V(30) correlated highly positively with MLD (r = 0.96, p < 0.001). CONCLUSION V(30) and MLD can be used to predict the risk of RP in lung cancer patients undergoing radical radiotherapy.
This paper references
Injury to the lung from cancer therapy: clinical syndromes, measurable endpoints, and potential scoring systems.
S. McDonald (1995)
Radiation and the lung: a reevaluation of the mechanisms mediating pulmonary injury.
G. Morgan (1995)
Radiation pneumonitis as a function of mean lung dose: an analysis of pooled data of 540 patients.
S. L. Kwa (1998)
A randomised phase III study of accelerated or standard fraction radiotherapy with or without concurrent carboplatin in inoperable non-small cell lung cancer: final report of an Australian multi-centre trial.
D. Ball (1999)
Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC)
M. Graham (1999)
Optimization of radiation therapy, III: A method of assessing complication probabilities from dose-volume histograms.
J. Lyman (1987)
Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy.
A. Trotti (2000)
A note on quantifying follow-up in studies of failure time.
M. Schemper (1996)
Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer.
M. L. Hernando (2001)
This paper is referenced by
Clinical dose-volume histogram analysis in predicting radiation pneumonitis in Hodgkin's lymphoma.
Eng-Siew Koh (2006)
Heart irradiation as a risk factor for radiation pneumonitis
E. Huang (2011)
Predictive Factors for Radiation Pneumonitis in Patients Receiving Intensity-modulated Radiation Therapy for Thoracic Malignancy
E AleksSorra (2013)
Incidence of radiation pneumonitis after thoracic irradiation: Dose-volume correlates.
J. Schallenkamp (2007)
A study on quantitative analysis of field size and dose by using gating system in 4D conformal radiation treatment
Youn-Sang Ji (2012)
Intensity-Modulated Radiation Therapy and Volumetric-Modulated Arc Therapy for Lung Cancer
Inga Siiner Grills (2011)
Chapter 14 – Late Effects after Radiation
Michael T Milano (2016)
adiotherapy in Lung CanCer
S. Vinod (2013)
Risk factors for radiation pneumonitis after radiotherapy in lung cancer patients : a systematic review and meta-analysis
D. Liu (2016)
Simultaneous integrated boost of intensity‐modulated radiation therapy to Stage II‐III non‐small cell lung cancer with metastatic lymph nodes
Q. Li (2020)
Inclusion of Incidental Radiation Dose to the Cardiac Atria and Ventricles Does Not Improve the Prediction of Radiation Pneumonitis in Advanced-Stage Non-Small Cell Lung Cancer Patients Treated With Intensity Modulated Radiation Therapy.
R. Wijsman (2017)
Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters.
A. Hope (2006)
Chapter 75 – Non-Hodgkin's Lymphoma
R. W. Tsang (2012)
Radiation-induced lung damage - Clinical risk profiles and predictive imaging on their way to risk-adapted individualized treatment planning?
N. Ebert (2015)
The importance of patient characteristics for the prediction of radiation-induced lung toxicity.
C. Dehing-Oberije (2009)
Relationship between radiation doses to heart substructures and radiation pneumonitis in patients with thymic epithelial tumors
N. Tomita (2020)
Analysis of Clinical and Dosimetric Factors Influencing Radiation-Induced Lung Injury in Patients with Lung Cancer
Shuiyun Han (2015)
Biological considerations when comparing proton therapy with photon therapy.
H. Paganetti (2013)
Acute severe radiation pneumonitis among non-small cell lung cancer (NSCLC) patients with moderate pulmonary dysfunction receiving definitive concurrent chemoradiotherapy: Impact of pre-treatment pulmonary function parameters
Y. Zhou (2019)
Chapter 13 – Survivorship and Late Effects
M. Milano (2011)
Lyman-Kutcher-Burman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data.
V. Semenenko (2008)
Dosimetric evaluation of a simple planning method for improving intensity-modulated radiotherapy for stage III lung cancer
J. Lu (2016)
Inhalative steroids as an individual treatment in symptomatic lung cancer patients with radiation pneumonitis grade II after radiotherapy – a single-centre experience
C. Henkenberens (2016)
A Dose Volume Histogram Analyzer Program for External Beam Radiotherapy
J. Kim (2009)
Impact of toxicity grade and scoring system on the relationship between mean lung dose and risk of radiation pneumonitis in a large cohort of patients with non-small cell lung cancer.
S. Tucker (2010)
[18F]-FDG uptake dose-response correlates with radiation pneumonitis in lung cancer patients.
M. McCurdy (2012)
Prediction of radiation pneumonitis following high-dose thoracic radiation therapy by 3 Gy/fraction for non-small cell lung cancer: analysis of clinical and dosimetric factors.
D. Oh (2009)
Association between Systemic Chemotherapy before Chemoradiation and Increased Risk of Treatment-Related Pneumonitis in Esophageal Cancer Patients Treated with Definitive Chemoradiotherapy
S. Wang (2008)
Correlation of normal lung density changes with dose after stereotactic body radiotherapy (SBRT) for early stage lung cancer
K. A. Al Feghali (2020)
Immunological Aspect of Radiation-Induced Pneumonitis, Current Treatment Strategies, and Future Prospects
A. Kainthola (2017)
Dose-volume analysis of radiation pneumonitis in non-small-cell lung cancer patients treated with concurrent cisplatinum and etoposide with or without consolidation docetaxel.
R. Bryan Barriger (2010)
Lung dose for minimally moving thoracic lesions treated with respiration gating.
I. Mihaylov (2010)See more