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Preparation And Characterization Of Propranolol Hydrochloride Nanoparticles: A Comparative Study.
N. Ubrich, P. Bouillot, C. Pellerin, M. Hoffman, P. Maincent
Published 2004 · Chemistry, Medicine
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The water-in-oil-in-water (w/o/w) emulsification process is the method of choice for the encapsulation inside polymeric particles of hydrophilic drugs such as proteins and peptides which are high molecular weight macromolecules. Our objective was to apply this technique in order to formulate nanoparticles loaded with both a hydrophilic and a low molecular weight drug such as propranolol-HCl. Nanoparticles were prepared using a pressure homogenization device with various polymers (poly--caprolactone, poly(lactide-co-glycolide), ethylcellulose) and different amounts of drug and were compared in terms of particle size, encapsulation efficiency and drug release. Higher encapsulation efficiencies were obtained with both PCL (77.3%) and PLGA (83.3%) compared to ethylcellulose (66.8%). The in vitro drug release was characterized by an initial burst and an incomplete dissolution of the drug. When decreasing the polymer/drug ratio, the release appeared more controlled and prolonged up to 8 h. It can be concluded that nanoparticles prepared by w/o/w emulsification followed by solvent evaporation might be potential drug carriers for low molecular weight and hydrophilic drugs.
This paper references
Novel Stereoselective Synthesis of the C-1-C-7 Segment of Oleandonolide and Lankanotide
A. F. Sviridov (1992)
New Approach for Oral Administration of Insulin With Polyalkylcyanoacrylate Nanocapsules as Drug Carrier
C. Damgé (1988)
Preparation and In Vitro Evaluation of Heparin-Loaded Polymeric Nanoparticles
Y. Jiao (2001)
In Vitro and In Vivo Evaluation of Oral Heparin–Loaded Polymeric Nanoparticles in Rabbits
Y. Jiao (2002)
The preparation and evaluation of poly(ϵ-caprolactone) microparticles containing both a lipophilic and a hydrophilic drug
M. H. Pérez (2000)
Distribution, kinetics and elimination of radioactivity after intravenous and intramuscular injection of 14C-savoxepine loaded poly(D,L-lactic acid) nanospheres to rats
E. Allémann (1994)
Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification–solvent evaporation
Yulia V. Chernysheva (2003)
PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug.
T. Govender (1999)
Design of nanoparticles of less than 50 nm diameter: preparation, characterization and drug loading
B. Seijo (1990)
Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers
T. Verrecchia (1995)
Protein release from poly(epsilon-caprolactone) microspheres prepared by melt encapsulation and solvent evaporation techniques: a comparative study.
S. R. Jameela (1997)
Biodegradable submicron carriers for peptide drugs : Preparation of DL-lactide/glycolide copolymer(PLGA)nanospheres with nafarelin acetate by a novel emulsion-phase separation method in an oil system.
Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen
R. Bodmeier (1989)
Biodegradable nanoparticles for subcutaneous administration of growth hormone releasing factor (hGRF)
J. Gautier (1992)
AN INVESTIGATION OF THE EFFECTS OF SOME PROCESS VARIABLES ON THE MICROENCAPSULATION OF PROPRANOLOL HYDROCHLORIDE BY THE SOLVENT EVAPORATION METHOD
D. Jones (1995)
A formulation method using D,L-lactic acid oligomer for protein release with reduced initial burst
Y. Tabata (1993)
Protein release from poly(lactic-co-glycolic acid) microspheres: protein stability problems.
W. Lu (1995)
Properties of a peptide containing DL-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods.
Y. Kawashima (1998)
The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state
C. Ahlneck (1990)
Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres
M. D. Blanco (1997)
Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment.
R. Alex (1990)
Specific interaction of lectins with liposomes and monolayers bearing neoglycolipids.
V. Faivre (2003)
Low Molecular Weight Heparin-Loaded Polymeric Nanoparticles: Formulation, Characterization, and Release Characteristics
V. Hoffart (2002)
Preparation and characterization of nanoparticles containing an antihypertensive agent.
M. Leroueil-Le Verger (1998)
Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement.
J. Molpeceres (1996)
Poly (DL-lactide) nanocapsules containing diclofenac: I. Formulation and stability study
S. Guterres (1995)
Nanosuspensions for the formulation of poorly soluble drugs: I. Preparation by a size-reduction technique
R. Mueller (1998)
A poly(D,L-lactide-co-glycolide) microsphere depot system for delivery of haloperidol.
Y. Cheng (1998)
Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers
Hiroaki Okada (2004)
In vitro drug release behavior of D,L-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method.
T. Niwa (1994)
Nanocapsule formation by interfacial polymer deposition following solvent displacement
H. Fessi (1989)
The effects of drug physico-chemical properties on release from copoly (lactic/glycolic acid) matrix
M. Miyajima (1998)
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