Online citations, reference lists, and bibliographies.
← Back to Search

Preparation And Characterization Of Propranolol Hydrochloride Nanoparticles: A Comparative Study.

N. Ubrich, P. Bouillot, C. Pellerin, M. Hoffman, P. Maincent
Published 2004 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The water-in-oil-in-water (w/o/w) emulsification process is the method of choice for the encapsulation inside polymeric particles of hydrophilic drugs such as proteins and peptides which are high molecular weight macromolecules. Our objective was to apply this technique in order to formulate nanoparticles loaded with both a hydrophilic and a low molecular weight drug such as propranolol-HCl. Nanoparticles were prepared using a pressure homogenization device with various polymers (poly--caprolactone, poly(lactide-co-glycolide), ethylcellulose) and different amounts of drug and were compared in terms of particle size, encapsulation efficiency and drug release. Higher encapsulation efficiencies were obtained with both PCL (77.3%) and PLGA (83.3%) compared to ethylcellulose (66.8%). The in vitro drug release was characterized by an initial burst and an incomplete dissolution of the drug. When decreasing the polymer/drug ratio, the release appeared more controlled and prolonged up to 8 h. It can be concluded that nanoparticles prepared by w/o/w emulsification followed by solvent evaporation might be potential drug carriers for low molecular weight and hydrophilic drugs.
This paper references
10.1070/MC1992V002N02ABEH000137
Novel Stereoselective Synthesis of the C-1-C-7 Segment of Oleandonolide and Lankanotide
A. F. Sviridov (1992)
10.2337/diab.37.2.246
New Approach for Oral Administration of Insulin With Polyalkylcyanoacrylate Nanocapsules as Drug Carrier
C. Damgé (1988)
10.1080/107175401316906892
Preparation and In Vitro Evaluation of Heparin-Loaded Polymeric Nanoparticles
Y. Jiao (2001)
10.1161/HC0202.101988
In Vitro and In Vivo Evaluation of Oral Heparin–Loaded Polymeric Nanoparticles in Rabbits
Y. Jiao (2002)
10.1016/S0168-3659(99)00253-9
The preparation and evaluation of poly(ϵ-caprolactone) microparticles containing both a lipophilic and a hydrophilic drug
M. H. Pérez (2000)
10.1016/0168-3659(94)90125-2
Distribution, kinetics and elimination of radioactivity after intravenous and intramuscular injection of 14C-savoxepine loaded poly(D,L-lactic acid) nanospheres to rats
E. Allémann (1994)
10.1070/MC2003V013N02ABEH001690
Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification–solvent evaporation
Yulia V. Chernysheva (2003)
10.1016/S0168-3659(98)00116-3
PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug.
T. Govender (1999)
10.1016/0378-5173(90)90024-X
Design of nanoparticles of less than 50 nm diameter: preparation, characterization and drug loading
B. Seijo (1990)
10.1016/0168-3659(95)00053-B
Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers
T. Verrecchia (1995)
10.1163/156856297X00380
Protein release from poly(epsilon-caprolactone) microspheres prepared by melt encapsulation and solvent evaporation techniques: a comparative study.
S. R. Jameela (1997)
10.1016/0378-5173(95)00002-Z
Biodegradable submicron carriers for peptide drugs : Preparation of DL-lactide/glycolide copolymer(PLGA)nanospheres with nafarelin acetate by a novel emulsion-phase separation method in an oil system.
Toshiyuki (1995)
10.1016/0168-3659(89)90059-X
Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen
R. Bodmeier (1989)
10.1016/0168-3659(92)90140-M
Biodegradable nanoparticles for subcutaneous administration of growth hormone releasing factor (hGRF)
J. Gautier (1992)
10.1016/0378-5173(94)00355-9
AN INVESTIGATION OF THE EFFECTS OF SOME PROCESS VARIABLES ON THE MICROENCAPSULATION OF PROPRANOLOL HYDROCHLORIDE BY THE SOLVENT EVAPORATION METHOD
D. Jones (1995)
10.1016/0168-3659(93)90070-L
A formulation method using D,L-lactic acid oligomer for protein release with reduced initial burst
Y. Tabata (1993)
Protein release from poly(lactic-co-glycolic acid) microspheres: protein stability problems.
W. Lu (1995)
10.1016/S0939-6411(97)00121-5
Properties of a peptide containing DL-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods.
Y. Kawashima (1998)
10.1016/0378-5173(90)90221-O
The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state
C. Ahlneck (1990)
10.1016/S0939-6411(97)00056-8
Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres
M. D. Blanco (1997)
10.3109/02652049009021845
Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment.
R. Alex (1990)
10.1016/S0009-3084(03)00088-4
Specific interaction of lectins with liposomes and monolayers bearing neoglycolipids.
V. Faivre (2003)
10.1081/DDC-120014576
Low Molecular Weight Heparin-Loaded Polymeric Nanoparticles: Formulation, Characterization, and Release Characteristics
V. Hoffart (2002)
10.1016/S0939-6411(98)00015-0
Preparation and characterization of nanoparticles containing an antihypertensive agent.
M. Leroueil-Le Verger (1998)
10.1021/JS950164R
Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement.
J. Molpeceres (1996)
10.1016/0378-5173(94)00177-7
Poly (DL-lactide) nanocapsules containing diclofenac: I. Formulation and stability study
S. Guterres (1995)
10.1016/S0378-5173(97)00311-6
Nanosuspensions for the formulation of poorly soluble drugs: I. Preparation by a size-reduction technique
R. Mueller (1998)
10.1016/S0168-3659(98)00056-X
A poly(D,L-lactide-co-glycolide) microsphere depot system for delivery of haloperidol.
Y. Cheng (1998)
10.1023/A:1018936815654
Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers
Hiroaki Okada (2004)
10.1002/JPS.2600830527
In vitro drug release behavior of D,L-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method.
T. Niwa (1994)
10.1016/0378-5173(89)90281-0
Nanocapsule formation by interfacial polymer deposition following solvent displacement
H. Fessi (1989)
10.1016/S0378-5173(98)00133-1
The effects of drug physico-chemical properties on release from copoly (lactic/glycolic acid) matrix
M. Miyajima (1998)



This paper is referenced by
10.1016/J.EURPOLYMJ.2006.08.023
The role of polymer/drug interactions on the sustained release from poly(dl-lactic acid) tablets
C. S. Proikakis (2006)
10.1016/j.carbpol.2016.06.096
Transdermal delivery of propranolol hydrochloride through chitosan nanoparticles dispersed in mucoadhesive gel.
Raida Al-Kassas (2016)
10.1007/S00289-010-0273-2
Encapsulation of BSA in polylactic acid–hyperbranched polyglycerol conjugate nanoparticles: preparation, characterization, and release kinetics
X. Gao (2010)
Evaluation and optimization of factors affecting novel diclofenac sodium-eudragit RS 100 nanoparticles
Khosro Adibkia (2012)
10.22028/D291-22374
The potential of nanoscale carriers for drug delivery to intestinal mucosa and skin
B. Weiss (2007)
10.3109/03639045.2013.817417
Formulation and characterization of ethylcellulose microparticles containing .l-alanyl- l-glutamine peptide
Mônica Villa Nova (2014)
10.1002/APP.31868
Synthesis and characterization of an amphiphilic hyperbranched poly(amine‐ester)‐co‐D,L‐lactide (HPAE‐co‐PLA) copolymers and their nanoparticles for protein drug delivery
Ming Jiang (2010)
Nanoparticle: An overview of preparation and characterization
S. Pal (2011)
10.1016/j.colsurfb.2009.08.043
Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents.
R. Manchanda (2010)
10.1517/17425247.2010.491508
pH modulation: a mechanism to obtain pH-independent drug release
P. Bassi (2010)
Développement de nanoparticules furtives
Marie Socha (2007)
10.1016/J.IJPHARM.2007.08.034
PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiency.
Xiangrong Song (2008)
10.1039/c3sm53003e
Modified nanoprecipitation method for polysulfone nanoparticles preparation.
Y. Liu (2014)
10.14227/DT190112P42
In Vitro Dissolution Kinetics of Captopril from Microspheres Manufactured by Solvent Evaporation
S. M. Khamanga (2012)
10.1080/02652040600682390
Celecoxib-loaded poly(D,L-lactide-co-glycolide) nanoparticles prepared using a novel and controllable combination of diffusion and emulsification steps as part of the salting-out procedure
P. McCarron (2006)
10.1002/PI.2489
Micelles formed by self-assembly of hyperbranched poly[(amine-ester)-co-(D,L-lactide)] (HPAE-co-PLA) copolymers for protein drug delivery
M. Jiang (2009)
OBTENÇÃO E CARACTERIZAÇÃO DE HIDROGÉIS DE POLIACRILAMIDA-CO-METILCELULOSE COMO SISTEMAS CARREADORES DE CLORIDRATO DE PROPRANOLOL
T. Alves (2011)
ON NANOPARTICLES : THEIR PREPARATION METHOD AND APPLICATIONS ”
B. Kumari (2018)
10.5897/AJPP2013.3463
Polymeric microparticles containing protein prepared using a controllable combination of diffusion and emulsification steps as part of the salting out procedure
González Álvarez Erika (2013)
10.1016/j.ijpharm.2011.08.016
PLGA nanoparticles loaded with the antileishmanial saponin β-aescin: factor influence study and in vitro efficacy evaluation.
H Van de Ven (2011)
10.1016/j.colsurfb.2012.09.010
Construction of amphiphilic copolymer nanoparticles based on gelatin as drug carriers for doxorubicin delivery.
Siyuan Han (2013)
10.1016/j.colsurfb.2013.06.013
The effective encapsulation of a hydrophobic lipid-insoluble drug in solid lipid nanoparticles using a modified double emulsion solvent evaporation method.
M. Nabi-Meibodi (2013)
PHARMACEUTICAL NANOTECHNOLOGY Polymer-Surfactant Nanoparticles for Sustained Release of Water-Soluble Drugs
M. Chavanpatil (2007)
10.1016/j.ijpharm.2010.01.032
Solubilization of sagopilone, a poorly water-soluble anticancer drug, using polymeric micelles for parenteral delivery.
A. Richter (2010)
10.14227/DT160109P15
The Evaluation of Eudragit Microcapsules Manufactured by Solvent Evaporation Using USP Apparatus 1
S. M. Khamanga (2009)
Formulation of nanoparticles encapsulating hydrophilic molecules following their ionic complexation
Ripal Gaudana (2011)
Targeting metastatic colorectal cancer with PLGA nanoparticles carrying MACC1 siRNA
A. R. Sousa (2018)
10.1080/17425247.2019.1651716
Biodegradable synthetic polyesters in the technology of controlled dosage forms of antihypertensive drugs – the overview
Maria Bialik (2019)
10.1602/neurorx.2.1.108
Drug transport to brain with targeted nanoparticles
J. Olivier (2011)
10.1016/J.CBPA.2005.06.006
Recent advances in small molecule drug delivery.
Argaw Kidane (2005)
10.1002/smtd.201700147
Preparation of particulate polymeric therapeutics for medical applications.
J. Zhuang (2017)
10.1109/ISIEA.2009.5356412
Realization assessment of stabilizer with presonication on size-distribution of itraconazole nanoparticulate in wet-nanomilling
R. Radzuan (2009)
See more
Semantic Scholar Logo Some data provided by SemanticScholar