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In Vitro Degradation And Controlled Release Behavior Of D,L-PLGA50 And PCL-b-D,L-PLGA50 Copolymer Microspheres.

Chang-Ming Dong, Ying-Zhi Guo, Kun-yuan Qiu, Z. Gu, X. Feng
Published 2005 · Chemistry, Medicine

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Blank and bovine serum albumin (BSA)-loaded microspheres based on poly(lactic-acid-alt-glycolic acid) (D,L-PLGA50) and poly(epsilon-caprolactone)-b-poly(lactic-acid-alt-glycolic acid) (PCL-b-D,L-PLGA50) were successfully fabricated using water-in-oil-in-water (w/o/w) double-emulsion extraction/evaporation technique. In vitro degradation of the blank microspheres was characterized by techniques including nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The PCL-b-D,L-PLGA50 copolymer (Mn: number-average molecular weight, Mw: weight-average molecular weight, Mn=44800, Mw/Mn=MWD=1.24, epsilon-caprolactone (CL) %=20.4% in molar ratio) had similar rate of molecular weight reduction compared with the D,L-PLGA50 copolymer before 5 weeks of in vitro degradation. The BSA % loading efficiency of microspheres was mainly controlled by both block copolymer composition and macromolecular architecture, while the sequence structure and the molecular weight of copolymer had no apparent effect on it. Significantly, The PCL-b-D,L-PLGA50 copolymer microspheres showed good release profiles with a nearly constant release during 20-110 days.
This paper references
10.1016/0168-3659(92)90171-M
Poly (glycolic acid-co-dl-lactic acid): diffusion or degradation controlled drug delivery?
Subodh Shah (1992)
10.1021/MA9906940
Mechanism of Cyclic Ester Polymerization Initiated with Tin(II) Octoate. 2.† Macromolecules Fitted with Tin(II) Alkoxide Species Observed Directly in MALDI−TOF Spectra
A. Kowalski (2000)
10.1016/S0032-3861(97)00178-X
Biodegradable brush-like graft polymers from poly(d,l-lactide) or poly(d,l-lactide-co-glycolide) and charge-modified, hydrophilic dextrans as backbone—Synthesis, characterization and in vitro degradation properties
Y. Li (1997)
10.1016/S0032-3861(97)10077-5
Biodegradable comb polyesters: Part 1 synthesis, characterization and structural analysis of poly(lactide) and poly(lactide-coglycolide) grafted onto water-soluble poly(vinyl alcohol) as backbone
A. Breitenbach (1998)
10.1016/0032-3861(95)94344-S
Novel star-shaped polylactide with glycerol using stannous octoate or tetraphenyl tin as catalyst: 1. Synthesis, characterization and study of their biodegradability
I. Arvanitoyannis (1995)
10.1038/71916
Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide)
Gaozhong Zhu (2000)
10.1021/MA010005W
Synthesis of Star-Shaped Poly(ε-caprolactone)-b-poly(dl-lactic acid-alt-glycolic acid) with Multifunctional Initiator and Stannous Octoate Catalyst
Chang-Ming Dong (2001)
10.1016/S0169-409X(01)00244-7
ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins.
T. Kissel (2002)
10.1002/MACP.1993.021941202
Preparation of star‐shaped polylactide with pentaerythritol and stannous octoate
S. Kim (1993)
10.1002/MASY.19900330122
Biodegradable polymeric matrix for long‐acting and zero‐order release drug delivery systems
You-Xin Li (1990)
10.1038/71889
Synthetic DNA delivery systems
D. Luo (2000)
10.1016/0142-9612(95)93575-X
Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition.
T. Park (1995)
10.1016/0032-3861(79)90009-0
Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1
D. K. Gilding (1979)
10.1016/S0168-3659(99)00149-2
Effect of polymer/basic drug interactions on the two-stage diffusion-controlled release from a poly(L-lactic acid) matrix.
M. Miyajima (1999)
10.1021/BM034247A
Recent developments in ring opening polymerization of lactones for biomedical applications.
A. Albertsson (2003)
10.1021/AR9800993
Biomaterials in drug delivery and tissue engineering: one laboratory's experience.
R. Langer (2000)
10.1002/1099-0518(20001201)38:23<4179::AID-POLA20>3.0.CO;2-5
Synthesis of poly(D,L‐lactic acid‐alt‐glycolic acid) from D,L‐3‐methylglycolide
Chang-Ming Dong (2000)
10.1007/3-540-45734-8_3
Degradable polymer microspheres for controlled drug delivery
U. Edlund (2002)
10.1016/0168-3659(90)90152-J
Mechanistic studies of macromolecular drug release from macroporous polymers. II. Models for the slow kinetics of drug release
R. Siegel (1990)
10.1016/S0168-3659(97)00188-0
Influence of the microencapsulation method and peptide loading on poly(lactic acid) and poly(lactic-co-glycolic acid) degradation during in vitro testing.
C. Witschi (1998)
10.1016/S0168-3659(03)00194-9
Biodegradable microspheres for protein delivery.
V. Sinha (2003)
10.1016/0168-3659(93)90155-X
Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(l-lactic acid) or poly (l-lactic-co-glycolic acid) A-blocks attached to central poly ( oxyethylene ) B-blocks
L. You-xin (1993)
10.1002/POLA.10848
Design of lactide copolymers as biomaterials
T. Ouchi (2004)
10.1016/S0168-3659(00)00291-1
Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method.
Y. Yang (2000)
10.1021/MA00098A003
Synthesis of O-(2'-Bromopropionyl)glycolic Acid and Its Polymerization: Synthesis of an Alternating Lactic and Glycolic Acid Copolymer
N. W. Rebert (1994)
10.1016/0032-3861(95)95307-M
Novel polylactides with aminopropanediol or aminohydroxymethylpropanediol using stannous octoate as catalyst; synthesis, characterization and study of their biodegradability: 2
I. Arvanitoyannis (1995)
10.1016/S0032-3861(01)00180-X
Synthesis of star-shaped poly(d,l-lactic acid-alt-glycolic acid) with multifunctional initiator and SnOct2 catalyst
Chang-Ming Dong (2001)
10.1002/JPS.2600730927
Controlled release of a luteinizing hormone-releasing hormone analogue from poly(d,l-lactide-co-glycolide) microspheres.
L. M. Sanders (1984)



This paper is referenced by
10.1517/17425247.2.6.1039
Current advances in sustained-release systems for parenteral drug delivery
Y. Shi (2005)
10.3390/POLYM3031377
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.
Hirenkumar K. Makadia (2011)
10.1002/MABI.200700131
Biodegradable and biomimetic poly(epsilon-caprolactone)/poly(lactobionamidoethyl methacrylate) biohybrids: synthesis, lactose-installed nanoparticles and recognition properties.
Wei Zhou (2008)
10.1021/BK-2014-1170.CH018
Engineering Hydrolytic Degradation Behavior of Poly(lactic-co-glycolic acid) through Precise Control of Monomer Sequence
J. Li (2014)
10.1080/09205063.2017.1394711
PCL and PCL-based materials in biomedical applications
Elbay Malikmammadov (2018)
10.3109/9781420086447-10
Formulation of depot delivery systems
James Joseph Cunningham (2016)
10.1016/J.COLSURFB.2007.07.008
Biodegradable microspheres containing poly(epsilon-caprolactone)-Pluronic block copolymers for temperature-responsive release of proteins.
J. Lee (2008)
Polyesters de polyols ramifiés, mélanges et formulations pharmaceutiques
Thomas R. Tice (2011)
10.1002/JBM.A.31167
Synthesis, characterization, effect of architecture on crystallization of biodegradable poly(epsilon-caprolactone)-b-poly(ethylene oxide) copolymers with different arms and nanoparticles thereof.
C. Hua (2007)
10.1002/POLA.22426
Synthesis, self‐assembly and recognition properties of biomimetic star‐shaped poly(ε‐caprolactone)‐b‐glycopolymer block copolymers
Xiaohui Dai (2008)
10.1016/j.biomaterials.2012.12.011
Engineering ear-shaped cartilage using electrospun fibrous membranes of gelatin/polycaprolactone.
J. Xue (2013)
10.1016/J.EURPOLYMJ.2009.10.020
Functionalization of carbon nanotubes with biodegradable supramolecular polypseudorotaxanes from grafted-poly(ε-caprolactone) and α-cyclodextrins
Yingkui Yang (2010)
10.1021/bm300304t
Photoresponsive poly(S-(o-nitrobenzyl)-L-cysteine)-b-PEO from a L-cysteine N-carboxyanhydride monomer: synthesis, self-assembly, and phototriggered drug release.
G. Liu (2012)
10.1002/9781118015810.CH16
Biodegradable Polymers for Emerging Clinical Use in Tissue Engineering
Shalini Verma (2011)
In vitro Tissue Engineering of Liver and Primary Lymphoid Tissues with Inverted Colloidal Crystal Scaffolds for Drug Testing Application.
J. Lee (2009)
10.1111/j.2042-7158.2012.01482.x
Accelerated in‐vitro release testing methods for extended‐release parenteral dosage forms
Jie Shen (2012)
Formulation optimization of long-acting depot injection of aripiprazole by using D-optimal mixture design.
T. Nahata (2009)
10.1177/1740349912450828
Electrospun composite polycaprolactone scaffolds for optimized tissue regeneration
M. Nelson (2012)
10.1002/JPS.20935
Formulation of spray-dried phenytoin loaded poly(epsilon-caprolactone) microcarrier intended for brain delivery to treat epilepsy.
Zhuzhu Li (2007)
Liraglutide sustained-release microsphere preparation and preparation method thereof
潘俊锋 (2011)
10.3109/9781420086447-8
Formulation development of small and large volume injections
Madhav Kamat and Patrick P. DeLuca (2016)
10.1089/teb.2007.0150
Three-dimensional cell culture matrices: state of the art.
J. Lee (2008)
10.1002/POLA.24255
Synthesis, self-assembly, drug-release behavior, and cytotoxicity of triblock and pentablock copolymers composed of poly(ε-caprolactone), poly(L-lactide), and poly(ethylene glycol)
Lin Sun (2010)
10.1002/smll.201001729
Two-photon-sensitive and sugar-targeted nanocarriers from degradable and dendritic amphiphiles.
L. Sun (2011)
10.1016/j.ijpharm.2010.07.018
Effect of medium-chain triglycerides on the release behavior of Endostar encapsulated PLGA microspheres.
Boyu Meng (2010)
10.3390/ma12091457
Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres
Xiangyu Zheng (2019)
10.1016/J.SUPFLU.2012.06.007
Carbon dioxide infusion of composite electrospun fibers for tissue engineering
M. Nelson (2012)
10.1016/J.POLYMDEGRADSTAB.2008.10.023
Enzyme-catalyzed degradation of poly(l-lactide)/poly(ɛ-caprolactone) diblock, triblock and four-armed copolymers
F. Liu (2009)
10.1016/J.SUPFLU.2010.12.013
In vitro release profiles of β-carotene encapsulated in PHBV by means of supercritical carbon dioxide micronization technique
Wagner Luiz Priamo (2011)
10.1002/jbm.a.31945
Poly(L-lactide)-b-poly(ethylene oxide) copolymers with different arms: hydrophilicity, biodegradable nanoparticles, in vitro degradation, and drug-release behavior.
Qing Liu (2009)
10.1080/15583724.2018.1437547
Approaches to Improve Therapeutic Efficacy of Biodegradable PLA/PLGA Microspheres: A Review
S. Bee (2018)
10.1002/9780470649848.CH6
Chemical Structure of Poly(Lactic Acid)
Xue Jiang (2010)
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